Dominic M. Walsh - Publications, H-index & Citations

Dominic M. Walsh

harvard medical school

86H指数

228论文数

4.2W被引数

收录论文 86

发表时间

Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice 使用针对Aβ寡聚体的B28抗体进行免疫治疗，可显著降低APP基因敲入小鼠的淀粉样斑块、小胶质细胞增生和记忆衰退

Cell Reports

IF6.9

2026-06-30

OAAI

Ting Yang; Yi Ran Xu; Shaomin Li; Jean-Pierre Bellier; Youqi Tao; Anna E. Francis; Andrew M. Stern; Shanxue Jin; Beth L. Ostaszewski; Trebor L. Lawton; Laurent Pradier; David Reczek; Cynthia A. Lemere; Dominic M. Walsh; Dennis J. Selkoe

Transferrin receptor–targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA 转铁蛋白受体靶向抗淀粉样蛋白抗体增强脑递送并减轻ARIA

Science

IF45.8

2025-08-07

PREAI

Michelle E. Pizzo; Edward D. Plowey; Nathalie Khoury; Wanda Kwan; Jordan Abettan; Sarah L. DeVos; Claire B. Discenza; Timothy Earr; David Joy; Ming Lye-Barthel; Elysia Roche; Darren Chan; Jason C. Dugas; Kapil Gadkar; Stefan Hamann; René Meisner; Jennifer Sebalusky; Ana Claudia Silva Amaral; Isabel Becerra; Roni Chau; Johann Chow; Allisa J. Clemens; Mark S. Dennis; Joseph Duque; Laura Fusaro; Jennifer A. Getz; Mihalis S. Kariolis; Do Jin Kim; Kendra J. Lechtenberg; Amy Wing-Sze Leung; Arash Moshkforoush; Hoang N. Nguyen; Emmanuel S. Ojo; Elliot R. Thomsen; Vanessa O. Torres; Pascal E. Sanchez; Lu Shan; Adam P. Silverman; Zachary K. Sweeney; Hilda Solanoy; Raymond Tong; Meredith E. Calvert; Ryan J. Watts; Robert G. Thorne; Paul H. Weinreb; Dominic M. Walsh; Joseph W. Lewcock; Thierry Bussiere; Y. Joy Yu Zuchero

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region 细胞外tau蛋白的突触毒性效应由其微管结合区介导

Acta Neuropathologica

IF9.3

2025-06-02

OAAI

Tomas Ondrejcak; Neng-Wei Hu; Emily Coode; Tom Campbell; Grant T. Corbett; Ivan Doykov; Kevin Mills; Dominic M. Walsh; Frederick J. Livesey; Michael J. Rowan; Igor Klyubin

Patient-derived tau and amyloid-β facilitate long-term depression in vivo: role of tumour necrosis factor-α and the integrated stress response

BRAIN COMMUNICATIONS

IF4.5

2024-09-27

OAAI

Hu, Neng-Wei; Ondrejcak, Tomas; Klyubin, Igor; Yang, Yin; Walsh, Dominic M.; Livesey, Frederick J.; Rowan, Michael J.

Methods for the isolation and analysis of Aβ from postmortem brain

FRONTIERS IN NEUROSCIENCE

IF3.2

2023-01-26

OAAI

Hong, Wei; Liu, Wen; Desousa, Alexandra O.; Young-Pearse, Tracy; Walsh, Dominic M.

NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression

CELLS

IF5.2

2021-12-13

OAAI

Mengel, David; Mok, Tze How; Nihat, Akin; Liu, Wen; Rissman, Robert A.; Galasko, Douglas; Zetterberg, Henrik; Mead, Simon; Collinge, John; Walsh, Dominic M.

Laboratory evolution of a sortase enzyme that modifies amyloid-β protein

NATURE CHEMICAL BIOLOGY

IF13.7

2021-01-11

OAAI

Podracky, Christopher J.; An, Chihui; DeSousa, Alexandra; Dorr, Brent M.; Walsh, Dominic M.; Liu, David R.

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease 阿尔茨海默病早期血浆纵向p-tau217升高

Brain

IF11.7

2020-10-17

173

OAAI

Mattsson-Carlgren, Niklas; Janelidze, Shorena; Palmqvist, Sebastian; Cullen, Nicholas; Svenningsson, Anna L.; Strandberg, Olof; Mengel, David; Walsh, Dominic M.; Stomrud, Erik; Dage, Jeffrey L.; Hansson, Oskar

PlasmaNT1Tau is a Specific and Early Marker of Alzheimer's Disease

ANNALS OF NEUROLOGY

IF7.7

2020-09-25

PREAI

Mengel, David; Janelidze, Shorena; Glynn, Robert J.; Liu, Wen; Hansson, Oskar; Walsh, Dominic M.

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

ALZHEIMERS RESEARCH & THERAPY

IF7.6

2020-03-19

OAAI

Mengel, David; Liu, Wen; Glynn, Robert J.; Selkoe, Dennis J.; Strydom, Andre; Lai, Florence; Rosas, H. Diana; Torres, Amy; Patsiogiannis, Vasiliki; Skotko, Brian; Walsh, Dominic M.

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

ACTA NEUROPATHOLOGICA

IF9.3

2019-12-18

110

OAAI

Corbett, Grant T.; Wang, Zemin; Hong, Wei; Colom-Cadena, Marti; Rose, Jamie; Liao, Meichen; Asfaw, Adhana; Hall, Tia C.; Ding, Lai; DeSousa, Alexandra; Frosch, Matthew P.; Collinge, John; Harris, David A.; Perkinton, Michael S.; Spires-Jones, Tara L.; Young-Pearse, Tracy L.; Billinton, Andrew; Walsh, Dominic M.

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients

FRONTIERS IN NEUROSCIENCE

IF3.2

2019-11-26

151

OAAI

Cha, Diana J.; Mengel, David; Mustapic, Maja; Liu, Wen; Selkoe, Dennis J.; Kapogiannis, Dimitrios; Galasko, Douglas; Rissman, Robert A.; Bennett, David A.; Walsh, Dominic M.

Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo 可溶性tau聚集体在体内抑制突触长期抑制和淀粉样蛋白 β 促进的LTD

NEUROBIOLOGY OF DISEASE

IF5.6

2019-07-01

PREAI

Ondrejcak, Tomas; Hu, Neng-Wei; Qi, Yingjie; Klyubin, Igor; Corbett, Grant T.; Fraser, Graham; Perkinton, Michael S.; Walsh, Dominic M.; Billinton, Andrew; Rowan, Michael J.

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid

ANNALS OF NEUROLOGY

IF7.7

2019-06-22

OAAI

Yang, Ting; Dang, Yifan; Ostaszewski, Beth; Mengel, David; Steffen, Verena; Rabe, Christina; Bittner, Tobias; Walsh, Dominic M.; Selkoe, Dennis J.

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain

BRAIN

IF11.7

2019-04-29

OAAI

Brinkmalm, Gunnar; Hong, Wei; Wang, Zemin; Liu, Wen; O'Malley, Tiernan T.; Sun, Xin; Frosch, Matthew P.; Selkoe, Dennis J.; Portelius, Erik; Zetterberg, Henrik; Blennow, Kaj; Walsh, Dominic M.

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease

ALZHEIMERS & DEMENTIA

IF11.1

2018-11-09

OAAI

Chen, Zhicheng; Mengel, David; Keshavan, Ashvini; Rissman, Robert A.; Billinton, Andrew; Perkinton, Michael; Percival-Alwyn, Jennifer; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Selkoe, Dennis J.; Sperling, Reisa A.; Patel, Purvish; Zetterberg, Henrik; Galasko, Douglas; Schott, Jonathan M.; Walsh, Dominic M.

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease

NATURE COMMUNICATIONS

IF15.7

2018-07-11

OAAI

Jin, Ming; O'Nuallain, Brian; Hong, Wei; Boyd, Justin; Lagomarsino, Valentina N.; O'Malley, Tiernan T.; Liu, Wen; Vanderburg, Charles R.; Frosch, Matthew P.; Young-Pearse, Tracy; Selkoe, Dennis J.; Walsh, Dominic M.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways MicroRNA-132通过多种信号通路为tau蛋白病提供神经保护

ACTA NEUROPATHOLOGICA

IF9.3

2018-07-07

116

OAAI

El Fatimy, Rachid; Li, Shaomin; Chen, Zhicheng; Mushannen, Tasnim; Gongala, Sree; Wei, Zhiyun; Balu, Darrick T.; Rabinovsky, Rosalia; Cantlon, Adam; Elkhal, Abdallah; Selkoe, Dennis J.; Sonntag, Kai C.; Walsh, Dominic M.; Krichevsky, Anna M.

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

CELL REPORTS

IF6.9

2018-05-01

OAAI

Hu, Neng-Wei; Corbett, Grant T.; Moore, Steven; Klyubin, Igor; O'Malley, Tiernan T.; Walsh, Dominic M.; Livesey, Frederick J.; Rowan, Michael J.

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain

ACTA NEUROPATHOLOGICA

IF9.3

2018-04-23

103

OAAI

Hong, Wei; Wang, Zemin; Liu, Wen; O'Malley, Tiernan T.; Jin, Ming; Willem, Michael; Haass, Christian; Frosch, Matthew P.; Walsh, Dominic M.

研究方向