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THE APPROACH TRIAL (ANALYSIS OF PROTON VS PHOTON RADIOTHERAPY IN OLIGODENDROGLIOMA AND ASSESSMENT OF COGNITIVE HEALTH): OPEN AND RECRUITING IN THE UK Murray, L. J.; Boele, F.; Brown, S.; Powell, J.; Borland, M.; Bruce, A.; Bulbeck, H.; Burnet, N.; Chang, Y.; Colaco, R.; Currie, S.; Egleston, D.; Fersht, N.; Hudson, E.; Klein, M.; Lilley, J.; Lowe, M.; Murray, R. D.; Norris, M.; Noutch, S.; O'Hara, D.; Parbutt, C.; Smith, A.; Smith, C.; Whitfield, G. A.; Short, S. 分享 收藏
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Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling Chen, Huifen; Volgraf, Matthew; Do, Steven; Kolesnikov, Aleksandr; Shore, Daniel G.; Verma, Vishal A.; Villemure, Elisia; Wang, Lan; Chen, Yong; Hu, Baihua; Lu, Ai-Jun; Wu, Guosheng; Xu, Xiaofeng; Yuen, Po-Wai; Zhang, Yamin; Erickson, Shawn D.; Dahl, Martin; Brotherton-Pleiss, Christine; Tay, Suzanne; Ly, Justin Q.; Murray, Lesley J.; Chen, Jun; Amm, Desiree; Lange, Wienke; Hackos, David H.; Reese, Rebecca M.; Shields, Shannon D.; Lyssikatos, Joseph P.; Safina, Brian S.; Estrada, Anthony A. 分享 收藏
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Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window Rudolph, Joachim; Murray, Lesley J.; Ndubaku, Chudi O.; O'Brien, Thomas; Blackwood, Elizabeth; Wang, Weiru; Aliagas, Ignacio; Gazzard, Lewis; Crawford, James J.; Drobnick, Joy; Lee, Wendy; Zhao, Xianrui; Hoeflich, Klaus P.; Favor, David A.; Dong, Ping; Zhang, Haiming; Heise, Christopher E.; Oh, Angela; Ong, Christy C.; La, Hank; Chakravarty, Paroma; Chan, Connie; Jakubiak, Diana; Epler, Jennifer; Ramaswamy, Sreemathy; Vega, Roxanne; Cain, Gary; Diaz, Dolores; Zhong, Yu 分享 收藏
Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety Ndubaku, Chudi O.; Crawford, James J.; Drobnick, Joy; Aliagas, Ignacio; Campbell, David; Dong, Ping; Dornan, Laura M.; Duron, Sergio; Epler, Jennifer; Gazzard, Lewis; Heise, Christopher E.; Hoeflich, Klaus P.; Jakubiak, Diana; La, Hank; Lee, Wendy; Lin, Baiwei; Lyssikatos, Joseph P.; Maksimoska, Jasna; Marmorstein, Ronen; Murray, Lesley J.; O'Brien, Thomas; Oh, Angela; Ramaswamy, Sreemathy; Wang, Weiru; Zhao, Xianrui; Zhong, Yu; Blackwood, Elizabeth; Rudolph, Joachim 分享 收藏
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis Ndubaku, Chudi O.; Crawford, Terry D.; Chen, Huifen; Boggs, Jason W.; Drobnick, Joy; Harris, Seth F.; Jesudason, Rajiv; McNamara, Erin; Nonomiya, Jim; Sambrone, Amy; Schmidt, Stephen; Smyczek, Tanya; Vitorino, Philip; Wang, Lan; Wu, Ping; Yeung, Stacey; Chen, Jinhua; Chen, Kevin; Ding, Charles Z.; Wang, Tao; Xu, Zijin; Gould, Stephen E.; Murray, Lesley J.; Ye, Weilan 分享 收藏
Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors Crawford, James J.; Lee, Wendy; Aliagas, Ignacio; Mathieu, Simon; Hoeflich, Klaus P.; Zhou, Wei; Wang, Weiru; Rouge, Lionel; Murray, Lesley; La, Hank; Liu, Ning; Fan, Peter W.; Cheong, Jonathan; Heise, Christopher E.; Ramaswamy, Sreemathy; Mintzer, Robert; Liu, Yanzhou; Chao, Qi; Rudolph, Joachim 分享 收藏
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Leveraging the Pre-DFG Residue Thr-406 To Obtain High Kinase Selectivity in an Aminopyrazole-Type PAK1 Inhibitor Series 利用pre-dfg残基Thr-406在氨基吡唑型PAK1抑制剂系列中获得高激酶选择性 Rudolph, Joachim; Aliagas, Ignacio; Crawford, James J.; Mathieu, Simon; Lee, Wendy; Chao, Qi; Dong, Ping; Rouge, Lionel; Wang, Weiru; Heise, Christopher; Murray, Lesley J.; La, Hank; Liu, Yanzhou; Manning, Gerard; Diederich, Francois; Hoeflich, Klaus P. 分享 收藏
Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization Crawford, Terry D.; Ndubaku, Chudi O.; Chen, Huifen; Boggs, Jason W.; Bravo, Brandon J.; DeLaTorre, Kelly; Giannetti, Anthony M.; Gould, Stephen E.; Harris, Seth F.; Magnuson, Steven R.; McNamara, Erin; Murray, Lesley J.; Nonomiya, Jim; Sambrone, Amy; Schmidt, Stephen; Smyczek, Tanya; Stanley, Mark; Vitorino, Philip; Wang, Lan; West, Kristina; Wu, Ping; Ye, Weilan 分享 收藏
The Cancer Cell Line Encyclopedia - Using Preclinical Models to Predict Anticancer Drug Sensitivity Barretina, J.; Caponigro, G.; Stransky, N.; Venkatesan, K.; Margolin, A. A.; Kim, S.; Wilson, C. J.; Lehar, J.; Kryukov, G. V.; Murray, L.; Morrissey, M. P.; Sellers, W. R.; Schlegel, R.; Garraway, L. A. 分享 收藏
Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152) Flygare, John A.; Beresini, Maureen; Budha, Nageshwar; Chan, Helen; Chan, Iris T.; Cheeti, Sravanthi; Cohen, Frederick; Deshayes, Kurt; Doerner, Karl; Eckhardt, S. Gail; Elliott, Linda O.; Feng, Bainian; Franklin, Matthew C.; Reisner, Stacy Frankovitz; Gazzard, Lewis; Halladay, Jason; Hymowitz, Sarah G.; La, Hank; LoRusso, Patricia; Maurer, Brigitte; Murray, Lesley; Plise, Emile; Quan, Clifford; Stephan, Jean-Philippe; Young, Shin G.; Tom, Jeffrey; Tsui, Vickie; Um, Joanne; Varfolomeev, Eugene; Vucic, Domagoj; Wagner, Andrew J.; Wallweber, Heidi J. A.; Wang, Lan; Ware, Joseph; Wen, Zhaoyang; Wong, Harvey; Wong, Jonathan M.; Wong, Melisa; Wong, Susan; Yu, Ron; Zobel, Kerry; Fairbrother, Wayne J. 分享 收藏
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Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression Hoeflich, Klaus P.; Herter, Sylvia; Tien, Janet; Wong, Leo; Berry, Leanne; Chan, Jocelyn; O'Brien, Carol; Modrusan, Zora; Seshagiri, Somasekar; Lackner, Mark; Stern, Howard; Choo, Edna; Murray, Lesley; Friedman, Lori S.; Belvin, Marcia 分享 收藏
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