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3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain Daly, Sam; Bulovaite, Edita; Handa, Anoushka; Morris, Katie; Muresan, Leila; Adams, Candace; Kaizuka, Takeshi; Kitching, Alexandre; Spark, Alexander; Chant, Gregory; O'Holleran, Kevin; Grant, Seth G. N.; Horrocks, Mathew H.; Lee, Steven F. 分享 收藏
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RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS RNA适体揭示核TDP-43病理学是早期的聚集事件，与STMN-2的隐性剪接相吻合，并在ALS的临床表现之前 Spence, Holly; Waldron, Fergal M.; Saleeb, Rebecca S.; Brown, Anna-Leigh; Rifai, Olivia M.; Gilodi, Martina; Read, Fiona; Roberts, Kristine; Milne, Gillian; Wilkinson, Debbie; O'Shaughnessy, Judi; Pastore, Annalisa; Fratta, Pietro; Shneider, Neil; Tartaglia, Gian Gaetano; Zacco, Elsa; Horrocks, Mathew H.; Gregory, Jenna M. 分享 收藏
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Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates Saleeb, Rebecca S.; Leighton, Craig; Lee, Ji-Eun; O'Shaughnessy, Judi; Jeacock, Kiani; Chappard, Alexandre; Cumberland, Robyn; Zhao, Tianxiao; Ball, Sarah R.; Sunde, Margaret; Clarke, David J.; Piche, Kristin; McPhail, Jacob A.; Louwrier, Ariel; Angers, Rachel; Gandhi, Sonia; Downey, Patrick; Kunath, Tilo; Horrocks, Mathew H. 分享 收藏
Imaging Proteins Sensitive to Direct Fusions Using Transient Peptide-Peptide Interactions 使用瞬时肽-肽相互作用对直接融合敏感的成像蛋白 Gidden, Zoe; Oi, Curran; Johnston, Emily J.; Konieczna, Zuzanna; Bhaskar, Haresh; Mendive-Tapia, Lorena; de Moliner, Fabio; Rosser, Susan J.; Mochrie, Simon G. J.; Vendrell, Marc; Horrocks, Mathew H.; Regan, Lynne 分享 收藏
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Prediction of mechanistic subtypes of Parkinson's using patient-derived stem cell models D'Sa, Karishma; Evans, James R.; Virdi, Gurvir S.; Vecchi, Giulia; Adam, Alexander; Bertolli, Ottavia; Fleming, James; Chang, Hojong; Leighton, Craig; Horrocks, Mathew H.; Athauda, Dilan; Choi, Minee L.; Gandhi, Sonia 分享 收藏
Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain 阿尔茨海默病中的突触寡聚tau-通过大脑传播tau病理的潜在罪魁祸首 Colom-Cadena, Marti; Davies, Caitlin; Sirisi, Sonia; Lee, Ji-Eun; Simzer, Elizabeth M.; Tzioras, Makis; Querol-Vilaseca, Marta; Sanchez-Aced, Erika; Chang, Ya Yin; Holt, Kristjan; McGeachan, Robert I.; Rose, Jamie; Tulloch, Jane; Wilkins, Lewis; Smith, Colin; Andrian, Teodora; Belbin, Olivia; Pujals, Silvia; Horrocks, Mathew H.; Lleo, Alberto; Spires-Jones, Tara L. 分享 收藏
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Small Fluorogenic Amino Acids for Peptide-Guided Background-Free Imaging 用于肽引导的无背景成像的小荧光氨基酸 de Moliner, Fabio; Konieczna, Zuzanna; Mendive-Tapia, Lorena; Saleeb, Rebecca S.; Morris, Katie; Gonzalez-Vera, Juan Antonio; Kaizuka, Takeshi; Grant, Seth G. N.; Horrocks, Mathew H.; Vendrell, Marc 分享 收藏
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons Virdi, Gurvir S.; Choi, Minee L.; Evans, James R.; Yao, Zhi; Athauda, Dilan; Strohbuecker, Stephanie; Nirujogi, Raja S.; Wernick, Anna, I; Pelegrina-Hidalgo, Noelia; Leighton, Craig; Saleeb, Rebecca S.; Kopach, Olga; Alrashidi, Haya; Melandri, Daniela; Perez-Lloret, Jimena; Angelova, Plamena R.; Sylantyev, Sergiy; Eaton, Simon; Heales, Simon; Rusakov, Dmitri A.; Alessi, Dario R.; Kunath, Tilo; Horrocks, Mathew H.; Abramov, Andrey Y.; Patani, Rickie; Gandhi, Sonia 分享 收藏
pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data Pattle, Samuel B.; O'Shaughnessy, Judi; Kantelberg, Owen; Rifai, Olivia M.; Pate, Judith; Nellany, Kristine; Hays, Nadine; Arends, Mark J.; Horrocks, Mathew H.; Waldron, Fergal M.; Gregory, Jenna M. 分享 收藏
Probing TDP-43 condensation using an in silico designed aptamer Zacco, Elsa; Kantelberg, Owen; Milanetti, Edoardo; Armaos, Alexandros; Panei, Francesco Paolo; Gregory, Jenna; Jeacock, Kiani; Clarke, David J.; Chandran, Siddharthan; Ruocco, Giancarlo; Gustincich, Stefano; Horrocks, Mathew H.; Pastore, Annalisa; Tartaglia, Gian Gaetano 分享 收藏
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (vol 27, pg 2781, 2020) Angelova, Plamena R.; Choi, Minee L.; Berezhnov, Alexey V.; Horrocks, Mathew H.; Hughes, Craig D.; De, Suman; Rodrigues, Margarida; Yapom, Ratsuda; Little, Daniel; Dolt, Karamjit S.; Kunath, Tilo; Devine, Michael J.; Gissen, Paul; Shchepinov, Mikhail S.; Sylantyev, Sergiy; Pavlov, Evgeny V.; Klenerman, David; Abramov, Andrey Y.; Gandhi, Sonia 分享 收藏
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Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (vol 45, pg 128, 2020) Angelova, Plamena R.; Choi, Minee L.; Berezhnov, Alexey V.; Horrocks, Mathew H.; Hughes, Craig D.; De, Suman; Rodrigues, Margarida; Yapom, Ratsuda; Little, Daniel; Dolt, Karamjit S.; Kunath, Tilo; Devine, Michael J.; Gissen, Paul; Shchepinov, Mikhail S.; Sylantyev, Sergiy; Pavlov, Evgeny V.; Klenerman, David; Abramov, Andrey Y.; Gandhi, Sonia 分享 收藏
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation Angelova, Plamena R.; Choil, Minee L.; Berezhnov, Alexey, V; Horrocks, Mathew H.; Hughes, Craig D.; De, Suman; Rodrigues, Margarida; Yapom, Ratsuda; Little, Daniel; Dolt, Karamjit S.; Kunath, Tilo; Devine, Michael J.; Gissen, Paul; Shchepinov, Mikhail S.; Sylantyev, Sergiy; Pavlov, Evgeny, V; Klenerman, David; Abramov, Andrey Y.; Gandhi, Sonia 分享 收藏
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