未登录 Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026 Featured Updates to the NCCN Guidelines 陈, H.H.; 吉里, V.N.; 戈根斯, M.; 尤尔格伦, M.B.; 卡兰, B.Y.; 诺奎斯特, B.S.; 戴利, M.B.; 帕尔, T.; 阿利利, Z.; 阿伦, B.; 等. NCCN指南(R)要点:遗传/家族高风险评估:乳腺、卵巢、胰腺和前列腺,版本2.2026. J. Natl. Compr. Cancer Netw. 2026, 24, 2–10. [Google Scholar] [CrossRef] [PubMed] Cheng, Heather H.; Giri, Veda N.; Goggins, Michael; Yurgelun, Matthew B.; Karlan, Beth Y.; Norquist, Barbara S.; Daly, Mary B.; Pal, Tuya; Alhilli, Zahraa; Arun, Banu; Churpek, Jane; Colonna, Sarah; Domchek, Susan M.; Escobar, Mauricio R.; Fejerman, Laura; Friedman, Susan; Hagemann, Andrea; Hendrix, Ashley; Huo, Dezheng; Hutton, Mollie L.; Kassem, Nawal; Khan, Seema; Kurian, Allison W.; Laronga, Christine; Mak, Julie S.; Maxwell, Kara N.; Mcdonnell, Kevin; Merajver, Sofia D.; Mersch, Jacqueline; Offit, Kenneth; Plichta, Jennifer; Rash, Dominique; Reiser, Gwen; Senter-Jamieson, Leigha; Shannon, Kristen Mahoney; Welborn, Jeanna; Wick, Myra J.; Wood, Marie; Darlow, Susan; Diwan, Zeenat; Dwyer, Mary 分享 收藏
USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I USP22通过mhc-i的EZH2-mediated表观遗传沉默驱动肿瘤免疫逃避和检查点阻断抵抗 Liu, Kun; Iyer, Radhika; Li, Yi; Zhu, Jun; Cai, Zhaomeng; Wei, Juncheng; Cheng, Yang; Tang, Amy Y.; Wang, Hai; Gao, Qiong; Mani, Nikita Lavanya; Marx, Noah; Gao, Beixue; Watterson, D. Martin; Khan, Seema A.; Gradishar, William J.; Liu, Huiping; Fang, Deyu 分享 收藏
Reprogramming SREBP1-dependent lipogenesis and inflammation in high-risk breast with licochalcone A: A novel path to cancer prevention 通过甘草查尔酮A重编程高风险乳腺癌中SREBP1依赖性脂质合成和炎症：癌症预防的新途径 Hajirahimkhan, Atieh; Bartom, Elizabeth T.; Chung, Carolina H.; Guo, Xingyu; Berkley, Kyli; Hosseinibarkooie, Seyyedmohsen; Assadi, Zahra; Weng, Shao Huan Samuel; Moellering, Raymond; Lee, Oukseub; Chen, Ruohui; Cho, Wonhwa; Chandrasekaran, Sriram; Clare, Susan E.; Khan, Seema A. 分享 收藏
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MRI-based Radiomic Features for Risk Stratification of Ductal Carcinoma in Situ in a Multicenter Setting (ECOG-ACRIN E4112 Trial) 基于MRI的放射组学特征在多中心环境下对导管原位癌进行风险分层（ECOG-ACRIN E4112试验） Slavkova, Kalina P.; Kang, Ruya; Kazerouni, Anum S.; Biswas, Debosmita; Belenky, Vivian; Chitalia, Rhea; Horng, Hannah; Hirano, Michael; Xiao, Jennifer; Corsetti, Ralph L.; Javid, Sara H.; Spell, Derrick W.; Wolff, Antonio C.; Sparano, Joseph A.; Khan, Seema A.; Comstock, Christopher E.; Romanoff, Justin; Gatsonis, Constantine; Lehman, Constance D.; Partridge, Savannah C.; Steingrimsson, Jon; Kontos, Despina; Rahbar, Habib 分享 收藏
MRI-based Radiomic Features for Risk Stratification of Ductal Carcinoma in Situ in a Multicenter Setting (ECOG-ACRIN E4112 Trial) (vol 315, e241628, 2025) 基于MRI的放射组学特征用于多中心环境下导管原位癌的风险分层（ECOG-ACRIN E4112试验）（卷315，e241628，2025） Slavkova, Kalina P.; Kang, Ruya; Kazerouni, Anum S.; Biswas, Debosmita; Belenky, Vivian; Chitalia, Rhea; Horng, Hannah; Hirano, Michael; Xiao, Jennifer; Corsetti, Ralph L.; Javid, Sara H.; Spell, Derrick W.; Wolff, Antonio C.; Sparano, Joseph A.; Khan, Seema A.; Comstock, Christopher E.; Romanoff, Justin; Gatsonis, Constantine; Lehman, Constance D.; Partridge, Savannah C.; Steingrimsson, Jon; Kontos, Despina; Rahbar, Habib 分享 收藏
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Effect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial Akasheh, Rand Talal; Ankireddy, Aparna; Gabel, Kelsey; Ezpeleta, Mark; Lin, Shuhao; Tamatam, Chandra Mohan; Reddy, Sekhar P.; Spring, Bonnie; Cheng, Ting-Yuan David; Fontana, Luigi; Khan, Seema Ahsan; Varady, Krista A.; Cienfuegos, Sofia; Kalam, Faiza 分享 收藏
IDE196 (darovasertib) in combination with crizotinib versus investigator's choice of treatment as first-line therapy in HLA-A2 negative metastatic uveal melanoma IDE196（darovasertib）联合crizotinib与研究者选择的治疗方案作为HLA-A2阴性转移性眼黑色素瘤的一线治疗 Butler, M. O.; Weight, R.; Haq, R.; Javed, A.; Chandana, S.; Chmielowski, B.; Dummer, R.; Carlino, M. S.; Mckean, M.; Moser, J.; Chandrasekaran, S.; Khan, S.; Kim, K. B.; Lutzky, J.; Shackleton, M.; Atkinson, V. G.; Beaupre, D.; Cole, G. W., Jr.; Patel, H.; Orloff, M. 分享 收藏
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Magnetic Resonance Imaging and a 12-Gene Expression Assay to Optimize Local Therapy for Ductal Carcinoma In Situ: 5-year clinical outcomes of E4112 Khan, Seema; Romanoff, Justin; Gatsonis, Constantine; Rahbar, Habib; Carlos, Ruth; Badve, Sunil; Wright, Jean; Lehman, Constance; McCaskill-Stevens, Worta; Corsetti, Ralph; Spell, Derrick; Blankstein, Kenneth; Han, Linda; Sabol, Jennifer; Bumberry, John; Gareen, Ilana; Snyder, Bradley; Wagner, Lynne; Miller, Kathy; Sparano, Joseph; Comstock, Christopher 分享 收藏
MRI Radiomic phenotypes derived from the ECOG-ACRIN E4112 Trial to assess high-risk ductal carcinoma in situ Slavkova, Kalina; Kang, Ruya; Belenky, Vivian; Kazerouni, Anum; Biswas, Debosmita; Horng, Hannah; Chitalia, Rhea; Hirano, Michael; Xiao, Jennifer; Corsetti, Ralph; Javid, Sarah; Spell, Derrick; Wolff, Antonio; Sparano, Joseph; Khan, Seema; Comstock, Christopher; Romanoff, Justin; Steingrimsson, Jon; Gatsonis, Constantine; Lehman, Constance; Partridge, Savannah; Kontos, Despina; Rahbar, Habib 分享 收藏
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A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: evaluation of dermal safety, intra-mammary drug distribution, and biologic effects Lee, Oukseub; Bazzi, Latifa; Xu, Yanfei; Pearson, Erik; Wang, Minhua; Hosseini, Omid; Akasha, Azza; Choi, Jennifer; Kocherginsky, Masha; Benante, Kelly; Helland, Thomas; Mellgren, Gunnar; Dimond, Eileen; Perloff, Marjorie; Heckman-Stoddard, Brandy; Khan, Seema; Karlan, Scott; Pilewskie, Melissa 分享 收藏
Lipid exposure re-wires cellular metabolism away from glycolysis toward the serine pathway conferring oncogenic properties to non-transformed breast cells Eduardo, Mariana Bustamante; Cottone, Gannon; Liu, Shiyu; Palma, Flavio R.; Zappia, Maria Paula; Islam, Abul B. M. M. K.; Benevolenskaya, Elizaveta V.; Frolov, Maxim V.; Locasale, Jason; Bonini, Marcelo G.; Chandel, Navdeep S.; Khan, Seema; Clare, Susan 分享 收藏
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