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Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1 通过结合酶抑制和蛋白水解激活来靶向草酸盐的产生: 1型原发性高草酸尿症的新治疗方法 Arias, Fabio; Rohilla, Sumati; Sixto-Lopez, Yudibeth; Richard, Koral S. E.; Das, Sandeep; Anand, Sumit K.; Luque-Navarro, Pilar Maria; Banuelos-Sanchez, Guillermo; Pacheco-Garcia, Juan Luis; Gade, Reethika; Mckinney, M. Peyton; Kumar, Dhananjay; Maxie, Jemiah; Corr, W. Rylan; Pandey, Nilesh; Kaur, Harpreet; Ding, Jibin; Tan, Lin; Scott, Elisha; Nam, Hyung; Gottlieb, Eyal; Orr, A. Wayne; Dhanesha, Nirav; Yurdagul Jr, Arif; Pey, Angel L.; Franco-Montalban, Francisco; Gomez Vidal, Jose A.; Rom, Oren; Diaz-Gavilan, Monica 分享 收藏
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Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells 纤维连接蛋白依赖的整合素信号驱动血管平滑肌细胞中EphA2的表达 Pearson-Gallion, B; Finney, AC; Scott, ML; Connelly, Z; Alam, S; Peretik, JM; Ben Dhaou, C; Bhuiyan, MS; Traylor, JG; Degrado, WF; Jo, H; Yu, XP; Rom, O; Pattillo, CB; Dhanesha, N; Yurdagul, A Jr; Orr, AW 分享 收藏
Mitochondrial Ca2+uniporter b (MCUb) regulates neuronal Ca2+dynamics and resistance to ischemic stroke 线粒体Ca2+单链体b (MCUb)调节神经元Ca2+动力学和对缺血性卒中的抵抗性 Nguyen, Tam; Lin, Zhihong; Dhanesha, Nirav; Patel, Rakesh B.; Lane, Mallorie; Walters, Grant C.; Shutov, Leonid P.; Strack, Stefan; Chauhan, Anil K.; Usachev, Yuriy M. 分享 收藏
Targeting Neutrophil Integrin a9 Enhances Microglial Efferocytosis and Improves Sensorimotor and Cognitive Recovery Following Subarachnoid Hemorrhage in Mice 靶向中性粒细胞整合素a9可增强小鼠蛛网膜下腔出血后小胶质细胞的吞噬作用，并改善感觉运动和认知功能的恢复。 Kaur, Harpreet; Pandey, Nilesh; Kumar, Dhananjay; Chandaluri, Lakshmi; Martinez, Alexa; Reece, Erika; Gaddam, Ravinder; Murnane, Kevin; Vikram, Ajit; Mohandas, Rajesh; Orr, Wayne; Lu, Xiao-Hong; Rom, Oren; Yurdagul, Arif; Dhanesha, Nirav 分享 收藏
Enhanced venous thrombosis and hypercoagulability in murine and human metabolic dysfunction-associated steatohepatitis 小鼠和人类代谢功能障碍相关的脂肪性肝炎的静脉血栓形成和高凝性增强 Pandey, Nilesh; Anand, Sumit Kumar; Kaur, Harpreet; Richard, Koral S. E.; Chandaluri, Lakshmi; Butler, Megan E.; Zhang, Xiaolu; Pearson-Gallion, Brenna; Rohilla, Sumati; Das, Sandeep; Magdy, Tarek; Sethu, Palaniappan; Nunez, Kelley G.; Orr, A. Wayne; Stokes, Karen Y.; Thevenot, Paul T.; Cohen, Ari J.; Rom, Oren; Dhanesha, Nirav 分享 收藏
Targeting Neutrophil CD14 Inhibits Deep Vein Thrombus Formation and Enhances Thrombus Resolution Following Inferior Vena Cava Stenosis in Mice 靶向中性粒细胞CD14可抑制小鼠下腔静脉狭窄后的深静脉血栓形成并促进血栓溶解 Pandey, Nilesh; Kaur, Harpreet; Chandaluri, Lakshmi; Anand, Sumit Kumar; Mohamed, Tarek Magdy; Stokes, Karen; Beedupalli, Kavitha; Orr, A. Wayne; Rom, Oren; Dhanesha, Nirav 分享 收藏
Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis 抑制肝草酸盐过量产生可改善代谢功能障碍相关的脂肪性肝炎 Das, Sandeep; Finney, Alexandra C.; Anand, Sumit Kumar; Rohilla, Sumati; Liu, Yuhao; Pandey, Nilesh; Ghrayeb, Alia; Kumar, Dhananjay; Nunez, Kelley; Liu, Zhipeng; Arias, Fabio; Zhao, Ying; Pearson-Gallion, Brenna H.; McKinney, M. Peyton; Richard, Koral S. E.; Gomez-Vidal, Jose A.; Abdullah, Chowdhury S.; Cockerham, Elizabeth D.; Eniafe, Joseph; Yurochko, Andrew D.; Magdy, Tarek; Pattillo, Christopher B.; Kevil, Christopher G.; Razani, Babak; Bhuiyan, Md. Shenuarin; Seeley, Erin H.; Galliano, Gretchen E.; Wei, Bo; Tan, Lin; Mahmud, Iqbal; Surakka, Ida; Garcia-Barrio, Minerva T.; Lorenzi, Philip L.; Gottlieb, Eyal; Salido, Eduardo; Zhang, Jifeng; Orr, A. Wayne; Liu, Wanqing; Diaz-Gavilan, Monica; Chen, Y. Eugene; Dhanesha, Nirav; Thevenot, Paul T.; Cohen, Ari J.; Yurdagul Jr, Arif; Rom, Oren 分享 收藏
Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial 卒中临床前评估网络 (SPAN) 试验结果的生物学和程序性预测因素 Morais, Andreia; Imai, Takahiko; Jin, Xuyan; Locascio, Joseph J.; Boisserand, Ligia; Herman, Alison L.; Chauhan, Anjali; Lamb, Jessica; Nagarkatti, Karisma; Diniz, Marcio A.; Kumskova, Mariia; Dhanesha, Nirav; Kamat, Pradip K.; Badruzzaman Khan, Mohammad; Dhandapani, Krishnan M.; Patel, Rakesh B.; Sutariya, Brijesh; Shi, Yanrong; van Leyen, Klaus; Kimberly, W. Taylor; Hess, David C.; Aronowski, Jaroslaw; Leira, Enrique C.; Koehler, Raymond C.; Chauhan, Anil K.; Sansing, Lauren H.; Lyden, Patrick D.; Ayata, Cenk 分享 收藏
Diastolic dysfunction in Alzheimer's disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunction 阿尔茨海默病模型小鼠的舒张功能障碍与a β-淀粉样蛋白聚集体形成和线粒体功能障碍有关 Aishwarya, Richa; Abdullah, Chowdhury S.; Remex, Naznin Sultana; Bhuiyan, Mohammad Alfrad Nobel; Lu, Xiao-Hong; Dhanesha, Nirav; Stokes, Karen Y.; Orr, A. Wayne; Kevil, Christopher G.; Bhuiyan, Md. Shenuarin 分享 收藏
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Interactions between integrin α9β1 and VCAM-1 promote neutrophil hyperactivation and mediate poststroke DVT Pandey, Nilesh; Kaur, Harpreet; Chorawala, Mehul R.; Anand, Sumit Kumar; Chandaluri, Lakshmi; Butler, Megan E.; Aishwarya, Richa; Gaddam, Shiva J.; Shen, Xinggui; Alfaidi, Mabruka; Wang, Jian; Zhang, Xiaolu; Beedupalli, Kavitha; Bhuiyan, Md. Shenuarin; Bhuiyan, Mohammad Alfrad Nobel; Buchhanolla, Prabandh; Rai, Prashant; Shah, Rahul; Chokhawala, Himanshu; Jordan, J. Dedrick; Magdy, Tarek; Orr, A. Wayne; Stokes, Karen Y.; Rom, Oren; Dhanesha, Nirav 分享 收藏
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A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke Lyden, Patrick D.; Diniz, Marcio A.; Bosetti, Francesca; Lamb, Jessica; Nagarkatti, Karisma A.; Rogatko, Andre; Kim, Sungjin; Cabeen, Ryan P.; Koenig, James I.; Akhter, Kazi; Arbab, Ali S.; Avery, Brooklyn D.; Beatty, Hannah E.; Bibic, Adnan; Cao, Suyi; Simoes Braga Boisserand, Ligia; Chamorro, Angel; Chauhan, Anjali; Diaz-Perez, Sebastian; Dhandapani, Krishnan; Dhanesha, Nirav; Goh, Andrew; Herman, Alison L.; Hyder, Fahmeed; Imai, Takahiko; Johnson, Conor W.; Khan, Mohammad B.; Kamat, Pradip; Karuppagounder, Senthilkumar S.; Kumskova, Mariia; Mihailovic, Jelena M.; Mandeville, Joseph B.; Morais, Andreia; Patel, Rakesh B.; Sanganahalli, Basavaraju G.; Smith, Cameron; Shi, Yanrong; Sutariya, Brijesh; Thedens, Daniel; Qin, Tao; Velazquez, Sofia E.; Aronowski, Jaroslaw; Ayata, Cenk; Chauhan, Anil K.; Leira, Enrique C.; Hess, David C.; Koehler, Raymond C.; Mccullough, Louise D.; Sansing, Lauren H. 分享 收藏
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