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Leveraging selective late-stage functionalization reactions for SAR vector interrogation in BCR/ABL kinase inhibitors 利用选择性晚期功能化反应进行BCR/ABL激酶抑制剂的SAR向量探查 Horwitz, Matthew A.; Villalgordo, Jose Manuel; Perez, Maria Gonzalez; Kranidiotis-Hisatomi, Nektarios; Mrowiec, Anna; Walker, Martin; Jahnke, Vanessa; Breuils, Laure; Chaigne, Justine; Reix, Axel; Boutillier, Romain; Fontenault, Xavier; Sage, Carleton 分享 收藏
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Diazepine Agonists of the 5-HT2C Receptor with Unprecedented Selectivity: Discovery of Bexicaserin (LP352) 5-HT2C受体具有前所未有的选择性的二氮杂䓬激动剂：Bexicaserin（LP352）的发现 Ren, Albert; Zhu, Xiuwen; Lehmann, Juerg; Kasem, Michelle; Schrader, Thomas O.; Dang, Huong; Le, Minh; Frazer, John; Unett, David J.; Grottick, Andrew J.; Whelan, Kevin T.; Morgan, Michael E.; Sage, Carleton R.; Srinivas, Nuggehally R.; Mclin, Dewey; Semple, Graeme 分享 收藏
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Discovery of 2-(((1r,4r)-4-(((4Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy) acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension Thuy-Anh Tran; Kramer, Bryan; Shin, Young-Jun; Vallar, Pureza; Boatman, P. Douglas; Zou, Ning; Sage, Carleton R.; Gharbaoui, Tawfik; Krishnan, Ashwin; Pal, Biman; Shakya, Sagar R.; Montalban, Antonio Garrido; Adams, John W.; Ramirez, Juan; Behan, Dominic P.; Shifrina, Anna; Blackburn, Anthony; Leakakos, Tina; Shi, Yunqing; Morgan, Michael; Sadeque, Abu; Chen, Weichao; Unett, David J.; Gaidarov, Ibragim; Chen, Xiaohua; Chang, Steve; Shu, Hsin-Hui; Tung, Shiu-Feng; Semple, Graeme 分享 收藏
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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor Buzard, Daniel J.; Kim, Sun Hee; Lopez, Luis; Kawasaki, Andrew; Zhu, Xiuwen; Moody, Jeanne; Thoresen, Lars; Calderon, Imelda; Ullman, Brett; Han, Sangdon; Lehmann, Juerg; Gharbaoui, Tawfik; Sengupta, Dipanjan; Calvano, Lorene; Montalban, Antonio Garrido; Ma, You-An; Sage, Carleton; Gao, Yinghong; Semple, Graeme; Edwards, Jeff; Barden, Jeremy; Morgan, Michael; Chen, Weichao; Usmani, Khawja; Chen, Chuan; Sadeque, Abu; Christopher, Ronald J.; Thatte, Jayant; Fu, Lixia; Solomon, Michelle; Mills, David; Whelan, Kevin; Al-Shamma, Hussien; Gatlin, Joel; Minh Le; Gaidarov, Ibragim; Anthony, Todd; Unett, David J.; Blackburn, Anthony; Rueter, Jaimie; Stirn, Scott; Behan, Dominic P.; Jones, Robert M. 分享 收藏
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic Acid (MK-1903): A Potent GPR109a Agonist that Lowers Free Fatty Acids in Humans Boatman, P. Douglas; Lauring, Brett; Schrader, Thomas O.; Kasem, Michelle; Johnson, Benjamin R.; Skinner, Philip; Jung, Jae-Kyu; Xu, Jerry; Cherrier, Martin C.; Webb, Peter J.; Semple, Graeme; Sage, Carleton R.; Knudsen, Jens; Chen, Ruoping; Luo, Wen-Lin; Caro, Luzelena; Cote, Josee; Lai, Eseng; Wagner, John; Taggart, Andrew K.; Carballo-Jane, Ester; Hammond, Milton; Colletti, Steven L.; Tata, James R.; Connolly, Daniel T.; Waters, M. Gerard; Richman, Jeremy G. 分享 收藏
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3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354):: A partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice Semple, Graeme; Skinner, Philip J.; Gharbaoui, Tawfik; Shin, Young-Jun; Jung, Jae-Kyu; Cherrier, Martin C.; Webb, Peter J.; Tamura, Susan Y.; Boatman, P. Douglas; Sage, Carleton R.; Schrader, Thornas O.; Chen, Ruoping; Colletti, Steven L.; Tata, James R.; Waters, M. Gerard; Cheng, Kang; Taggart, Andrew K.; Cai, Tian-Quan; Carballo-Jane, Ester; Behan, Dominic P.; Connolly, Daniel T.; Richman, Jeremy G. 分享 收藏
Analogues of Acifran: Agonists of the high and low affinity niacin receptors, GPR109a and GPR109b Jung, Jae-Kyu; Johnson, Benjamin R.; Duong, Tracy; Decaire, Marc; Uy, Jane; Gharbaoui, Tawfik; Boatman, P. Douglas; Sage, Carleton R.; Chen, Ruoping; Richman, Jeremy G.; Connolly, Daniel T.; Semple, Graeme 分享 收藏
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