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H

Hartmut Kühn

charité—university medicine berlin

72H指数
418论文数
1.7W被引数
收录论文 164
发表时间
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Structural Improvement of the Allosteric ALOX15 Inhibitor Octyl (N-(5-(1H-Indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamate别构ALOX15抑制剂辛基[N-(5-(1H-吲哚-2-基)-2-甲氧基苯基)磺酰胺基]氨基甲酸酯的结构优化
errMolecules
IF4.6
err2026-07-23
err0
errOAAI
errViktor Gavrilyuk; Vladislav Aksenov; Kirill Petrov; Angelina V. Kurchatova; Dmitriy Bortnevskij; Alexander Zhuravlev; Alexey Golovanov; Hartmut Kuhn; Igor Ivanov
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err收藏
ALLOSTERIC PROPERTIES OF MAMMALIAN ALOX15 ORTHOLOGS
errJournal of Biological Chemistry
IF3.9
err2026-02-05
err0
errOAAI
errJiaxing Yang; Astrid Borchert; Hartmut Kuhn
err分享
err收藏
Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Development of Endometriosis巨噬细胞介导的氧化应激促进血管生成和子宫内膜异位症的早期发展
errAntioxidants
IF6.6
err2026-01-24
err0
errOAAI
errGene Chi Wai Man; Astrid Borchert; Tao Zhang; Sze Wan Hung; Hartmut Kühn; Chi Chiu Wang
err分享
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Exploring allosteric properties of mammalian ALOX15: octyl (N-(4-(benzofuran-2-yl)-2-methoxyphenyl)sulfamoyl)- and octyl (N-(4-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates as ALOX inhibitors探索哺乳动物ALOX15的别构特性：辛基(N-(4-(2-苯并呋喃基)-2-甲氧基苯基)磺酰胺基)-和辛基(N-(4-(1H-吲哚-2-基)-2-甲氧基苯基)磺酰胺基)氨基甲酸酯作为ALOX抑制剂
errRSC Adv.
IF4.6
err2025-09-22
err0
errOAAI
errViktor Gavrilyuk; Alejandro Cruz; Vladislav Aksenov; Danila Nurgaliev; Alexander Zhuravlev; Alexey Golovanov; José M. Lluch; Hartmut Kuhn; Igor Ivanov; Àngels González-Lafont
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Arachidonoyl-carnitine and arachidonoyl-coenzyme A are suitable substrates for mammalian ALOX isoforms.花生四烯酰肉碱和花生四烯酰辅酶A是哺乳动物ALOX同工酶的合适底物。
errJournal of Lipid Research
IF4.1
err2025-07-17
err0
errOAAI
errXin Chen; Sahanawaz Parvez; Hannah F. Wiegand; Liuhui Wu; Sabine Stehling; Astrid Borchert; Junlin Yang; Polamarasetty Aparoy; Hartmut Kuhn
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err收藏
The reaction specificity of mammalian ALOX15B orthologs does not depend on the evolutionary ranking of the animals哺乳动物ALOX15B同源物的反应特异性不依赖于动物的进化等级。
errJOURNAL OF LIPID RESEARCH
IF4.1
err2025-04-01
err0
errOAAI
errGuendem, Eda; Stehling, Sabine; Borchert, Astrid; Kuhn, Hartmut
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Eicosanoid biosynthesizing enzymes in Prototheria
errBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
IF3.3
err2025-01-01
err0
errOAAI
errKakularam, Kumar R.; Guendem, Eda; Stehling, Sabine; Rothe, Michael; Heydeck, Dagmar; Kuhn, Hartmut
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Oral administration of butylated hydroxytoluene induces neuroprotection in a streptozotocin-induced rat Alzheimer's disease model via inhibition of neuronal ferroptosis
errMOLECULAR MEDICINE
IF6.4
err2024-11-08
err0
errOAAI
errFaraji, Parisa; Parandavar, Elham; Kuhn, Hartmut; Habibi-Rezaei, Mehran; Borchert, Astrid; Zahedi, Elham; Ahmadian, Shahin
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Butylated Hydroxytoluene (BHT) Protects SH-SY5Y Neuroblastoma Cells from Ferroptotic Cell Death: Insights from In Vitro and In Vivo Studies
errANTIOXIDANTS
IF6.6
err2024-02-17
err7
errOAAI
errFaraji, Parisa; Borchert, Astrid; Ahmadian, Shahin; Kuhn, Hartmut
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Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin-angiotensin-aldosterone system on COVID-19 disease
errVIROLOGY JOURNAL
IF3.8
err2024-01-10
err5
errOAAI
errZobel, Christian M.; Kuhn, Hartmut; Schreiner, Maximilian; Wenzel, Werner; Wendtland, Jasper; Goekeri, Cengiz; Scheit, Lorenz; Oltmanns, Klaas; Rauschning, Dominic; Grossegesse, Marica; Hofmann, Natalie; Wirtz, Hubert; Spethmann, Sebastian
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Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
errCELLULAR & MOLECULAR BIOLOGY LETTERS
IF10.2
err2023-11-29
err3
errOAAI
errReisch, Florian; Heydeck, Dagmar; Schaefer, Marjann; Rothe, Michael; Yang, Jiaxing; Stehling, Sabine; Pueschel, Gerhard P.; Kuhn, Hartmut
err分享
err收藏
Adipokines in cachexia of patients with lung cancer
errEUROPEAN RESPIRATORY JOURNAL
IF21
err2023-10-27
err1
PREAI
errHofmann, Lukas; Frommelt, Charlotte; Ossenberg, Malte; Oberhuber-Kurth, Jonas; Pappisch, Johanna; Kerkhoff, Teresa; Linder, Nicolas; Busse, Harald; Ebert, Thomas; Toenjes, Anke; Kraemer, Sebastian; Kuhn, Hartmut; Wirtz, Hubert; Frille, Armin
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Different Structures-Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
errMOLECULES
IF4.6
err2023-07-14
err1
errOAAI
errZhuravlev, Alexander; Cruz, Alejandro; Aksenov, Vladislav; Golovanov, Alexey; Lluch, Jose M.; Kuhn, Hartmut; Gonzalez-Lafont, Angels; Ivanov, Igor
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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome
errENGINEERING
IF11.6
err2023-04-01
err1
errOAAI
errWu, Xiaoke; Wang, Chi Chiu; Cao, Yijuan; Li, Jian; Li, Zhiqiang; Ma, Hongli; Gao, Jingshu; Chang, Hui; Zhang, Duojia; Cong, Jing; Wang, Yu; Wu, Qi; Han, Xiaoxiao; Chung, Pui Wah Jacqueline; Li, Yiran; Zheng, Xu; Chen, Lingxi; Zeng, Lin; Borchert, Astrid; Kuhn, Hartmut; Chen, Zi-Jiang; Ng, Ernest Hung Yu; Stener-Victorin, Elisabet; Zhang, Heping; Legro, Richard S.; Mol, Ben Willem J.; Shi, Yongyong
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Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1-/-) gain less body weight during adolescence and adulthood
errCELL AND BIOSCIENCE
IF6.2
err2022-12-09
err4
errOAAI
errDumoulin, Bernhard; Heydeck, Dagmar; Jaehn, Desiree; Lasse, Moritz; Sofi, Sajad; Ufer, Christoph; Kuhn, Hartmut
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Structural and functional evaluation mammalian and plant lipoxygenases upon association with nanodics as membrane mimetics
errBIOPHYSICAL CHEMISTRY
IF2.2
err2022-09-01
err3
PREAI
errUlusan, Sinem; Sheraj, Ilir; Stehling, Sabine; Ivanov, Igor; Das, Aditi; Kuehn, Hartmut; Banerjee, Sreeparna
err分享
err收藏
Male Knock-in Mice Expressing an Arachidonic Acid Lipoxygenase 15B (Alox15B) with Humanized Reaction Specificity Are Prematurely Growth Arrested When Aging
errBIOMEDICINES
IF3.9
err2022-06-10
err13
errOAAI
errSchaefer, Marjann; Kakularam, Kumar R.; Reisch, Florian; Rothe, Michael; Stehling, Sabine; Heydeck, Dagmar; Pueschel, Gerhard P.; Kuhn, Hartmut
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N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-01-25
err7
errOAAI
errGolovanov, Alexey; Zhuravlev, Alexander; Cruz, Alejandro; Aksenov, Vladislav; Shafiullina, Rania; Kakularam, Kumar R.; Lluch, Jose M.; Kuhn, Hartmut; Gonzalez-Lafont, Angels; Ivanov, Igor
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err收藏
Paralog- and ortholog-specificity of inhibitors of human and mouse lipoxygenase-isoforms
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2022-01-01
err8
errOAAI
errKakularam, Kumar Reddy; Karst, Felix; Polamarasetty, Aparoy; Ivanov, Igor; Heydeck, Dagmar; Kuhn, Hartmut
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err收藏
Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5-/- Mice
errMETABOLITES
IF3.7
err2021-10-12
err13
errOAAI
errMarbach-Breitrueck, Eugenia; Rohwer, Nadine; Infante-Duarte, Carmen; Romero-Suarez, Silvina; Labuz, Dominika; Machelska, Halina; Kutzner, Laura; Schebb, Nils Helge; Rothe, Michael; Reddanna, Pallu; Weylandt, Karsten H.; Wieler, Lothar H.; Heydeck, Dagmar; Kuhn, Hartmut
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