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L

Lars Wittler

Charité Universitätsmedizin Berlin

34H指数
90论文数
8.4K被引数
收录论文 40
发表时间
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Temporal loss of En1 during limb development causes distinct phenotypesEn1在肢体发育期间的时间性缺失导致不同的表型
errGENES & DEVELOPMENT
IF7.7
err2026-05-01
err0
PREAI
errRingel, Alessa R.; Benetti, Natalia; Magg, Andreas; Groll, Fabian; Schopflin, Robert; Kuhnlein, Mira; Stiege, Asita Carola; Fischer, Ute; Wittler, Lars; Game, Laurence; Lorenz, Stephan; Young, George; Mundlos, Stefan; Allou, Lila
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err收藏
Female- or male-biased offspring generated by targeted distortion of sex chromosome transmission in the mouse通过靶向调控小鼠性染色体传递产生的雌性或雄性偏向的后代
errGENETICS
IF5.1
err2025-12-01
err0
errOAAI
errBauer, Hermann; Koch, Frederic; Lipkowitz, Bettina; Willert, Jurgen; Blass, Gaby; Scholze-Wittler, Manuela; Wahrisch, Sandra; Wittler, Lars; Herrmann, Bernhard G.
err分享
err收藏
Single-cell activation screen identifies hepatic maturation regulators with zonal resolution单细胞激活筛选以区域分辨率为基础鉴定肝成熟调控因子
errDevelopmental Cell
IF8.7
err2025-11-20
err0
errOAAI
errAtsuhiro Taguchi; Alexandre P. Magalhães; Adriano Bolondi; Ming-Kang Lee; Helene Kretzmer; Lars Wittler; Denes Hnisz; Alexander Meissner
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err收藏
A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia一种缺失的酶-拯救代谢物作为罕见骨骼发育不良的病因
errNature
IF48.5
err2025-08-20
err0
errOAAI
errJean Jacobs; Hristiana Lyubenova; Sven Potelle; Johannes Kopp; Isabelle Gerin; Wing Lee Chan; Miguel Rodriguez de los Santos; Wiebke Hülsemann; Martin A. Mensah; Valérie Cormier-Daire; Marieke Joosten; Hennie T. Bruggenwirth; Kyra E. Stuurman; Valancy Miranda; Philippe M. Campeau; Lars Wittler; Julie Graff; Stefan Mundlos; Daniel M. Ibrahim; Emile Van Schaftingen; Björn Fischer-Zirnsak; Uwe Kornak; Nadja Ehmke; Guido T. Bommer
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Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes长末端重复序列逆转座子通过增强子获取产生类似病毒的颗粒，导致发育性肢体表型。
errNature Genetics
IF0
err2025-07-09
err0
errOAAI
errJuliane Glaser; Giulia Cova; Beatrix Fauler; Cesar A. Prada-Medina; Virginie Stanislas; Mai H. Q. Phan; Robert Schöpflin; Yasmin Aktas; Martin Franke; Guillaume Andrey; Natalia Bartzoka; Christina Paliou; Verena Laupert; Wing-Lee Chan; Lars Wittler; Thorsten Mielke; Stefan Mundlos
err分享
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SRF promotes long-range chromatin loop formation and stem cell pluripotency
errCELL REPORTS
IF6.9
err2024-10-01
err0
PREAI
errTsaytler, Pavel; Blaess, Gaby; Scholze-Wittler, Manuela; Meierhofer, David; Wittler, Lars; Koch, Frederic; Herrmann, Bernhard G.
err分享
err收藏
Extraembryonic gut endoderm cells undergo programmed cell death during development
errNATURE CELL BIOLOGY
IF19.1
err2024-06-07
err1
errOAAI
errBatki, Julia; Hetzel, Sara; Schifferl, Dennis; Bolondi, Adriano; Walther, Maria; Wittler, Lars; Grosswendt, Stefanie; Herrmann, Bernhard G.; Meissner, Alexander
err分享
err收藏
Combinatorial microRNA activity is essential for the transition of pluripotent cells from proliferation into dormancy
errGENOME RESEARCH
IF5.5
err2024-05-06
err3
errOAAI
errIyer, Dhanur P.; Moyon, Lambert; Wittler, Lars; Cheng, Chieh-Yu; Ringeling, Francisca R.; Canzar, Stefan; Marsico, Annalisa; Bulut-Karslioglu, Aydan
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Genome-wide identification of notochord enhancers comprising the regulatory landscape of the brachyury locus in mouse
errDEVELOPMENT
IF3.6
err2023-11-09
err3
errOAAI
errSchifferl, Dennis; Scholze-Wittler, Manuela; Luque, Alba Villaronga; Pustet, Milena; Wittler, Lars; V. Veenvliet, Jesse; Koch, Frederic; Herrmann, Bernhard G.
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err收藏
GATA transcription factors drive initial Xist upregulation after fertilization through direct activation of long-range enhancers
errNATURE CELL BIOLOGY
IF19.1
err2023-11-06
err7
errOAAI
errLustig, Liat Ravid; Kumar, Abhishek Sampath; Schwaemmle, Till; Dunkel, Ilona; Noviello, Gemma; Limberg, Elodie; Weigert, Raha; Pacini, Guido; Buschow, Rene; Ghauri, Afrah; Stoetzel, Maximilian; Wittler, Lars; Meissner, Alexander; Schulz, Edda G.
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err收藏
Induction of kidney-related gene programs through co-option of SALL1 in mole ovotestes
errDEVELOPMENT
IF3.6
err2023-09-01
err0
errOAAI
errSchindler, Magdalena; Osterwalder, Marco; Harabula, Izabela; Wittler, Lars; Tzika, Athanasia C.; Dechmann, Dina K. N.; Vingron, Martin; Visel, Axel; Haas, Stefan A.; Real, Francisca M.
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err收藏
Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis
errNATURE GENETICS
IF31.8
err2023-07-06
err10
errOAAI
errKumar, Abhishek Sampath; Tian, Luyi; Bolondi, Adriano; Hernandez, Amelia Aragones; Stickels, Robert; Kretzmer, Helene; Murray, Evan; Wittler, Lars; Walther, Maria; Barakat, Gabriel; Haut, Leah; Elkabetz, Yechiel; Macosko, Evan Z.; Guignard, Leo; Chen, Fei; Meissner, Alexander
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err收藏
BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage
errDEVELOPMENT
IF3.6
err2023-05-22
err11
errOAAI
errTsaytler, Pavel; Liu, Jinhua; Blaess, Gaby; Schifferl, Dennis; Veenvliet, Jesse.; Wittler, Lars; Timmermann, Bernd; Herrmann, Bernhard G.; Koch, Frederic
err分享
err收藏
Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3 (vol 14, 1475, 2023)对Lbx1/Fgf8基因座基因表达的组合效应解决了3型分裂手/脚畸形 (第14卷，1475，2023)
errNATURE COMMUNICATIONS
IF15.7
err2023-05-18
err0
errOAAI
errCova, Giulia; Glaser, Juliane; Schoepflin, Robert; Prada-Medina, Cesar Augusto; Ali, Salaheddine; Franke, Martin; Falcone, Rita; Federer, Miriam; Ponzi, Emanuela; Ficarella, Romina; Novara, Francesca; Wittler, Lars; Timmermann, Bernd; Gentile, Mattia; Zuffardi, Orsetta; Spielmann, Malte; Mundlos, Stefan
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err收藏
Hijacking of transcriptional condensates by endogenous retroviruses
errNATURE GENETICS
IF31.8
err2022-07-21
err37
errOAAI
errAsimi, Vahid; Kumar, Abhishek Sampath; Niskanen, Henri; Riemenschneider, Christina; Hetzel, Sara; Naderi, Julian; Fasching, Nina; Popitsch, Niko; Du, Manyu; Kretzmer, Helene; Smith, Zachary D.; Weigert, Raha; Walther, Maria; Mamde, Sainath; Meierhofer, David; Wittler, Lars; Buschow, Rene; Timmermann, Bernd; Cisse, Ibrahim I.; Ameres, Stefan L.; Meissner, Alexander; Hnisz, Denes
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err收藏
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylationPolycomb介导的基因组结构可实现H3K27甲基化的长距离传播
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-05-26
err43
errOAAI
errKraft, Katerina; Yost, Kathryn E.; Murphy, Sedona E.; Magg, Andreas; Long, Yicheng; Corces, M. Ryan; Granja, Jeffrey M.; Wittler, Lars; Mundlos, Stefan; Cech, Thomas R.; Boettiger, Alistair N.; Chang, Howard Y.
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Naive-like pluripotency to pave the way for saving the northern white rhinoceros from extinction
errSCIENTIFIC REPORTS
IF3.9
err2022-03-08
err16
errOAAI
errZywitza, Vera; Rusha, Ejona; Shaposhnikov, Dmitry; Ruiz-Orera, Jorge; Telugu, Narasimha; Rishko, Valentyna; Hayashi, Masafumi; Michel, Geert; Wittler, Lars; Stejskal, Jan; Holtze, Susanne; Goeritz, Frank; Hermes, Robert; Wang, Jichang; Izsvak, Zsuzsanna; Colleoni, Silvia; Lazzari, Giovanna; Galli, Cesare; Hildebrandt, Thomas B.; Hayashi, Katsuhiko; Diecke, Sebastian; Drukker, Micha
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A 37 kb region upstream of brachyury comprising a notochord enhancer is essential for notochord and tail development包含脊索增强子的brachyury上游37 kb区域对于脊索和尾巴发育至关重要
errDEVELOPMENT
IF3.6
err2021-12-15
err11
errOAAI
errSchifferl, Dennis; Scholze-Wittler, Manuela; Wittler, Lars; Veenvliet, Jesse V.; Koch, Frederic; Herrmann, Bernhard G.
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err收藏
Dnmt1 has de novo activity targeted to transposable elements
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2021-06-17
err94
errOAAI
errHaggerty, Chuck; Kretzmer, Helene; Riemenschneider, Christina; Kumar, Abhishek Sampath; Mattei, Alexandra L.; Bailly, Nina; Gottfreund, Judith; Giesselmann, Pay; Weigert, Raha; Braendl, Bjoern; Giehr, Pascal; Buschow, Rene; Galonska, Christina; von Meyenn, Ferdinand; Pappalardi, Melissa B.; McCabe, Michael T.; Wittler, Lars; Giesecke-Thiel, Claudia; Mielke, Thorsten; Meierhofer, David; Timmermann, Bernd; Mueller, Franz-Josef; Walter, Joern; Meissner, Alexander
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err收藏
A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-01-05
err6
errOAAI
errde Los Santos, Miguel Rodriguez; Rivalan, Marion; David, Friederike S.; Stumpf, Alexander; Pitsch, Julika; Tsortouktzidis, Despina; Velasquez, Laura Moreno; Voigt, Anne; Schilling, Karl; Mattei, Daniele; Long, Melissa; Vogt, Guido; Knaus, Alexej; Fischer-Zirnsak, Bjorn; Wittler, Lars; Timmermann, Bernd; Robinson, Peter N.; Horn, Denise; Mundlos, Stefan; Kornak, Uwe; Becker, Albert J.; Schmitz, Dietmar; Winter, York; Krawitz, Peter M.
err分享
err收藏

研究方向

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