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K

Kevan M. Shokat

University of California

115H指数
742论文数
5.5W被引数
收录论文 246
发表时间
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Adaptive mechanisms and emerging cancer therapeutics for CDK2 inhibitors
errNature Chemical Biology
IF13.7
err2026-08-31
err0
PREAI
errChanghao He; Kevan M. Shokat
err分享
err收藏
Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model急性雷帕霉素处理揭示母体炎症小鼠模型中功能障碍的不同机制
errNature Communications
IF15.7
err2026-07-23
err0
errOAAI
errJE Le Belle; M. C. Condro; C. Cepeda; KD Oikonomou; K. Tessema; L. Dudley; J. Schoenfield; R. Kawaguchi; D. Geschwind; AJ Silva; Z. Zhang; K. Shokat; NG Harris; HI Kornblum
err分享
err收藏
Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis单细胞转录组揭示肿瘤介导的中性粒细胞重编程及其抑制转移的独特易感性
errScience Advances
IF12.5
err2026-07-15
err0
errOAAI
errWilliam Putzbach; Maria P. Zappia; Ahmed Magdy; Jing Li; Veronique Nogueira; Kevin Lou; Kevan M. Shokat; Abul B. M. M. K. Islam; Maxim Frolov; Nissim Hay
err分享
err收藏
Benzoxaboroles Are Structurally Unique Binders of Eukaryotic Translation Initiation Factor 4E苯并恶硼唑是结构独特的真核翻译起始因子4E的结合剂
errJournal of the American Chemical Society
IF15.6
err2026-07-09
err0
errOAAI
errJoshua B. Combs; D. Matthew Peacock; Gregory B. Craven; Sungwon Jung; Ying Chen; Sang M. Le; Jack Taunton; Kevan M. Shokat
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Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes单序列深度学习提供共价K-Ras G12热点复合物的晶体级模型
errIUBMB Life
IF3.2
err2026-06-13
err0
errOAAI
errSungwon Jung; Qinheng Zheng; Kevan M. Shokat
err分享
err收藏
GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition泛Ras TCI抑制剂daraxonrasib的GAP模拟活性与K-Ras开关-II口袋抑制具有协同作用
errBiological Chemistry
IF2.4
err2026-05-26
err1
errOAAI
errPfaff, Patrick; Shokat, Kevan M.
err分享
err收藏
Targeting the Protein–Membrane Interface Enables Design of Long-Acting CFTR Potentiators靶向蛋白质-膜界面实现长效CFTR potentiators的设计
errACS Chemical Biology
IF3.8
err2026-04-28
err0
errOAAI
errJohannes Morstein; Jonathan Borowsky; Shenghui Hu; YooJin Sheen; Victoria Nisoli; Tzyh-Chang Hwang; Michael Grabe; Kevan M. Shokat
err分享
err收藏
The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinationsGENEVA平台模拟肿瘤嵌合体，以揭示对KRAS抑制剂的反应差异并识别更优的药物组合
errNature Cancer
IF28.5
err2026-02-24
err0
errOAAI
errJohnny X. Yu; Jung Min Suh; Katerina D. Popova; Kristle Garcia; Tanvi Joshi; Bruce Culbertson; Jessica B. Spinelli; Vishvak Subramanyam; Kevin Lou; Trey Charbonneau; Kevan M. Shokat; Jonathan Weissman; Hani Goodarzi
err分享
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Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer基因组规模CRISPR筛选确定PTGES3为晚期前列腺癌雄激素受体功能的直接调节因子
errNature Genetics
IF29
err2025-11-05
err0
errOAAI
errHaolong Li; James E. Melnyk; Becky Xu Hua Fu; Raunak Shrestha; Meng Zhang; Martin Sjöström; Siyu Feng; Jasmine A. Anderson; Wanting Han; Lisa N. Chesner; Hyun Jin Shin; Tatyanah Farsh; Humberto J. Suarez; Seema Nath; Jonathan Chou; Rajdeep Das; Emily A. Egusa; Marsha Calvert; Audrey Kishishita; Abhilash Barpanda; Jun Zhu; Ashutosh Maheshwari; William S. Chen; Mohammed Alshalalfa; Aidan Winters; Junjie T. Hua; Tianyi Liu; Elai Davicioni; Arun P. Wiita; Bradley A. Stohr; Javed Siddiqui; Bo Huang; Eric J. Small; Kevan M. Shokat; Peter S. Nelson; David A. Quigley; Elizabeth V. Wasmuth; Luke A. Gilbert; Felix Y. Feng
err分享
err收藏
Bitopic inhibitors of mTORC1 cooperate with inhibitors of mitogen-activated protein kinase kinase to drive cytotoxicity in glioblastomamTORC1双位点抑制剂与丝裂原活化蛋白激酶激酶抑制剂协同作用，以驱动胶质母细胞瘤的细胞毒性。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errFan, Qiwen; Koach, Jessica; Luo, Karen; Clark, Sydney; Reddy, Shruthi; Ozawa, Tomoko; Wang, Linyu; Yoda, Hiroyuki; Sale, Matthew; Mccormick, Frank; Raleigh, David R.; Gustafson, William C.; Meyerowitz, Justin; Singh, Mallika; Berger, Mitchel; Shokat, Kevan M.; Weiss, William A.
err分享
err收藏
Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity去氮嘌呤化是一种核碱基-蛋白质共价结合，是IV型CBASS免疫所必需的。
errScience
IF45.8
err2025-09-25
err0
errOAAI
errDouglas R. Wassarman; Patrick Pfaff; Joao A. Paulo; Steven P. Gygi; Kevan M. Shokat; Philip J. Kranzusch
err分享
err收藏
Introduction: Drugging the Undruggable引言：靶向“不可成药”靶点
errChemical Reviews
IF55.8
err2025-07-23
err0
PREAI
errZiyang Zhang; Kevan M. Shokat
err分享
err收藏
Promise and Challenge of β-Lactone Electrophiles to Target Aspartate 12 of Mutant KRASG12Dβ-内酰胺亲电体靶向KRASG12D突变体天冬氨酸12的机遇与挑战
errJournal of Medicinal Chemistry
IF6.8
err2025-07-10
err0
PREAI
errBalázs Budai; Andrea Vaupel; Callum J. Dickson; Kim S. Beyer; Daniel A. Guthy; Nils Ostermann; Lynn M. McGregor; Ruben De Kanter; Andreas Weiss; Markus Linder; Emine Sager; Claudio Bomio-Confaglia; Rupert Proctor; Catherine Leblanc; Jun Yuan; Simona Cotesta; Rainer Wilcken; Aaron D. Danilack; Francisco Garcia; Phuong Rogemoser; Malika Kazic-Legueux; Ziyang Zhang; Qinheng Zheng; Kevan M. Shokat; Saskia M. Brachmann; Veronika Ehmke
err分享
err收藏
Subcellular activation of β- adrenergic receptors using a spatially restricted antagonist
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-09-27
err0
errOAAI
errLiccardo, Federica; Morstein, Johannes; Lin, Ting-Yu; Pampel, Julius; Lang, Di; Shokat, Kevan M.; Irannejad, Roshanak
err分享
err收藏
Direct RAS inhibitors turn 10
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-07-26
err1
PREAI
errOstrem, Jonathan M. L.; Peters, Ulf; Shokat, Kevan M.
err分享
err收藏
Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12DAsp12的菌株释放烷基化使K-Ras-G12D的突变体选择性靶向
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-03-05
err23
errOAAI
errZheng, Qinheng; Zhang, Ziyang; Guiley, Keelan Z.; Shokat, Kevan M.
err分享
err收藏
Mutant-selective, covalent inhibitors of K-Ras(G12D)
errCANCER RESEARCH
IF16.6
err2024-01-16
err0
PREAI
errZheng, Qinheng; Zhang, Ziyang; Guiley, Keelan; Shokat, Kevan
err分享
err收藏
Development of covalent inhibitors targeting Ras Q61 hotspot mutants
errCANCER RESEARCH
IF16.6
err2024-01-16
err0
PREAI
errPampel, Julius; Morstein, Johannes; Zheng, Qinheng; Peacock, David M.; Shokat, Kevan M.
err分享
err收藏
Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes
errANALYTICAL CHEMISTRY
IF6.7
err2023-12-07
err1
errOAAI
errMalakoutikhah, Morteza; Mahran, Randa; Gooran, Negin; Masoumi, Ahmadreza; Lundell, Katri; Liljeblad, Arto; Guiley, Keelan; Dai, Shizhong; Zheng, Qinheng; Zhu, Lawrence; Shokat, Kevan M.; Kopra, Kari; Harma, Harri
err分享
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Direct Modulators of K-Ras-Membrane Interactions
errACS CHEMICAL BIOLOGY
IF3.8
err2023-08-14
err7
errOAAI
errMorstein, Johannes; Shrestha, Rebika; Van, Que N.; Lopez, Cesar A.; Arora, Neha; Tonelli, Marco; Liang, Hong; Chen, De; Zhou, Yong; Hancock, John F.; Stephen, Andrew G.; Turbyville, Thomas J.; Shokat, Kevan M.
err分享
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研究方向

暂无研究方向
合作学者
合作期刊
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Richard A. Flavell
H 指数: 246 · 论文数: 1.5K
G
Gordon B. Mills
H 指数: 231 · 论文数: 3.5K
L
Lewis C. Cantley
H 指数: 214 · 论文数: 1.4K
S
Steven P. Gygi
H 指数: 195 · 论文数: 1.0K
M
Michael A. Matthay
H 指数: 169 · 论文数: 1.3K
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