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Andrew E. Aplin

thomas jefferson university

55H指数
507论文数
1.1W被引数
收录论文 143
发表时间
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A Phase II Trial of Defactinib Combined with Avutometinib in Patients with Metastatic Uveal MelanomaII期临床试验：defactinib联合avutometinib治疗转移性葡萄膜黑色素瘤患者
errCancers
IF4.4
err2026-07-28
err0
errOAAI
errRino S. Seedor; Mizue Terai; Sergei Koshkin; Andrew E. Aplin; Marlana Orloff; Erin Sharpe-Mills; Madeleine Naccarato; Aurora Mills; Alfredo A. Molinolo; J. Silvio Gutkind; Takami Sato
err分享
err收藏
S-phase targeted treatment triggers caspase-dependent lytic immunogenic cell death with pyroptotic features in cancersS期靶向治疗在癌症中触发具有焦亡特征的半胱天冬酶依赖性裂解性免疫原性细胞死亡
errCell Death and Differentiation
IF15.4
err2026-07-10
err0
errOAAI
errRituparna Bhatt; Si En Ong; Dan A. Erkes; Katia Maria Xavier Leung; Koyo Kinase; Khai Yee Lim; Alexis Bonfim-Melo; Enaam Alghamdi; Sheena Daignault-Mill; Yoon Lim; Nur Jannah Abdul Rahim; Aditya Gopalakrishnan; Xin Yee Ong; Nicole Lisa Li-Ann Goh; Anastasia Gandini; Martina Proctor; Sharad Kumar; Zhen Zeng; Nikolas K. Haass; Mathew JK Jones; Paul Clarke; Andrew E. Aplin; Brian Gabrielli
err分享
err收藏
Meeting Report From the 2025 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Amsterdam, the Netherlands, October 20252025年治愈眼黑色素瘤（CURE OM）全球科学会议（荷兰阿姆斯特丹，2025年10月）会议报告
errPigment Cell & Melanoma Research
IF2.6
err2026-06-23
err0
errOAAI
errAndrew E. Aplin; Katherina Alsina; Allison S. Betof; Joseph Birkett; Marcus O. Butler; George Cole Jr.; Rizwan Haq; Florian A. Karreth; Vinit B. Mahajan; Rahul Marpadga; Prithvi Mruthyunjaya; Paul Nathan; Jonas A. Nilsson; Gary Palmer; Joseph J. Sacco; Takami Sato; Sarah Stanhope; Pang-ning Teng; Kyleigh LiPira
err分享
err收藏
Diacylglycerol Kinase Eta as a Novel Target in NRAS Mutant Melanoma二酰基甘油激酶η作为NRAS突变黑色素瘤的新型靶点
errPigment Cell & Melanoma Research
IF2.6
err2026-05-21
err0
errOAAI
errHaley P. Wilson; Casey D. Stefanski; Signe Caksa; Glenn L. Mersky; Scott D. Varney; Jelan I. Haj; Dan A. Erkes; Timothy J. Purwin; Vivian Chua; Andrew E. Aplin
err分享
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Aqueous humor biomarkers in ocular oncology: Insights and advances眼科学中房水生物标志物：见解与进展
errCell Reports Medicine
IF10.6
err2025-11-07
err0
errOAAI
errLara Cheslow; Signe Caksa; Rachel E. Cain; Scott A. Waldman; Andrew E. Aplin
err分享
err收藏
Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models靶向TAZ-TEAD在微小残留病灶中增强了黑色素瘤模型中靶向治疗的持续时间
errNature Communications
IF15.7
err2025-11-05
err0
errOAAI
errConnor A. Ott; Timothy J. Purwin; Pan-Yu Chen; Somenath Chowdhury; George L. Mellor; Kristine Luo; Glenn L. Mersky; Manoela Tiago; William D. Madden; Scott D. Varney; Dan A. Erkes; John Lamar; Claudia Capparelli; Gideon Bollag; Andrew E. Aplin
err分享
err收藏
SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic targetSETDB1是脉络膜黑色素瘤生长所必需的关键因素，并代表一个有希望的 therapeutic target。
errCell Death & Disease
IF9.6
err2025-10-24
err0
errOAAI
errImène Krossa; Céline Pisibon; Yann Cheli; Karine Bille; Mélanie Dalmasso; Sabah Hamadat; Chrystel Husser; Marie Irondelle; Julien Cherfils-Vicini; Frédéric Soysouvanh; Sacha Nahon-Esteve; Arnaud Martel; Sandra Lassalle; Jean-Pierre Caujolle; Célia Maschi; Stéphanie Baillif; Dan Hasson; Saul Carcamo; Andrew E. Aplin; Irwin Davidson; Emily Bernstein; Valeria Naim; Robert Ballotti; Corine Bertolotto; Thomas Strub
err分享
err收藏
Inhibition of anti-apoptotic BCL2 overcomes adaptive resistance to co-targeting of the protein kinase FAK and MEK in GNAQ-driven uveal melanoma抑制抗凋亡BCL2克服了针对FAK和MEK蛋白激酶联合靶向在GNAQ驱动的眼葡萄膜黑色素瘤中的适应性耐药
errJournal of Biological Chemistry
IF3.9
err2025-09-11
err0
errOAAI
errSimone Lubrano; Rodolfo Daniel Cervantes-Villagrana; Nadia Arang; Adam Officer; Sendi Rafael Adame-Garcia; Gabriela Cuesta-Margolles; Andrew E. Aplin; J.Silvio Gutkind
err分享
err收藏
Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023
errPIGMENT CELL & MELANOMA RESEARCH
IF2.6
err2024-10-09
err0
errOAAI
errSeedor, Rino S.; Aplin, Andrew E.; Bertolotto, Corine; Carvajal, Richard D.; Deacon, Nigel; Doble, Katie; Hamid, Omid; Haq, Rizwan; Kadosh, Miriam; Khan, Shaheer; Kraska, Jacqueline; Lutzky, Jose; McKean, Meredith; Montazeri, Kamaneh; Moser, Justin; Onken, Michael; Orloff, Marlana; Sacco, Joseph J.; Smalley, Keiran; Selig, Sara M.
err分享
err收藏
Slow proliferation of BAP1-deficient uveal melanoma cells is associated with reduced S6 signaling and resistance to nutrient stress
errSCIENCE SIGNALING
IF6.6
err2024-06-11
err0
errOAAI
errChua, Vivian; Lopez-Anton, Melisa; Teral, Mizue; Tanaka, Ryota; Baqai, Usman; Purwin, Timothy J.; Haj, Jelan I.; Waltrich, Francis J.; Trachtenberg, Isabella; Luo, Kristine; Tudi, Rohith; Jeon, Angela; Han, Anna; Chervoneva, Inna; Davies, Michael A.; Aguirre-Ghiso, Julio A.; Sato, Takami; Aplin, Andrew E.
err分享
err收藏
Mcl-1 mediates intrinsic resistance to RAF inhibitors in mutant BRAF papillary thyroid carcinoma
errCELL DEATH DISCOVERY
IF7
err2024-04-15
err3
errOAAI
errCavallo, Maria R.; Yo, Jacob C.; Gallant, Kayla C.; Cunanan, Camille J.; Amirfallah, Amirali; Daniali, Marzieh; Sanders, Alyssa B.; Aplin, Andrew E.; Pribitkin, Edmund A.; Hartsough, Edward J.
err分享
err收藏
A phase II trial of defactinib combined with avutometinib in patients with metastatic uveal melanoma
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errSeedor, Rino S.; Terai, Mizue; Majeed, Amry; Tanaka, Ryota; Aplin, Andrew E.; Orloff, Marlana; Molinolo, Alfredo A.; Gutkind, J. Silvio; Sato, Takami
err分享
err收藏
Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errOtt, Connor A.; Purwin, Timothy; Tiago, Manoela; Lou, Kristine; Chen, Pan-Yu; Chowdhury, Somaneth; Mersky, Glenn; Hacohen, Nir; Lamar, John; Capparelli, Claudia; Bollag, Gideon; Aplin, Andrew
err分享
err收藏
Single cell resolution of intrapatient drug resistance mechanisms in metastatic melanoma
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errWilson, Haley P.; Mersky, Glenn L.; Haj, Jelan I.; Teh, Jessica; Cheng, Phil F.; Caksa, Signe; Stefanski, Casey D.; Chua, Vivian; Capparelli, Claudia; Levesque, Mitch P.; Dummer, Reinhard; Purwin, Timothy J.; Aplin, Andrew E.
err分享
err收藏
Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-12-01
err3
errOAAI
errBaqai, Usman; Kurimchak, Alison M.; Trachtenberg, Isabella V.; Purwin, Timothy J.; Haj, Jelan I.; Han, Anna; Luo, Kristine; Pachon, Nikole Fandino; Jeon, Angela; Gutkind, J. Silvio; Chua, Vivian; Davies, Michael A.; Benovic, Jeffrey L.; Duncan, James S.; Aplin, Andrew E.
err分享
err收藏
High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
errCELL REPORTS MEDICINE
IF10.6
err2023-11-01
err6
errOAAI
errArang, Nadia; Lubrano, Simone; Ceribelli, Michele; Rigiracciolo, Damiano C.; Saddawi-Konefka, Robert; Faraji, Farhoud; Ramirez, Sydney I.; Kim, Daehwan; Tosto, Frances A.; Stevenson, Erica; Zhou, Yuan; Wang, Zhiyong; Bogomolovas, Julius; Molinolo, Alfredo A.; Swaney, Danielle L.; Krogan, Nevan J.; Yang, Jing; Coma, Silvia; Pachter, Jonathan A.; Aplin, Andrew E.; Alessi, Dario R.; Thomas, Craig J.; Gutking, J. Silvio
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20th Anniversary of the Society for Melanoma Research: Celebrating two decades of progress in melanoma research
errPIGMENT CELL & MELANOMA RESEARCH
IF2.6
err2023-10-30
err0
errOAAI
errAmaravadi, Ravi; Aplin, Andrew; Herlyn, Meenhard; Holmen, Sheri; White, Richard; Villanueva, Jessie
err分享
err收藏
SOX10 Loss Sensitizes Melanoma Cells to Cytokine-Mediated Inflammatory Cell Death
errMOLECULAR CANCER RESEARCH
IF4.7
err2023-10-17
err3
errOAAI
errRosenbaum, Sheera R.; Caksa, Signe; Stefanski, Casey D.; Trachtenberg, Isabella V.; Wilson, Haley P.; Wilski, Nicole A.; Ott, Connor A.; Purwin, Timothy J.; Haj, Jelan I.; Pomante, Danielle; Kotas, Daniel; Chervoneva, Inna; Capparelli, Claudia; Aplin, Andrew E.
err分享
err收藏
Targeting TEAD-ious resistance
errTRENDS IN CANCER
IF17.5
err2023-10-01
err0
errOAAI
errOtt, Connor A.; Aplin, Andrew E.
err分享
err收藏
MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping
errNATURE CELL BIOLOGY
IF19.1
err2023-08-21
err10
errOAAI
errFilipescu, Dan; Carcamo, Saul; Agarwal, Aman; Tung, Navpreet; Humblin, Etienne; Goldberg, Matthew S.; Vyas, Nikki S.; Beaumont, Kristin G.; Demircioglu, Deniz; Sridhar, Subhasree; Ghiraldini, Flavia G.; Capparelli, Claudia; Aplin, Andrew E.; Salmon, Helene; Sebra, Robert; Kamphorst, Alice O.; Merad, Miriam; Hasson, Dan; Bernstein, Emily
err分享
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研究方向

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