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张

张亮仁 (Liangren Zhang)

peking university

45H指数
292论文数
7.7K被引数
收录论文 148
发表时间
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Discovery of Novel Thiazolo[4; 5-d]pyrimidin-7(6H)-Ones as Extrasynaptic δ-GABAA Receptor-Preferring PAMs with Rapid Antidepressant-like Efficacy
errJournal of Medicinal Chemistry
IF6.8
err2026-06-01
err0
PREAI
errHan Wang; Weiming Liao; Yunzhe Li; Aiping Guo; Zhenyu Liu; Xinyu Guo; Kexin Wang; Yulin Zheng; Zihan Wang; Wei Wang; Xiaowei Wang; Liangren Zhang; Qi Sun; Zhuo Huang
err分享
err收藏
Pretraining a foundation model for small-molecule natural products预训练小分子天然产物的基础模型
errNature Machine Intelligence
IF23.9
err2026-04-29
err0
PREAI
errYuheng Ding; Bo Qiang; Shaoning Li; Yiran Zhou; Jie Yu; Qi Li; Cheng Shi; Liangren Zhang; Yusong Wang; Nanning Zheng; Zhenmin Liu
err分享
err收藏
Discovery of Potent and Subtype-Selective α7 nAChR Antagonists for Organophosphate Poisoning Protection发现用于有机磷中毒保护的强效且亚型选择性的α7 nAChR拮抗剂
errJournal of Medicinal Chemistry
IF6.8
err2026-03-03
err0
PREAI
errHan Zhang; Litian Jia; Genping Xue; Long Tian; Zhenhai Hu; Cheng Shi; Yuanyuan Liu; Huijian Zeng; Liangren Zhang; Qingbin Meng
err分享
err收藏
A Structure-Based Deep Learning Framework for Correcting Marine Natural Products’ Misannotations Attributed to Host–Microbe Symbiosis基于结构的深度学习框架，用于纠正由宿主-微生物共生引起的海洋天然产物的误注释
errMarine Drugs
IF5.4
err2026-01-01
err0
errOAAI
errXiaohe Tian; Chuanyu Lyu; Yiran Zhou; Liangren Zhang; Aili Fan; Zhenming Liu
err分享
err收藏
Explaining Isoform Selectivity of c-Jun N-Terminal Kinase 3 (JNK3) Inhibitors through Its Development and Structural Insights
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-12-01
err0
PREAI
errYu, Haoqing; Zhang, Xiangyu; Liu, Zhenming; Zhang, Liangren
err分享
err收藏
Geometry-based BERT: An experimentally validated deep learning model for molecular property prediction in drug discovery基于几何的BERT：一个在药物发现中用于分子性质预测并经过实验验证的深度学习模型
errJournal of Pharmaceutical Analysis
IF8.9
err2025-10-09
err0
errOAAI
errXiang Zhang; Chenliang Qian; Bochao Yang; Hongwei Jin; Song Wu; Jie Xia; Fan Yang; Liangren Zhang
err分享
err收藏
Low-molecular-weight dextran sulfate sodium as novel heparanase inhibitor preventing breast cancer metastasis in mice by inhibiting migration and angiogenesis低分子量右旋糖酐硫酸钠作为新型肝素酶抑制剂，通过抑制迁移和血管生成，预防小鼠乳腺癌转移
errCarbohydrate Polymers
IF12.5
err2025-08-22
err0
PREAI
errYidian Mo; Guohao Song; Linbo Fu; Yuchao Wang; Tongtong Geng; Ao Sun; Baodi Gou; Xiangbao Meng; Liangren Zhang; Heng Wang; Zhongjun Li; Zhongtang Li
err分享
err收藏
AI-Driven Discovery and Optimization of Positive Allosteric Modulators for NMDA Receptors: Potential Applications in DepressionAI驱动下NMDA受体正位变构调节剂的发现与优化：在抑郁症中的潜在应用
errJournal of Medicinal Chemistry
IF6.8
err2025-07-31
err0
PREAI
errTingting Yang; Tianrui Xiong; Yixiao Wang; Bin Xi; Ruyun Liu; Zihan Wang; Wenyu Zhu; Dehua Lu; Zhongwei Wang; Zhenming Liu; Zhuo Huang; Lin Ma; Juan Du; Zhongtang Li; Liangren Zhang
err分享
err收藏
Structure-Based Discovery of Quinazolin-2-amine Derivatives as Potent ROR1 Pseudokinase Inhibitors with In Vitro and In Vivo Efficacy against Triple-Negative Breast Cancer基于结构的喹唑啉-2-胺衍生物作为具有体外和体内抗三阴性乳腺癌活性的强效ROR1伪激酶抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2025-07-30
err0
PREAI
errDehua Lu; Weiping Lyu; Xiaowei Chi; Qi Li; Yiran Zhou; Bin lu; Xiangyu Zhang; Xiaojiao Sun; Zhiqi Wang; Siyu Xiu; Tingting Yang; Zhongwei Wang; Ruqiu Zheng; Jiaxu Zhou; Yanming Chen; Cheng Shi; Song Song; Liangren Zhang; Zhenming Liu
err分享
err收藏
Novel 2-(2-Thienyl)-thiazolo[4; 5-d]pyrimidin-7(6H)-ones Binding β+/α– Subunit Interface as GABAAR Positive Allosteric Modulator for the Treatment of Status Epilepticus in Mouse新型2-(2-噻吩基)-噻唑并[4;5-d]嘧啶-7(6H)-酮类化合物与GABAAR的β+/α–亚基界面结合，作为治疗小鼠癫痫持续状态的正向别构调节剂。
errJournal of Medicinal Chemistry
IF6.8
err2025-07-10
err0
PREAI
errWeiming Liao; Zihan Wang; Han Wang; Yulin Zheng; Jie Wang; Yunzhe Li; Wei Wang; Xiaowei Wang; Liangren Zhang; Qi Sun; Zhuo Huang
err分享
err收藏
Discovery of novel PI3KC2γ inhibitors with high potency, selectivity, and favorable pharmacokinetics for glycogen metabolism regulation发现具有高活性、高选择性和良好药代动力学特性的新型PI3KC2γ抑制剂，用于调节糖原代谢。
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-07-01
err0
PREAI
errZhong, Yi; Jiao, Peili; Wang, Yuxi; Mao, Beibei; Huang, Han; Shi, Cheng; Sun, Xiaojiao; Liu, Zhenming; Zhang, Liangren
err分享
err收藏
Design, synthesis, and antitumor activity of NSDs inhibitors targeting lung squamous cell carcinoma
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-01
err0
PREAI
errXiu, Siyu; Jia, Zhenyu; Wang, Zhiqi; Liu, Huiyu; Shi, Cheng; Sun, Xiaojiao; Zhang, Xiangyu; Chi, Xiaowei; Liu, Zhenming; Zhang, Liangren
err分享
err收藏
Novel mechanistic insights - A brand new Era for anti-HBV drugs
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err2
PREAI
errLyu, Weiping; Qin, Haoming; Li, Qi; Lu, Dehua; Shi, Cheng; Zhao, Kangchen; Zhang, Shengran; Yu, Ruohan; Zhang, Huiying; Zhou, Xiaonan; Xia, Sitian; Zhang, Liangren; Wang, Xiaoqian; Chi, Xiaowei; Liu, Zhenming
err分享
err收藏
Scaffold hopping-driven optimization for the identification of NLRP3 inhibitors as potential gout therapeutics
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
PREAI
errShi, Cheng; Lyu, Weiping; Yu, Jie; Chen, Yanming; Xiu, Siyu; Zhang, Xiangyu; Zhang, Liangren; Liu, Zhenming
err分享
err收藏
Discovery of Potent and Selective Blockers Targeting the Epilepsy-Associated KNa1.1 Channel
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-10-24
err0
PREAI
errZheng, Ruqiu; Li, Zhongtang; Wang, Qiufeng; Liu, Shiqi; Liu, Ningfeng; Li, Yiyan; Zhu, Guiwang; Liu, Zhenming; Huang, Zhuo; Zhang, Liangren
err分享
err收藏
Ferroptosis-inducing compounds synergize with docetaxel to overcome chemoresistance in docetaxel-resistant non-small cell lung cancer cells
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-10-01
err0
PREAI
errHuang, Wei; Guo, Yi; Qian, Yazhi; Liu, Xiaoang; Li, Gaoxiang; Wang, Jun; Yang, Xiaozhou; Wu, Mo; Fan, Ying; Luo, Haojun; Chen, Yuzhu; Zhang, Liangren; Yang, Nan; Liu, Zhenming; Liu, Yanyong
err分享
err收藏
Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-20
err0
PREAI
errShi, Cheng; Gao, Tongfei; Lyu, Weiping; Qiang, Bo; Chen, Yanming; Chen, Qixuan; Zhang, Liangren; Liu, Zhenming
err分享
err收藏
Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-04-01
err0
PREAI
errDou, Xiaodong; Huo, Tongyu; Liu, Yameng; Pang, Zichen; Su, Lingyu; Zhao, Xinyi; Peng, Xing; Liu, Zhenming; Zhang, Liangren; Jiao, Ning
err分享
err收藏
Exploring Chemical Reaction Space with Machine Learning Models: Representation and Feature Perspective
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2024-03-15
err7
PREAI
errDing, Yuheng; Qiang, Bo; Chen, Qixuan; Liu, Yiqiao; Zhang, Liangren; Liu, Zhenming
err分享
err收藏
Deep reinforcement learning enables better bias control in benchmark for virtual screening
errCOMPUTERS IN BIOLOGY AND MEDICINE
IF6.3
err2024-03-01
err0
errOAAI
errShen, Tao; Li, Shan; Wang, Xiang Simon; Wang, Dongmei; Wu, Song; Xia, Jie; Zhang, Liangren
err分享
err收藏

研究方向

核苷核苷酸及寡核苷酸药物的设计与合成以结构为基础的药物设计与合成以及构效关系研究有机小分子对细胞信号传导系统的调控研究
合作学者
合作期刊
仉华 封面图
仉华 (Hua Zhang)
H 指数: 205 · 论文数: 2.7K
姜
姜世勃 (Shibo Jiang)
H 指数: 107 · 论文数: 671
汪超 封面图
汪超 (Chao Wang)
H 指数: 99 · 论文数: 487
徐
徐平 (Ping Xu)
H 指数: 97 · 论文数: 878
W
William C. Cho
H 指数: 96 · 论文数: 812
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