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J

João Agostinho Machado‐Neto

instituto de ciências biomédicas

27H指数
300论文数
2.1K被引数
收录论文 80
发表时间
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Nutrient deprivation enhances the cytotoxic effects of a sulfonamide-chalcone hybrid in PC-3 prostate cancer cells营养剥夺增强了磺胺-查尔酮杂合体在PC-3前列腺癌细胞中的细胞毒性效应
errMolecular and Cellular Biochemistry
IF3.7
err2026-09-11
err0
errOAAI
errGisele Santos de Araújo; Rodrigo Elísio de Sá; Stéphanie Aguiar de Negreiros Matos Silva; Fabrício dos Santos Machado; Caridad Noda Perez; Mirian Rita Carrilho de Castro; Anali Del Milagro Bernabe Garnique; Bruna Oliveira de Almeida; Keli Lima; João Agostinho Machado Neto; Letícia Veras Costa Lotufo; José Delano Barreto Marinho Filho; Ana Jérsia Araujo
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O-GlcNAc transferase as an oncogenic regulator in hematologic malignancies: Mechanisms, disease contexts, and therapeutic perspectivesO-GlcNAc转移酶作为血液系统恶性肿瘤中的癌基因调节剂：机制、疾病背景和治疗前景
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2026-08-03
err0
errOAAI
errMarissa El Hajje; Juan Luiz Coelho-Silva; João Agostinho Machado-Neto; Gustavo Henrique Goulart Trossini
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err收藏
Ribosome biogenesis and selective translational control as oncogenic vulnerabilities in hematologic malignancies核糖体生物发生和选择性翻译调控作为血液系统恶性肿瘤中的致癌易损性
errMolecular Cancer
IF33.9
err2026-07-23
err0
errOAAI
errJuan Luiz Coelho-Silva; João Agostinho Machado-Neto
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The blood remembers: HSC-iM and the cancer continuum血液记得：HSC-iM 与癌症连续体
errBlood Cancer Journal
IF11.6
err2026-07-20
err0
errOAAI
errJuan L. Coelho-Silva; Diego A. Pereira-Martins; João A. Machado-Neto
err分享
err收藏
The murine Irs1 knockout model, generated by the spontaneous Irs1S57X mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis由自发性Irs1S57X突变纯合子产生的鼠类Irs1敲除模型，表现出高胚胎致死率，限制了成年造血的研究
errHematology Transfusion and Cell Therapy
IF1.6
err2026-07-01
err0
errOAAI
errFenerich, Bruna Alves; Fernandes, Jaqueline Cristina; Silva, Cleide Lucia Araujo; Machado-Neto, Joao Agostinho; Traina, Fabiola
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Exploring the prognostic impact and biological functions of mutant-like TP53-related genes in acute myeloid leukemia探究突变样TP53相关基因在急性髓系白血病中的预后影响及生物学功能
errHematology Transfusion and Cell Therapy
IF1.6
err2026-07-01
err0
errOAAI
errBertoline, Leticia Machado Favery; Coelho-Silva, Juan Luiz; Lima, Keli; Rego, Eduardo Magalhaes; Machado-Neto, Joao Agostinho
err分享
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Targeting "undruggable" cancer proteins: pharmacological challenges and emerging strategies靶向“不可成药”的癌症蛋白：药理学挑战与新兴策略
errTranslational Cancer Research
IF1.7
err2026-04-30
err1
PREAI
errCoelho-Silva, Juan Luiz; Parducci, Natalia Sudan; Carvalho, Maria Fernanda Lopes; Vahedian, Vahid; Lima, Keli; de Almeida, Bruna Oliveira; Machado-Neto, Joao Agostinho
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Quizartinib-induced resistance drives clonal emergence of MV4-11 cells with molecular alterations enabling multidrug antileukemic escapeQuizartinib诱导的耐药性驱动具有分子改变以实现多药抗白血病逃逸的MV4-11细胞的克隆出现
errEuropean Journal of Pharmacology
IF4.7
err2026-04-15
err0
errOAAI
errLivia Bassani Lins de Miranda; Keli Lima; Diego A. Pereira-Martins; Juan Luiz Coelho-Silva; Victoria Tomaz; Luiz Gustavo Ferreira Cortez; Marina de Franca Basto Silva; Rafael Lucas Muniz Guedes; Paulo Vidal Campregher; Dominique Sternadt; Eduardo Magalhães Rego; Fabiola Traina; Jan Jacob Schuringa; João Agostinho Machado-Neto
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Synthesis of N-Substituted Acenaphtho[1; 2-b]pyrroles and Dibenzo[e; g]indoles with Promising Antileukemic Activity from Morita–Baylis–Hillman Adducts以Morita–Baylis–Hillman加合物为原料合成具有良好抗白血病活性的N-取代acenaphtho[1; 2-b]pyrroles和dibenzo[e; g]indoles
errACS Omega
IF4.3
err2026-03-06
err0
errOAAI
errJoão Arantes; Manoel T. Rodrigues Jr.; Giovani Rosendo; Rafael Porreca; Hugo P. Vicari; Hugo Santos; João A. Machado-Neto; Fernando Coelho
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Molecular and Antiangiogenic Effects of Paclitaxel-Loaded Nanoparticles: Influence of the Nanocarrier Type负载紫杉醇纳米粒的分子和抗血管生成效应：纳米载体类型的影响
errMolecular Pharmaceutics
IF4.5
err2026-03-06
err0
errOAAI
errJulia Sapienza Passos; Giovanna B. de Melo; Giovanna C. Salata; João Agostinho Machado-Neto; Alyssa Panitch; Luciana B. Lopes
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err收藏
Repositioning HDAC Inhibitors for Glioma Treatment: Synthesis and Biological Evaluation
errACS Omega
IF4.3
err2026-02-02
err0
errOAAI
errLuciana Costa Furtado; Karoline de Barros Waitman; Nuno A. T. F. Silva; Leticia Marcelino Gouvea; Thales Kronenberger; Mônica Franco Zannini Junqueira Toledo; Elthon Gois Ferreira; João Agostinho Machado-Neto; Frank A. E. Kruyt; Roberto Parise Filho; Letícia V. Costa-Lotufo
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Capsaicin-Inspired Hydroxamate Hybrids as Selective HDAC6 Inhibitors with Antiproliferative Activity in Hematological Malignancies辣椒素激发的异羟肟酸酯杂合体作为选择性HDAC6抑制剂，在血液系统恶性肿瘤中具有抗增殖活性
errACS Omega
IF4.3
err2026-01-28
err0
errOAAI
errLara Gimenez Borges; Thais Nascimento de Oliveira Alves; Sandra Valeria Vassiliades; Jorge Antonio Elias Godoy Carlos; Karoline de Barros Waitman; Sebastian Hilscher; Mike Schutkowski; Wolfgang Sippl; Maurício Temotheo Tavares; Monica Franco Zannini Junqueira Toledo; Letícia Veras Costa-Lotufo; Thales Kronenberger; João Agostinho Machado-Neto; Roberto Parise-Filho
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Cephalochromin Effects in Triple-Negative Breast Cancer Cells: Apoptosis Induction and Modulation of Survival PathwaysCephalochromin在 triple-negative 乳腺癌细胞中的作用：诱导凋亡和调节存活通路
errJournal of Natural Products
IF3.6
err2025-12-04
err0
errOAAI
errIsabelle Diccini; Natália Sudan Parducci; Bruna Oliveira de Almeida; Victor Farinella; Patrick Castilho dos Santos; Livia Bassani Lins de Miranda; Sabrina Mendes Botelho; Keli Lima; Jorge Antonio Elias Godoy Carlos; Anali Del Milagro Bernabe Garnique; Marcelo José Pena Ferreira; Leticia Veras Costa-Lotufo; João Agostinho Machado-Neto
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Silico, in vitro, and in vivo studies of a 2-substituted quinazolin-4(3H)-one in T-cell acute lymphoblastic leukemia硅基、体外和体内研究一种2-取代喹唑啉-4(3H)-酮在T细胞急性淋巴细胞白血病中的应用
errToxicology and Applied Pharmacology
IF3.4
err2025-12-04
err0
PREAI
errGiorgio Antoniolli; Gilberto Carlos Franchi Junior; Keli Lima; Rayssa de Mello Lopes; Euzebio Guimarães Barbosa; João Agostinho Machado-Neto; Carmen Silva Passos Lima; Tiago Rodrigues; Fernando Coelho
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Automated Machine Learning in medical research: A systematic literature mapping study自动化机器学习在医学研究中的应用：一项系统性的文献映射研究
errArtificial Intelligence in Medicine
IF6.2
err2025-11-12
err0
PREAI
errGiovanna A. Castro; Luiza G. Barioto; Yu H. Cao; Renato M. Silva; Helena M. Caseli; João A. Machado-Neto; Ricardo Cerri; Aline Villavicencio; Tiago A. Almeida
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ZnO nanoparticles enhance the cytotoxic effects of a chalcone-sulfonamide hybrid by impairing the autophagic flux and upregulating HIF-1α expressionZnO纳米粒子通过抑制自噬流和上调HIF-1α表达，增强了查尔酮-磺酰胺杂合物的细胞毒性效应。
errBioorganic Chemistry
IF4.7
err2025-10-22
err0
PREAI
errJessica Maria Teles Souza; Stéphanie Aguiar de Negreiros Matos Silva; Rodrigo Elísio de Sá; Rafaela Maria Ribeiro; Antônio Joaquim de Souza Castro; Peter Eaton; Mirian Rita Carrilho de Castro; Caridad Noda Pérez; João Agostinho Machado-Neto; Durcilene Alves da Silva; Nádia Aline de Oliveira Pitombeira; Regina Célia Monteiro De Paula; José Delano Barreto Marinho-Filho; Ana Jérsia Araújo
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Metabolic reprogramming represents a targetable mechanism to overcome acquired resistance to venetoclax in acute myeloid leukemia代谢重编程代表了克服急性髓系白血病中维奈克拉获得性耐药的可靶向机制。
errBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
IF0
err2025-10-01
err0
PREAI
errGustavo Nery de Queiroz; Keli Lima; Marcella Cipelli; Victoria Tomaz; Luiz Gustavo Ferreira Cortez; Marina de Franca Basto Silva; Rafael Lucas Muniz Guedes; Paulo Vidal Campregher; Eduardo Magalhães Rego; Niels Olsen Saraiva Câmara; Leticia Veras Costa-Lotufo; João Agostinho Machado-Neto
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New molecular targets in acute leukemias :cytoskeletal regulatory proteins急性白血病中的新分子靶点：细胞骨架调节蛋白
errBIOCHEMICAL SOCIETY TRANSACTIONS
IF4.3
err2025-09-01
err0
errOAAI
errMachado-Neto, Joao Agostinho; Vicari, Hugo Passos; da Silva, Jean Carlos Lipreri; Lima, Keli
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err收藏
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment多娜·弗洛尔与她的两个丈夫：用于髓系癌症治疗的HDAC6/AKT2新型抑制剂的发现
errComputers in Biology and Medicine
IF6.3
err2025-08-28
err0
PREAI
errKaroline B. Waitman; Holli-Joi Martin; Jorge A.E.G. Carlos; Rodolpho C. Braga; Vinícius A.M. Souza; Cleber C. Melo-Filho; Sebastian Hilscher; Mônica F.Z. J. Toledo; Maurício T. Tavares; Letícia V. Costa-Lotufo; João A. Machado-Neto; Mike Schutkowski; Wolfgang Sippl; Thales Kronenberger; Vinicius M. Alves; Roberto Parise-Filho; Eugene N. Muratov
err分享
err收藏
Molecular effects of paclitaxel-elacridar nanoemulsions in breast cancer cells: impact on uptake, cell cycle and signaling pathways紫杉醇-艾克拉瑞达纳米乳液的分子效应：对摄取、细胞周期和信号通路的影响
errEuropean Journal of Pharmaceutics and Biopharmaceutics
IF4.3
err2025-08-09
err0
PREAI
errGiovanna C. Salata; Isabella D. Malagó; Giovanna Barros de Melo; João Agostinho Machado-Neto; Luciana B. Lopes
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err收藏

研究方向

暂无研究方向
合作学者
合作期刊
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H 指数: 109 · 论文数: 1.0K
W
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H 指数: 107 · 论文数: 701
A
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H 指数: 103 · 论文数: 481
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