Peter J. Tonge - Publications, H-index & Citations

Peter J. Tonge

stony brook university

57H指数

338论文数

1.1W被引数

收录论文 127

发表时间

The post antibiotic effect of streptogramins on gram-positive bacteria primarily arises from the type a component 大环内酯类抗生素对革兰氏阳性菌的抗菌后效应主要来源于其A型组分

Microbial Pathogenesis

IF3.5

2026-06-06

OAAI

Aya K. Sabbah; Brandon M. Thrope; Stephen G. Walker; Peter J. Tonge

Only time will tell: Modelling the kinetics of covalent inhibitors 只有时间能证明：共价抑制剂的动力学建模

British Journal of Pharmacology

IF7.7

2026-02-12

PREAI

Madeeha I. Ali; Peter J. Tonge

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells 一种用于测量细胞中PRMT5复合物非竞争性结合的BRET生物传感器

Nature Communications

IF15.7

2025-12-03

OAAI

Elisabeth M. Rothweiler; Ani Michaud; Jakub Stefaniak; Usha Singh; Brynwood B. Mikulsky; James D. Vasta; Michael T. Beck; Jennifer Wilkinson; Jennifer A. Ward; Catherine M. Rogers; Esra Balıkçı; Jeppe Tranberg-Jensen; Jesper S. Hansen; Peter Loppnau; Adrian Whitty; Paul E. Brennan; Peter J. Tonge; Matthew B. Robers; Kilian V. M. Huber

Selectivity of the Time-Dependent M. tuberculosis LeuRS Inhibitor Ganfeborole Is Driven by Target Vulnerability 时依赖性M. tuberculosis LeuRS抑制剂Ganfeborole的选择性由靶点易感性驱动

ACS CHEMICAL BIOLOGY

IF3.8

2025-12-01

PREAI

Wang, Mingqian; He, Yongle; Cohen, Siobhan A.; Strohm, Amanda R.; Shetye, Gauri; Franzblau, Scott G.; Walker, Stephen G.; Alley, M. R. K.; Tonge, Peter J.

An Assessment of Kinase Selectivity; Enzyme Inhibition Kinetics and in Vitro Activity for Several Bruton Tyrosine Kinase (BTK) Inhibitors 对激酶选择性的评估；几种布鲁顿酪氨酸激酶（BTK）抑制剂的酶抑制动力学及体外活性

ACS Pharmacology & Translational Science

IF3.7

2025-11-18

OAAI

Ana Corrionero; Xiaohu Zhang; Patricia Alfonso; Patrick J. Morris; Carleen Klumpp-Thomas; Christopher Melani; Crystal McKnight; James D. Phelan; David Holland; Kelli Wilson; Scott B. Hoyt; Mark Roschewski; Peter J. Tonge; Wyndham Wilson; Michele Ceribelli; Louis M. Staudt; Craig J. Thomas

Dynamics and Mechanism of Off- to On-Switching in Dreiklang a Decoupled Reversibly Switchable Fluorescent Protein Dreiklang中关闭到开启状态切换的动力学与机制：一种解耦的可逆光开关荧光蛋白

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2025-11-01

OAAI

Fatima, Anam; He, Yongle; Rosenberger, Danielle; Greetham, Gregory M.; Malakar, Partha; Lukacs, Andras; Tonge, Peter J.; Meech, Stephen R.

Ultrafast Photophysics of a Positive Reversibly Switchable Fluorescent Protein 正可逆开关荧光蛋白的超快光物理特性

Chem. Sci.

IF7.4

2025-08-07

OAAI

Anam Fatima; Yongle He; James Nicholas Iuliano; Gregory M Greetham; Partha Malakar; Christopher R. Hall; Helena A Woroniecka; Brian C Richardson; Jarrod B French; Andras Lukacs; Peter Tonge; Steve R. Meech

Modulating the Binding Kinetics of Bruton’s Tyrosine Kinase Inhibitors through Transition-State Effects 通过过渡态效应调节Bruton’s Tyrosine Kinase抑制剂的结合动力学

Journal of the American Chemical Society

IF15.6

2025-07-29

PREAI

Eduardo Bravo Jr; Yong Li; David Yin-Wei Lin; Bharath Srinivasan; Marco Barone; Stan Xiaogang Li; Francesca DelloRusso; Anza Suneer Rahiyanath; Ana Corrionero; Patricia Alfonso; Niall Prendiville; Dima Kozakov; Amy H. Andreotti; Peter J. Tonge

Time-Dependent Inhibition of Leucyl-tRNA-Synthetase (LeuRS): Insight into Target Vulnerability 时间依赖性亮氨酰-tRNA合成酶(LeuRS)的抑制：对靶点脆弱性的认识

ACS INFECTIOUS DISEASES

IF3.8

2025-04-02

PREAI

Wang, MQ; He, YL; Cohen, SA; Strohm, AR; Haley, JD; Walker, SG; Alley, MRK; Tonge, PJ

Probing the Signal Transduction Mechanism of the Light-Activated Adenylate Cyclase OaPAC Using Unnatural Amino Acid Mutagenesis

ACS CHEMICAL BIOLOGY

IF3.8

2025-01-23

PREAI

Jewlikar, Samruddhi S.; Collado, Jinnette Tolentino; Ali, Madeeha I.; Sabbah, Aya; He, Yongle; Iuliano, James N.; Hall, Christopher R.; Adamczyk, Katrin; Greetham, Gregory M.; Lukacs, Andras; Meech, Stephen R.; Tonge, Peter J.

Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[18F]F-p-Aminobenzoic Acid ([18F]F-PABA)

ACS INFECTIOUS DISEASES

IF3.8

2024-10-21

PREAI

Pollard-Kerning, Alyssa C.; Li, Kaixuan; Li, Yong; Ahn, Shin Hye; Wang, Mingqian; Akoglu, Melike; Bravo, Eduardo; DelloRusso, Francesca; Akula, Hari K.; Qu, Wenchao; Meimetis, Labros; Schlyer, David J.; Komatsu, David E.; Tonge, Peter J.

Ready-to-use iPSC-derived microglia progenitors for the treatment of CNS disease in mouse models of neuropathic mucopolysaccharidoses

NATURE COMMUNICATIONS

IF15.7

2024-09-16

OAAI

Douvaras, Panagiotis; Buenaventura, Diego F.; Sun, Bruce; Lepack, Ashley; Baker, Elizabeth; Simpson, Elizabeth; Ebel, Mark; Lallos, Gregory; LoSchiavo, Deven; Stitt, Nicholas; Adams, Nathaniel; McAuliffe, Conor; Forton-Juarez, Ana; Kosmyna, Brian; Pereira, Elizabeth; Burnett, Benjamin; Dilworth, David; Fisher, Stephanie; Wang, Jing; Tonge, Peter; Tomishima, Mark; Paladini, Carlos; Wilkinson, Dan; Soh, Chew-Li; Srinivas, Maya; Patsch, Christoph; Irion, Stefan

Biological Evaluation of d-[18F]Fluoroalanine and d-[18F]Fluoroalanine-d 3 as Positron Emission Tomography Imaging Tracers for Bacterial Infection

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-07-31

PREAI

Li, Kaixuan; Collado, Jinnette Tolentino; Marden, Jocelyn A.; Pollard, Alyssa C.; Guo, Shuwen; Tonge, Peter J.; Qu, Wenchao

Synthesis and Biological Evaluation of Fluorine-18 and Deuterium Labeled l-Fluoroalanines as Positron Emission Tomography Imaging Agents for Cancer Detection

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-06-05

PREAI

Li, Kaixuan; Gilberti, Alexa L.; Marden, Jocelyn A.; Akula, Hari K.; Pollard, Alyssa C.; Guo, Shuwen; Hu, Bao; Tonge, Peter J.; Qu, Wenchao

Elucidating the Signal Transduction Mechanism of the Blue-Light-Regulated Photoreceptor YtvA: From Photoactivation to Downstream Regulation

ACS CHEMICAL BIOLOGY

IF3.8

2024-02-22

OAAI

He, YongLe; Collado, Jinnette Tolentino; Iuliano, James N.; Woroniecka, Helena A.; Hall, Christopher R.; Gil, Agnieszka A.; Laptenok, Sergey P.; Greetham, Gregory M.; Illarionov, Boris; Bacher, Adelbert; Fischer, Markus; French, Jarrod B.; Lukacs, Andras; Meech, Stephen R.; Tonge, Peter J.

Photocycle alteration and increased enzymatic activity in genetically modified photoactivated adenylate cyclase OaPAC

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-08-01

OAAI

Raics, Katalin; Pirisi, Katalin; Zhuang, Bo; Fekete, Zsuzsanna; Kis-Bicskei, Nikolett; Pecsi, Ildiko; Ujfalusi, Kinga Pozsonyi; Telek, Elek; Li, Yin; Collado, Jinnette Tolentino; Tonge, Peter J.; Meech, Stephen R.; Vos, Marten H.; Bodis, Emoke; Lukacs, Andras

Discovery of Novel Bruton's Tyrosine Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-05-17

PREAI

Li, Yi-Qian; Lannigan, William G.; Davoodi, Shabnam; Daryaee, Fereidoon; Corrionero, Ana; Alfonso, Patricia; Rodriguez-Santamaria, Jose A.; Wang, Nan; Haley, John D.; Tonge, Peter J.

High Accuracy Prediction of PROTAC Complex Structures

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-03-24

PREAI

Ignatov, Mikhail; Jindal, Akhil; Kotelnikov, Sergei; Beglov, Dmitri; Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Poda, Gennady; Batey, Robert A.; Sicheri, Frank; Whitty, Adrian; Tonge, Peter J.; Vajda, Sandor; Kozakov, Dima

Elucidating signal transduction pathway in light-activated adenylyl cyclase using unnatural amino acid mutagenesis

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-01

OAAI

Jewlikar, Samruddhi; Ali, Madeeha; Collado, Jinnette Tolentino; Tonge, Peter

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-02

OAAI

Cifone, Matthew T.; He, YongLe; Basu, Rajeswari; Wang, Nan; Davoodi, Shabnam; Spagnuolo, Lauren A.; Si, Yuanyuan; Daryaee, Taraneh; Stivala, Craig E.; Walker, Stephen G.; Tonge, Peter J.

研究方向