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D

Daniel J. Anderson

eikon therapeutics inc.
H指数:25
被引数:7,020

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荣誉奖项

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Rapid Optimization Enabled by Single-Molecule Tracking: Discovery of a Potent RUVBL1/2 Inhibitor to Evaluate the Targeting of MYC-Driven Cancers

单分子追踪赋能的快速优化：发现一种强效RUVBL1/2抑制剂以评估MYC驱动型癌症的靶向治疗

Journal of Medicinal Chemistry
IF6.8
2026-04-220
OA
Li Zheng; Eugene Park; Jason Lenihan; William S. R. Forrest; Xin Zhou; Charmaine Fong; Yangzhong Tang; Marcus P. Kelly; Amine Driouchi; Ali Tabatabaei; Helen Wong; Jesse D. Vargas; Samuel T. Albright; Zachary Howard; Maité B. Silva; Liam A. Elliott; Michael Farley; José Ortega; Stephen Jones; Xiao Chang; Taylor Heuer; Quan Zheng; Huntly M. Morrison; Daniel Bracho; Qian Du; Jennifer Le; Abhijit Tarafder; Grzegorz Nawrocki; Patric Schyman; Lakshmi Akella; Mai K. Nguyen; Daisy Ding; Arnold Tao; Fernando Rodríguez Pérez; Kayla VanBuren; Rohit Malik; Melissa Dumble; Daniel J. Anderson; Leah Cleary; David W. Piotrowski; Hilary P. Beck
2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA plus ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
NEUROBIOLOGY OF DISEASE
IF5.6
2025-03-010
OA
Peck, A.; Dadi, A.; Yavarow, Z.; Alfano, L. N.; Anderson, D.; Arkin, M. R.; Chou, T. F.; D'Ambrosio, E. S.; Diaz-Manera, J.; Dudley, J. P.; Elder, A. G.; Ghoshal, N.; Hart, C. E.; Hart, M. M.; Huryn, D. M.; Johnson, A. E.; Jones, K. B.; Kimonis, V.; Kiskinis, E.; Lee, E. B.; Lloyd, T. E.; Mapstone, M.; Martin, A.; Meyer, H.; Mozaffar, T.; Onyike, C. U.; Pfeffer, G.; Pindon, A.; Raman, M.; Richard, I.; Rubinsztein, D. C.; Schiava, M.; Schuetz, A. K.; Shen, P. S.; Southworth, D. R.; Staffaroni, A. M.; Taralio-Gravovac, M.; Weihl, C. C.; Yao, Q.; Ye, Y.; Peck, N.
WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis
NATURE COMMUNICATIONS
IF15.7
2024-07-182
OAAI
Perez, Fernando Rodriguez; Natwick, Dean; Schiff, Lauren; McSwiggen, David; Heckert, Alec; Huey, Melina; Morrison, Huntly; Loo, Mandy; Miranda, Rafael G.; Filbin, John; Ortega, Jose; Van Buren, Kayla; Murnock, Danny; Tao, Arnold; Butler, Renee; Cheng, Kylie; Tarvestad, William; Zhang, Zhengjian; Gonzalez, Eric; Miller, Rand M.; Kelly, Marcus; Tang, Yangzhong; Ho, Jaclyn; Anderson, Daniel; Bashore, Charlene; Basham, Stephen
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor

通过选择性第二代小分子抑制剂靶向急性髓系白血病对VCP介导的DNA修复的依赖性

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-03-3135
OA
Roux, Blandine; Vaganay, Camille; Vargas, Jesse D.; Alexe, Gabriela; Benaksas, Chaima; Pardieu, Bryann; Fenouille, Nina; Ellegast, Jana M.; Malolepsza, Edyta; Ling, Frank; Rol, Gaetano Soda; Ross, Linda; Pikman, Yana; Conwa, Amy S. Y.; Tang, Yangzhong; Wu, Tony; Anderson, Daniel J.; Le Moigne, Ronan; Zhou, Ha N-Jie; Luciano, Frederic; Hartigan, Christina R.; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Auberger, Patrick; Schenone, Monica; Rr, Steven A. Ca; Guirouilh-Barbat, Josee; Lopez, Bernard; Khaled, Mehdi; Lage, Kasper; Hermine, Olivier; Hemann, Michael T.; Puissant, Alexandre; Stegmaier, Kimberly; Benajiba, Lina
The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma
MOLECULAR CANCER THERAPEUTICS
IF5.5
2017-11-0195
OAAI
Le Moigne, Ronan; Aftab, Blake T.; Djakovic, Stevan; Dhimolea, Eugen; Valle, Eduardo; Murnane, Megan; King, Emily M.; Soriano, Ferdie; Menon, Mary-Kamala; Wu, Zhi Yong; Wong, Stephen T.; Lee, Grace J.; Yao, Bing; Wiita, Arun P.; Lam, Christine; Rice, Julie; Wang, Jinhai; Chesi, Marta; Bergsagel, P. Leif; Kraus, Marianne; Driessen, Christoph; Von Soly, Szerenke Kiss; Yakes, F. Michael; DavidWustrow; Shawver, Laura; Zhou, Han-Jie; Martin, Thomas G., III; Wolf, Jeffrey L.; Mitsiades, Constantine S.; Anderson, Daniel J.; Rolfe, Mark
Utilization of K48 poly-ubiquitin modulation as a biomarker of target engagement for a protein homeostasis inhibitor in the clinic: Preclinical validation with CB-5083 a first-in-class inhibitor of the AAA ATPase p97
CANCER RESEARCH
IF16.6
2016-07-150
PRE
Menon, Mary-Kamala; Soriano, Ferdie; Wong, Steve; Valle, Eduardo; Djakovic, Stevan; Kumar, Brajesh; Yao, Bing; Madriaga, Antonett; Wu, Tony; Rice, Julie; Wang, Jinhai; Cesano, Alessandra; Shawver, Laura; Zhou, Han-Jie; Wustrow, David; Anderson, Daniel; Rolfe, Mark; Le Moigne, Ronan
Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-12-04155
OAAI
Zhou, Han-Jie; Wang, Jinhai; Yao, Bing; Wong, Steve; Djakovic, Stevan; Kumar, Brajesh; Rice, Julie; Valle, Eduardo; Soriano, Ferdie; Menon, Mary-Kamala; Madriaga, Antonett; von Soly, Szerenke Kiss; Kumar, Abhinav; Parlati, Francesco; Yakes, F. Michael; Shawver, Laura; Le Moigne, Ronan; Anderson, Daniel J.; Rolfe, Mark; Wustrow, David
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
CELL DEATH & DISEASE
IF9.6
2015-01-15431
OAAI
Leverson, J. D.; Zhang, H.; Chen, J.; Tahir, S. K.; Phillips, D. C.; Xue, J.; Nimmer, P.; Jin, S.; Smith, M.; Xiao, Y.; Kovar, P.; Tanaka, A.; Bruncko, M.; Sheppard, G. S.; Wang, L.; Gierke, S.; Kategaya, L.; Anderson, D. J.; Wong, C.; Eastham-Anderson, J.; Ludlam, M. J. C.; Sampath, D.; Fairbrother, W. J.; Wertz, I.; Rosenberg, S. H.; Tse, C.; Elmore, S. W.; Souers, A. J.
CB-5083 is a novel first in class p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models
CANCER RESEARCH
IF16.6
2014-10-010
PRE
Moigne, Ronan L.; Wong, Steve; Soriano, Ferdie; Valle, Eduardo; Anderson, Daniel J.; Djakovic, Stevan; Menon, Mary-Kamala; Yao, Bing; Rice, Julie; Wang, Jinhai; Von Soly, Szerenke Kiss; Kumar, Brajesh; Chesi, Marta; Bergsagel, P. Leif; Zhou, Han-Jie; Wustrow, David; Rolfe, Mark; Yakes, F. Michael
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
NATURE CHEMICAL BIOLOGY
IF13.7
2013-07-28306
PRE
Magnaghi, Paola; D'Alessio, Roberto; Valsasina, Barbara; Avanzi, Nilla; Rizzi, Simona; Asa, Daniela; Gasparri, Fabio; Cozzi, Liviana; Cucchi, Ulisse; Orrenius, Christian; Polucci, Paolo; Ballinari, Dario; Perrera, Claudia; Leone, Antonella; Cervi, Giovanni; Casale, Elena; Xiao, Yang; Wong, Chihunt; Anderson, Daniel J.; Galvani, Arturo; Donati, Daniele; O'Brien, Tom; Jackson, Peter K.; Isacchi, Antonella

研究方向

暂未获取到该数据
R
Ronan Le Moigne
H 指数:12论文数:46被引数:1,191
H
Han-Jie Zhou
H 指数:11论文数:54被引数:1,350
M
Mark Rolfe
H 指数:38论文数:130被引数:1.0万
S
Stevan Djakovic
H 指数:12论文数:47被引数:1,679
姚兵 封面图
姚兵
H 指数:73论文数:725被引数:2.2万
M
Martin W. Hetzer
H 指数:56论文数:119被引数:1.3万
J
Julie Rice
H 指数:8论文数:27被引数:2,372
J
Jesse D. Vargas
H 指数:14论文数:27被引数:1,993
J
Jinhai Wang
H 指数:28论文数:186被引数:4,295
E
Eduardo Valle
H 指数:27论文数:157被引数:3,686