Paul A. J. Janssen - Publications, H-index & Citations

Paul A. J. Janssen

机构信息待补充

80H指数

398论文数

1.9W被引数

收录论文 10

发表时间

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2005-02-26

148

PREAI

Frenkel, YV; Clark, AD; Das, K; Wang, YH; Lewi, PJ; Janssen, PAJ; Arnold, E

Structure based activity prediction of HIV-1 reverse transcriptase inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2005-01-15

PREAI

de Jonge, MR; Koymans, LMH; Vinkers, HM; Daeyaert, FFD; Heeres, J; Lewi, PJ; Janssen, PAJ

Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-11-18

142

PREAI

Guillemont, J; Pasquier, E; Palandjian, P; Vernier, D; Gaurrand, S; Lewi, PJ; Heeres, J; de Jonge, MR; Koymans, LMH; Daeyaert, FFD; Vinkers, MH; Arnold, E; Das, K; Pauwels, R; Andries, K; de Béthune, MP; Bettens, E; Hertogs, K; Wigerinck, P; Timmerman, P; Janssen, PAJ

Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-11-09

PREAI

Heeres, J; de Jonge, MR; Koymans, LMH; Daeyaert, FFD; Vinkers, M; Van Aken, KJA; Arnold, E; Das, K; Kilonda, A; Hoornaert, GJ; Compernolle, F; Cegla, M; Azzam, RA; Andries, K; de Béthune, MP; Azijn, H; Pauwels, R; Lewi, PJ; Janssen, PAJ

In search of a novel anti-HIV drug:: Multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6dimethylphenyl] amino]-2-pyrimidinyl]amino]-benzonitrile (R278474, rilpivirine)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-11-06

353

PREAI

Janssen, PAJ; Lewi, PJ; Arnold, E; Daeyaert, F; de Jonge, M; Heeres, J; Koymans, L; Vinkers, M; Guillemont, J; Pasquier, E; Kukla, M; Ludovici, D; Andries, K; de Béthune, MP; Pauwels, R; Das, K; Clark, AD; Frenkel, YV; Hughes, SH; Medaer, B; De Knaep, F; Bohets, H; De Clerck, F; Lampo, A; Williams, P; Stoffels, P

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2004-04-06

557

PREAI

Das, K; Clark, AD; Lewi, PJ; Heeres, J; de Jonge, MR; Koymans, LMH; Vinkers, HM; Daeyaert, F; Ludovici, DW; Kukla, MJ; De Corte, B; Kavash, RW; Ho, CY; Ye, H; Lichtenstein, MA; Andries, K; Pauwels, R; de Béthune, MP; Boyer, PL; Clark, P; Hughes, SH; Janssen, PAJ; Arnold, E

A pharmacophore docking algorithm and its application to the cross-docking of 18 HIV-NNRTI's in their binding pockets

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2003-12-19

PREAI

Daeyaert, F; de Jonge, M; Heeres, J; Koymans, L; Lewi, P; Vinkers, MH; Janssen, PAJ

Inhibition and substrate recognition - a computational approach applied to HIV protease

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2003-09-01

PREAI

Vinkers, HM; de Jonge, MR; Daeyaert, FD; Heeres, J; Koymans, LMH; van Lenthe, JH; Lewi, PJ; Timmerman, H; Janssen, PAJ

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

IF3.1

2003-01-01

PREAI

Lewis, PJ; de Jonge, M; Daeyaert, F; Koymans, L; Vinkers, M; Heeres, J; Janssen, PAJ; Arnold, E; Das, K; Clark, AD; Hughes, SH; Boyer, PL; de Béthune, MP; Pauwels, R; Andries, K; Kukla, M; Ludovici, D; De Corte, B; Kavash, R; Ho, C

Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

1998-12-01

102

PREAI

Smith, RH; Jorgensen, WL; Tirado-Rives, J; Lamb, ML; Janssen, PAJ; Michejda, CJ; Smith, MBK

研究方向