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Matthieu Schapira

university of toronto

60H指数
412论文数
1.7W被引数
收录论文 119
发表时间
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Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space基于机器学习增强的化学空间筛选，发现SARS-CoV-2非结构蛋白-3的Mac1结构域抑制剂的结构方法
errScientific Reports
IF3.9
err2026-08-03
err0
errOAAI
errFuqiang Ban; Rahul Ravichandran; Galen J. Correy; Oleksandra Herasymenko; Madhushika Silva; Suzanne Ackloo; Albina Bolotokova; Irene Chau; Elisa Gibson; Rachel Harding; Ashley Hutchinson; Peter Loppnau; James S. Fraser; Matthieu Schapira; Artem Cherkasov; Francesco Gentile
err分享
err收藏
Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding DomainUSP16和HDAC6锌指泛素结合域的双化学探针开发
errJournal of Medicinal Chemistry
IF6.8
err2026-02-01
err0
PREAI
errSilva, Madhushika; Mann, Mandeep; Mirabi, Bijan; Szewczyk, Magdalena M.; Loup, Joachim; Dupeux, Aurelien; Chandrasekaran, Renu; Bajohr, Jonathan; Arrowsmith, Cheryl; Schapira, Matthieu; Lautens, Mark; Barsyte-Lovejoy, Dalia; Harding, Rachel J.; Santhakumar, Vijayaratnam
err分享
err收藏
CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2缓存挑战 #3: 以SARS-CoV-2的Nsp3宏域为目标
errJournal of Chemical Information and Modeling
IF5.3
err2026-01-21
err0
errOAAI
errOleksandra Herasymenko; Madhushika Silva; Galen J. Correy; Abd Al-Aziz A. Abu-Saleh; Suzanne Ackloo; Cheryl Arrowsmith; Alan Ashworth; Fuqiang Ban; Hartmut Beck; Kevin P. Bishop; Hugo J. Bohórquez; Albina Bolotokova; Marko Breznik; Irene Chau; Yu Chen; Artem Cherkasov; Wim Dehaen; Dennis Della Corte; Katrin Denzinger; Niklas P. Doering; Kristina Edfeldt; Aled Edwards; Darren Fayne; Francesco Gentile; Elisa Gibson; Ozan Gokdemir; Anders Gunnarsson; Judith Günther; John J. Irwin; Jan Halborg Jensen; Rachel J. Harding; Alexander Hillisch; Laurent Hoffer; Anders Hogner; Ashley Hutchinson; Shubhangi Kandwal; Andrea Karlova; Kushal Koirala; Sergei Kotelnikov; Dima Kozakov; Juyong Lee; Soowon Lee; Uta Lessel; Sijie Liu; Xuefeng Liu; Peter Loppnau; Jens Meiler; Rocco Moretti; Yurii S. Moroz; Charuvaka Muvva; Tudor I. Oprea; Brooks Paige; Amit Pandit; Keunwan Park; Gennady Poda; Mykola V. Protopopov; Vera Pütter; Rahul Ravichandran; Didier Rognan; Edina Rosta; Yogesh Sabnis; Thomas Scott; Almagul Seitova; Purshotam Sharma; François Sindt; Minghu Song; Casper Steinmann; Rick Stevens; Valerij Talagayev; Valentyna V. Tararina; Olga Tarkhanova; Damon Tingey; John F. Trant; Dakota Treleaven; Alexander Tropsha; Patrick Walters; Jude Wells; Yvonne Westermaier; Gerhard Wolber; Lars Wortmann; Shuangjia Zheng; James S. Fraser; Matthieu Schapira
err分享
err收藏
Enantioselective protein affinity selection mass spectrometry (E-ASMS)手性蛋白质亲和选择质谱法 (E-ASMS)
errNature Communications
IF15.7
err2025-12-17
err0
errOAAI
errXiaoyun Wang; Jianxian Sun; Shabbir Ahmad; Diwen Yang; Fengling Li; U. Hang Chan; Hong Zeng; Conrad V. Simoben; Stuart R. Green; Madhushika Silva; Scott Houliston; Aiping Dong; Albina Bolotokova; Elisa Gibson; Maria Kutera; Pegah Ghiabi; Ivan Kondratov; Tetiana Matviyuk; Alexander Chuprina; Danai Mavridi; Christopher Lenz; Andreas C. Joerger; Benjamin D. Brown; Richard B. Heath; Wyatt W. Yue; Lucy K. Robbie; Tyler S. Beyett; Susanne Müller; Stefan Knapp; Dafydd R. Owen; Rachel Harding; Matthieu Schapira; Peter J. Brown; Vijayaratnam Santhakumar; Suzanne Ackloo; Cheryl H. Arrowsmith; Aled M. Edwards; Hui Peng; Levon Halabelian
err分享
err收藏
CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13CACHE挑战赛#2：靶向SARS-CoV-2解旋酶Nsp13的RNA位点
errJournal of Chemical Information and Modeling
IF5.3
err2025-06-20
err0
PREAI
errOleksandra Herasymenko; Madhushika Silva; Abd Al-Aziz A. Abu-Saleh; Ayaz Ahmad; Jesus Alvarado-Huayhuaz; Oscar E. A. Arce; Roly J. Armstrong; Cheryl Arrowsmith; Kelly E. Bachta; Hartmut Beck; Denes Berta; Mateusz K. Bieniek; Vincent Blay; Albina Bolotokova; Philip E. Bourne; Marko Breznik; Peter J. Brown; Aaron D. G. Campbell; Emanuele Carosati; Irene Chau; Daniel J. Cole; Ben Cree; Wim Dehaen; Katrin Denzinger; Karina dos Santos Machado; Ian Dunn; Prasannavenkatesh Durai; Kristina Edfeldt; Aled Edwards; Darren Fayne; Daniel Felfoldi; Kallie Friston; Pegah Ghiabi; Elisa Gibson; Judith Günther; Anders Gunnarsson; Alexander Hillisch; Douglas R. Houston; Jan Halborg Jensen; Rachel J. Harding; Kate S. Harris; Laurent Hoffer; Anders Hogner; Joshua T. Horton; Scott Houliston; Judd F. Hultquist; Ashley Hutchinson; John J. Irwin; Marko Jukič; Shubhangi Kandwal; Andrea Karlova; Vittorio L. Katis; Ryan P. Kich; Dmitri Kireev; David Koes; Nicole L. Inniss; Uta Lessel; Sijie Liu; Peter Loppnau; Wei Lu; Sam Martino; Miles McGibbon; Jens Meiler; Akhila Mettu; Sam Money-Kyrle; Rocco Moretti; Yurii S. Moroz; Charuvaka Muvva; Joseph A. Newman; Leon Obendorf; Brooks Paige; Amit Pandit; Keunwan Park; Sumera Perveen; Rachael Pirie; Gennady Poda; Mykola Protopopov; Vera Pütter; Federico Ricci; Natalie J. Roper; Edina Rosta; Margarita Rzhetskaya; Yogesh Sabnis; Karla J. F. Satchell; Frederico Schmitt Kremer; Thomas Scott; Almagul Seitova; Casper Steinmann; Valerij Talagayev; Olga O. Tarkhanova; Natalie J. Tatum; Dakota Treleaven; Adriano Velasque Werhli; W. Patrick Walters; Xiaowen Wang; Jude Wells; Geoffrey Wells; Yvonne Westermaier; Gerhard Wolber; Lars Wortmann; Jixian Zhang; Zheng Zhao; Shuangjia Zheng; Matthieu Schapira
err分享
err收藏
Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities基于模拟配体结合亲和力的主动学习引导的富含亮氨酸重复激酶2 WDR结构域命中优化
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-05-26
err0
errOAAI
errGusev, Filipp; Gutkin, Evgeny; Gentile, Francesco; Ban, Fuqiang; Koby, S. Benjamin; Li, Fengling; Chau, Irene; Ackloo, Suzanne; Arrowsmith, Cheryl H.; Bolotokova, Albina; Ghiabi, Pegah; Gibson, Elisa; Halabelian, Levon; Houliston, Scott; Harding, Rachel J.; Hutchinson, Ashley; Loppnau, Peter; Perveen, Sumera; Seitova, Almagul; Zeng, Hong; Schapira, Matthieu; Isayev, Olexandr; Kurnikova, Maria G.
err分享
err收藏
The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-02-14
err0
PREAI
errKramer, Christian; Chodera, John; Damm-Ganamet, Kelly L.; Gilson, Michael K.; Guenther, Judith; Lessel, Uta; Lewis, Richard A.; Mobley, David; Nittinger, Eva; Pecina, Adam; Schapira, Matthieu; Walters, W. Patrick
err分享
err收藏
Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1由FRASE-bot在CACHE Challenge #1中鉴定的靶向LRRK2 WD40重复结构域的功能性活性调节剂
errCHEMICAL SCIENCE
IF7.4
err2025-01-01
err0
errOAAI
errMettu, Akhila; Glavatskikh, Marta; Wang, Xiaowen; Ordonez, Antonio Jesus Lara; Li, Fengling; Chau, Irene; Ackloo, Suzanne; Arrowsmith, Cheryl; Bolotokova, Albina; Ghiabi, Pegah; Gibson, Elisa; Halabelian, Levon; Houliston, Scott; Harding, Rachel J.; Hutchinson, Ashley; Loppnau, Peter; Perveen, Sumera; Seitova, Almagul; Zeng, Hong; Schapira, Matthieu; Taymans, Jean-Marc; Kireev, Dmitri
err分享
err收藏
Probe my Pathway (PmP): a portal to explore the chemical coverage of the human Reactome
errDATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
IF3.6
err2024-12-03
err0
errOAAI
errKwak, Haejin Angela; Liu, Lihua; Schapira, Matthieu
err分享
err收藏
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-11-05
err4
errOAAI
errLi, Fengling; Ackloo, Suzanne; Arrowsmith, Cheryl H.; Ban, Fuqiang; Barden, Christopher J.; Beck, Hartmut; Beranek, Jan; Berenger, Francois; Bolotokova, Albina; Bret, Guillaume; Breznik, Marko; Carosati, Emanuele; Chau, Irene; Chen, Yu; Cherkasov, Artem; Della Corte, Dennis; Denzinger, Katrin; Dong, Aiping; Draga, Sorin; Dunn, Ian; Edfeldt, Kristina; Edwards, Aled; Eguida, Merveille; Eisenhuth, Paul; Friedrich, Lukas; Fuerll, Alexander; Gardiner, Spencer S.; Gentile, Francesco; Ghiabi, Pegah; Gibson, Elisa; Glavatskikh, Marta; Gorgulla, Christoph; Guenther, Judith; Gunnarsson, Anders; Gusev, Filipp; Gutkin, Evgeny; Halabelian, Levon; Harding, Rachel J.; Hillisch, Alexander; Hoffer, Laurent; Hogner, Anders; Houliston, Scott; Irwin, John J.; Isayev, Olexandr; Ivanova, Aleksandra; Jacquemard, Celien; Jarrett, Austin J.; Jensen, Jan H.; Kireev, Dmitri; Kleber, Julian; Koby, S. Benjamin; Koes, David; Kumar, Ashutosh; Kurnikova, Maria G.; Kutlushina, Alina; Lessel, Uta; Liessmann, Fabian; Liu, Sijie; Lu, Wei; Meiler, Jens; Mettu, Akhila; Minibaeva, Guzel; Moretti, Rocco; Morris, Connor J.; Narangoda, Chamali; Noonan, Theresa; Obendorf, Leon; Pach, Szymon; Pandit, Amit; Perveen, Sumera; Poda, Gennady; Polishchuk, Pavel; Puls, Kristina; Puetter, Vera; Rognan, Didier; Roskams-Edris, Dylan; Schindler, Christina; Sindt, Francois; Spiwok, Vojtech; Steinmann, Casper; Stevens, Rick L.; Talagayev, Valerij; Tingey, Damon; Vu, Oanh; Walters, W. Patrick; Wang, Xiaowen; Wang, Zhenyu; Wolber, Gerhard; Wolf, Clemens Alexander; Wortmann, Lars; Zeng, Hong; Zepeda, Carlos A.; Zhang, Kam Y. J.; Zhang, Jixian; Zheng, Shuangjia; Schapira, Matthieu
err分享
err收藏
A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-04
err0
errOAAI
errAckloo, Suzanne; Li, Fengling; Szewczyk, Magda; Seitova, Almagul; Loppnau, Peter; Zeng, Hong; Xu, Jin; Ahmad, Shabbir; Arnautova, Yelena A.; Baghaie, A. J.; Beldar, Serap; Bolotokova, Albina; Centrella, Paolo A.; Chau, Irene; Clark, Matthew A.; Cuozzo, John W.; Dehghani-Tafti, Saba; Disch, Jeremy S.; Dong, Aiping; Dumas, Antoine; Feng, Jianwen A.; Ghiabi, Pegah; Gibson, Elisa; Gilmer, Justin; Goldman, Brian; Green, Stuart R.; Guie, Marie-Aude; Guilinger, John P.; Harms, Nathan; Herasymenko, Oleksandra; Houliston, Scott; Hutchinson, Ashley; Kearnes, Steven; Keefe, Anthony D.; Kimani, Serah W.; Kramer, Trevor; Kutera, Maria; Kwak, Haejin A.; Lento, Cristina; Li, Yanjun; Liu, Jenny; Loup, Joachim; Machado, Raquel A. C.; Mulhern, Christopher J.; Perveen, Sumera; Righetto, Germanna L.; Riley, Patrick; Shrestha, Suman; Sigel, Eric A.; Silva, Madhushika; Sintchak, Michael D.; Slakman, Belinda L.; Taylor, Rhys D.; Thompson, James; Torng, Wen; Underkoffler, Carl; von Rechenberg, Moritz; Walsh, Ryan T.; Watson, Ian; Wilson, Derek J.; Wolf, Esther; Yadav, Manisha; Yazdi, Aliakbar K.; Zhang, Junyi; Zhang, Ying; Santhakumar, Vijayaratnam; Edwards, Aled M.; Barsyte-Lovejoy, Dalia; Schapira, Matthieu; Brown, Peter J.; Halabelian, Levon; Arrowsmith, Cheryl H.
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err收藏
Chemical coverage of human biological pathways
errDRUG DISCOVERY TODAY
IF7.5
err2024-10-01
err2
errOAAI
errKwak, Haejin Angela; Liu, Lihua; Tredup, Claudia; Roehm, Sandra; Prinos, Panagiotis; Boettcher, Jark; Schapira, Matthieu
err分享
err收藏
Benchmarking Methods for PROTAC Ternary Complex Structure Prediction
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-08-01
err6
PREAI
errRovers, Evianne; Schapira, Matthieu
err分享
err收藏
A data science roadmap for open science organizations engaged in early-stage drug discovery面向从事早期药物发现的开放科学组织的数据科学路线图
errNATURE COMMUNICATIONS
IF15.7
err2024-07-05
err4
errOAAI
errEdfeldt, Kristina; Edwards, Aled M.; Engkvist, Ola; Guenther, Judith; Hartley, Matthew; Hulcoop, David G.; Leach, Andrew R.; Marsden, Brian D.; Menge, Amelie; Misquitta, Leonie; Mueller, Susanne; Owen, Dafydd R.; Schuett, Kristof T.; Skelton, Nicholas; Steffen, Andreas; Tropsha, Alexander; Vernet, Erik; Wang, Yanli; Wellnitz, James; Willson, Timothy M.; Clevert, Djork-Arne; Haibe-Kains, Benjamin; Schiavone, Lovisa Holmberg; Schapira, Matthieu
err分享
err收藏
Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-06-25
err2
errOAAI
errEguida, Merveille; Bret, Guillaume; Sindt, Francois; Li, Fengling; Chau, Irene; Ackloo, Suzanne; Arrowsmith, Cheryl; Bolotokova, Albina; Ghiabi, Pegah; Gibson, Elisa; Halabelian, Levon; Houliston, Scott; Harding, Rachel J.; Hutchinson, Ashley; Loppnau, Peter; Perveen, Sumera; Seitova, Almagul; Zeng, Hong; Schapira, Matthieu; Rognan, Didier
err分享
err收藏
Emerging structure-based computational methods to screen the exploding accessible chemical space
errCURRENT OPINION IN STRUCTURAL BIOLOGY
IF7
err2024-06-01
err4
errOAAI
errBedart, Corentin; Simoben, Conrad Veranso; Schapira, Matthieu
err分享
err收藏
A chemical probe to modulate human GID4 Pro/N-degron interactions
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-05-21
err4
PREAI
errOwens, Dominic D. G.; Maitland, Matthew E. R.; Yazdi, Aliakbar Khalili; Song, Xiaosheng; Reber, Viviane; Schwalm, Martin P.; Machado, Raquel A. C.; Bauer, Nicolas; Wang, Xu; Szewczyk, Magdalena M.; Dong, Cheng; Dong, Aiping; Loppnau, Peter; Calabrese, Matthew F.; Dowling, Matthew S.; Lee, Jisun; Montgomery, Justin I.; O'Connell, Thomas N.; Subramanyam, Chakrapani; Wang, Feng; Adamson, Ella C.; Schapira, Matthieu; Gstaiger, Matthias; Knapp, Stefan; Vedadi, Masoud; Min, Jinrong; Lajoie, Gilles A.; Barsyte-Lovejoy, Dalia; Owen, Dafydd R.; Schild-Poulter, Caroline; Arrowsmith, Cheryl H.
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err收藏
Big data and benchmarking initiatives to bridge the gap from AlphaFold to drug design
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-03-08
err1
PREAI
errSchapira, Matthieu; Halabelian, Levon; Arrowsmith, Cheryl H.; Harding, Rachel J.
err分享
err收藏
Application of established computational techniques to identify potential SARS-CoV-2 Nsp14-MTase inhibitors in low data regimes
errDIGITAL DISCOVERY
IF5.6
err2024-01-01
err2
errOAAI
errNigam, Akshatkumar; Hurley, Matthew F. D.; Li, Fengling; Konkolova, Eva; Klima, Martin; Trylcova, Jana; Pollice, Robert; Cinaroglu, Suleyman Selim; Levin-Konigsberg, Roni; Handjaya, Jasemine; Schapira, Matthieu; Chau, Irene; Perveen, Sumera; Ng, Ho-Leung; Kaniskan, H. Umit; Han, Yulin; Singh, Sukrit; Gorgulla, Christoph; Kundaje, Anshul; Jin, Jian; Voelz, Vincent A.; Weber, Jan; Nencka, Radim; Boura, Evzen; Vedadi, Masoud; Aspuru-Guzik, Alan
err分享
err收藏
Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle
errACS OMEGA
IF4.3
err2023-12-15
err2
errOAAI
errMann, Mandeep K.; Wolf, Esther; Silva, Madhushika; Kwak, Haejin Angela; Wilson, Brian; Bolotokova, Albina; Wilson, Derek J.; Harding, Rachel J.; Schapira, Matthieu
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
Y
Yoshua Bengio
H 指数: 183 · 论文数: 1.3K
S
Stuart L. Schreiber
H 指数: 166 · 论文数: 1.3K
P
Philip Cohen
H 指数: 156 · 论文数: 581
N
Nathanael S. Gray
H 指数: 145 · 论文数: 1.5K
B
Bryan L. Roth
H 指数: 139 · 论文数: 971
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