未登录 Molecular architecture of synaptic vesicles 突触小泡的分子结构 Kravcenko, Uljana; Ruwolt, Max; Kroll, Jana; Yushkevich, Artsemi; Zenkner, Martina; Ruta, Julia; Lotfy, Rowaa; Wanker, Erich E.; Rosenmund, Christian; Liu, Fan; Kudryashev, Mikhail 分享 收藏
AI Promoted Virtual Screening, Structure-Based Hit Optimization, and Synthesis of Novel COVID-19 S-RBD Domain Inhibitors Gkekas, Ioannis; Katsamakas, Sotirios; Mylonas, Stelios; Fotopoulou, Theano; Magoulas, George E.; Tenchiu, Alia Cristina; Dimitriou, Marios; Axenopoulos, Apostolos; Rossopoulou, Nafsika; Kostova, Simona; Wanker, Erich E.; Katsila, Theodora; Papahatjis, Demetris; Gorgoulis, Vassilis G.; Koufaki, Maria; Karakasiliotis, Ioannis; Calogeropoulou, Theodora; Daras, Petros; Petrakis, Spyros 分享 收藏
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure Lisowski, Pawel; Lickfett, Selene; Rybak-Wolf, Agnieszka; Menacho, Carmen; Le, Stephanie; Pentimalli, Tancredi Massimo; Notopoulou, Sofia; Dykstra, Werner; Oehler, Daniel; Lopez-Calcerrada, Sandra; Mlody, Barbara; Otto, Maximilian; Wu, Haijia; Richter, Yasmin; Roth, Philipp; Anand, Ruchika; Kulka, Linda A. M.; Meierhofer, David; Glazar, Petar; Legnini, Ivano; Telugu, Narasimha Swamy; Hahn, Tobias; Neuendorf, Nancy; Miller, Duncan C.; Boeddrich, Annett; Polzin, Amin; Mayatepek, Ertan; Diecke, Sebastian; Olzscha, Heidi; Kirstein, Janine; Ugalde, Cristina; Petrakis, Spyros; Cambridge, Sidney; Rajewsky, Nikolaus; Kuehn, Ralf; Wanker, Erich E.; Priller, Josef; Metzger, Jakob J.; Prigione, Alessandro 分享 收藏
分享 收藏
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor Trepte, Philipp; Secker, Christopher; Olivet, Julien; Blavier, Jeremy; Kostova, Simona; Maseko, Sibusiso B.; Minia, Igor; Silva Ramos, Eduardo; Cassonnet, Patricia; Golusik, Sabrina; Zenkner, Martina; Beetz, Stephanie; Liebich, Mara J.; Scharek, Nadine; Schuetz, Anja; Sperling, Marcel; Lisurek, Michael; Wang, Yang; Spirohn, Kerstin; Hao, Tong; Calderwood, Michael A.; Hill, David E.; Landthaler, Markus; Choi, Soon Gang; Twizere, Jean-Claude; Vidal, Marc; Wanker, Erich E. 分享 收藏
Nuclear oncoprotein prothymosin α is a partner of Keap1:: Implications for expression of oxidative stress-protecting genes Karapetian, RN; Evstafieva, AG; Abaeva, IS; Chichkova, NV; Filonov, GS; Rubtsov, YP; Sukhacheva, EA; Melnikov, SV; Schneider, U; Wanker, EE; Vartapetian, AB 分享 收藏
Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches Smith, Edward J.; Sathasivam, Kirupa; Landles, Christian; Osborne, Georgina F.; Mason, Michael A.; Gomez-Paredes, Casandra; Taxy, Bridget A.; Milton, Rebecca E.; Ast, Anne; Schindler, Franziska; Zhang, Chuangchuang; Duan, Wenzhen; Wanker, Erich E.; Bates, Gillian P. 分享 收藏
分享 收藏
Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease Greco, Todd M.; Secker, Christopher; Ramos, Eduardo Silva; Federspiel, Joel D.; Liu, Jeh-Ping; Perez, Alma M.; Al-Ramahi, Ismael; Cantle, Jeffrey P.; Carroll, Jeffrey B.; Botas, Juan; Zeitlin, Scott O.; Wanker, Erich E.; Cristea, Ileana M. 分享 收藏
Complete suppression of Htt fibrillization and disaggregation of Htt fibrils by a trimeric chaperone complex (vol 37, pg 282, 2018) 三聚体伴侣复合物完全抑制Htt纤维化和Htt原纤维的解聚 (第37卷，282页，2018) Scior, Annika; Arnsburg, Kristin; Iburg, Manuel; Juenemann, Katrin; Lucia Pigazzini, Maria; Mlody, Barbara; Puchkov, Dmytro; Ast, Anne; Buntru, Alexander; Priller, Josef; Wanker, Erich E.; Prigione, Alessandro; Kirstein, Janine 分享 收藏
Small, Seeding-Competent Huntingtin Fibrils Are Prominent Aggregate Species in Brains of zQ175 Huntington's Disease Knock-in Mice 小的，具有播种能力的亨廷顿蛋白原纤维是zQ175亨廷顿氏病敲入小鼠大脑中突出的聚集物种 Schindler, Franziska; Praedel, Nicole; Neuendorf, Nancy; Kunz, Severine; Schnoegl, Sigrid; Mason, Michael A.; Taxy, Bridget A.; Bates, Gillian P.; Khoshnan, Ali; Priller, Josef; Grimm, Jan; Maier, Marcel; Boeddrich, Annett; Wanker, Erich E. 分享 收藏
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome 有缺陷的代谢程序会损害神经培养物中的早期神经元形态发生和Leigh综合征的类器官模型 Inak, Gizem; Rybak-Wolf, Agnieszka; Lisowski, Pawel; Pentimalli, Tancredi M.; Juettner, Rene; Glazar, Petar; Uppal, Karan; Bottani, Emanuela; Brunetti, Dario; Secker, Christopher; Zink, Annika; Meierhofer, David; Henke, Marie-Therese; Dey, Monishita; Ciptasari, Ummi; Mlody, Barbara; Hahn, Tobias; Berruezo-Llacuna, Maria; Karaiskos, Nikos; Di Virgilio, Michela; Mayr, Johannes A.; Wortmann, Saskia B.; Priller, Josef; Gotthardt, Michael; Jones, Dean P.; Mayatepek, Ertan; Stenzel, Werner; Diecke, Sebastian; Kuehn, Ralf; Wanker, Erich E.; Rajewsky, Nikolaus; Schuelke, Markus; Prigione, Alessandro 分享 收藏
The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic 13-cells ARFRP1-dependent高尔基支架蛋白GOPC是胰腺13细胞分泌胰岛素所必需的 Wilhelmi, Ilka; Grunwald, Stephan; Gimber, Niclas; Popp, Oliver; Dittmar, Gunnar; Arumughan, Anup; Wanker, Erich E.; Laeger, Thomas; Schmoranzer, Jan; Daumke, Oliver; Schuermann, Annette 分享 收藏
分享 收藏
Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington'S Disease Model Landles, Christian; Milton, Rebecca E.; Ali, Nadira; Flomen, Rachel; Flower, Michael; Schindler, Franziska; Gomez-Paredes, Casandra; Bondulich, Marie K.; Osborne, Georgina F.; Goodwin, Daniel; Salsbury, Grace; Benn, Caroline L.; Sathasivam, Kirupa; Smith, Edward J.; Tabrizi, Sarah J.; Wanker, Erich E.; Bates, Gillian P. 分享 收藏
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains 相互作用组映射提供了神经退行性疾病蛋白质的网络，并揭示了受影响大脑中广泛的蛋白质聚集 Haenig, Christian; Atias, Nir; Taylor, Alexander K.; Mazza, Arnon; Schaefer, Martin H.; Russ, Jenny; Riechers, Sean-Patrick; Jain, Shushant; Coughlin, Maura; Fontaine, Jean-Fred; Freibaum, Brian D.; Brusendorf, Lydia; Zenkner, Martina; Porras, Pablo; Stroedicke, Martin; Schnoegl, Sigrid; Arnsburg, Kristin; Boeddrich, Annett; Pigazzini, Lucia; Heutink, Peter; Taylor, J. Paul; Kirstein, Janine; Andrade-Navarro, Miguel A.; Sharan, Roded; Wanker, Erich E. 分享 收藏
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology (Jun, 10.1038/s41380-020-0787-4, 2020) 揭示亨廷顿氏病的新光: 血液如何既可以传播又可以改善疾病病理学 (6月，10.1038/s41380-020-0787-4，2020) Rieux, Marie; Alpaugh, Melanie; Sciacca, Giacomo; Saint-Pierre, Martine; Masnata, Maria; Denis, Helena L.; Levesque, Sebastien A.; Herrmann, Frank; Bazenet, Chantal; Garneau, Alexandre P.; Isenring, Paul; Truant, Ray; Oueslati, Abid; Gould, Peter V.; Ast, Anne; Wanker, Erich E.; Lacroix, Steve; Cicchetti, Francesca 分享 收藏
Shedding a new light on Huntington's disease: how blood can both propagate and ameliorate disease pathology 为亨廷顿氏病提供新的照明: 血液如何既可以传播又可以改善疾病病理学 Rieux, Marie; Alpaugh, Melanie; Sciacca, Giacomo; Saint-Pierre, Martine; Masnata, Maria; Denis, Helena L.; Levesque, Sebastien A.; Herrmann, Frank; Bazenet, Chantal; Garneau, Alexandre P.; Isenring, Paul; Truant, Ray; Oueslati, Abid; Gould, Peter, V; Ast, Anne; Wanker, Erich E.; Lacroix, Steve; Cicchetti, Francesca 分享 收藏
Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice Interleukin-12/23缺陷对雄性和雌性阿尔茨海默病样小鼠的病理学影响不同 Eede, Pascale; Obst, Juliane; Benke, Eileen; Yvon-Durocher, Genevieve; Richard, Bernhard C.; Gimber, Niclas; Schmoranzer, Jan; Boeddrich, Annett; Wanker, Erich E.; Prokop, Stefan; Heppner, Frank L. 分享 收藏
Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils 混合a β(1-40) 和a β(1-42) 肽产生独特的淀粉样蛋白原纤维 Cerofolini, Linda; Ravera, Enrico; Bologna, Sara; Wiglenda, Thomas; Boeddrich, Annett; Purfuerst, Bettina; Benilova, Iryna; Korsak, Magdalena; Gallo, Gianluca; Rizzo, Domenico; Gonnelli, Leonardo; Fragai, Marco; De Strooper, Bart; Wanker, Erich E.; Luchinat, Claudio 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
