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Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies Zhai, Shiyang; Kemkes, Marie; Kponomaizoun, Cindy-Esther; Gerhartz, Jan; Feller, Felix; Tu, Jia-Wey; Pienkowska, Dominika Ewa; Schliehe-Diecks, Julian; Dressel, Ina; Gutschow, Michael; Nowak, Radoslaw P.; Steinebach, Christian; Bhatia, Sanil; Hansen, Finn K. 分享 收藏
A Facile Protocol for C(sp2)-C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands 面向功能化E3连接酶配体的C(sp2)-C(sp3) 键形成反应的简便方案 Maksutova, Anita; Geiger, Thomas M.; Cianni, Lorenzo; Pienkowska, Dominika E.; Gerhartz, Jan; Read, Lina; Bricelj, Alesa; Herrmann, Alexander; Nelles, Maurice Leon; Ng, Yuen Lam Dora; Hartmann, Marcus D.; Kronke, Jan; Sosic, Izidor; Nowak, Radoslaw P.; Gutschow, Michael; Steinebach, Christian 分享 收藏
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Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs BCL-2靶向PROTACs的设计、合成与评价 Bricelj, Alesa; Ng, Yuen Lam Dora; Gobec, Martina; Kuchta, Robert; Hu, Wanyi; Javornik, Spela; Rozic, Miha; Guetschow, Michael; Zheng, Guangrong; Kroenke, Jan; Steinebach, Christian; Sosic, Izidor 分享 收藏
USP7 IS AN INTERACTION PARTNER OF EZHIP AND POTENTIAL DRUGGABLE TARGET IN PFA EPENDYMOMAS Jenseit, Anne; Camgoez, Aylin; Mauermann, Monika; Mack, Norman; Schwalm, Benjamin; Mohr, Jacqueline; Wittenburg, Sophie; Steinebach, Christian; Guetschow, Michael; Peterziel, Heike; Friedenauer, Aileen; Jaunecker, Carola; Loetsch-Gojo, Daniela; Oehme, Ina; Pfister, Stefan M.; Kool, Marcel 分享 收藏
Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics Voget, Rabea; Breidenbach, Julian; Claff, Tobias; Hingst, Alexandra; Sylvester, Katharina; Steinebach, Christian; Vu, Lan Phuong; Weisse, Renato H.; Bartz, Ulrike; Straeter, Norbert; Mueller, Christa E.; Guetschow, Michael 分享 收藏
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs Steinebach, Christian; Bricelj, Alesa; Murgai, Arunima; Sosic, Izidor; Bischof, Luca; Ng, Yuen Lam Dora; Heim, Christopher; Maiwald, Samuel; Proj, Matic; Voget, Rabea; Feller, Felix; Kosmrlj, Janez; Sapozhnikova, Valeriia; Schmidt, Annika; Zuleeg, Maximilian Rudolf; Lemnitzer, Patricia; Mertins, Philipp; Hansen, Finn K.; Guetschow, Michael; Kroenke, Jan; Hartmann, Marcus D. 分享 收藏
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers Vu, Lan Phuong; Diehl, Claudia J.; Casement, Ryan; Bond, Adam G.; Steinebach, Christian; Strasek, Nika; Bricelj, Alesa; Perdih, Andrej; Schnakenburg, Gregor; Sosic, Izidor; Ciulli, Alessio; Guetschow, Michael 分享 收藏
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins Ng, Yuen Lam Dora; Bricelj, Alesa; Jansen, Jacqueline A.; Murgai, Arunima; Peter, Kirsten; Donovan, Katherine A.; Guetschow, Michael; Kroenke, Jan; Steinebach, Christian; Sosic, Izidor 分享 收藏
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Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design Kuchta, Robert; Heim, Christopher; Herrmann, Alexander; Maiwald, Samuel; Ng, Yuen Lam Dora; Sosic, Izidor; Keuler, Tim; Kroenke, Jan; Guetschow, Michael; Hartmann, Marcus D.; Steinebach, Christian 分享 收藏
Proteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma 蛋白质组学分析揭示CDK6上调是多发性骨髓瘤来那度胺的靶向耐药机制 Ng, Yuen Lam Dora; Ramberger, Evelyn; Bohl, Stephan R.; Dolnik, Anna; Steinebach, Christian; Conrad, Theresia; Mueller, Sina; Popp, Oliver; Kull, Miriam; Haji, Mohamed; Guetschow, Michael; Doehner, Hartmut; Walther, Wolfgang; Keller, Ulrich; Bullinger, Lars; Mertins, Philipp; Kroenke, Jan 分享 收藏
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity Schulte, Bianca; Koenig, Maria; Escher, Beate, I; Wittenburg, Sophie; Proj, Matic; Wolf, Valentina; Lemke, Carina; Schnakenburg, Gregor; Sosic, Izidor; Streeck, Hendrik; Mueller, Christa E.; Guetschow, Michael; Steinebach, Christian 分享 收藏
Targeting the deubiquitinase USP7 for degradation with PROTACs Murgai, Arunima; Sosic, Izidor; Gobec, Martina; Lemnitzer, Patricia; Proj, Matic; Wittenburg, Sophie; Voget, Rabea; Guetschow, Michael; Kroenke, Jan; Steinebach, Christian 分享 收藏
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