Howard Y. Chang

Howard Hughes Medical Institute

H指数:162

被引数:13.5万

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Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

微核中的染色体外DNA限制肿瘤细胞适应性并与患者良好生存相关

Nature Genetics

IF29

2026-10-120

OAAI

Lotte Brückner; Robin Xu; Jun Tang; Aditi Gnanasekar; Alexander Herrmann; Ivy Tsz-Lo Wong; Shu Zhang; Fengyu Tu; Madison Pilon; Alexander Kukalev; Katharina Pardon; Olga Sidorova; Joshua Atta; Qinghao Yu; Giulia Montuori; Davide Pradella; Mila Ilić; Kentaro Suina; Marco Novais-Cruz; Sarah Kaltenbach; Denise Treue; Mădălina Giurgiu-Kraljič; Sergej Herzog; Ann-Sophie Hollinger; Nadine Wittstruck; Martina Fernandez; Nicole Wolozyn; Finnja Becker; Varvara-Rigina Louma; Xiaowei Yan; Rachel Schmargon; Jan R. Dörr; David Gamlin; Annika Lehmann; Dennis Gürgen; Matthias Richter; Frank Dubois; Fabrizio Simeoni; Betheney R. Pennycook; Alastair Hamilton; Ralph K. Lindemann; Courtney Dawes; Gabriel Balmus; Barbara Hero; Matthias Fischer; Vineet Bafna; Roel Verhaak; Geoffrey Wahl; Yang Liu; Richard P. Koche; Stamatis Papathanasiou; René Medema; Bastiaan Spanjaard; Andrea Ventura; Ana Pombo; Weini Huang; Monika Scheer; Benjamin Werner; Howard Y. Chang; Paul S. Mischel; Anton G. Henssen

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis

空间谱系示踪揭示了肿瘤生长和转移的动态空间架构

Nature Genetics

IF29

2026-09-020

PRE

Matthew G. Jones; Dawei Sun; Kyung Hoi Joseph Min; William N. Colgan; Haoyu Wang; Tivadar Török; Juliano Ribeiro; Jessie Xue; Erik C. Cardoso; Yao Rong; Luyi Tian; Jackson A. Weir; Victor Z. Chen; Luke W. Koblan; Kathryn E. Yost; Nicolas Mathey-Andrews; Edridge D’Souza; Andrew J. C. Russell; Robert R. Stickels; Karol S. Balderrama; William M. Rideout; Min Dai; Giovanni Marrero; Vipin Kumar; Anjali Saqi; Benjamin Herzberg; Benjamin Izar; Howard Y. Chang; Joo-Hyeon Lee; Tyler Jacks; Fei Chen; Jonathan S. Weissman; Nir Yosef; Dian Yang

scAmp enables focal gene amplification analysis from single-cell data

scAmp实现从单细胞数据中分析局部基因扩增

Nature Communications

IF15.7

2026-08-080

Somatic mutations reveal the ontogeny of microglia in human aging

体细胞突变揭示了人脑衰老过程中小胶质细胞的发育起源

Nature

IF48.5

2026-07-300

PRE

Julia A. Belk; Yaowen Zhang; Emily E. Reilly; Quanming Shi; Daniel Dan Liu; Nicole Womack-Gambrel; Maarten van der Linde; Lisa Ma; Debasmita Paul; Alejandro Medina Enciso; Raja Kalluru; Jacob Weiss; Rui Li; Anna E. Eastman; Chunfang Zhu; Arnav Chakravarthy; Syed Bukhari; Dipabarna Bhattacharya; Suyash Raj; Daniel Richard; Simone Brioschi; Matthew R. Chrostek; Daniel C. Nachun; Christopher M. Arends; Jayakrishnan Gopakumar; Isak W. Tengesdal; Ademar Bynum; Shaneice Mitchell; Katalin Sandor; Wenxi Zhang; Badri N. Vardarajan; Inma Cobos; Donald E. Born; Robert B. West; Anne Brunet; Marco Colonna; Krishna L. Bharani; Hannes Vogel; Thomas J. Montine; Caitlin S. Latimer; Irving L. Weissman; Magdalena Matusiak; Jody E. Hooper; C. Dirk Keene; Howard Y. Chang; Siddhartha Jaiswal

Epigenetic landscape; key transcriptional regulators; and in vivo identification of human Tr1 cells

表观遗传景观；关键转录调控因子；以及人Tr1细胞在体内的鉴定

Science Advances

IF12.5

2026-07-100