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Verification of In Vivo Estrogenic Activity for Four Per- and Polyfluoroalkyl Substances (PFAS) Identified as Estrogen Receptor Agonists via New Approach Methodologies 通过新方法方法验证四种被鉴定为雌激素受体激动剂的全氟和多氟烷基物质 (PFAS) 的体内雌激素活性 Villeneuve, Daniel L.; Blackwell, Brett R.; Cavallin, Jenna E.; Collins, Jacob; Hoang, John X.; Hofer, Rachel N.; Houck, Keith A.; Jensen, Kathleen M.; Kahl, Michael D.; Kutsi, Robin N.; Opseth, Anne S.; Rodriguez, Kelvin J. Santana; Schaupp, Christopher; Stacy, Emma H.; Ankley, Gerald T. 分享 收藏
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Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay 通过多重报告NR分析对NR配体多药理学进行综合评估 Medvedev, Alexander; Moeser, Matt; Medvedeva, Liubov; Martsen, Elena; Granick, Alexander; Raines, Lydia; Gorman, Kristen; Lin, Benjamin; Zeng, Ming; Houck, Keith A.; Makarov, Sergei S. 分享 收藏
A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio) Han, Jiajun; Gu, Wen; Barrett, Holly; Yang, Diwen; Tang, Song; Sun, Jianxian; Liu, Jiabao; Krause, Henry M.; Houck, Keith A.; Peng, Hui 分享 收藏
Quantitative Chemical Proteomics Reveals Interspecies Variations on Binding Schemes of L-FABP with Perfluorooctanesulfonate 定量化学蛋白质组学揭示了l-fabp与全氟辛烷磺酸结合方案的种间变化 Han, Jiajun; Fu, Jesse; Sun, Jianxian; Hall, David Ross; Yang, Diwen; Blatz, Donovan; Houck, Keith; Ng, Carla; Doering, Jon; LaLone, Carlie; Peng, Hui 分享 收藏
Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure 全氟和多氟烷基物质 (PFAS) 的生物活性分析确定了与分子结构相关的潜在毒性途径 Houck, Keith A.; Patlewicz, Grace; Richard, Ann M.; Williams, Antony J.; Shobair, Mahmoud A.; Smeltz, Marci; Clifton, M. Scott; Wetmore, Barbara; Medvedev, Alex; Makarov, Sergei 分享 收藏
Characterisation and validation of an in vitro transactivation assay based on the 22Rv1/MMTV_GR-KO cell line to detect human androgen receptor agonists and antagonists Park, Yooheon; Jung, Da-Woon; Milcamps, Anne; Takeyoshi, Masahiro; Jacobs, Miriam N.; Houck, Keith A.; Ono, Atsushi; Bovee, Toine F. H.; Browne, Patience; Delrue, Nathalie; Kang, YunSook; Lee, Hee-Seok 分享 收藏
High-throughput toxicogenomic screening of chemicals in the environment using metabolically competent hepatic cell cultures Franzosa, Jill A.; Bonzo, Jessica A.; Jack, John; Baker, Nancy C.; Kothiya, Parth; Witek, Rafal P.; Hurban, Patrick; Siferd, Stephen; Hester, Susan; Shah, Imran; Ferguson, Stephen S.; Houck, Keith A.; Wambaugh, John F. 分享 收藏
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology Tox21 10k化合物库: 协同化学推进毒理学 Richard, Ann M.; Huang, Ruili; Waidyanatha, Suramya; Shinn, Paul; Collins, Bradley J.; Thillainadarajah, Inthirany; Grulke, Christopher M.; Williams, Antony J.; Lougee, Ryan R.; Judson, Richard S.; Houck, Keith A.; Shobair, Mahmoud; Yang, Chihae; Rathman, James F.; Yasgar, Adam; Fitzpatrick, Suzanne C.; Simeonov, Anton; Thomas, Russell S.; Crofton, Kevin M.; Paules, Richard S.; Bucher, John R.; Austin, Christopher P.; Kavlock, Robert J.; Tice, Raymond R. 分享 收藏
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The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them 致癌物的关键特征: 与癌症特征的关系，相关的生物标志物以及测量它们的方法 Smith, Martyn T.; Guyton, Kathryn Z.; Kleinstreuer, Nicole; Borrel, Alexandre; Cardenas, Andres; Chiu, Weihsueh A.; Felsher, Dean W.; Gibbons, Catherine F.; Goodson, William H., III; Houck, Keith A.; Kane, Agnes B.; La Merrill, Michele A.; Lebrec, Herve; Lowe, Leroy; McHale, Cliona M.; Minocherhomji, Sheroy; Rieswijk, Linda; Sandy, Martha S.; Sone, Hideko; Wang, Amy; Zhang, Luoping; Zeise, Lauren; Fielden, Mark 分享 收藏
Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay 通过Ecotox析因测定法对内分泌和代谢干扰物进行协调的跨物种评估 Medvedev, Alexander V.; Medvedeva, Lyubov A.; Martsen, Elena; Moeser, Mathew; Gorman, Kristen L.; Lin, Benjamin; Blackwell, Brett; Villeneuve, Daniel L.; Houck, Keith A.; Crofton, Kevin M.; Makarov, Sergei S. 分享 收藏
Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity (vol 174, pg 189, 2020) Zurlinden, Todd J.; Saili, Katerine S.; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S.; Houck, Keith A.; Hunter, E. Sidney; Baker, Nancy C.; Palmer, Jessica A.; Thomas, Russell S.; Knudsen, Thomas B. 分享 收藏
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Nontarget Screening of Per- and Polyfluoroalkyl Substances Binding to Human Liver Fatty Acid Binding Protein Yang, Diwen; Han, Jiajun; Hall, David Ross; Sun, Jianxian; Fu, Jesse; Kutarna, Steven; Houck, Keith A.; LaLone, Carlie A.; Doering, Jon A.; Ng, Carla A.; Peng, Hui 分享 收藏
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Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity 用基于多能人类 (H9) 干细胞系的生物标志物测定法对ToxCast文库进行发育毒性分析 Zurlinden, Todd J.; Saili, Katerine S.; Rush, Nathaniel; Kothiya, Parth; Judson, Richard S.; Houck, Keith A.; Hunter, E. Sidney; Baker, Nancy C.; Palmer, Jessica A.; Thomas, Russell S.; Knudsen, Thomas B. 分享 收藏
Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library 发现有限的化学结构多样性可调节Tox21化学库中的甲状腺激素受体 Paul-Friedman, Katie; Martin, Matt; Crofton, Kevin M.; Hsu, Chia-Wen; Sakamuru, Srilatha; Zhao, Jinghua; Xia, Menghang; Huang, Ruili; Stavreva, Diana A.; Soni, Vikas; Varticovski, Lyuba; Raziuddin, Razi; Hager, Gordon L.; Houck, Keith A. 分享 收藏
Methods for evaluating variability in human health dose-response characterization 评估人类健康剂量反应表征变异性的方法 Axelrad, Daniel A.; Setzer, R. Woodrow; Bateson, Thomas F.; DeVito, Michael; Dzubow, Rebecca C.; Fitzpatrick, Julie W.; Frame, Alicia M.; Hogan, Karen A.; Houck, Keith; Stewart, Michael 分享 收藏
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