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D

David M. Sabatini

broad institute
H指数:149
被引数:15.4万

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荣誉奖项

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Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

溶酶体衰老图谱揭示了一种与溶酶体贮积症共享的代谢物特征

Science
IF45.8
2026-07-300
PRE
Anna M. Puszynska; Thao P. Nguyen; Andrew L. Cangelosi; Andrea Armani; Justin M. Roberts; Kristin A. Singh; James C. Cameron; Tenzin Tseyang; Grace Y. Liu; Steven Lai; Hans-Georg Sprenger; Jason Yang; William N. Colgan; Jibril F. Kedir; Kathrin M. Kajderowicz; Theodore K. Esantsi; Yuancheng Ryan Lu; Millenia Waite; Tenzin Kunchok; Caroline A. Lewis; Fabian Schulte; George W. Bell; David M. Sabatini; Jonathan S. Weissman
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

mTORC2招募和选择性磷酸化Akt的结构基础

Science
IF45.8
2025-11-270
PRE
Martin S. Taylor; Maggie Chen; Matthew Hancock; Maximilian Wranik; Bryant D. Miller; Timothy R. O’Meara; Brad A. Palanski; Scott B. Ficarro; Brian J. Groendyke; Yufei Xiang; Kazuma T. Kondo; Karen Y. Linde-Garelli; Michelle J. Lee; Dibyendu Mondal; Daniel Freund; Samantha Congreve; Kaay Matas; Maximiliaan Hennink; Kera Xibinaku; Max L. Valenstein; Trevor van Eeuwen; Jarrod A. Marto; Andrej Sali; Yi Shi; Nathanael S. Gray; David M. Sabatini; Nam Chu; Kacper B. Rogala; Philip A. Cole
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST

谷胱甘肽硫转移酶通过直接激活MPST来调控线粒体功能和运动表现。

CELL METABOLISM
IF30.9
2025-02-010
PRE
Sprenger, Hans-Georg; Mittenbuhler, Melanie J.; Sun, Yizhi; Van Vranken, Jonathan G.; Schindler, Sebastian; Jayaraj, Abhilash; Khetarpal, Sumeet A.; Smythers, Amanda L.; Vargas-Castillo, Ariana; Puszynska, Anna M.; Spinelli, Jessica B.; Armani, Andrea; Kunchok, Tenzin; Ryback, Birgitta; Seo, Hyuk-Soo; Song, Kijun; Sebastian, Luke; O'Young, Coby; Braithwaite, Chelsea; Dhe-Paganon, Sirano; Burger, Nils; Mills, Evanna L.; Gygi, Steven P.; Paulo, Joao A.; Arthanari, Haribabu; Chouchani, Edward T.; Sabatini, David M.; Spiegelman, Bruce M.
Rhodoquinone carries electrons in the mammalian electron transport chain

罗多醌在哺乳动物电子传递链中携带电子。

CELL
IF42.5
2025-02-011
OAAI
Valeros, Jonathan; Jerome, Madison; Tseyang, Tenzin; Vo, Paula; Do, Thang; Palomino, Diana Fajardo; Grotehans, Nils; Kunala, Manisha; Jerrett, Alexandra E.; Hathiramani, Nicolai R.; Mireku, Michael; Magesh, Rayna Y.; Yenilmez, Batuhan; Rosen, Paul C.; Mann, Jessica L.; Myers, Jacob W.; Kunchok, Tenzin; Manning, Tanner L.; Boercker, Lily N.; Carr, Paige E.; Bin Munim, Muhammad; Lewis, Caroline A.; Sabatini, David M.; Kelly, Mark; Xie, Jun; Czech, Michael P.; Gao, Guangping; Shepherd, Jennifer N.; Walker, Amy K.; Kim, Hahn; V. Watson, Emma; Spinelli, Jessica B.
Collateral deletion of the mitochondrial AAA plus ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

线粒体AAA加ATPase ATAD1的附带缺失使癌细胞对蛋白酶体功能障碍敏感

ELIFE
IF0
2022-11-217
OA
Winter, Jacob M.; Fresenius, Heidi L.; Cunningham, Corey N.; Wei, Peng; Keys, Heather R.; Berg, Jordan; Bott, Alex; Yadav, Tarun; Ryan, Jeremy; Sirohi, Deepika; Tripp, Sheryl R.; Barta, Paige; Agarwal, Neeraj; Letai, Anthony; Sabatini, David M.; Wohlever, Matthew L.; Rutter, Jared
GCN2 adapts protein synthesis to scavenging-dependent growth

GCN2使蛋白质合成适应清除依赖性生长

CELL SYSTEMS
IF7.7
2022-02-0117
OAAI
Nofal, Michel; Wang, Tim; Yang, Lifeng; Jankowski, Connor S. R.; Li, Sophia Hsin-Jung; Han, Seunghun; Parsons, Lance; Frese, Alexander N.; Gitai, Zemer; Anthony, Tracy G.; Wuhr, Martin; Sabatini, David M.; Rabinowitz, Joshua D.
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling
NATURE COMMUNICATIONS
IF15.7
2021-06-1616
OAAI
de la Calle Arregui, Celia; Belen Plata-Gomez, Ana; Deleyto-Seldas, Nerea; Garcia, Fernando; Ortega-Molina, Ana; Abril-Garrido, Julio; Rodriguez, Elena; Nemazanyy, Ivan; Tribouillard, Laura; de Martino, Alba; Caleiras, Eduardo; Campos-Olivas, Ramon; Mulero, Francisca; Laplante, Mathieu; Munoz, Javier; Pende, Mario; Sabio, Guadalupe; Sabatini, David M.; Efeyan, Alejo

研究方向

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Carson C. Thoreen
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K
Kıvanç Birsoy
H 指数:70论文数:210被引数:5.2万
D
Dudley W. Lamming
H 指数:57论文数:213被引数:1.8万
N
Nathanael S. Gray
H 指数:145论文数:1,469被引数:8.4万
A
Alejo Efeyan
H 指数:32论文数:91被引数:1.2万
C
Caroline A. Lewis
H 指数:45论文数:138被引数:1.3万
S
Seong A. Kang
H 指数:19论文数:69被引数:8,634
M
Monther Abu-Remaileh
H 指数:32论文数:102被引数:9,221
A
Anne E. Carpenter
H 指数:79论文数:376被引数:3.7万
D
David A. Guertin
H 指数:43论文数:91被引数:2.7万