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D

David H. Phillips

king's college london

H指数:87

被引数:2.8万

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Use of the IARC key characteristics of carcinogens KC1 (electrophilicity), KC2 (genotoxicity), and KC3 (DNA repair/genomic instability) for cancer hazard identification

利用IARC致癌物关键特征KC1（亲电性）、KC2（致突变性）和KC3（DNA修复/基因组不稳定性）进行致癌性危害识别

Current Opinion in Toxicology

IF3.6

2026-07-130

PRE

Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2024-01-174

OAAI

Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo [4,5-b] pyridine (N-OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2021-01-014

PREAI

Mutagenicity of acrylamide and glycidamide in humanTP53knock-in (Hupki) mouse embryo fibroblasts

ARCHIVES OF TOXICOLOGY

IF6.9

2020-09-0425

OAAI

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

ARCHIVES OF TOXICOLOGY

IF6.9

2019-10-1018

OAAI

Protein Adductomics: Analytical Developments and Applications in Human Biomonitoring

IF4.1

2019-05-2516

OAAI

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2019-03-013

OAAI

The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity

PARTICLE AND FIBRE TOXICOLOGY

IF8.2

2019-01-0813

OAAI

Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

IF3.1

2018-11-1316

OAAI

Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair

IF2.7

2018-11-0157

OAAI

α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster

Α-肌动蛋白解释了肌动蛋白制剂在果蝇中诱导STAT靶基因的生物活性

IF0

2018-09-2717

OA

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox

IF2.9

2018-05-0362

OAAI

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo [a] pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells

IF4.6

2018-04-0116

OAAI

Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53 (vol 232, pg 86, 2008)

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2018-04-013

PREAI

EXPOsOMICS: final policy workshop and stakeholder consultation

BMC PUBLIC HEALTH

IF3.6

2018-02-1529

OAAI

Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of luminal muscle-invasive bladder cancers

MOLECULAR CARCINOGENESIS

IF3.2

2018-02-0112

OAAI

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

ARCHIVES OF TOXICOLOGY

IF6.9

2018-01-2427

OAAI

Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2017-11-1711

OAAI

From the exposome to mechanistic understanding of chemical-induced adverse effects

ENVIRONMENT INTERNATIONAL

IF9.7

2017-02-01148

OAAI

Escher, Beate I.; Hackermuller, Joerg; Polte, Tobias; Scholz, Stefan; Aigner, Achim; Altenburger, Rolf; Boehme, Alexander; Bopp, Stephanie K.; Brack, Werner; Busch, Wibke; Chadeau-Hyam, Marc; Covaci, Adrian; Eisentraeger, Adolf; Galligan, James J.; Garcia-Reyero, Natalia; Hartung, Thomas; Hein, Michaela; Herberth, Gunda; Jahnke, Annika; Kleinjans, Jos; Kluever, Nils; Krauss, Martin; Lamoree, Marja; Lehmann, Irina; Luckenbach, Till; Miller, Gary W.; Mueller, Andrea; Phillips, David H.; Reemtsma, Thorsten; Rolle-Kampczyk, Ulrike; Schueuermann, Gerrit; Schwikowski, Benno; Tan, Yu-Mei; Trump, Saskia; Walter-Rohde, Susanne; Wambaugh, John F.

Nutlin-3a selects for cells harbouring TP53 mutations

INTERNATIONAL JOURNAL OF CANCER

IF4.7

2016-11-2223

OAAI