E. B. Sirota - Publications, H-index & Citations

E. B. Sirota

Merck & Co., Inc.

43H指数

150论文数

7.1K被引数

收录论文 51

发表时间

Screening Crystallization Solvents for Yield and Purity Upgrade Using High-Throughput Solubility 利用高通量溶解度筛选结晶溶剂以提高收率和纯度

Crystal Growth & Design

IF0

2026-06-04

PREAI

Phoebe Eccles; Kobi Felton; Eric Sirota; Joseph P. Smith; Melodie Christensen; Derek S. Frank

Controlling the Size and Shape of Monoclonal Antibody Particles through Crystallization Process Design 通过结晶过程设计控制单克隆抗体颗粒的大小和形状

Molecular Pharmaceutics

IF4.5

2026-05-12

PREAI

L. Codan; P. Larpent; R. Kalapos-Dobszay; B. Medrán; P. Reichert; E. Sirota; A. Cote

Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联实现大环肽enlicitide的制造

Science

IF45.8

2026-05-07

PREAI

Artis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong

Biocatalytic Aerobic Oxidation for Large-Scale Production of trans-3-Hydroxy-l-Proline 生物催化好氧氧化法制备反式-3-羟基-L-脯氨酸的规模化生产

Organic Process Research & Development

IF3.5

2025-07-14

PREAI

Kai-Jiong Xiao; Christopher K. Prier; Anna Fryszkowska; Yangzhong Qin; Alexandra C. Sun; Yingju Xu; Jonathan Vroom; Jeffrey T. Kuethe; Michelle Zheng; Yonggang Chen; Lushi Tan; Teng Peng; Erica L. Schwalm; Summer A. Baker Dockrey; Keith A. Mattern; Mengbin Chen; Eric Sirota; Mary Stanik; Jack Liang; Gregory A. Cope; Nikki D. Kruse; Wenbing Xi; Sriram Saripalli; Jianjun Duan; David A. Thaisrivongs; Sarah S. Co

Attribute ranging as a coordinated strategy between drug substance and drug product to accelerate commercial process nomination

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2025-02-01

PREAI

Hartmanshenn, Clara; Bechtold, Alexander; Kwok, Thomas; Mora, Jeff; Contrella, Nathan; Confer, Alex; Bade, Rachel; Andreani, Teresa; Hughes, Jonathan M. E.; Chen, Billy; Sirota, Eric; Codan, Lorenzo; Lamberto, David J.; Xu, Yingju; Salehi, Nastaran; Crowley, Stephen

Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-01-26

PREAI

Nordstrom, Fredrik L.; Paolello, Mitchell; Yao, Na; Armiger, Travis; Jiang, Qi; Nicholson, James; Kratz, Joseph; Toresco, Michael; Lipp, Alexander; Witte, Swjatoslaw; Henry, Manuel; Shultz, C. Scott; Sirota, Eric; Capellades, Gerard

Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization - Part 2: Industrial Case Studies

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-01-24

PREAI

Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)Nemtabrutinib (MK-1026) 的联芳基醚片段的制造工艺开发

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-10-24

PREAI

Deprez, Nicholas R.; Rose, Harrison B.; Peters, Byron K.; Diaz-Santana, Anthony; Liu, Zhuqing; Kuhl, Nadine; Chung, Cheol K.; Liu, Zhu; Newman, Justin A.; Corry, James; Guetschow, Erik D.; Hoyt, Erik; Jellett, Lisa; Kapil, Sunayana; Poirier, Marc; Shevlin, Michael; Sirota, Eric; Solovyov, Andrew; Sun, Alexandra C.; Thaisrivongs, David A.

Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-10-20

PREAI

Bade, Rachel; Bothe, Jameson R.; Sirota, Eric; Brunskill, Andrew P. J.; Newman, Justin A.; Zhang, Yongqian; Tan, Melissa; Zheng, Michelle; Brito, Gilmar; Poirier, Marc; Fier, Patrick S.; Xu, Yingju; Ward, Michael D.; Stone, Kevin; Lee, Ivan H.; Gmitter, Andrew J.; Bernardoni, Frank; Zompa, Michael A.; Luo, Hanlin; Patel, Sanjaykumar; Masiuk, Tina; Mora, Jeff; Ni, Tong; Okoh, Grace A.; Tarabokija, James; Liu, Jiaying; Lowinger, Michael B.; Mahmood, Tariq

New Bench-Scale Method To Elucidate Active Pharmaceutical Ingredient Drying Mechanisms

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-05-19

PREAI

Lamberto, David J. J.; Sirota, Eric; Zhou, George

Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-03-24

OAAI

Nordstrom, Fredrik L.; Sirota, Eric; Hartmanshenn, Clara; Kwok, Thomas T.; Paolello, Mitchell; Li, Huayu; Abeyta, Vincent; Bramante, Tommasina; Madrigal, Emma; Behre, Taylor; Capellades, Gerard

Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib 在开发Nemtabrutinib的直接隔离过程中利用协同溶解度

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-03-10

PREAI

Chen, Yonggang; Iuzzolino, Luca; Burgess, Samantha A.; Chung, Cheol K.; Corry, James; Crawford, Morgan; Desmond, Richard; Guetschow, Erik; Hartmanshenn, Clara; Kuhl, Nadine; Liu, Zhu; Luo, Hanlin; McQuilken, Alison C.; Newman, Justin A.; Ren, Hong; Thaisrivongs, David A.; Wang, Zhixun; Sirota, Eric

Method to Rapidly Identify Potential Solvent Systems for Crystallization of Cocrystals

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-03-06

PREAI

Codan, Lorenzo; Daza, Laura; Sirota, Eric

Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-12-10

PREAI

Fier, Patrick S.; Xu, Yingju; Poirier, Marc; Brito, Gilmar; Zheng, Michelle; Bade, Rachel; Sirota, Eric; Stone, Kevin; Tan, Lushi; Humphrey, Guy R.; Chang, Darryl; Bothe, Jameson; Zhang, Yongqian; Bernardoni, Frank; Castro, Steve; Zompa, Michael A.; Taylor, Jerry; Sirk, Kevin M.; Diaz-Santana, Anthony; Diribe, Ike; Emerson, Khateeta M.; Krishnamurthi, Bharath; Zhao, Ralph; Ward, Michael; Xiao, Chengqian; Ouyand, Honggui; Zhan, Jianfeng; Morris, William J.

Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination-Dynamic Kinetic Resolution Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-11-15

PREAI

Wang, Tao; Phillips, Eric M.; Dalby, Stephen M.; Sirota, Eric; Axnanda, Stephanus; Shultz, C. Scott; Patel, Pratiq; Waldman, Jacob H.; Alwedi, Embarek; Wang, Xiao; Zawatzky, Kerstin; Chow, Matthew; Padivitage, Nilusha; Weisel, Mark; Whittington, Michael; Duan, Jianjun; Lu, Taotao

Cross-Pharma Collaboration for the Development of a Simulation Tool for the Model-Based Digital Design of Pharmaceutical Crystallization Processes (CrySiV)

CRYSTAL GROWTH & DESIGN

IF3.4

2021-10-05

PREAI

Szilagyi, Botond; Wu, Wei-Lee; Eren, Ayse; Mackey, Jaron; Kshirsagar, Shivani; Szilagyi, Emoke; Ostergaard, Iben; Qu, Haiyan; Sinha, Kushal; Mlinar, Laurie; Pohlman, Daniel; Chen, Jie; Nere, Nandkishor; Boukerche, Moussa; Korde, Akshay; Ellis, Ryan; Lovette, Michael; Black, Simon; Jawor-Baczynska, Anna; Li, Huayu; Yang, Bing-Shiou; Irdam, Erwin; Patience, Daniel; McKeown, Rahn; Ketchum, Megan; Green, Daniel A.; Reddy, Venkata Ramana; Polster, Christopher; Burcham, Christopher; Jarmer, Daniel; Merritt, Jeremy Miles; Cote, Aaron; Sirota, Eric; Codan, Lorenzo; Schoell, Jochen; Liu, Yiqing Claire; Girard, Kevin P.; Kulkarni, Samir A.; Yang, Yihui; Quon, Justin L.; Nagy, Zoltan K.

Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-02-09

PREAI

Mohan, Anne E.; DiBenedetto, Michael; Alwedi, Embarek; Ang, Yee Swan; Sihombing, Muhammad Sofian Bin Asi; Chang, Hsieh Yao D.; Cote, Aaron; Desmond, Richard; Diaz-Santana, Anthony; Khong, Eric; Lee, Ivan H.; Liu, Wenjun; Maloney, Kevin M.; Mattern, Keith; Pridgen, Christopher; Ren, Hong; Sirk, Kevin; Sirota, Eric; Spencer, Glenn; Tao, Beata; Whittington, Michael; Yang, Cuixian; Zhang, Si-Wei

Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2021-01-22

PREAI

Sirota, Eric; Kwok, Thomas; Varsolona, Richard J.; Whittaker, Aaron; Andreani, Teresa; Quirie, Scott; Margelefsky, Eric; Lamberto, David J.

Perspectives on the Current State, Challenges, and Opportunities in Pharmaceutical Crystallization Process Development

CRYSTAL GROWTH & DESIGN

IF3.4

2020-11-05

PREAI

Cote, Aaron; Erdemir, Deniz; Girard, Kevin P.; Green, Daniel A.; Lovette, Michael A.; Sirota, Eric; Nere, Nandkishor K.

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-23

PREAI

Maloney, Kevin M.; Zhang, Si-Wei; Mohan, Anne E.; Lee, Alfred Y.; Larpent, Patrick; Ren, Hong; Humphrey, Guy R.; Desmond, Richard; DiBenedetto, Michael; Liu, Wenjun; Lee, Ivan H.; Sirota, Eric; Di Maso, Michael J.; Alwedi, Embarek; Song, Siqing; Chang, Hsieh Yao D.

研究方向