Robin J. Leatherbarrow - Publications, H-index & Citations

Robin J. Leatherbarrow

Imperial College London

47H指数

166论文数

5.9K被引数

收录论文 41

发表时间

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-06-24

OAAI

Bell, Andrew S.; Yu, Zhiyong; Hutton, Jennie A.; Wright, Megan H.; Brannigan, James A.; Paape, Daniel; Roberts, Shirley M.; Sutherell, Charlotte L.; Ritzefeld, Markus; Wilkinson, Anthony J.; Smith, Deborah F.; Leatherbarrow, Robin J.; Tate, Edward W.

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus 人类N-肉豆蔻酰基转移酶的片段衍生抑制剂阻断衣壳组装和普通感冒病毒的复制

NATURE CHEMISTRY

IF20.2

2018-05-14

OAAI

Mousnier, Aurelie; Bell, Andrew S.; Swieboda, Dawid P.; Morales-Sanfrutos, Julia; Perez-Dorado, Inmaculada; Brannigan, James A.; Newman, Joseph; Ritzefeld, Markus; Hutton, Jennie A.; Guedan, Anabel; Asfor, Amin S.; Robinson, Sean W.; Hopkins-Navratilova, Iva; Wilkinson, Anthony J.; Johnston, Sebastian L.; Leatherbarrow, Robin J.; Tuthill, Tobias J.; Solari, Roberto; Tate, Edward W.

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II

THROMBOSIS AND HAEMOSTASIS

IF4.3

2017-11-21

OAAI

Gray, Kelly; Elghadban, Salma; Thongyoo, Panumart; Owen, Kate A.; Szabo, Roman; Bugge, Thomas H.; Tate, Edward W.; Leatherbarrow, Robin J.; Ellis, Vincent

A tri-functional vanadium(IV) complex to detect cysteine oxidation

DALTON TRANSACTIONS

IF3.3

2017-01-01

OAAI

Cilibrizzi, Agostino; Fedorova, Marina; Collins, Juliet; Leatherbarrow, Robin; Woscholski, Rudiger; Vilar, Ramon

Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies

DALTON TRANSACTIONS

IF3.3

2016-01-01

OAAI

Collins, Juliet; Cilibrizzi, Agostino; Fedorova, Marina; Whyte, Gillian; Mak, Lok Hang; Guterman, Inna; Leatherbarrow, Robin; Woscholski, Rudiger; Vilar, Ramon

Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform

ACS NANO

IF16

2015-02-09

OAAI

Pitchford, William H.; Kim, Hyung-Jun; Ivanov, Aleksander P.; Kim, Hyun-Mi; Yu, Jae-Seok; Leatherbarrow, Robin J.; Albrecht, Tim; Kim, Ki-Bum; Edel, Joshua B.

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2014-12-18

OAAI

Paape, Daniel; Bell, Andrew S.; Heal, William P.; Hutton, Jennie A.; Leatherbarrow, Robin J.; Tate, Edward W.; Smith, Deborah F.

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-10-01

OAAI

Hutton, Jennie A.; Goncalves, Victor; Brannigan, James A.; Paape, Daniel; Wright, Megan H.; Waugh, Thomas M.; Roberts, Shirley M.; Bell, Andrew S.; Wilkinson, Anthony J.; Smith, Deborah F.; Leatherbarrow, Robin J.; Tate, Edward W.

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-03-18

OAAI

Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

NATURE CHEMISTRY

IF20.2

2013-12-22

188

OAAI

Wright, Megan H.; Clough, Barbara; Rackham, Mark D.; Rangachari, Kaveri; Brannigan, James A.; Grainger, Munira; Moss, David K.; Bottrill, Andrew R.; Heal, William P.; Broncel, Malgorzata; Serwa, Remigiusz A.; Brady, Declan; Mann, David J.; Leatherbarrow, Robin J.; Tewari, Rita; Wilkinson, Anthony J.; Holder, Anthony A.; Tate, Edward W.

Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies

FUTURE MEDICINAL CHEMISTRY

IF3.4

2013-08-07

PREAI

Smith, Lucy D.; Leatherbarrow, Robin J.; Spivey, Alan C.

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-12-17

OAAI

Rackham, Mark D.; Brannigan, James A.; Moss, David K.; Yu, Zhiyong; Wilkinson, Anthony J.; Holder, Anthony A.; Tate, Edward W.; Leatherbarrow, Robin J.

Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-10-15

OAAI

Yu, Zhiyong; Brannigan, James A.; Moss, David K.; Brzozowski, A. Marek; Wilkinson, Anthony J.; Holder, Anthony A.; Tate, Edward W.; Leatherbarrow, Robin J.

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2012-04-24

OAAI

Bell, Andrew S.; Mills, James E.; Williams, Gareth P.; Brannigan, James A.; Wilkinson, Anthony J.; Parkinson, Tanya; Leatherbarrow, Robin J.; Tate, Edward W.; Holder, Anthony A.; Smith, Deborah F.

Discovery of Plasmodium vivax N-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-04-03

OAAI

Goncalves, Victor; Brannigan, James A.; Whalley, David; Ansell, Keith H.; Saxty, Barbara; Holder, Anthony A.; Wilkinson, Anthony J.; Tate, Edward W.; Leatherbarrow, Robin J.

Synthesis and Incorporation into Cyclic Peptides of Tolan Amino Acids and Their Hydrogenated Congeners: Construction of an Array of A-B-loop Mimetics of the Cε3 Domain of Human IgE

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2012-03-07

PREAI

Offermann, Daniel A.; McKendrick, John E.; Sejberg, Jimmy J. P.; Mo, Bingli; Holdom, Mary D.; Helm, Birgit A.; Leatherbarrow, Robin J.; Beavil, Andrew J.; Sutton, Brian J.; Spivey, Alan C.

Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein-protein interfaces

CHEMICAL SCIENCE

IF7.4

2012-01-01

PREAI

Bradshaw, Richard T.; Aronica, Pietro G. A.; Tate, Edward W.; Leatherbarrow, Robin J.; Gould, Ian R.

A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-01-01

OAAI

Stuart, Sarah F.; Leatherbarrow, Robin J.; Willison, Keith R.