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J

Jack A. Terrett

Genentech Inc
H指数:16
被引数:4,316

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Discovery and Characterization of Divarasib (GDC-6036); a Potent Covalent Inhibitor of KRAS G12C

Divarasib (GDC-6036)的发现与表征：一种强效的KRAS G12C共价抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-03-020
PRE
Nicholas F. Endres; Steven Do; Rana Mroue; Jack A. Terrett; Matt Saabye; Angela Oh; Thomas Hunsaker; Emily Chan; John C. Tran; Lan K. Nguyen; Qihui Lian; Taylur P. Ma; Thomas Garner; Luca Gerosa; Maureen Beresini; Aaron Boudreau; Sarah M. Bronner; Patrick Cyr; Noriko Ishisoko; Yevgeniy Izrayelit; Fan Jiang; Terry Kellar; Hank La; Sharada Labadie; Matthew Lardy; Liling Liu; Wendy Liu; Sarah Miller; Joachim Rudolph; Emile Plise; Benjamin D. Sellers; Cheng Shao; Weiru Wang; Yanguang Wang; Wentao Wei; Susan Wong; Christine Yu; Kebing Yu; Po-Wai Yuen; Richard Zang; Chenghong Zhang; Yuhui Zhou; Xiaoyu Zhu; John G. Quinn; Xin Ye; James R. Kiefer; Jialin Mao; Marie Evangelista; Mark Merchant; Matthew L. Landry; Sushant Malhotra; Hans E. Purkey
Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-03-035
OA
Terrett, Jack A.; Ly, Justin Q.; Katavolos, Paula; Hasselgren, Catrin; Laing, Steven; Zhong, Fiona; Villemure, Elisia; Dery, Martin; Larouche-Gauthier, Robin; Chen, Huifen; Shore, Daniel G.; Lee, Wyne P.; Suto, Eric; Johnson, Kevin; Brooks, Marjory; Stablein, Alyssa; Beaumier, Francis; Constantineau-Forget, Lea; Grand-Maitre, Chantal; Lepissier, Luce; Ciblat, Stephane; Sturino, Claudio; Chen, Yong; Hu, Baihua; Elstrott, Justin; Gandham, Vineela; Joseph, Victory; Booler, Helen; Cain, Gary; Chou, Carolina; Fullerton, Aaron; Lepherd, Michelle; Stainton, Shannon; Torres, Elizabeth; Urban, Konnie; Yu, Lanlan; Zhong, Yu; Bao, Linda; Chou, Kang-Jye; Lin, Jessica; Zhang, Wei; La, Hank; Liu, Liling; Mulder, Teresa; Chen, Jun; Chernov-Rogan, Tania; Johnson, Adam R.; Hackos, David H.; Leahey, Rebecca; Shields, Shannon D.; Balestrini, Alessia; Riol-Blanco, Lorena; Safina, Brian S.; Volgraf, Matthew; Magnuson, Steven; Kakiuchi-Kiyota, Satoko
Green Chemistry Articles of Interest to the Pharmaceutical Industry
ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2022-02-025
PRE
Bryan, Marian C.; Dalton, Charlotte; Diaz-Rodriguez, Alba; Doerfler, Jaika; Engl, Oliver D.; Ferguson, Paul; Molina, Alejandro Gimenez; Han, Zhengxu S.; Hosford, Joseph; Howell, Gareth P.; Hutchby, Marc; Li, Wei; Munday, Rachel H.; Navarro, Antonio; Parmentier, Michael; Pawlas, Jan; Richardson, Paul F.; Smith, William J., III; Steven, Alan; Takale, Balaram S.; Terrett, Jack A.; Treitler, Daniel S.; Zeng, Mingshuo
Green Chemistry Articles of Interest to the Pharmaceutical Industry
ORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
2021-10-062
PREAI
Bryan, Marian C.; Dalton, Charlotte; Diorazio, Louis J.; Doerfler, Jaika; Doyle, Lisa M.; Engl, Oliver D.; Molina, Alejandro Gimenez; Han, Zhengxu S.; Hosford, Joseph; Howell, Gareth P.; Hutchby, Marc; Latham, Jonathan; Li, Wei; Munday, Rachel H.; Navarro, Antonio; Parmentier, Michael; Pawlas, Jan; Richardson, Paul F.; Steven, Alan; Terrett, Jack A.; Zeng, Mingshuo
Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-03-2229
PRE
Terrett, Jack A.; Chen, Huifen; Shore, Daniel G.; Villemure, Elisia; Larouche-Gauthier, Robin; Dery, Martin; Beaumier, Francis; Constantineau-Forget, Lea; Grand-Maitre, Chantal; Lepissier, Luce; Ciblat, Stephane; Sturino, Claudio; Chen, Yong; Hu, Baihua; Lu, Aijun; Wang, Yunli; Cridland, Andrew P.; Ward, Stuart, I; Hackos, David H.; Reese, Rebecca M.; Shields, Shannon D.; Chen, Jun; Balestrini, Alessia; Riol-Blanco, Lorena; Lee, Wyne P.; Liu, John; Suto, Eric; Wu, Xiumin; Zhang, Juan; Ly, Justin Q.; La, Hank; Johnson, Kevin; Baumgardner, Matt; Chou, Kang-Jye; Rohou, Alexis; Rouge, Lionel; Safina, Brian S.; Magnuson, Steven; Volgraf, Matthew

研究方向

暂未获取到该数据
P
Paul Richardson
H 指数:35论文数:541被引数:5,138
A
Alan Steven
H 指数:15论文数:149被引数:1,820
L
Louis J. Diorazio
H 指数:20论文数:73被引数:1,564
O
Oliver D. Engl
H 指数:10论文数:59被引数:572
李威 封面图
李威
H 指数:107论文数:2,240被引数:7.2万
R
Rachel H. Munday
H 指数:20论文数:62被引数:1,711
M
Mingshuo Zeng
H 指数:9论文数:33被引数:577
J
Jonathan Latham
H 指数:8论文数:23被引数:995
T
Timothy White
H 指数:13论文数:45被引数:951
J
Jaika Doerfler
H 指数:3论文数:8被引数:59