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Z

Zhenquan Hu

alphamol science ltd, allschwil, switzerland
H指数:19
被引数:2,165

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Discovery of 6′-chloro-N-methyl-5′-(phenylsulfonamido)-[3,3′-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2020-02-0118
PREAI
Liang, Xiaofei; Jiang, Zongru; Huang, Zhenghui; Li, Feng; Chen, Cheng; Hu, Chen; Wang, Wenliang; Hu, Zhenquan; Liu, Qingwang; Wang, Beilei; Wang, Li; Qi, Ziping; Liu, Jing; Jiang, Lubin; Liu, Qingsong
Discovery of 2-(4-chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal Tumors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-06-1723
PREAI
Wu, Yun; Wang, Beilei; Wang, Junjie; Qi, Shuang; Zou, Fengming; Qi, Ziping; Liu, Feiyang; Liu, Qingwang; Chen, Cheng; Hu, Chen; Hu, Zhenquan; Wang, Aoli; Wang, Li; Wang, Wenchao; Ren, Tao; Cai, Yujiao; Bai, Mingfeng; Liu, Qingsong; Liu, Jing
Discovery of (E)-N1-(3-Fluorophenyl)-N3-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-05-0217
PREAI
Liu, Xuesong; Wang, Beilei; Chen, Cheng; Qi, Ziping; Zou, Fengming; Wang, Junjie; Hu, Chen; Wang, Aoli; Ge, Juan; Liu, Qingwang; Yu, Kailin; Hu, Zhenquan; Jiang, Zongru; Wang, Wei; Wang, Li; Wang, Wenchao; Ren, Tao; Bai, Mingfeng; Liu, Qingsong; Liu, Jing
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-12-1925
PREAI
Liang, Xiaofei; Wang, Beilei; Chen, Cheng; Wang, Aoli; Hu, Chen; Zou, Fengming; Yu, Kailin; Liu, Qingwang; Li, Feng; Hu, Zhenquan; Lu, Tingting; Wang, Junjie; Wang, Li; Weisberg, Ellen L.; Li, Lili; Xia, Ruixiang; Wang, Wenchao; Ren, Tao; Ge, Jian; Liu, Jing; Liu, Qinsong
Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2018-12-0112
PREAI
Liu, Xuesong; Wang, Beilei; Chen, Cheng; Jiang, Zongru; Hu, Chen; Wu, Hong; Zhang, Yicong; Liu, Xiaochuan; Wang, Wenliang; Wang, Junjie; Hu, Zhenquan; Wang, Aoli; Huang, Tao; Liu, Qingwang; Wang, Wei; Wang, Li; Wang, Wenchao; Ren, Tao; Li, Lili; Xia, Ruixiang; Ge, Jian; Liu, Qingsong; Liu, Jing
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2018-10-0143
PREAI
Wang, Beilei; Wu, Jiaxin; Wu, Yun; Chen, Cheng; Zou, Fengming; Wang, Aoli; Wu, Hong; Hu, Zhenquan; Jiang, Zongru; Liu, Qingwang; Wang, Wei; Zhang, Yicong; Liu, Feiyang; Zhao, Ming; Hu, Jie; Huang, Tao; Ge, Juan; Wang, Li; Ren, Tao; Wang, Yuxin; Liu, Jing; Liu, Qingsong
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2018-08-0111
PREAI
Liang, Xiaofei; Li, Feng; Chen, Cheng; Jiang, Zongru; Wang, Aoli; Liu, Xiaochuan; Ge, Juan; Hu, Zhenquan; Yu, Kailin; Wang, Wenliang; Zou, Fengming; Liu, Qingwang; Wang, Beilei; Wang, Li; Zhang, Shanchun; Wang, Yuxin; Liu, Qingsong; Liu, Jing

研究方向

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A
Aoli Wang
H 指数:24论文数:104被引数:3,056
J
Jing Liu
H 指数:43论文数:358被引数:8,243
刘
刘青松
H 指数:54论文数:435被引数:2.0万
B
Beilei Wang
H 指数:31论文数:197被引数:3,406
Z
Ziping Qi
H 指数:18论文数:77被引数:1,479
C
Cheng Chen
H 指数:28论文数:233被引数:3,290
F
Fengming Zou
H 指数:19论文数:114被引数:1,976
W
Wu Hong
H 指数:37论文数:165被引数:3,450
C
Chen Hu
H 指数:22论文数:162被引数:2,023
K
Kailin Yu
H 指数:15论文数:59被引数:549