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D

Dhirendra K. Simanshu

Frederick National Laboratory for Cancer Research

32H指数
177论文数
5.9K被引数
收录论文 68
发表时间
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Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific regionKRAS与BRAF结合的分子机制及其受BRAF特异性区域的调控
errStructure
IF4.3
err2026-10-12
err0
PREAI
errDaniel A. Bonsor; Suzanne I. Sandin Lawrence; Timothy H. Tran; Monalisa Swain; Srisathiyanarayanan Dharmaiah; Jennifer Mehalko; Simon A. Messing; Dwight V. Nissley; Frank McCormick; Andrew G. Stephen; Dhirendra K. Simanshu
err分享
err收藏
Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRASKRAS中抗Switch-II口袋抑制剂的分子结构机制
errNature Communications
IF15.7
err2026-09-29
err0
errOAAI
errMatthew J. Whitley; Marcin Dyba; Mayukh Chakrabarti; Brian P. Smith; Albert H. Chan; John-Paul Denson; Simon A. Messing; Ken Lin; Gabriel Cornilescu; Trent E. Balius; Dwight V. Nissley; Frank McCormick; Anna E. Maciag; Dhirendra K. Simanshu
err分享
err收藏
Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass重新审视RAS家族GTP酶信号传导：效应器选择性和致癌性绕过
errBiochemical Journal
IF4.3
err2026-05-01
err1
PREAI
errSimanshu, Dhirendra K.; McCormick, Frank
err分享
err收藏
Disulfide tethering reveals cryptic pockets in oncogenic KRAS二硫键连接技术揭示了致癌性KRAS中的隐匿口袋
errCommunications Chemistry
IF6.2
err2026-03-30
err0
errOAAI
errTrent E. Balius; Marcin Dyba; Vandana Kumari; John-Paul Denson; Ming Yi; Alok K. Sharma; Priyanka Prakash; Emily Alberico; Simon Messing; Vanessa Wall; Albert H. Chan; Dhirendra K. Simanshu; Dwight V. Nissley; Frank McCormick; Dominic Esposito; Anna E. Maciag; David M. Turner
err分享
err收藏
KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics
errJournal of Biological Chemistry
IF3.9
err2026-02-04
err0
errOAAI
errKonstantia Georgouli; Jeremy O.B. Tempkin; Liam G. Stanton; Tomas Oppelstrup; Rebika Shrestha; Timothy S. Carpenter; Fikret Aydin; Xiaohua Zhang; Harsh Bhatia; Yue Yang; Que N. Van; Pedro Andrade Bonilla; Gulcin Gulten; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Joseph Y. Moon; Gautham Dharuman; Nicolas W. Hengartner; Dhirendra K. Simanshu
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Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitorsSHOC2-KRAS-PP1C复合物的结构揭示了RAS亚型特异性的决定因素以及RAS抑制剂靶向复合物组装的见解
errNature Communications
IF15.7
err2026-01-10
err0
errOAAI
errDaniel A. Bonsor; Lorenzo I. Finci; Jacob R. Potter; Lucy C. Young; Vanessa E. Wall; Ruby Goldstein de Salazar; Katie R. Geis; Tyler Stephens; Joseph Finney; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu
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Structural basis for LZTR1 recognition of RAS GTPases for degradationLZTR1识别RAS GTPases以促进其降解的结构基础
errScience
IF45.8
err2025-09-11
err0
PREAI
errSrisathiyanarayanan Dharmaiah; Daniel A. Bonsor; Stephanie P. Mo; Alvaro Fernandez-Cabrera; Albert H. Chan; Simon Messing; Matthew Drew; Martha Vega; Dwight V. Nissley; Dominic Esposito; Pau Castel; Dhirendra K. Simanshu
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Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin促进RAS与PI3Kα结合的分子胶水可促进无胰岛素依赖的葡萄糖摄取
errScience
IF45.8
err2025-07-24
err0
PREAI
errKoji Terayama; Shinji Furuzono; Nicole Fer; Wupeng Yan; Lucy C. Young; Daniel J. Czyzyk; Ruby Goldstein de Salazar; Masato Sasaki; Akihiro Uozumi; Masahiro Konishi; Shoichi Kanda; Yoshitaka Sogawa; Mitsuhiro Yamaguchi; Takashi Tsuji; Junichi Kuroyanagi; Mayumi Hayashi; Yuji Ogura; Dhirendra K. Simanshu; Kazuishi Kubota; Jun Tanaka; Frank McCormick
err分享
err收藏
Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraintsKRAS开关-II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性的结合限制
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errPatrick Alexander; Albert H. Chan; Dana Rabara; Monalisa Swain; Erik K. Larsen; Marcin Dyba; Oleg Chertov; Mariam Ashraf; Allison Champagne; Ken Lin; Anna Maciag; William K. Gillette; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu; Andrew G. Stephen
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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interactionBBO-10203通过阻断RAS-PI3Kα相互作用抑制肿瘤生长，而不诱导高血糖症
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
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err收藏
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine通过直接共价攻击CaaX盒半胱氨酸来阻断KRAS4b的C末端加工
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
err分享
err收藏
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation结构洞察：异构体特异性的RAS-PI3Kα相互作用及其RAS在PI3Kα激活中的作用
errNATURE COMMUNICATIONS
IF15.7
err2025-01-09
err0
errOAAI
errCzyzyk, Daniel; Yan, Wupeng; Messing, Simon; Gillette, William; Tsuji, Takashi; Yamaguchi, Mitsuhiro; Furuzono, Shinji; Turner, David M.; Esposito, Dominic; Nissley, Dwight V.; Mccormick, Frank; Simanshu, Dhirendra K.
err分享
err收藏
BBO-10203, an orally bioavailable small molecule that disrupts the RAS-PI3Kα interaction leading to pAKT and tumor growth inhibition in models of breast, lung and colorectal cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errSimanshu, D.; Xu, R.; Stice, J.; Czyzyk, D.; Feng, S.; Yang, Y.; Denson, J. P.; Riegler, E.; Zhang, C.; Fu, L.; Lin, K.; Lightstone, F. C.; Wang, K.; Stephen, A. G.; Maciag, A. E.; Sinkevicius, K.; Nissley, D. V.; Wallace, E. M.; McCormick, F.; Beltran, P.
err分享
err收藏
Functional and structural insights into RAS effector proteins对RAS效应蛋白的功能和结构洞察
errMOLECULAR CELL
IF16.6
err2024-08-01
err1
PREAI
errMozzarelli, Alessandro M.; Simanshu, Dhirendra K.; Castel, Pau
err分享
err收藏
Functional and structural insights into RAS effector proteins (vol 84, pg 2807, 2024)
errMOLECULAR CELL
IF16.6
err2024-08-01
err0
errOAAI
errMozzarelli, Alessandro M.; Simanshu, Dhirendra K.; Castel, Pau
err分享
err收藏
BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
err分享
err收藏
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-03-02
err5
errOAAI
errFinci, Lorenzo I.; Chakrabarti, Mayukh; Gulten, Gulcin; Finney, Joseph; Grose, Carissa; Fox, Tara; Yang, Renbin; Nissley, Dwight V.; McCormick, Frank; Esposito, Dominic; Balius, Trent E.; Simanshu, Dhirendra K.
err分享
err收藏
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties
errSCIENCE ADVANCES
IF12.5
err2024-02-16
err5
errOAAI
errWhitley, Matthew J.; Tran, Timothy H.; Rigby, Megan; Yi, Ming; Dharmaiah, Srisathiyanarayanan; Waybright, Timothy J.; Ramakrishnan, Nitya; Perkins, Shelley; Taylor, Troy; Messing, Simon; Esposito, Dominic; Nissley, Dwight V.; McCormick, Frank; Stephen, Andrew G.; Turbyville, Thomas; Cornilescu, Gabriel; Simanshu, Dhirendra K.
err分享
err收藏
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity
errCANCER RESEARCH
IF16.6
err2023-08-09
err4
PREAI
errYang, Moon Hee; Tran, Timothy H.; Hunt, Bethany; Agnor, Rebecca; Johnson, Christian W.; Shui, Bing; Waybright, Timothy J.; Nowak, Jonathan A.; Stephen, Andrew G.; Simanshu, Dhirendra K.; Haigis, Kevin M.
err分享
err收藏
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy
errSCIENCE ADVANCES
IF12.5
err2023-07-14
err8
errOAAI
errCuevas-Navarro, Antonio; Wagner, Morgan; Van, Richard; Swain, Monalisa; Mo, Stephanie; Columbus, John; Allison, Madeline R.; Cheng, Alice; Messing, Simon; Turbyville, Thomas J.; Simanshu, Dhirendra K.; Sale, Matthew J.; McCormick, Frank; Stephen, Andrew G.; Castel, Pau
err分享
err收藏

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