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V

Varadha Balaji Venkadakrishnan

Harvard Medical School
H指数:12
被引数:589

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Targeting Wnt/β-catenin and circadian regulator restores PRC2/EZH2-controlled chromatin bivalency and suppresses cell state diversity

靶向Wnt/β-catenin和昼夜节律调节因子恢复PRC2/EZH2调控的染色质双相性并抑制细胞状态多样性

Journal of Clinical Investigation
IF13.6
2026-05-010
PRE
Yang, Yatian; Zhang, Xiong; Venkadakrishnan, Varadha Balaji; Zou, Hongye; Zheng, Xingling; Guo, Shiyao; Chen, Christopher Z.; Borowsky, Alexander D.; Corey, Eva; Evans, Ronald M.; Gao, Allen C.; Dall'Era, Marc A.; Zoubeidi, Amina; Lara, Primo N.; Kung, Hsing-Jien; Chen, Xinbin; Beltran, Himisha; Chen, Hong-Wu
Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity

EZH2与DNA甲基化之间的串扰介导神经内分泌前列腺癌细胞系的塑性

Nature Communications
IF15.7
2026-02-210
OAAI
Richa Singh; Varadha Balaji Venkadakrishnan; Eddie Imada; Yasutaka Yamada; Nicholas J. Brady; Kate E. Dunmore; Richard Garner; Matthew A. Booker; Brian Hanratty; Michael C. Haffner; Michael Y. Tolstorukov; Luigi Marchionni; Brian D. Robinson; David S. Rickman; Himisha Beltran
Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

个体内表观遗传异质性是晚期前列腺癌表型亚型的基础

Nature Communications
IF15.7
2025-07-010
OAAI
Kei Mizuno; Sheng-Yu Ku; Varadha Balaji Venkadakrishnan; Martin K. Bakht; Michael Sigouros; Joanna Chan; Anna Trigos; Jordan H. Driskill; Jyothi Manohar; Abigail King; Adam G. Presser; Min Jin Kim; Alok K. Tewari; Henry W. Long; David Quigley; Toni K. Choueiri; Steven Balk; Sarah Hill; Juan Miguel Mosquera; David Einstein; Shahneen Sandhu; Mary-Ellen Taplin; Himisha Beltran
Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes
NATURE COMMUNICATIONS
IF15.7
2024-08-082
OAAI
Venkadakrishnan, Varadha Balaji; Presser, Adam G.; Singh, Richa; Booker, Matthew A.; Traphagen, Nicole A.; Weng, Kenny; Voss, Nathaniel C. E.; Mahadevan, Navin R.; Mizuno, Kei; Puca, Loredana; Idahor, Osasenaga; Ku, Sheng-Yu; Bakht, Martin K.; Borah, Ashir A.; Herbert, Zachary T.; Tolstorukov, Michael Y.; Barbie, David A.; Rickman, David S.; Brown, Myles; Beltran, Himisha
Notch signaling suppresses neuroendocrine differentiation and alters the immune microenvironment in advanced prostate cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-07-185
OAAI
Ku, Sheng-Yu; Wang, Yanqing; Garcia, Maria Mica; Yamada, Yasutaka; Mizuno, Kei; Long, Mark D.; Rosario, Spencer; Chinnam, Meenalakshmi; Al Assaad, Majd; Puca, Loredana; Kim, Min Jin; Bakht, Martin K.; Venkadakrishnan, Varadha Balaji; Robinson, Brian D.; Acosta, Andres M.; Wadosky, Kristine M.; Mosquera, Juan Miguel; Goodrich, David W.; Beltran, Himisha
Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
CANCER RESEARCH
IF16.6
2023-10-064
OA
Rawat, Chitra; Ben-Salem, Salma; Singh, Nidhi; Chauhan, Gaurav; Rabljenovic, Anja; Vaghela, Vishwa; Venkadakrishnan, Varadha Balaji; Macdonald, Jonathan D.; Dahiya, Ujjwal R.; Ghanem, Yara; Bachour, Salam; Su, Yixue; Depriest, Adam D.; Lee, Sanghee; Muldong, Michelle; Kim, Hyun-Tae; Kumari, Sangeeta; Valenzuela, Malyn May; Zhang, Dingxiao; Hu, Qiang; Cortes Gomez, Eduardo; Dehm, Scott M.; Zoubeidi, Amina; Jamieson, Christina A. M.; Nicolas, Marlo; Mckenney, Jesse; Willard, Belinda; Klein, Eric A.; Magi-Galluzzi, Cristina; Stauffer, Shaun R.; Liu, Song; Heemers, Hannelore V.
Citron kinase is a novel driver of prostate cancer progression and controls alternative splicing associated with treatment-resistance
CANCER RESEARCH
IF16.6
2023-06-020
PRE
Rawat, Chitra; Singh, Nidhi; Chauhan, Gaurav; Rabljenovic, Anja; Ben-Salem, Salma; Vaghela, Vishwa; Venkadakrishnan, Varadha B.; MacDonald, Jonathan; Dahiya, Ujjwal; DePriest, Adam D.; Lee, Sanghee; Muldong, Michelle; Kim, Hyun-Tae; Kumari, Sangeeta; Hu, Qiang; Cortes, Eduardo; Dehm, Scott M.; Zoubeidi, Amina; Jamieson, Christina A. M.; Nicolas, Marlo; McKenney, Jesse; Willard, Belinda; Klein, Eric A.; Magi-Galluzzi, Cristina; Stauffer, Shaun R.; Liu, Song; Heemers, Hannelore V.
Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
NATURE CANCER
IF28.5
2023-04-1042
OA
Bakht, Martin K.; Yamada, Yasutaka; Ku, Sheng-Yu; Venkadakrishnan, Varadha Balaji; Korsen, Joshua A.; Kalidindi, Teja M.; Mizuno, Kei; Ahn, Shin Hye; Seo, Ji-Heui; Garcia, Maria Mica; Khani, Francesca; Elemento, Olivier; Long, Henry W. W.; Chaglassian, Alain; Pillarsetty, Nagavarakishore; Lewis, Jason S.; Freedman, Matthew; Belanger, Anthony P.; Nguyen, Quang-De; Beltran, Himisha
A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer
ELIFE
IF0
2022-04-0149
PRE
Liu, Song; Kumari, Sangeeta; Hu, Qiang; Senapati, Dhirodatta; Venkadakrishnan, Varadha Balaji; Wang, Dan; DePriest, Adam D.; Schlanger, Simon E.; Ben-Salem, Salma; Valenzuela, Malyn May; Willard, Belinda; Mudambi, Shaila; Swetzig, Wendy M.; Das, Gokul M.; Shourideh, Mojgan; Koochekpour, Shahriah; Falzarano, Sara Moscovita; Magi-Galluzzi, Cristina; Yadav, Neelu; Chen, Xiwei; Lao, Changshi; Wang, Jianmin; Billaud, Jean-Noel; Heemers, Hannelore V.
Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2022-01-2114
OAAI
Bakht, Martin K.; Hayward, John J.; Shahbazi-Raz, Farsheed; Skubal, Magdalena; Tamura, Ryo; Stringer, Keith F.; Meister, Daniel; Venkadakrishnan, Varadha Balaji; Xue, Hui; Pillon, Adam; Stover, Mathew; Tronchin, Adam; Fifield, Bre-Anne; Mader, Lavleen; Ku, Sheng-Yu; Cheon, Gi Jeong; Kang, Keon Wook; Wang, Yuzhuo; Dong, Xuesen; Beltran, Himisha; Grimm, Jan; Porter, Lisa A.; Trant, John F.
Diversity in Androgen Receptor Action Among Treatment-naive Prostate Cancers Is Reflected in Treatment Response Predictions and Molecular Subtypes
EUROPEAN UROLOGY OPEN SCIENCE
IF4.5
2020-12-017
OAAI
Ben-Salem, Salma; Hu, Qiang; Liu, Yang; Alshalalfa, Mohammed; Zhao, Xin; Wang, Irene; Venkadakrishnan, Varadha Balaji; Senapati, Dhirodatta; Kumari, Sangeeta; Liu, Deli; Sboner, Andrea; Barbieri, Christopher E.; Feng, Felix; Billaud, Jean-Noel; Davicioni, Elai; Liu, Song; Heemers, Hannelore, V

研究方向

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H
Himisha Beltran
H 指数:87论文数:901被引数:4.0万
S
Salma Ben‐Salem
H 指数:19论文数:85被引数:1,105
H
Hannelore V. Heemers
H 指数:28论文数:163被引数:4,623
M
Martin Bakht
H 指数:17论文数:66被引数:1,149
S
Sheng‐Yu Ku
H 指数:25论文数:209被引数:4,394
Q
Qiang Hu
H 指数:50论文数:396被引数:7,875
Y
Yasutaka Yamada
H 指数:31论文数:134被引数:2,715
S
Sangeeta Kumari
H 指数:17论文数:126被引数:989
K
Kei Mizuno
H 指数:21论文数:136被引数:1,576
C
Cristina Magi‐Galluzzi
H 指数:74论文数:480被引数:1.9万