Guohui Chuai - Publications, H-index & Citations

Guohui Chuai

Shanghai Skin Disease Hospital

18H指数

57论文数

1.7K被引数

收录论文 22

发表时间

DeepCas12a: a hybrid deep learning framework for accurate AsCas12a efficiency prediction from sequence and epigenetic information DeepCas12a：一种基于序列和表观遗传信息的AsCas12a效率预测的混合深度学习框架

BMC Genomics

IF3.7

2026-05-30

OAAI

Yiming Shi; Junkai Yin; Shurui Ning; Jinling Yuan; Degang Yang; Guohui Chuai

Reinforcement learning-based design of sequential drug treatment targeting the evolving tumour landscape with SequenTx 使用SequenTx针对不断发展的肿瘤景观的基于强化学习的序贯药物治疗设计

Nature Machine Intelligence

IF23.9

2026-03-04

PREAI

Xiaohan Chen; Yue Deng; Xingbo Yang; Ying Zhang; Yuting Huang; Shuxian Li; Hong Yang; Qiongyu Shi; Siqi Wu; Shaoqi Chen; Xuan Jin; Feiyang Xing; Chen Zhang; Yicheng Gao; Degang Yang; Guohui Chuai; Jian Ding; Xun Huang; Qi Liu

Benchmarking algorithms for generalizable single-cell perturbation response prediction 可推广的单细胞扰动响应预测的基准测试算法

Nature Methods

IF32.1

2025-12-11

PREAI

Zhiting Wei; Yiheng Wang; Yicheng Gao; Shuguang Wang; Ping Li; Duanmiao Si; Yuli Gao; Siqi Wu; Danlu Li; Kejing Dong; Xingbo Yang; Chen Tang; Shaliu Fu; Xiaohan Chen; Wannian Li; Yuzhou You; Chen Zhang; Aibin Liang; Guohui Chuai; Qi Liu

Benchmarking multi-slice integration and downstream applications in spatial transcriptomics data analysis 在空间转录组数据分析中评估多切片整合及下游应用

Genome Biology

IF9.4

2025-10-03

OAAI

Kejing Dong; Yicheng Gao; Qi Zou; Yan Cui; Chuangyi Han; Senlin Lin; Zhikang Wang; Chen Tang; Xiaojie Cheng; Fangliangzi Meng; Xiaohan Chen; Shuguang Wang; Xuan Jin; Jingya Yang; Chen Zhang; Guohui Chuai; Zhiyuan Yuan; Qi Liu

SpaLinker identifies phenotype-associated spatial tumor microenvironment features by integrating bulk and spatial sequencing data SpaLinker通过整合bulk和空间测序数据，识别与表型相关的空间肿瘤微环境特征。

Cell Genomics

IF9

2025-06-05

OAAI

Xiaojie Cheng; Chen Tang; Kejing Dong; Yuzhou You; Xueying Zhao; Bin Duan; Shaoqi Chen; Guohui Chuai; Zhenbo Zhang; Qi Liu

PrimeNet: rational design of Prime editing pegRNAs by deep learning PrimeNet：基于深度学习的碱基编辑pegRNA的理性设计

BRIEFINGS IN BIOINFORMATICS

IF7.7

2025-05-01

OAAI

Liao, Xichen; Liu, Qi; Chuai, Guohui

Toward subtask-decomposition-based learning and benchmarking for predicting genetic perturbation outcomes and beyond 走向基于子任务分解的学习和基准测试，以预测遗传扰动结果及以后

NATURE COMPUTATIONAL SCIENCE

IF18.3

2024-09-27

PREAI

Gao, Yicheng; Wei, Zhiting; Dong, Kejing; Chen, Ke; Yang, Jingya; Chuai, Guohui; Liu, Qi

Genome-wide CRISPR off-target prediction and optimization using RNA-DNA interaction fingerprints 使用rna-dna相互作用指纹图谱进行全基因组CRISPR脱靶预测和优化

NATURE COMMUNICATIONS

IF15.7

2023-11-18

OAAI

Chen, Qinchang; Chuai, Guohui; Zhang, Haihang; Tang, Jin; Duan, Liwen; Guan, Huan; Li, Wenhui; Li, Wannian; Wen, Jiaying; Zuo, Erwei; Zhang, Qing; Liu, Qi

Pan-Peptide Meta Learning for T-cell receptor-antigen binding recognition

NATURE MACHINE INTELLIGENCE

IF23.9

2023-03-06

OAAI

Gao, Yicheng; Gao, Yuli; Fan, Yuxiao; Zhu, Chengyu; Wei, Zhiting; Zhou, Chi; Chuai, Guohui; Chen, Qinchang; Zhang, He; Liu, Qi

Systematic Exploration of Optimized Base Editing gRNA Design and Pleiotropic Effects with BExplorer 用BExplorer系统探索优化的碱基编辑gRNA设计和多效性

GENOMICS PROTEOMICS & BIOINFORMATICS

IF7.9

2022-07-02

OAAI

Zhang, Gongchen; Zhu, Chenyu; Chen, Xiaohan; Yan, Jifang; Xue, Dongyu; Wei, Zixuan; Chuai, Guohui; Liu, Qi

Toward a molecular mechanism-based prediction of CRISPR-Cas9 targeting effects

SCIENCE BULLETIN

IF21.1

2022-06-01

PREAI

Chen, Qinchang; Chuai, Guohui; Zhang, Chao; Zhang, Qing; Liu, Qi

X-MOL: large-scale pre-training for molecular understanding and diverse molecular analysis

SCIENCE BULLETIN

IF21.1

2022-05-01

OAAI

Xue, Dongyu; Zhang, Han; Chen, Xiaohan; Xiao, Dongling; Gong, Yukang; Chuai, Guohui; Sun, Yu; Tian, Hao; Wu, Hua; Li, Yukun; Liu, Qi

A deep generative model for multi-view profiling of single-cell RNA-seq and ATAC-seq data

GENOME BIOLOGY

IF9.4

2022-01-12

OAAI

Li, Gaoyang; Fu, Shaliu; Wang, Shuguang; Zhu, Chenyu; Duan, Bin; Tang, Chen; Chen, Xiaohan; Chuai, Guohui; Wang, Ping; Liu, Qi

DeepReac plus : deep active learning for quantitative modeling of organic chemical reactions

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Gong, Yukang; Xue, Dongyu; Chuai, Guohui; Yu, Jing; Liu, Qi

Benchmarking and integrating genome-wide CRISPR off-target detection and prediction

NUCLEIC ACIDS RESEARCH

IF13.1

2020-11-02

OAAI

Yan, Jifang; Xue, Dongyu; Chuai, Guohui; Gao, Yuli; Zhang, Gongchen; Liu, Qi

Learning for single-cell assignment

SCIENCE ADVANCES

IF12.5

2020-10-30

OAAI

Duan, Bin; Zhu, Chenyu; Chuai, Guohui; Tang, Chen; Chen, Xiaohan; Chen, Shaoqi; Fu, Shaliu; Li, Gaoyang; Liu, Qi

Data imbalance in CRISPR off-target prediction CRISPR脱靶预测中的数据不平衡

BRIEFINGS IN BIOINFORMATICS

IF7.7

2019-07-02

PREAI

Gao, Yuli; Chuai, Guohui; Yu, Weichuan; Qu, Shen; Liu, Qi

Advances and challenges in deep generative models for de novo molecule generation 从头生成分子的深度生成模型的进展和挑战

WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE

IF27

2018-10-19

PREAI

Xue, Dongyu; Gong, Yukang; Yang, Zhaoyi; Chuai, Guohui; Qu, Sheng; Shen, Aizong; Yu, Jing; Liu, Qi

DeepCRISPR: optimized CRISPR guide RNA design by deep learning DeepCRISPR: 通过深度学习优化的CRISPR指导RNA设计

GENOME BIOLOGY

IF9.4

2018-06-26

293

OAAI

Chuai, Guohui; Ma, Hanhui; Yan, Jifang; Chen, Ming; Hong, Nanfang; Xue, Dongyu; Zhou, Chi; Zhu, Chenyu; Chen, Ke; Duan, Bin; Gu, Feng; Qu, Sheng; Huang, Deshuang; Wei, Jia; Liu, Qi

Benchmarking CRISPR on-target sgRNA design

BRIEFINGS IN BIOINFORMATICS

IF7.7

2017-02-15

PREAI

Yan, Jifang; Chuai, Guohui; Zhou, Chi; Zhu, Chenyu; Yang, Jing; Zhang, Chao; Gu, Feng; Xu, Han; Wei, Jia; Liu, Qi

研究方向