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Gennady M. Verkhivker
Chapman University
46H指数
255论文数
6.5K被引数
收录论文 81
发表时间
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Allosteric Control Overcomes Steric Limitations for Neutralizing Antibodies Targeting Conserved Binding Epitopes of the SARS-CoV-2 Spike Protein: Exploring the Intersection of Binding, Allostery, and Immune Escape with a Multimodal Computational Approach别构控制克服了针对SARS-CoV-2刺突蛋白保守结合表位的中和抗体的空间限制：通过一种多模态计算方法探索结合、别构和免疫逃逸的交叉点.png)
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收藏Dynamic Mutational Profiling of Binding Interactions and Allosteric Networks in Conformational Ensembles of the SARS-CoV-2 Spike Protein Complexes with Classes of Antibodies Targeting Cryptic Binding Sites: Confluence of Binding and Allostery Determines Molecular Mechanisms and Hotspots of Immune EscapeSARS-CoV-2刺突蛋白复合物与靶向隐秘结合位点的抗体类别的结合相互作用和别构网络的动态突变特征分析：结合与别构的汇聚决定了免疫逃逸的分子机制和热点位点
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分享收藏Probing binding and allosteric mechanisms of the KRAS interactions with monobodies and affimer proteins: ensemble-based mutational profiling and thermodynamic analysis of binding energetics and allostery reveal diversity of functional hotspots and cryptic pockets linked by conserved communication network探索KRAS与单体和affimer蛋白相互作用的结合和变构机制: 基于集合的突变分析和结合能量学和变构的热力学分析揭示了通过保守通讯网络连接的功能热点和隐秘口袋的多样性
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分享收藏AlphaFold2 Modeling and Molecular Dynamics Simulations of the Conformational Ensembles for the SARS-CoV-2 Spike Omicron JN.1, KP.2 and KP.3 Variants: Mutational Profiling of Binding Energetics Reveals Epistatic Drivers of the ACE2 Affinity and Escape Hotspots of Antibody Resistance.png)
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OAAI分享收藏Comparative Analysis of Conformational Dynamics and Systematic Characterization of Cryptic Pockets in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB.1 Spike Complexes with the ACE2 Host Receptor: Confluence of Binding and Structural Plasticity in Mediating Networks of Conserved Allosteric SitesVIRUSES-BASELOAAI
VIRUSES-BASELIF3.5
OAAI分享收藏Exploring Conformational Landscapes and Cryptic Binding Pockets in Distinct Functional States of the SARS-CoV-2 Omicron BA.1 and BA.2 Trimers: Mutation-Induced Modulation of Protein Dynamics and Network-Guided Prediction of Variant-Specific Allosteric Binding Sites探索SARS-CoV-2 Omicron BA.1和BA.2三聚体不同功能状态下的构象景观和隐性结合口袋: 突变诱导的蛋白质动力学调节和网络指导的变体特异性变构结合位点预测VIRUSES-BASELOAAI
VIRUSES-BASELIF3.5
OAAI分享收藏Balancing Functional Tradeoffs between Protein Stability and ACE2 Binding in the SARS-CoV-2 Omicron BA.2, BA.2.75 and XBB Lineages: Dynamics-Based Network Models Reveal Epistatic Effects Modulating Compensatory Dynamic and Energetic Changes平衡SARS-CoV-2 Omicron BA.2，BA.2.75和XBB谱系中蛋白质稳定性与ACE2结合之间的功能权衡: 基于动力学的网络模型揭示了调节补偿性动态和能量变化的上位效应VIRUSES-BASELOAAI
VIRUSES-BASELIF3.5
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