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Topoisomerase 1 Inhibition in MYC-Driven Cancer Promotes Aberrant R-Loop Accumulation to Induce Synthetic Lethality Lin, Peter; Lourenco, Corey; Cruickshank, Jennifer; Palomero, Luis; van Leeuwen, Jenna E.; Tong, Amy H. Y.; Chan, Katherine; El Ghamrasni, Samah; Pujana, Miquel Angel; Cescon, David W.; Moffat, Jason; Penn, Linda Z. 分享 收藏
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins van Leeuwen, Jenna E.; Ba-Alawi, Wail; Branchard, Emily; Cruickshank, Jennifer; Schormann, Wiebke; Longo, Joseph; Silvester, Jennifer; Gross, Peter L.; Andrews, David W.; Cescon, David W.; Haibe-Kains, Benjamin; Penn, Linda Z.; Gendoo, Deena M. A. 分享 收藏
The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations 纺锤体组装检查点是具有有丝分裂畸变的CDK4/6抑制剂抗性ER乳腺癌的治疗脆弱性 Soria-Bretones, Isabel; Thu, Kelsie L.; Silvester, Jennifer; Cruickshank, Jennifer; El Ghamrasni, Samah; Ba-alawi, Wail; Fletcher, Graham C.; Kiarash, Reza; Elliott, Mitchell J.; Chalmers, Jordan J.; Elia, Andrea C.; Cheng, Albert; Rose, April A. N.; Bray, Mark R.; Haibe-Kains, Benjamin; Mak, Tak W.; Cescon, David W. 分享 收藏
Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells Kuhlmann, Laura; Govindarajan, Meinusha; Mejia-Guerrero, Salvador; Ignatchenko, Vladimir; Liu, Lydia Y.; Grunwald, Barbara T.; Cruickshank, Jennifer; Berman, Hal; Khokha, Rama; Kislinger, Thomas 分享 收藏
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer PRMT抑制在三阴性乳腺癌中诱导病毒模仿反应 Wu, Qin; Nie, David Y.; Ba-alawi, Wail; Ji, YiShuai; Zhang, ZiWen; Cruickshank, Jennifer; Haight, Jillian; Ciamponi, Felipe E.; Chen, Jocelyn; Duan, Shili; Shen, Yudao; Liu, Jing; Marhon, Sajid A.; Mehdipour, Parinaz; Szewczyk, Magdalena M.; Dogan-Artun, Nergiz; Chen, WenJun; Zhang, Lan Xin; Deblois, Genevieve; Prinos, Panagiotis; Massirer, Katlin B.; Barsyte-Lovejoy, Dalia; Jin, Jian; De Carvalho, Daniel D.; Haibe-Kains, Benjamin; Wang, XiaoJia; Cescon, David W.; Lupien, Mathieu; Arrowsmith, Cheryl H. 分享 收藏
Biomimetic hydrogel supports initiation and growth of patient-derived breast tumor organoids Prince, Elisabeth; Cruickshank, Jennifer; Ba-Alawi, Wail; Hodgson, Kelsey; Haight, Jillian; Tobin, Chantal; Wakeman, Andrew; Avoulov, Alona; Topolskaia, Valentina; Elliott, Mitchell J.; McGuigan, Alison P.; Berman, Hal K.; Haibe-Kains, Benjamin; Cescon, David W.; Kumacheva, Eugenia 分享 收藏
Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies 用于药物筛选和个性化癌症治疗的乳腺肿瘤球体微流控阵列 Prince, Elisabeth; Kheiri, Sina; Wang, Yihe; Xu, Fei; Cruickshank, Jennifer; Topolskaia, Valentina; Tao, Huachen; Young, Edmond W. K.; McGuigan, Alison P.; Cescon, David W.; Kumacheva, Eugenia 分享 收藏
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Mammary epithelial cells have lineage-rooted metabolic identities 乳腺上皮细胞具有基于谱系的代谢特性 Mahendralingam, Mathepan Jeya; Kim, Hyeyeon; McCloskey, Curtis William; Aliar, Kazeera; Casey, Alison Elisabeth; Tharmapalan, Pirashaanthy; Pellacani, Davide; Ignatchenko, Vladimir; Garcia-Valero, Mar; Palomero, Luis; Sinha, Ankit; Cruickshank, Jennifer; Shetty, Ronak; Vellanki, Ravi N.; Koritzinsky, Marianne; Stambolic, Vid; Alam, Mina; Schimmer, Aaron David; Berman, Hal Kenneth; Eaves, Connie J.; Pujana, Miquel Angel; Kislinger, Thomas; Khokha, Rama 分享 收藏
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer GLUT1抑制阻断RB1-positive三阴性乳腺癌的生长 Wu, Qin; ba-alawi, Wail; Deblois, Genevieve; Cruickshank, Jennifer; Duan, Shili; Lima-Fernandes, Evelyne; Haight, Jillian; Tonekaboni, Seyed Ali Madani; Fortier, Anne-Marie; Kuasne, Hellen; McKee, Trevor D.; Mahmoud, Hassan; Kushida, Michelle; Cameron, Sarina; Dogan-Artun, Nergiz; Chen, WenJun; Nie, Yan; Zhang, Lan Xin; Vellanki, Ravi N.; Zhou, Stanley; Prinos, Panagiotis; Wouters, Bradly G.; Dirks, Peter B.; Done, Susan J.; Park, Morag; Cescon, David W.; Haibe-Kains, Benjamin; Lupien, Mathieu; Arrowsmith, Cheryl H. 分享 收藏
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Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities Casey, Alison E.; Sinha, Ankit; Singhania, Rajat; Livingstone, Julie; Waterhouse, Paul; Tharmapalan, Pirashaanthy; Cruickshank, Jennifer; Shehata, Mona; Drysdale, Erik; Fang, Hui; Kim, Hyeyeon; Isserlin, Ruth; Bailey, Swneke; Medina, Tiago; Deblois, Genevieve; Shiah, Yu-Jia; Barsyte-Lovejoy, Dalia; Hofer, Stefan; Bader, Gary; Lupien, Mathieu; Arrowsmith, Cheryl; Knapp, Stefan; De Carvalho, Daniel; Berman, Hal; Boutros, Paul C.; Kislinger, Thomas; Khokha, Rama 分享 收藏
RANKL/RANK control Brca1 mutation-driven mammary tumors RANKL/RANK控制Brca1突变驱动的乳腺肿瘤 Sigl, Verena; Owusu-Boaitey, Kwadwo; Joshi, Purna A.; Kavirayani, Anoop; Wirnsberger, Gerald; Novatchkova, Maria; Kozieradzki, Ivona; Schramek, Daniel; Edokobi, Nnamdi; Hersl, Jerome; Sampson, Aishia; Odai-Afotey, Ashley; Lazaro, Conxi; Gonzalez-Suarez, Eva; Pujana, Miguel A.; Heyn, Holger; Vidal, Enrique; Cruickshank, Jennifer; Berman, Hal; Sarao, Renu; Ticevic, Melita; Uribesalgo, Iris; Tortola, Luigi; Rao, Shuan; Tan, Yen; Pfeiler, Georg; Lee, Eva Y. H. P.; Bago-Horvath, Zsuzsanna; Kenner, Lukas; Popper, Helmuth; Singer, Christian; Khokha, Rama; Jones, Laundette P.; Penninger, Josef M. 分享 收藏
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival BRCA1与Nrf2相互作用调节抗氧化信号和细胞存活 Gorrini, Chiara; Baniasadi, Pegah S.; Harris, Isaac S.; Silvester, Jennifer; Inoue, Satoshi; Snow, Bryan; Joshi, Purna A.; Wakeham, Andrew; Molyneux, Sam D.; Martin, Bernard; Bouwman, Peter; Cescon, David W.; Elia, Andrew J.; Winterton-Perks, Zoe; Cruickshank, Jennifer; Brenner, Dirk; Tseng, Alan; Musgrave, Melinda; Berman, Hal K.; Khokha, Rama; Jonkers, Jos; Mak, Tak W.; Gauthier, Mona L. 分享 收藏
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