未登录 Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier Barker, Scarlett J.; Thayer, Mai B.; Kim, Chaeyoung; Tatarakis, David; Simon, Matthew J.; Dial, Rebekah; Nilewski, Lizanne; Wells, Robert C.; Zhou, Yinhan; Afetian, Megan; Akkapeddi, Padma; Chappell, Alfred; Chew, Kylie S.; Chow, Johann; Clemens, Allisa; Discenza, Claire B.; Dugas, Jason C.; Dwyer, Chrissa; Earr, Timothy; Ha, Connie; Ho, Yvonne S.; Huynh, David; Lozano, Edwin I.; Jayaraman, Srini; Kwan, Wanda; Mahon, Cathal; Pizzo, Michelle; Robles-Colmenares, Yaneth; Roche, Elysia; Sanders, Laura; Stergioulis, Alexander; Tong, Raymond; Tran, Hai; Zuchero, Joy Yu; Estrada, Anthony A.; Gadkar, Kapil; Koth, Christopher M. M.; Sanchez, Pascal E.; Thorne, Robert G.; Watts, Ryan J.; Sandmann, Thomas; Kane, Lesley A.; Rigo, Frank; Dennis, Mark S.; Lewcock, Joseph W.; Devos, Sarah L. 分享 收藏
CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023) Chew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; Mcinnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S. 分享 收藏
CD98hc is a target for brain delivery of biotherapeutics Chew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; McInnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S. 分享 收藏
Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme 分子结构决定了转铁蛋白受体靶向溶酶体酶的脑递送 Arguello, Annie; Mahon, Cathal S.; Calvert, Meredith E. K.; Chan, Darren; Dugas, Jason C.; Pizzo, Michelle E.; Thomsen, Elliot R.; Chau, Roni; Damo, Lorna A.; Duque, Joseph; Fang, Meng; Giese, Tina; Kim, Do Jin; Liang, Nicholas; Nguyen, Hoang N.; Solanoy, Hilda; Tsogtbaatar, Buyankhishig; Ullman, Julie C.; Wang, Junhua; Dennis, Mark S.; Diaz, Dolores; Gunasekaran, Kannan; Henne, Kirk R.; Lewcock, Joseph W.; Sanchez, Pascal E.; Troyer, Matthew D.; Harris, Jeffrey M.; Scearce-Levie, Kimberly; Shan, Lu; Watts, Ryan J.; Thorne, Robert G.; Henry, Anastasia G.; Kariolis, Mihalis S. 分享 收藏
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge Maun, Henry R.; Vij, Rajesh; Walters, Benjamin T.; Morando, Ashley; Jackman, Janet K.; Wu, Ping; Estevez, Alberto; Chen, Xiaocheng; Franke, Yvonne; Lipari, Michael T.; Dennis, Mark S.; Kirchhofer, Daniel; Ciferri, Claudio; Loyet, Kelly M.; Yi, Tangsheng; Eigenbrot, Charles; Lazarus, Robert A.; Koerber, James T. 分享 收藏
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys 在小鼠和猴子中使用Fc片段血脑屏障转运载体对治疗蛋白进行脑递送 Kariolis, Mihalis S.; Wells, Robert C.; Getz, Jennifer A.; Kwan, Wanda; Mahon, Cathal S.; Tong, Raymond; Kim, Jin; Srivastava, Ankita; Bedard, Catherine; Henne, Kirk R.; Giese, Tina; Assimon, Victoria A.; Chen, Xiaocheng; Zhang, Yin; Solanoy, Hilda; Jenkins, Katherine; Sanchez, Pascal E.; Kane, Lesley; Miyamoto, Takashi; Chew, Kylie S.; Pizzo, Michelle E.; Liang, Nicholas; Calvert, Meredith E. K.; DeVos, Sarah L.; Baskaran, Sulochanadevi; Hall, Sejal; Sweeney, Zachary K.; Thorne, Robert G.; Watts, Ryan J.; Dennis, Mark S.; Silverman, Adam P.; Zuchero, Y. Joy Yu 分享 收藏
Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice Ullman, Julie C.; Arguello, Annie; Getz, Jennifer A.; Bhalla, Akhil; Mahon, Cathal S.; Wang, Junhua; Giese, Tina; Bedard, Catherine; Kim, Do Jin; Blumenfeld, Jessica R.; Liang, Nicholas; Ravi, Ritesh; Nugent, Alicia A.; Davis, Sonnet S.; Ha, Connie; Duque, Joseph; Tran, Hai L.; Wells, Robert C.; Lianoglou, Steve; Daryani, Vinay M.; Kwan, Wanda; Solanoy, Hilda; Hoang Nguyen; Earr, Timothy; Dugas, Jason C.; Tuck, Michael D.; Harvey, Jennifer L.; Reyzer, Michelle L.; Caprioli, Richard M.; Hall, Sejal; Poda, Suresh; Sanchez, Pascal E.; Dennis, Mark S.; Gunasekaran, Kannan; Srivastava, Ankita; Sandmann, Thomas; Henne, Kirk R.; Thorne, Robert G.; Di Paolo, Gilbert; Astarita, Giuseppe; Diaz, Dolores; Silverman, Adam P.; Watts, Ryan J.; Sweeney, Zachary K.; Kariolis, Mihalis S.; Henry, Anastasia G. 分享 收藏
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody Staflin, Karin; de Zafra, Christina L. Zuch; Schutt, Leah K.; Clark, Vanessa; Zhong, Fiona; Hristopoulos, Maria; Clark, Robyn; Li, Ji; Mathieu, Mary; Chen, Xiaocheng; Johnston, Jennifer; Low, Justin; Ybarra, Ryan; Slaga, Dionysos; Yang, Jihong; Ovacik, Meric; Dybdal, Noel O.; Totpal, Klara; Junttila, Melissa R.; Ellerman, Diego; Lee, Genee; Dennis, Mark S.; Prell, Rodney; Junttila, Teemu T. 分享 收藏
Brain delivery and efficacy of an intravenously-administered lysosomal enzyme using a blood-brain barrier transport vehicle Henry, Anastasia G.; Ullman, Julie; Arguello, Annie; Getz, Jennifer; Bhalla, Akhil; Mahon, Cathal; Wang, Junhua; Giese, Tina; Bedard, Catherine; Blumenfeld, Jessica; Ravi, Ritesh; Nugent, Alicia; Lianoglou, Steve; Dennis, Mark; Gunasekaran, Kannan; Srivastava, Ankita; Henne, Kirk; Thorne, Robert; Di Paolo, Gilbert; Astarita, Giuseppe; Diaz, Dolores; Silverman, Adam; Watts, Ryan; Sweeney, Zachary; Kariolis, Mihalis 分享 收藏
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer (vol 17, pg 638, 2018) Bhakta, Sunil; Crocker, Lisa M.; Chen, Yvonne; Hazen, Meredith; Schutten, Melissa M.; Li, Dongwei; Kuijl, Coenraad; Ohri, Rachana; Zhong, Fiona; Poon, Kirsten A.; Go, Mary Ann T.; Cheng, Eric; Piskol, Robert; Firestein, Ron; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Raab, Helga; Hongo, Jo-Anne; Sampath, Deepak; Dennis, Mark S.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏
Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle Henry, Anastasia G.; Kariolis, Mihalis S.; Ullman, Julie C.; Getz, Jennifer A.; Arguello, Annie; Mahon, Cathal; Wang, Junhua; Bhalla, Akhil; Giese, Tina; Bedard, Catherine; Kim, Do Jin; Blumenfeld, Jessica; Liang, Nicholas; Duque, Joseph; Hai Tran; Wells, Robert C.; Astarita, Giuseppe; Dennis, Mark S.; Gunasekaran, Kannan; Srivastava, Ankita; Henne, Kirk R.; Diaz, Dolo; Silverman, Adam P.; Watts, Ryan J.; Sweeney, Zachary K. 分享 收藏
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model T细胞依赖性双特异性抗体的相对靶标亲和力决定了实体瘤小鼠模型中的生物分布 Mandikian, Danielle; Takahashi, Nene; Lo, Amy A.; Li, Ji; Eastham-Anderson, Jeffrey; Slaga, Dionysos; Ho, Jason; Hristopoulos, Maria; Clark, Robyn; Totpal, Klara; Lin, Kedan; Joseph, Sean B.; Dennis, Mark S.; Prabhu, Saileta; Junttila, Teemu T.; Boswell, C. Andrew 分享 收藏
Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation Liao, Fan; Li, Aimin; Xiong, Monica; Bien-Ly, Nga; Jiang, Hong; Zhang, Yin; Finn, Mary Beth; Hoyle, Rosa; Keyser, Jennifer; Lefton, Katheryn B.; Robinson, Grace O.; Serrano, Javier Remolina; Silverman, Adam P.; Guo, Jing L.; Getz, Jennifer; Henne, Kirk; Leyns, Cheryl E. G.; Gallardo, Gilbert; Ulrich, Jason D.; Sullivan, Patrick M.; Lerner, Eli Paul; Hudry, Eloise; Sweeney, Zachary K.; Dennis, Mark S.; Hyman, Bradley T.; Watts, Ryan J.; Holtzman, David M. 分享 收藏
An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer Bhakta, Sunil; Crocker, Lisa M.; Chen, Yvonne; Hazen, Meredith; Schutten, Melissa M.; Li, Dongwei; Kuijl, Coenraad; Ohri, Rachana; Zhong, Fiona; Poon, Kirsten A.; Go, Mary Ann T.; Cheng, Eric; Piskol, Robert; Firestein, Ron; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Raab, Helga; Hongo, Jo-Anne; Sampath, Deepak; Dennis, Mark S.; Scheller, Richard H.; Polakis, Paul; Junutula, Jagath R. 分享 收藏
T cell-dependent bispecific antibody anti-CD79b/CD3 as a potential therapy for B-cell malignancies Wang, Peiyin; Hristopoulos, Maria; Clark, Robyn; Chen, Yvonne; Ellerman, Diego; Mathieu, Mary; Spiess, Christoph; Li, Jessica; Chalouni, Cecile; Sukumaran, Siddharth; Stefanich, Eric; Wallin, Jeffrey; Li, Robert; Zabka, Tanja; Totpal, Klara; Dennis, Mark; Ebens, Allen; Gould, Stephen; Polson, Andrew; Sun, Liping Laura 分享 收藏
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice 维持抗体稳定性并降低小鼠毒性的效应子减毒取代 Lo, Megan; Kim, Hok Seon; Tong, Raymond K.; Bainbridge, Travis W.; Vernes, Jean-Michel; Zhang, Yin; Lin, Yuwen Linda; Chung, Shan; Dennis, Mark S.; Zuchero, Y. Joy Yu; Watts, Ryan J.; Couch, Jessica A.; Meng, Y. Gloria; Atwal, Jasvinder K.; Brezski, Randall J.; Spiess, Christoph; Ernst, James A. 分享 收藏
Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies Zuchero, Y. Joy Yu; Chen, Xiaocheng; Bien-Ly, Nga; Bumbaca, Daniela; Tong, Raymond K.; Gao, Xiaoying; Zhang, Shuo; Hoyte, Kwame; Luk, Wilman; Huntley, Melanie A.; Phu, Lilian; Tan, Christine; Kallop, Dara; Weimer, Robby M.; Lu, Yanmei; Kirkpatrick, Donald S.; Ernst, James A.; Chih, Ben; Dennis, Mark S.; Watts, Ryan J. 分享 收藏
Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies Anti-CD20/cd3t细胞依赖性双特异性抗体治疗b细胞恶性肿瘤 Sun, Liping L.; Ellerman, Diego; Mathieu, Mary; Hristopoulos, Maria; Chen, Xiaocheng; Li, Yijin; Yan, Xiaojie; Clark, Robyn; Reyes, Arthur; Stefanich, Eric; Mai, Elaine; Young, Judy; Johnson, Clarissa; Huseni, Mahrukh; Wang, Xinhua; Chen, Yvonne; Wang, Peiyin; Wang, Hong; Dybdal, Noel; Chu, Yu-Waye; Chiorazzi, Nicholas; Scheer, Justin M.; Junttila, Teemu; Totpal, Klara; Dennis, Mark S.; Ebens, Allen J. 分享 收藏
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