Ryan J. Watts - Publications, H-index & Citations

Ryan J. Watts

ucsf medical center

54H指数

116论文数

1.6W被引数

收录论文 58

发表时间

An Intravenous Brain-Penetrant Enzyme Therapy for Mucopolysaccharidosis II 静脉注射的脑穿透性酶疗法用于粘多糖贮积症II型

New England Journal of Medicine

IF78.5

2026-01-01

PREAI

Muenzer, Joseph; Burton, Barbara K.; Harmatz, Paul; Rajan, Deepa S.; Jones, Simon A.; van den Hout, Johanna M. P.; Mitchell, John J.; Bhalla, Akhil; Engmann, Natalie J.; Zubizarreta, Imanol; Dong, Wei; Model, Fabian; Watts, Ryan J.; Troyer, Matthew D.; Chin, Peter S.; Ho, Carole

Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer’s mouse model 转铁蛋白受体介导的血脑屏障转运在早期发育期间升高，并维持在整个衰老过程及阿尔茨海默病小鼠模型中。

Journal of Cerebral Blood Flow & Metabolism

IF4.5

2025-08-16

OAAI

Vanessa O Torres; Michelle E Pizzo; Darren Chan; Jason C Dugas; David Huynh; David Joy; Eric K Liang; Lily Sarrafha; Isabel Becerra; Roni Chau; Kylie S Chew; Johann Chow; Claire B Discenza; Timothy K Earr; Laura Furaso; Nathalie Khoury; Kendra J Lechtenberg; Amy W Leung; Hoang N Nguyen; Emmanuel S Ojo; Elysia Roche; Matthew J Simon; Hilda Solanoy; Mabel Tong; Raymond K Tong; Kirk Henne; Joseph W Lewcock; Ryan J Watts; Meredith E Calvert; Robert G Thorne; Y Joy Yu Zuchero

Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA 转铁蛋白受体靶向抗淀粉样蛋白抗体增强脑递送并减轻ARIA

Science

IF45.8

2025-08-07

PREAI

Michelle E. Pizzo; Edward D. Plowey; Nathalie Khoury; Wanda Kwan; Jordan Abettan; Sarah L. DeVos; Claire B. Discenza; Timothy Earr; David Joy; Ming Lye-Barthel; Elysia Roche; Darren Chan; Jason C. Dugas; Kapil Gadkar; Stefan Hamann; René Meisner; Jennifer Sebalusky; Ana Claudia Silva Amaral; Isabel Becerra; Roni Chau; Johann Chow; Allisa J. Clemens; Mark S. Dennis; Joseph Duque; Laura Fusaro; Jennifer A. Getz; Mihalis S. Kariolis; Do Jin Kim; Kendra J. Lechtenberg; Amy Wing-Sze Leung; Arash Moshkforoush; Hoang N. Nguyen; Emmanuel S. Ojo; Elliot R. Thomsen; Vanessa O. Torres; Pascal E. Sanchez; Lu Shan; Adam P. Silverman; Zachary K. Sweeney; Hilda Solanoy; Raymond Tong; Meredith E. Calvert; Ryan J. Watts; Robert G. Thorne; Paul H. Weinreb; Dominic M. Walsh; Joseph W. Lewcock; Thierry Bussiere; Y. Joy Yu Zuchero

Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules 双靶向转铁蛋白受体和CD98hc可增强大分子在脑内的暴露。

Cell Reports

IF6.9

2025-07-22

PREAI

Robert C. Wells; Padma Akkapeddi; Darren Chan; David Joy; Arash Moshkforoush; Roni Chau; Johann Chow; Gerald Maxwell Cherf; Ellen Y.T. Chien; Allisa Clemens; Michelle E. Pizzo; Ahlam N. Qerqez; Tiffany Tran; Isabel Becerra; Jason C. Dugas; Joseph Duque; Timothy K. Earr; David Huynh; Do Jin Kim; Amy Wing-Sze Leung; Eric Liang; Hoang N. Nguyen; Yaneth Robles-Colmenares; Holly Kane; Elysia Roche; Patricia Sacayon; Kaitlin Xa; Hilda Solanoy; Mark S. Dennis; Joseph W. Lewcock; Ryan J. Watts; Mihalis S. Kariolis; Robert G. Thorne; Christopher M. Koth; Meredith E.K. Calvert; Y. Joy Yu Zuchero; Kylie S. Chew

Non-coding RNAs in plant stress responses: molecular insights and agricultural applications 植物胁迫响应中的非编码RNA：分子洞察与农业应用

PLANT BIOTECHNOLOGY JOURNAL

IF10.5

2025-05-23

OAAI

Xiaotong Chen; Zhaohui Chen; Ryan Watts; Hong Luo

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-08-14

PREAI

Barker, Scarlett J.; Thayer, Mai B.; Kim, Chaeyoung; Tatarakis, David; Simon, Matthew J.; Dial, Rebekah; Nilewski, Lizanne; Wells, Robert C.; Zhou, Yinhan; Afetian, Megan; Akkapeddi, Padma; Chappell, Alfred; Chew, Kylie S.; Chow, Johann; Clemens, Allisa; Discenza, Claire B.; Dugas, Jason C.; Dwyer, Chrissa; Earr, Timothy; Ha, Connie; Ho, Yvonne S.; Huynh, David; Lozano, Edwin I.; Jayaraman, Srini; Kwan, Wanda; Mahon, Cathal; Pizzo, Michelle; Robles-Colmenares, Yaneth; Roche, Elysia; Sanders, Laura; Stergioulis, Alexander; Tong, Raymond; Tran, Hai; Zuchero, Joy Yu; Estrada, Anthony A.; Gadkar, Kapil; Koth, Christopher M. M.; Sanchez, Pascal E.; Thorne, Robert G.; Watts, Ryan J.; Sandmann, Thomas; Kane, Lesley A.; Rigo, Frank; Dennis, Mark S.; Lewcock, Joseph W.; Devos, Sarah L.

CD98hc is a target for brain delivery of biotherapeutics (vol 14, 5053, 2023)

NATURE COMMUNICATIONS

IF15.7

2023-09-07

OAAI

Chew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; Mcinnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S.

CD98hc is a target for brain delivery of biotherapeutics

NATURE COMMUNICATIONS

IF15.7

2023-08-19

OAAI

Chew, Kylie S.; Wells, Robert C.; Moshkforoush, Arash; Chan, Darren; Lechtenberg, Kendra J.; Tran, Hai L.; Chow, Johann; Kim, Do Jin; Robles-Colmenares, Yaneth; Srivastava, Devendra B.; Tong, Raymond K.; Tong, Mabel; Xa, Kaitlin; Yang, Alexander; Zhou, Yinhan; Akkapeddi, Padma; Annamalai, Lakshman; Bajc, Kaja; Blanchette, Marie; Cherf, Gerald Maxwell; Earr, Timothy K.; Gill, Audrey; Huynh, David; Joy, David; Knight, Kristen N.; Lac, Diana; Leung, Amy Wing-Sze; Lexa, Katrina W.; Liau, Nicholas P. D.; Becerra, Isabel; Malfavon, Mario; McInnes, Joseph; Nguyen, Hoang N.; Lozano, Edwin I.; Pizzo, Michelle E.; Roche, Elysia; Sacayon, Patricia; Calvert, Meredith E. K.; Daneman, Richard; Dennis, Mark S.; Duque, Joseph; Gadkar, Kapil; Lewcock, Joseph W.; Mahon, Cathal S.; Meisner, Rene; Solanoy, Hilda; Thorne, Robert G.; Watts, Ryan J.; Zuchero, Y. Joy Yu; Kariolis, Mihalis S.

Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme 分子结构决定了转铁蛋白受体靶向溶酶体酶的脑递送

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2022-02-28

OAAI

Arguello, Annie; Mahon, Cathal S.; Calvert, Meredith E. K.; Chan, Darren; Dugas, Jason C.; Pizzo, Michelle E.; Thomsen, Elliot R.; Chau, Roni; Damo, Lorna A.; Duque, Joseph; Fang, Meng; Giese, Tina; Kim, Do Jin; Liang, Nicholas; Nguyen, Hoang N.; Solanoy, Hilda; Tsogtbaatar, Buyankhishig; Ullman, Julie C.; Wang, Junhua; Dennis, Mark S.; Diaz, Dolores; Gunasekaran, Kannan; Henne, Kirk R.; Lewcock, Joseph W.; Sanchez, Pascal E.; Troyer, Matthew D.; Harris, Jeffrey M.; Scearce-Levie, Kimberly; Shan, Lu; Watts, Ryan J.; Thorne, Robert G.; Henry, Anastasia G.; Kariolis, Mihalis S.

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2021-02-17

OAAI

Xiong, Monica; Jiang, Hong; Serrano, Javier Remolina; Gonzales, Ernesto R.; Wang, Chao; Gratuze, Maud; Hoyle, Rosa; Bien-Ly, Nga; Silverman, Adam P.; Sullivan, Patrick M.; Watts, Ryan J.; Ulrich, Jason D.; Zipfel, Gregory J.; Holtzman, David M.

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys 在小鼠和猴子中使用Fc片段血脑屏障转运载体对治疗蛋白进行脑递送

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2020-05-27

208

PREAI

Kariolis, Mihalis S.; Wells, Robert C.; Getz, Jennifer A.; Kwan, Wanda; Mahon, Cathal S.; Tong, Raymond; Kim, Jin; Srivastava, Ankita; Bedard, Catherine; Henne, Kirk R.; Giese, Tina; Assimon, Victoria A.; Chen, Xiaocheng; Zhang, Yin; Solanoy, Hilda; Jenkins, Katherine; Sanchez, Pascal E.; Kane, Lesley; Miyamoto, Takashi; Chew, Kylie S.; Pizzo, Michelle E.; Liang, Nicholas; Calvert, Meredith E. K.; DeVos, Sarah L.; Baskaran, Sulochanadevi; Hall, Sejal; Sweeney, Zachary K.; Thorne, Robert G.; Watts, Ryan J.; Dennis, Mark S.; Silverman, Adam P.; Zuchero, Y. Joy Yu

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2020-05-27

132

PREAI

Ullman, Julie C.; Arguello, Annie; Getz, Jennifer A.; Bhalla, Akhil; Mahon, Cathal S.; Wang, Junhua; Giese, Tina; Bedard, Catherine; Kim, Do Jin; Blumenfeld, Jessica R.; Liang, Nicholas; Ravi, Ritesh; Nugent, Alicia A.; Davis, Sonnet S.; Ha, Connie; Duque, Joseph; Tran, Hai L.; Wells, Robert C.; Lianoglou, Steve; Daryani, Vinay M.; Kwan, Wanda; Solanoy, Hilda; Hoang Nguyen; Earr, Timothy; Dugas, Jason C.; Tuck, Michael D.; Harvey, Jennifer L.; Reyzer, Michelle L.; Caprioli, Richard M.; Hall, Sejal; Poda, Suresh; Sanchez, Pascal E.; Dennis, Mark S.; Gunasekaran, Kannan; Srivastava, Ankita; Sandmann, Thomas; Henne, Kirk R.; Thorne, Robert G.; Di Paolo, Gilbert; Astarita, Giuseppe; Diaz, Dolores; Silverman, Adam P.; Watts, Ryan J.; Sweeney, Zachary K.; Kariolis, Mihalis S.; Henry, Anastasia G.

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge TREM2在慢性吞噬细胞攻击后调节小胶质细胞胆固醇代谢

NEURON

IF15

2020-03-01

408

OAAI

Nugent, Alicia A.; Lin, Karin; van Lengerich, Bettina; Lianoglou, Steve; Przybyla, Laralynne; Davis, Sonnet S.; Llapashtica, Ceyda; Wang, Junhua; Kim, Do Jin; Xia, Dan; Lucas, Anthony; Baskaran, Sulochanadevi; Haddick, Patrick C. G.; Lenser, Melina; Earr, Timothy K.; Shi, Ju; Dugas, Jason C.; Andreone, Benjamin J.; Logan, Todd; Solanoy, Hilda O.; Chen, Hang; Srivastava, Ankita; Poda, Suresh B.; Sanchez, Pascal E.; Watts, Ryan J.; Sandmann, Thomas; Astarita, Giuseppe; Lewcock, Joseph W.; Monroe, Kathryn M.; Di Paolo, Gilbert

Brain delivery and efficacy of an intravenously-administered lysosomal enzyme using a blood-brain barrier transport vehicle

MOLECULAR GENETICS AND METABOLISM

IF3.5

2020-02-01

PREAI

Henry, Anastasia G.; Ullman, Julie; Arguello, Annie; Getz, Jennifer; Bhalla, Akhil; Mahon, Cathal; Wang, Junhua; Giese, Tina; Bedard, Catherine; Blumenfeld, Jessica; Ravi, Ritesh; Nugent, Alicia; Lianoglou, Steve; Dennis, Mark; Gunasekaran, Kannan; Srivastava, Ankita; Henne, Kirk; Thorne, Robert; Di Paolo, Gilbert; Astarita, Giuseppe; Diaz, Dolores; Silverman, Adam; Watts, Ryan; Sweeney, Zachary; Kariolis, Mihalis

Improved brain uptake and efficacy of iduronate 2-sulfatase with the enzyme transport vehicle

MOLECULAR GENETICS AND METABOLISM

IF3.5

2019-02-01

PREAI

Henry, Anastasia G.; Kariolis, Mihalis S.; Ullman, Julie C.; Getz, Jennifer A.; Arguello, Annie; Mahon, Cathal; Wang, Junhua; Bhalla, Akhil; Giese, Tina; Bedard, Catherine; Kim, Do Jin; Blumenfeld, Jessica; Liang, Nicholas; Duque, Joseph; Hai Tran; Wells, Robert C.; Astarita, Giuseppe; Dennis, Mark S.; Gunasekaran, Kannan; Srivastava, Ankita; Henne, Kirk R.; Diaz, Dolo; Silverman, Adam P.; Watts, Ryan J.; Sweeney, Zachary K.

SUPT4H1 Depletion Leads to a Global Reduction in RNA

CELL REPORTS

IF6.9

2019-01-01

OAAI

Naguib, Adam; Sandmann, Thomas; Yi, Fei; Watts, Ryan J.; Lewcock, Joseph W.; Dowdle, William E.

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2018-03-30

133

OAAI

Liao, Fan; Li, Aimin; Xiong, Monica; Bien-Ly, Nga; Jiang, Hong; Zhang, Yin; Finn, Mary Beth; Hoyle, Rosa; Keyser, Jennifer; Lefton, Katheryn B.; Robinson, Grace O.; Serrano, Javier Remolina; Silverman, Adam P.; Guo, Jing L.; Getz, Jennifer; Henne, Kirk; Leyns, Cheryl E. G.; Gallardo, Gilbert; Ulrich, Jason D.; Sullivan, Patrick M.; Lerner, Eli Paul; Hudry, Eloise; Sweeney, Zachary K.; Dennis, Mark S.; Hyman, Bradley T.; Watts, Ryan J.; Holtzman, David M.

Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2017-10-06

OAAI

Yadav, Daniela Bumbaca; Maloney, Janice A.; Wildsmith, Kristin R.; Fuji, Reina N.; Meilandt, William J.; Solanoy, Hilda; Lu, Yanmei; Peng, Kun; Wilson, Blair; Chan, Pamela; Gadkar, Kapil; Kosky, Andrew; Goo, Marisa; Daugherty, Ann; Couch, Jessica A.; Keene, Thomas; Hayes, Karen; Nikolas, Lisa Jungbauer; Lane, Deanna; Switzer, Robert; Adams, Eric; Watts, Ryan J.; Scearce-Levie, Kimberly; Prabhu, Saileta; Shafer, Lisa; Thakker, Deepak R.; Hildebrand, Keith; Atwal, Jasvinder K.

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats

SCIENTIFIC REPORTS

IF3.9

2017-03-10

OAAI

Weber, Martin; Wu, Tiffany; Meilandt, William J.; Dominguez, Sara L.; Solanoy, Hilda O.; Maloney, Janice A.; Ngu, Hai; Baca, Miriam; Kung, Chung; Lima, Lisa; Earr, Timothy K.; Fleck, Daniel; Shields, Shannon D.; Forrest, William F.; Foreman, Oded; Warming, Soren; Watts, Ryan J.; Scearce-Levie, Kimberly

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice 维持抗体稳定性并降低小鼠毒性的效应子减毒取代

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-03-01

281

OAAI

Lo, Megan; Kim, Hok Seon; Tong, Raymond K.; Bainbridge, Travis W.; Vernes, Jean-Michel; Zhang, Yin; Lin, Yuwen Linda; Chung, Shan; Dennis, Mark S.; Zuchero, Y. Joy Yu; Watts, Ryan J.; Couch, Jessica A.; Meng, Y. Gloria; Atwal, Jasvinder K.; Brezski, Randall J.; Spiess, Christoph; Ernst, James A.

研究方向