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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075 ALG-000184的发现和临床前概况，有效的乙型肝炎病毒衣壳组装调节剂ALG-001075的前药 Vendeville, Sandrine; Amblard, Franck; Bassit, Leda; Beigelman, Leonid N.; Blatt, Lawrence M.; Chen, Xiaoyuan; Chou, Lang; Kum, Dieudonne Buh; Chanda, Sushmita; Deval, Jerome; Geng, Xiu; Gupta, Kusum; Jekle, Andreas; Hu, Haiyang; Hu, Xiaojuan; Kang, Hyunsoon; Liu, Cheng; Liu, Jyanwei; Mcgowan, David C.; Misner, Dinah L.; Raboisson, Pierre; Sanchez, Abel Acosta; Serebryany, Vladimir; Stoycheva, Antitsa D.; Symons, Julian A.; Tan, Hua; Vanrusselt, Hannah; Williams, Caroline; Welch, Michael; Zhang, Liangliang; Zhang, Qingling; Zhang, Yafeng; Schinazi, Raymond F.; Smith, David B.; Debing, Yannick 分享 收藏
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules Kao, C. Cheng; Nie, Yuchun; Ren, Suping; De Costa, N. Tilani T. S.; Pandey, Rajendra K.; Hong, Jin; Smith, David B.; Symons, Julian A.; Beigelman, Leonid; Blatt, Lawrence M. 分享 收藏
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wu, Xiangyang; Chen, Tongqian; Huang, Wensheng; Rajwanshi, Vivek K.; Deval, Jerome; Fung, Amy; Jin, Zhinan; Stoycheva, Antitsa; Shaw, Kenneth; Gupta, Kusum; Tam, Yuen; Jekle, Andreas; Smith, David B.; Beigelman, Leonid 分享 收藏
Preclinical characterization of ALG-031048, a novel STING agonist with potent anti-tumor activity in mice Jekle, Andreas; Thatikonda, Santosh; Stevens, Sarah; Williams, Caroline; Kinkade, April; Ren, Suping; Jaisinghani, Ruchika; Zhang, Qingling; Misner, Dinah; Stoycheva, Antitsa; Deval, Jerome; Mukherjee, Sucheta; Gonzalvez, Francois; Chanda, Sushmita; Smith, David B.; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leonid 分享 收藏
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Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′-C-methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection Wang, Guangyi; Dyatkina, Natalia; Prhavc, Marija; Williams, Caroline; Serebryany, Vladimir; Hu, Yujian; Huang, Yongfei; Wan, Jinqiao; Wu, Xiangyang; Deval, Jerome; Fung, Amy; Jin, Zhinan; Fan, Hua; Shaw, Kenneth; Kang, Hyunsoon; Zhang, Qingling; Tam, Yuen; Stoycheva, Antitsa; Jekle, Andreas; Smith, David B.; Beigelman, Leonid 分享 收藏
Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues Wang, Guangyi; Wan, Jingiao; Hu, Yujian; Wu, Xiangyang; Prhavc, Marija; Dyatkina, Natalia; Rajwanshi, Vivek K.; Smith, David B.; Jekle, Andreas; Kinkade, April; Symons, Julian A.; Jin, Zhinan; Deval, Jerome; Zhang, Qjngling; Tam, Yuen; Chanda, Sushmita; Blatt, Lawrence; Beigelman, Leonid 分享 收藏
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2′-Fluoro-4′-Chloromethyl-Cytidine Triphosphate Deval, Jerome; Hong, Jin; Wang, Guangyi; Taylor, Josh; Smith, Lucas K.; Fung, Amy; Stevens, Sarah K.; Liu, Hong; Jin, Zhinan; Dyatkina, Natalia; Prhavc, Marija; Stoycheva, D.; Serebryany, Vladimir; Liu, Jyanwei; Smith, David B.; Tam, Yuen; Zhang, Qingling; Moore, Martin L.; Fearns, Rachel; Chanda, Sushmita M.; Blatt, Lawrence M.; Symons, Julian A.; Beigelman, Leo 分享 收藏
PRECLINICAL CHARACTERIZATION OF AL-335, A POTENT URIDINE BASED NUCLEOSIDE POLYMERASE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS C Tan, H.; Shaw, K.; Jekel, A.; Deval, J.; Jin, Z.; Fung, A.; Tam, Y.; Blatt, L. M.; Chanda, S. M.; Wang, G.; Prhavc, M.; Serebryany, V.; Zhang, Q.; Symons, J. A.; Beigelman, L.; Smith, D. B. 分享 收藏
Discovery of 4′-Chloromethyl-2′-deoxy-3′,5′-di-O-isobutyryl-2′-fluorocytidine (ALS-8176), A First-in-Class RSV Polymerase Inhibitor for Treatment of Human Respiratory Syncytial Virus Infection Wang, Guangyi; Deval, Jerome; Hong, Jin; Dyatkina, Natalia; Prhavc, Marija; Taylor, Joshua; Fung, Amy; Jin, Zhinan; Stevens, Sarah K.; Serebryany, Vladimir; Liu, Jyanwei; Zhang, Qingling; Tam, Yuen; Chanda, Sushmita M.; Smith, David B.; Symons, Julian A.; Blatt, Lawrence M.; Beigelman, Leo 分享 收藏
IN VITRO RESISTANCE TO ALS-2200, A POTENT NUCLEOTIDE POLYMERASE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS C Tan, H.; Jekle, A.; Kang, H.; Moy, C.; Deval, J.; Tigges, A.; Zhang, E.; Jiang, M.; Andzinski, A.; Dyatkina, N.; Wang, G.; Rijnbrand, R.; Kieffer, T. L.; Blatt, L. M.; Beigelman, L.; Smith, D. B.; Symons, J. A. 分享 收藏
Biochemical Study of the Comparative Inhibition of Hepatitis C Virus RNA Polymerase by VX-222 and Filibuvir Yi, Guanghui; Deval, Jerome; Fan, Baochang; Cai, Hui; Soulard, Charlotte; Ranjith-Kumar, C. T.; Smith, David B.; Blatt, Lawrence; Beigelman, Leonid; Kao, C. Cheng 分享 收藏
The Design, Synthesis, and Antiviral Activity of Monofluoro and Difluoro Analogues of 4′-Azidocytidine against Hepatitis C Virus Replication: The Discovery of 4′-Azido-2′-deoxy-2′-fluorocytidine and 4′-Azido-2′-dideoxy-2′,2′-difluorocytidine Smith, David B.; Kalayanov, Genadiy; Sund, Christian; Winqvist, Anna; Maltseva, Tatiana; Leveque, Vincent J. -P.; Rajyaguru, Sonal; Le Pogam, Sophie; Najera, Isabel; Benkestock, Kurt; Zhou, Xiao-Xiong; Kaiser, Ann C.; Maag, Hans; Cammack, Nick; Martin, Joseph A.; Swallow, Steven; Johansson, Nils Gunnar; Klumpp, Klaus; Smith, Mark 分享 收藏
2′-DEOXY-NUCLEOSIDE ANALOGS AS POTENT DUAL INHIBITORS OF HCV AND HIV REPLICATION, WITH SELECTIVITY AGAINST OTHER VIRAL AND HUMAN POLYMERASES Klumpp, K.; Su, G.; Deval, J.; Leveque, V.; Jekle, A.; Rajyaguru, S.; Gee, P.; Li, Y.; Hang, J.; Ma, H.; Inocencio, N.; Kalayanov, G.; Winqvist, A.; Smith, D.; Cammack, N.; Johansson, N. G.; Heilek, G.; Najera, I. 分享 收藏
The Design, Synthesis, and Antiviral Activity of 4′-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4′-Azidoarabinocytidine Smith, David B.; Kalayanov, Genadiy; Sund, Christian; Winqvist, Anna; Pinho, Pedro; Maltseva, Tatiana; Morisson, Veronique; Leveque, Vincent; Rajyaguru, Sonal; Le Pogam, Sophie; Najera, Isabel; Benkestock, Kurt; Zhou, Xiao-Xiong; Maag, Hans; Cammack, Nick; Martin, Joseph A.; Swallow, Steven; Johansson, Nils Gunnar; Klumpp, Klaus; Smith, Mark 分享 收藏
2′-deoxy-4′-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2′-α-hydroxyl groups Klumpp, Klaus; Kalayanov, Genadiy; Ma, Han; Le Pogam, Sophie; Leveque, Vincent; Jiang, Wen-Rong; Inocencio, Nicole; De Witte, Anniek; Rajyaguru, Sonal; Tai, Ezra; Chanda, Sushmita; Irwin, Michael R.; Sund, Christian; Winqist, Anna; Maltseva, Tatiana; Eriksson, Staffan; Usova, Elena; Smith, Mark; Alker, Andre; Najera, Isabel; Cammack, Nick; Martin, Joseph A.; Johansson, Nils Gunnar; Smith, David B. 分享 收藏
First example of phosphoramidate approach applied to a 4′-substituted purine nucleoside (4′-azidoadenosine):: Conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus Perrone, Plinio; Daverio, Felice; Valente, Rocco; Rajyaguru, Sonal; Martin, Joseph A.; Leveque, Vincent; Le Pogam, Sophie; Najera, Isabel; Klumpp, Klaus; Smith, David B.; McGuigan, Christopher 分享 收藏
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor β-D-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species Ma, Han; Jiang, Wen-Rong; Robledo, Nicole; Leveque, Vincent; Ali, Samir; Lara-Jaime, Teresa; Masjedizadeh, Mohammad; Smith, David B.; Cammack, Nick; Klumpp, Klaus; Symons, Julian 分享 收藏
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