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L

Lauri A. Aaltonen

university of helsinki
H指数:119
被引数:7.0万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Epithelial interferon-stimulated gene programs modulate chemotherapy sensitivity in colorectal cancer via EPSTI1

上皮干扰素刺激基因程序通过EPSTI1调节结直肠癌的化疗敏感性

Oncogene
IF7.3
2026-08-210
OA
Erdogan Pekcan Erkan; Emmi Hämäläinen; Julia Kolikova; Tiia Nikupaavola; Karishma Sajnani; Kornelia Kuc; Kalle Ojala; Meiju Kukkonen; Ismaïl Hermelo; Antti Kurttila; Selja Koskensalo; Timo Tarvainen; Alli Leppä; Ilona Keränen; Carola Haapamäki; Essi Karjalainen; Monika Carpelan-Holmström; Laura Renkonen-Sinisalo; Laura Koskenvuo; Pauli Puolakkainen; Jukka-Pekka Mecklin; Juha P. Väyrynen; Elina Virolainen; Matti Nykter; Lauri A. Aaltonen; Alfonso Urbanucci; Anna Lepistö; Ari Ristimäki; Toni T. Seppälä
Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer

纳米孔测序揭示了结直肠癌中短L1转导的隐藏景观

Communications Biology
IF5.1
2026-02-120
OAAI
Päivi Nummi; Aurora Taira; Janne Ravantti; Tuukka Norri; Niko Välimäki; Anna Lepistö; Laura Renkonen-Sinisalo; Selja Koskensalo; Toni T. Seppälä; Ari Ristimäki; Kyösti Tahkola; Anne Mattila; Jan Böhm; Jukka-Pekka Mecklin; Emma Siili; Annukka Pasanen; Oskari Heikinheimo; Ralf Bützow; Auli Karhu; Lauri A. Aaltonen; Kimmo Palin; Tatiana Cajuso
Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers

肿瘤免疫背景及免疫逃逸在散发性和林奇综合征相关微卫星不稳定结直肠癌中的作用

British Journal of Cancer
IF6.8
2026-01-140
OAAI
Samantha Martin; Hanna Elomaa; Juha P. Väyrynen; Maarit Ahtiainen; Erkki-Ville Wirta; Jan Böhm; Toni T. Seppälä; Ari Ristimäki; Kyösti Tahkola; Anne Mattila; Selja Koskensalo; Laura Renkonen-Sinisalo; Anna Lepistö; Jukka-Pekka Mecklin; Kimmo Palin; Kristiina Rajamäki; Lauri A. Aaltonen
Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

包括254,000多名东亚和欧洲后代的精细图谱分析确定了136个推定的结直肠癌易感基因

NATURE COMMUNICATIONS
IF15.7
2024-04-264
OAAI
Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R.; Law, Philip J.; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N.; Thomas, Minta; Schmit, Stephanie L.; Diez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E. W.; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M.; Blackmur, James; Vaughan-Shaw, Peter G.; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A.; Conti, David V.; Schumacher, Fredrick R.; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L.; Jenkins, Mark A.; Win, Aung Ko; Pai, Rish K.; Figueiredo, Jane C.; Haile, Robert W.; Gallinger, Steven; Woods, Michael O.; Newcomb, Polly A.; Duggan, David; Cheadle, Jeremy P.; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A.; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G.; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie J.; Ruiz-Narvaez, Edward; Palmer, Julie R.; Buchanan, Daniel D.; Platz, Elizabeth A.; Visvanathan, Kala; Ulrich, Cornelia M.; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T.; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L.; Potter, John D.; Tsilidis, Kostas K.; Schulze, Matthias B.; Gunter, Marc J.; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D. Timothy; Giles, Graham G.; Southey, Melissa C.; Idos, Gregory E.; McDonnell, Kevin J.; Abu-Ful, Zomoroda; Greenson, Joel K.; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O.; van Guelpen, Bethany; Hudson, Thomas J.; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I.; Hayes, Richard B.; Martinez, Marie Elena; Thomas, Sushma S.; Pharoah, Paul D. P.; Larsson, Susanna C.; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F.; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T.; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J.; Joshi, Amit D.; Schafmayer, Clemens; Scacheri, Peter C.; Kundaje, Anshul; Schoen, Robert E.; Hampe, Jochen; Stadler, Zsofia K.; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K.; Gauderman, W. James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J.; van Duijnhoven, Franzel; Feskens, Edith J. M.; Sakoda, Lori C.; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M.; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A.; Kooperberg, Charles; Li, Christopher I.; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H.; Qu, Chenxu; McNeil, Caroline E.; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J.; Harris, Sarah E.; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S.; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G.; Gruber, Stephen B.; Houlston, Richard S.; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei
Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5

全基因组关联研究确定了小肠神经内分泌肿瘤的4个新风险位点，包括LGR5中的错义突变

GASTROENTEROLOGY
IF25.1
2023-10-012
OA
Giri, Anil K.; Aavikko, Mervi; Wartiovaara, Linnea; Lemmetyinen, Toni; Karjalainen, Juha; Mehtonen, Juha; Palin, Kimmo; Valimaki, Niko; Tamlander, Max; Saikkonen, Riikka; Karhu, Auli; Morgunova, Ekaterina; Sun, Benjamin; Runz, Heiko; Palta, Priit; Luo, Shuang; Joensuu, Heikki; Makela, Tomi P.; Kostiainen, Iiro; Schalin-Jantti, Camilla; FinnGen; Palotie, Aarno; Aaltonen, Lauri A.; Ollila, Saara; Daly, Mark J.
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries (vol 55, pg 89, 2023)

通过对欧洲和东亚祖先的100,204例和154,587对照进行多组学分析来解读结直肠癌遗传学 (第55卷，第89页，2023页)

NATURE GENETICS
IF31.8
2023-02-131
OA
Fernandez-Rozadilla, Ceres; Timofeeva, Maria; Chen, Zhishan; Law, Philip; Thomas, Minta; Schmit, Stephanie; Diez-Obrero, Virginia; Hsu, Li; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan; Blackmur, James; Vaughan-Shaw, Peter; Shu, Xiao-ou; Long, Jirong; Cai, Qiuyin; Guo, Xingyi; Lu, Yingchang; Broderick, Peter; Studd, James; Huyghe, Jeroen; Harrison, Tabitha; Conti, David; Dampier, Christopher; Devall, Mathew; Schumacher, Fredrick; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Moratalla-Navarro, Ferran; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John; Jenkins, Mark; Win, Aung Ko; Pai, Rish; Figueiredo, Jane; Haile, Robert; Gallinger, Steven; Woods, Michael; Newcomb, Polly; Duggan, David; Cheadle, Jeremy; Kaplan, Richard; Maughan, Timothy; Kerr, Rachel; Kerr, David; Kirac, Iva; Bohm, Jan; Mecklin, Lukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Zanke, Brent; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie; Ruiz-Narvaez, Edward; Palmer, Julie; Buchanan, Daniel; Platz, Elizabeth; Visvanathan, Kala; Ulrich, Cornelia; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha; Potter, John; Tsilidis, Konstantinos; Schulze, Matthias; Gunter, Marc; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Stern, Mariana; Pardamean, Bens; Bishop, Timothy; Giles, Graham; Southey, Melissa; Idos, Gregory; McDonnell, Kevin; Abu-Ful, Zomoroda; Greenson, Joel; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope; van Guelpen, Bethany; Hudson, Thomas; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja; Hayes, Richard; Martinez, Marie Elena; Thomas, Sushma; Corley, Douglas; Pharoah, Paul; Larsson, Susanna; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David; Joshi, Amit; Schafmayer, Clemens; Scacheri, Peter; Kundaje, Anshul; Nickerson, Deborah; Schoen, Robert; Hampe, Jochen; Stadler, Zsofia; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Papadopoulos, Nickolas; Edlund, Chistopher; Gauderman, William; Thomas, Duncan; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen; van Duijnhoven, Franzel; Feskens, Edith; Sakoda, Lori; Gago-Dominguez, Manuela; Wolk, Alicja; Naccarati, Alessio; Pardini, Barbara; FitzGerald, Liesel; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie; Kooperberg, Charles; Li, Christopher; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Tangen, Catherine; Mardis, Elaine; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Haiman, Christopher; Le Marchand, Loic; Wu, Anna; Qu, Chenxu; McNeil, Caroline; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian; Harris, Sarah; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Moreno, Victor; Casey, Graham; Gruber, Stephen; Tomlinson, Ian; Zheng, Wei; Dunlop, Malcolm; Houlston, Richard; Peters, Ulrike
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

通过对欧洲和东亚祖先的100,204例病例和154,587对照进行多组学分析来破译结直肠癌遗传学

NATURE GENETICS
IF31.8
2022-12-2072
OA
Fernandez-Rozadilla, Ceres; Timofeeva, Maria; Chen, Zhishan; Law, Philip; Thomas, Minta; Bien, Stephanie; Diez-Obrero, Virginia; Li, Li; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Harris, Sarah; Svinti, Victoria; McDonnell, Kevin; Farrington, Susan; Studd, James; Vaughan-Shaw, Peter; Shu, Xiao-ou; Long, Jirong; Cai, Qiuyin; Guo, Xingyi; Lu, Yingchang; Scacheri, Peter; Studd, James; Huyghe, Jeroen; Harrison, Tabitha; Shibata, David; Haiman, Christopher; Devall, Mathew; Schumacher, Fredrick; Melas, Marilena; Rennert, Gad; Obon-Santacana, Mireia; Martin-Sanchez, Vicente; Moratalla-Navarro, Ferran; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Potter, John; Jenkins, Mark; Win, Aung Ko; Pai, Rish; Figueiredo, Jane; Haile, Robert; Gallinger, Steven; Woods, Michael; Newcomb, Polly; Shibata, David; Cheadle, Jeremy; Kaplan, Richard; Maughan, Timothy; Kerr, Rachel; Kerr, David; Kirac, Iva; Boehm, Jan; Mecklin, Lukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan; Cajuso, Tatiana; Hanninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Zanke, Brent; Mannisto, Satu; Albanes, Demetrius; Weinstein, Stephanie; Ruiz-Narvaez, Edward; Palmer, Julie; Buchanan, Daniel; Platz, Elizabeth; Visvanathan, Kala; Ulrich, Cornelia; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha; Potter, John; Tsilidis, Konstantinos; Schulze, Matthias; Gunter, Marc; Murphy, Neil; Castells, Antoni; Castellvi-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Stern, Mariana; Pardamean, Bens; Bishop, Timothy; Giles, Graham; Southey, Melissa; Idos, Gregory; McDonnell, Kevin; Abu-Ful, Zomoroda; Greenson, Joel; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope; van Guelpen, Bethany; Hudson, Thomas; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja; Hayes, Richard; Martinez, Marie Elena; Thomas, Sushma; Corley, Douglas; Pharoah, Paul; Larsson, Susanna; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew; Cruz-Correa, Marcia; Lindblom, Annika; Shibata, David; Joshi, Amit; Schafmayer, Clemens; Scacheri, Peter; Kundaje, Anshul; Nickerson, Deborah; Schoen, Robert; Hampe, Jochen; Stadler, Zsofia; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Papadopoulos, Nickolas; Edlund, Chistopher; Gauderman, William; Thomas, Duncan; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Gruber, Stephen; van Duijnhoven, Franzel; Feskens, Edith; Sakoda, Lori; Gago-Dominguez, Manuela; Wolk, Alicja; Naccarati, Alessio; Pardini, Barbara; FitzGerald, Liesel; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie; Kooperberg, Charles; Li, Christopher; Lin, Yi; Prentice, Ross; Qu, Conghui; Bezieau, Stephane; Tangen, Catherine; Mardis, Elaine; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Haiman, Christopher; Le Marchand, Loic; Wu, Anna; Qu, Chenxu; McNeil, Caroline; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian; Harris, Sarah; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Moreno, Victor; Casey, Graham; Gruber, Stephen; Tomlinson, Ian; Zheng, Wei; Dunlop, Malcolm; Houlston, Richard; Peters, Ulrike
Parity associates with chromosomal damage in uterine leiomyomas
NATURE COMMUNICATIONS
IF15.7
2021-09-142
OAAI
Kuisma, Heli; Bramante, Simona; Rajamaki, Kristiina; Sipila, Lauri J.; Kaasinen, Eevi; Kaukomaa, Jaana; Palin, Kimmo; Makinen, Netta; Sjoberg, Jari; Sarvilinna, Nanna; Taipale, Jussi; Kauppi, Liisa; Tumiati, Manuela; Hassinen, Antti; Pitkaniemi, Janne; Jalkanen, Jyrki; Heikkinen, Sanna; Pasanen, Annukka; Heikinheimo, Oskari; Butzow, Ralf; Valimaki, Niko; Aaltonen, Lauri A.
Uterine leiomyomas in hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome can be identified through distinct clinical characteristics and typical morphology

遗传性平滑肌瘤病和肾细胞癌 (HLRCC) 综合征中的子宫平滑肌瘤可以通过独特的临床特征和典型形态来识别

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
IF3.1
2021-09-0313
OA
Uimari, Outi; Ahtikoski, Anne; Kampjarvi, Kati; Butzow, Ralf; Jarvela, Ilkka Y.; Ryynanen, Markku; Aaltonen, Lauri A.; Vahteristo, Pia; Kuismin, Outi
Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma
Nature
IF48.5
2021-08-040
PREAI
Davide G. Berta; Heli Kuisma; Niko Välimäki; Maritta Räisänen; Maija Jäntti; Annukka Pasanen; Auli Karhu; Jaana Kaukomaa; Aurora Taira; Tatiana Cajuso; Sanna Nieminen; Rosa-Maria Penttinen; Saija Ahonen; Rainer Lehtonen; Miika Mehine; Pia Vahteristo; Jyrki Jalkanen; Biswajyoti Sahu; Janne Ravantti; Netta Mäkinen; Kristiina Rajamäki; Kimmo Palin; Jussi Taipale; Oskari Heikinheimo; Ralf Bützow; Eevi Kaasinen; Lauri A. Aaltonen

研究方向

暂未获取到该数据
J
Jukka‐Pekka Mecklin
H 指数:98论文数:522被引数:4.6万
A
Auli Karhu
H 指数:42论文数:129被引数:9,928
H
Heikki Järvinen
H 指数:85论文数:353被引数:3.1万
K
Kimmo Palin
H 指数:40论文数:143被引数:1.2万
P
Pia Vahteristo
H 指数:44论文数:161被引数:7,143
E
Eevi Kaasinen
H 指数:37论文数:123被引数:6,658
R
Riku Katainen
H 指数:26论文数:88被引数:3,957
R
Richard S. Houlston
H 指数:120论文数:1,251被引数:6.1万
S
Sari Tuupanen
H 指数:28论文数:137被引数:4,073
E
Esa Pitkänen
H 指数:43论文数:199被引数:1.3万