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David R. Liu

Broad Institute of Harvard and MIT

124H指数
379论文数
7.7W被引数
收录论文 208
发表时间
In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson-Gilford Progeria Syndrome体内碱基编辑部分挽救 Hutchinson-Gilford 早衰综合征小鼠模型的骨发育不良
err2026-09-04
err0
errOAAI
errWayne A. Cabral; Caleb M. Grenko; Diana Yeritsyan; Indeevar Beeram; Shubham Laiwala; Lukas R. Johnson; Urraca L. Tavarez; Tingfen Yan; Stephen M. Wincovitch; Luke W. Koblan; Xin D. Gao; Meirui An; Narisu Narisu; Leslie G. Biesecker; David R. Liu; Ara Nazarian; Francis S. Collins; Michael R. Erdos
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Mechanistic machine learning for prediction of prime editing outcomes机器学习方法预测碱基编辑结果机制
err2026-08-12
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errOAAI
errAlvin Hsu; Peter J. Chen; Angus H. Li; Colin F. Hemez; Xin D. Gao; Markus Terrey; Charlie Nelson; Vijay Selvam; Ana Cristian; Amber N. McElroy; Benjamin J. Steinbeck; Gandhar K. Mahadeshwar; Smriti Pandey; Zachary Barsdale; Paul Z. Chen; Alexander A. Sousa; Holt A. Sakai; Rachel A. Silverstein; Ilias Morad; Ryan K. Krueger; Max W. Shen; Benjamin P. Kleinstiver; Cathleen M. Lutz; Jakub Tolar; Bruce R. Blazar; Mark J. Osborn; David R. Liu
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Evolution of botulinum neurotoxin serotype X proteases to induce inflammatory cell death in cancer cells肉毒杆菌神经毒素血清型X蛋白酶的进化以诱导癌细胞中的炎症性细胞死亡
err2026-08-03
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errOAAI
errJulia McCreary; Colin F. Hemez; Michael H. Raymond; Travis R. Blum; Angel Gonzalez-Valero; Teresa L. Augustin; Nicholas A. Krasnow; Stephan J. DeCarlo; Yan Qin; Kaitlin Rhee; Wei Jiang; Blanche C. Ip; Ahmad S. Khalil; David R. Liu
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AI-redesigned starting points and outcomes enhance protein evolutionAI再设计起始点和结果以增强蛋白质进化
errNature
IF48.5
err2026-07-22
err0
errOAAI
errNicholas A. Krasnow; Joy A. Xu; Emily Zhang; Gandhar K. Mahadeshwar; Y. Allen Tao; Julia McCreary; Colin F. Hemez; Logan E. Brown; Wei Jiang; David R. Liu
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AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editingAI指导的实验室进化逆转录酶的重新设计增强了prime编辑
err2026-05-21
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errOAAI
errY. Allen Tao; Holt A. Sakai; Allen Y. Jiang; Nicholas A. Krasnow; Vasilii S. Vaganov; Brian Shim; Zachary Barsdale; Smriti Pandey; Nouraiz Ahmed; Man Na; Ting-Wei Liao; Keyede Oye; Ana Cristian; Emily Zhang; Joy A. Xu; Mattijs Bulcaen; David R. Liu
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In vivo adenine base editing ameliorates Dravet syndrome phenotypes in a mouse model体内腺嘌呤碱基编辑改善小鼠模型中的Dravet综合征表型
err2026-05-13
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PREAI
errAndrew T. Nelson; Sophie F. Hill; Matthew Simon; Jérôme Clatot; Holt A. Sakai; Jun Xie; Alexander A. Sousa; Meirui An; Guangping Gao; Cathleen M. Lutz; Ethan M. Goldberg; David R. Liu
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In vivo base editing rescues liver pathophysiology and peroxisome dysfunction in a mouse model of Zellweger spectrum disorder体内碱基编辑纠正Zellweger谱系障碍小鼠模型的肝脏病理生理学和过氧化物酶体功能障碍
err2026-04-14
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errOAAI
errXin D. Gao; Maximiliano Presa; Jordyn E. Duby; Jennifer Ryan; Pierre-Alexandre Piec; Alvin Hsu; Samagya Banskota; Allen Yujie Jiang; Lingxiao Chen; Gregory A. Newby; Erminia Di Pietro; Jonathan M. Levy; Bradford H. Steele; Sarah Lecordier; Fangfei Qin; Ann B. Moser; Jun Xie; Guangping Gao; Nancy E. Braverman; Aamir R. Zuberi; Joseph G. Hacia; Cathleen M. Lutz; David R. Liu
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Small-molecule binding and sensing with a designed protein family与设计的蛋白质家族的小分子结合和传感
err2026-03-28
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errOAAI
errGyu Rie Lee; Samuel J. Pellock; Christoffer Norn; Doug Tischer; Justas Dauparas; Ivan Anishchenko; Jaron A. M. Mercer; Alex Kang; Asim K. Bera; Hannah Nguyen; Evans Brackenbrough; Banumathi Sankaran; Inna Goreshnik; Dionne Vafeados; Nicole Roullier; Hannah L. Han; Brian Coventry; Hugh K. Haddox; David R. Liu; Andy Hsien-Wei Yeh; David Baker
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Prime editing-installed suppressor tRNAs for disease-agnostic genome editingPrime editing技术安装的抑制性tRNAs,用于无疾病特异性的基因组编辑
errNature
IF48.5
err2025-11-19
err0
errOAAI
errSarah E. Pierce; Steven Erwood; Keyede Oye; Meirui An; Nicholas Krasnow; Emily Zhang; Aditya Raguram; Davis Seelig; Mark J. Osborn; David R. Liu
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Scalable purification enables high-quality virus-like particles for therapeutic translation可扩展纯化技术能够为治疗性转化提供高质量病毒样颗粒
err2025-11-13
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errOAAI
errRafal Hołubowicz; Fangyuan Gao; Samuel W. Du; Carolline Rodrigues Menezes; Jianye Zhang; Maria W. Hołubowicz; Paul Z. Chen; Niklas Armbrust; Julian Geilenkeuser; David R. Liu; Dong-Jiunn Jeffery Truong; Gil Gregor Westmeyer; Grazyna Palczewska; Krzysztof Palczewski
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Improved utilization of operating room acid-fast bacilli and fungal culture ordering through quick button modification通过快速按钮修改提高手术室抗酸杆菌和真菌培养的利用率
err2025-11-01
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PREAI
errSatia, Shivani; Pfeiffer, Jennifer; Kuang, Yingzhe; Chua, Kristine; Russell, Sarah; Cullen, Regina; Wu, Fann; Liu, David; Goss, Cheryl; Stone, Elizabeth F.; Berry, Gregory J.; Westblade, Lars F.; Green, Daniel A.
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Engraftment and persistence of HBB base-edited hematopoietic stem cells in nonhuman primatesHBB碱基编辑造血干细胞的植入与持久性在非人灵长类动物中的研究
err2025-08-13
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PREAI
errStefan Radtke; Emily Fields; Kyle Swing; Greta Kanestrom; Jonathan S. Yen; Dnyanada Pande; Mark R. Enstrom; Olivier Humbert; Mitchell J. Weiss; David R. Liu; Gregory A. Newby; Hans-Peter Kiem
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GFP-on mouse model for interrogation of in vivo gene editingGFP-on 小鼠模型用于体内基因编辑的探究
err2025-07-31
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errOAAI
errCarla Dib; Jack A. Queenan; Leah Swartzrock; Hana Willner; Morgane Denis; Nouraiz Ahmed; Fareha Moulana Zada; Beltran Borges; Carsten T. Charlesworth; Tony Lum; Bradley P. Yates; Caleb Y. Kwon; Augustino V. Scorzo; Scott C. Davis; Jessie R. Davis; Ran He; Jun Xie; Guangping Gao; Tippi C. MacKenzie; David R. Liu; Gregory A. Newby; Agnieszka D. Czechowicz
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Precisely defining disease variant effects in CRISPR-edited single cells在CRISPR编辑的单细胞中精确定义疾病变异效应
errNature
IF48.5
err2025-07-23
err0
errOAAI
errYuriy Baglaenko; Zepeng Mu; Michelle Curtis; Hafsa M. Mire; Vidyashree Jayanthi; Majd Al Suqri; Cassidy Liu; Ryan Agnew; Aparna Nathan; Annelise Yoo Mah-Som; David R. Liu; Gregory A. Newby; Soumya Raychaudhuri
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In vivo prime editing rescues alternating hemiplegia of childhood in mice体内碱基编辑可恢复儿童交替性偏瘫小鼠模型
errCell
IF42.5
err2025-07-21
err0
errOAAI
errAlexander A. Sousa; Markus Terrey; Holt A. Sakai; Christine Q. Simmons; Elena Arystarkhova; Natalia S. Morsci; Laura C. Anderson; Jun Xie; Fabian Suri-Payer; Linda C. Laux; Emmanuel Roze; Sylvie Forlani; Guangping Gao; Simon Frost; Nina Frost; Kathleen J. Sweadner; Alfred L. George; Cathleen M. Lutz; David R. Liu
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Platform solutions for commercial challenges to expanding patient access and making gene editing sustainable针对商业挑战的平台解决方案,以扩大患者访问范围并使基因编辑可持续发展
err2025-07-15
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PREAI
errSadik H. Kassim; Fyodor Urnov; Kiran Musunuru; Ann Lee; Luis Barrera; Pamela Stetkiewicz; Julianne Bruno; Matthew Hewitt; Troy Lister; Harry Malech; Lindsay Gasch; Matt Diver; Nicholas Gertler; Felix Grignon; Audrey Le; Michael Lehmicke; Edwin M. Horwitz; David R. Liu; Josephine Lembong; Vanessa Almendro-Navarro
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Advancing gene-editing platforms to improve the viability of rare-disease therapeutics: key insights from a 2024 Scientific Exchange hosted by ARM, ISCT, and Danaher推进基因编辑平台以改善罕见病治疗方案的可行性:2024年由ARM、ISCT和Danaher主办的科学交流会的关键见解
err2025-06-24
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PREAI
errFyodor Urnov; Sadik Kassim; Kiran Musunuru; David Liu; Ann Lee; Luis Barrera; Pam Stetkiewicz; Julianne Bruno; Matthew Hewitt; Troy Lister; Harry Malech; Lindsay Gasch; Matt Diver; Nicholas Gertler; Felix Grignon; Audrey Le; Michael Lehmicke; Vanessa Almendro-Navarro; Josephine Lembong
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Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in mice对引起亨廷顿病和弗里德赖希共济失调的三核苷酸重复序列进行碱基编辑,可降低患者细胞和小鼠中的体细胞重复序列扩增。
err2025-05-26
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errOAAI
errMatuszek, Zaneta; Arbab, Mandana; Kesavan, Maheswaran; Hsu, Alvin; Roy, Jennie C. L.; Zhao, Jing; Yu, Tian; Weisburd, Ben; Newby, Gregory A.; Doherty, Neil J.; Wu, Muzhou; Shibata, Shota; Cristian, Ana; Tao, Y. Allen; Fearnley, Liam G.; Bahlo, Melanie; Rehm, Heidi L.; Xie, Jun; Gao, Guangping; Mouro Pinto, Ricardo; Liu, David R.
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Self-assembling protein nanoparticles for cytosolic delivery of nucleic acids and proteins自组装蛋白纳米颗粒用于细胞质递送核酸和蛋白质
err2025-05-15
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PREAI
errFeyisayo Eweje; Vanessa Ibrahim; Aram Shajii; Michelle L. Walsh; Kiran Ahmad; Assma Alrefai; Dominie Miyasato; Jessie R. Davis; Hyunok Ham; Kaicheng Li; Michael Roehrl; Carolyn A. Haller; David R. Liu; Jiaxuan Chen; Elliot L. Chaikof
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