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Afaf H. El‐Sagheer

chemistry research laboratory

44H指数
212论文数
6.6K被引数
收录论文 104
发表时间
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Non-enzymatic conversion of RNA sequence information into DNA by squaramide ligation for accurate RNA quantification通过squaramide连接将RNA序列信息非酶促转化为DNA以实现精确RNA定量
errCommunications Chemistry
IF6.2
err2026-05-19
err0
errOAAI
errLapatrada Taemaitree; Friedrich Burba; Nina Harvey; Arun Shivalingam; Tom Brown; Afaf H. El-Sagheer
err分享
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Enzymatic Synthesis of Modified RNA Containing 5-Methyl- or 5-Ethylpyrimidines or Substituted 7-Deazapurines and Influence of the Modifications on Stability; Translation; and CRISPR-Cas9 Cleavage酶促合成含5-甲基-或5-乙基嘧啶或取代7-脱氮嘌呤的修饰RNA及其修饰对稳定性、翻译和CRISPR-Cas9切割的影响
errACS Chemical Biology
IF3.8
err2025-11-05
err0
errOAAI
errTania Sanchez-Quirante; Erika Kužmová; Miguel Riopedre-Fernandez; Sebastian Golojuch; Pavel Vopálenský; Veronika Raindlová; Afaf H. El-Sagheer; Tom Brown; Michal Hocek
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Enhancing cap-independent translation of linear mRNA增强线性mRNA的非帽依赖性翻译
errNature Communications
IF15.7
err2025-10-16
err0
errOAAI
errSebastian Golojuch; Brendan Largey; Afaf H. El-Sagheer; Tom Brown
err分享
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Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense OligonucleotidesLNA-电荷中性连接体的合成、生物活性及分子动力学模拟：用于增强剪接开关反义寡核苷酸
errAngewandte Chemie International Edition
IF0
err2025-09-21
err0
errOAAI
errAlice Kennett; Lillian Lie; Martin Flerin; Belma Zengin Kurt; Ysobel R. Baker; Alyssa C. Hill; Abinaya Ramesh; Matthew J.A. Wood; Debashis Dhara; Afaf H. El-Sagheer; Fernanda Duarte; Tom Brown
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Measurements of molecular size and shape on a chip芯片上的分子尺寸和形状测量
errSCIENCE
IF45.8
err2025-05-08
err0
PREAI
errZhu, Xin; Bennett, Timothy J. D.; Zouboulis, Konstantin C.; Soulias, Dimitrios; Grzybek, Michal; Benesch, Justin L. P.; El-Sagheer, Afaf H.; Coskun, Uenal; Krishnan, Madhavi
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Novel Catalyst-Free Synthesis of Some 3-Alkylaminoquinoxaline-2(1H)-thiones and 3-Alkyloxyquinoxaline-2(1H)-thiones in Ethanol
errACS OMEGA
IF4.3
err2025-01-07
err0
errOAAI
errEl Rayes, Samir M.; Ali, Ibrahim A. I.; Fathalla, Walid; Ghanem, Mohamed A.; El-Sagheer, Afaf H.
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Synthesis, Biophysical and Biological Evaluation of Splice-Switching Oligonucleotides with Multiple LNA-Phosphothiotriester Backbones
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-10-14
err0
errOAAI
errDhara, Debashis; Hill, Alyssa C.; Ramesh, Abinaya; Wood, Matthew J. A.; El-Sagheer, Afaf H.; Brown, Tom
err分享
err收藏
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-07-25
err0
errOAAI
errYi, Gangshun; Ye, Mingda; Carrique, Loic; El-Sagheer, Afaf; Brown, Tom; Norbury, Chris J.; Zhang, Peijun; Gilbert, Robert J. C.
err分享
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Synthesis of N-Alkyl-3-[2-oxoquinolin-1(2H)-yl]propanoic Acid Derivatives and Related Compounds: Cytotoxicity and EGFR Inhibition of Some Propanamide Derivatives
errACS OMEGA
IF4.3
err2024-07-16
err1
errOAAI
errEl Rayes, Samir M.; Ali, Ibrahim A. I.; Fathalla, Walid; Ghanem, Mohamed A.; El-sagheer, Afaf H.; Nafie, Mohamed S.
err分享
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Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages
errORGANIC LETTERS
IF5
err2024-05-08
err3
errOAAI
errZengin Kurt, Belma; Dhara, Debashis; El-Sagheer, Afaf H.; Brown, Tom
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err收藏
An effective delivery platform for nucleic acid therapeutics: Enhanced cancer cell internalization and endosomal escape
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errLi, Siqi; Tietz, Ole; El-Sagheer, Afaf H.; Brown, Tom; Vallis, Katherine A.
err分享
err收藏
Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking
errRSC MEDICINAL CHEMISTRY
IF3.6
err2024-01-01
err2
errOAAI
errHennessy, Joseph; Klimkowski, Piotr; Singleton, Daniel; Gibney, Alex; Coche, Malou; Farrell, Nicholas P.; El-Sagheer, Afaf H.; Brown, Tom; Kellett, Andrew
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Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads
errRSC CHEMICAL BIOLOGY
IF3.1
err2024-01-01
err1
errOAAI
errJin, Cheng; Li, Siqi; Vallis, Katherine A.; El-Sagheer, Afaf H.; Brown, Tom
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err收藏
Single-cell RNA-sequence analysis of human bone marrow reveals new targets for isolation of skeletal stem cells using spherical nucleic acids人骨髓的单细胞RNA序列分析揭示了使用球形核酸隔离骨骼干细胞的新靶标
errJOURNAL OF TISSUE ENGINEERING
IF7
err2023-05-16
err1
errOAAI
errMatthews, Elloise Z.; Lanham, Stuart; White, Kate; Kyriazi, Maria-Eleni; Alexaki, Konstantina; El-Sagheer, Afaf H.; Brown, Tom; Kanaras, Antonios G.; West, Jonathan; MacArthur, Ben D.; Stumpf, Patrick S.; Oreffo, Richard O. C.
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Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks (vol 145, pg 5431, 2023)
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-03-31
err0
errOAAI
errOrsborne, Sarah R. E.; Gorman, Jeffrey; Weiss, Leah R. .; Sridhar, Akshay; Panjwani, Naitik A. .; Divitini, Giorgio; Budden, Peter; Palecek, David; Ryan, Sean T. J.; Rao, Akshay; Collepardo-Guevara, Rosana; El-Sagheer, Afaf H.; Brown, Tom; Behrends, Jan; Friend, Richard H.; Auras, Florian
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Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-02-24
err13
errOAAI
errOrsborne, Sarah R. E.; Gorman, Jeffrey; Weiss, Leah R.; Sridhar, Akshay; Panjwani, Naitik A.; Divitini, Giorgio; Budden, Peter; Palecek, David; Ryan, Sean T. J.; Rao, Akshay; Collepardo-Guevara, Rosana; El-Sagheer, Afaf H.; Brown, Tom; Behrends, Jan; Friend, Richard H.; Auras, Florian
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An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides
errNATURE COMMUNICATIONS
IF15.7
err2022-07-12
err22
errOAAI
errBaker, Ysobel R.; Thorpe, Cameron; Chen, Jinfeng; Poller, Laura M.; Cox, Lina; Kumar, Pawan; Lim, Wooi F.; Lie, Lillian; McClorey, Graham; Epple, Sven; Singleton, Daniel; McDonough, Michael A.; Hardwick, Jack S.; Christensen, Kirsten E.; Wood, Matthew J. A.; Hall, James P.; El-Sagheer, Afaf H.; Brown, Tom
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Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
errNUCLEIC ACIDS RESEARCH
IF13.1
err2022-05-30
err13
errOAAI
errMcGorman, Brionna; Fantoni, Nicolo Zuin; O'Carroll, Sinead; Ziemele, Anna; El-Sagheer, Afaf H.; Brown, Tom; Kellett, Andrew
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err收藏
An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation
errBIOCONJUGATE CHEMISTRY
IF3.9
err2022-01-10
err13
PREAI
errKyriazi, Maria-Eleni; El-Sagheer, Afaf H.; Medintz, Igor L.; Brown, Tom; Kanaras, Antonios G.
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Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
errRSC CHEMICAL BIOLOGY
IF3.1
err2022-01-01
err3
errOAAI
errDysko, Anna; Baker, Ysobel R.; McClorey, Graham; Wood, Matthew J. A.; Fenner, Sabine; Williams, Glynn; El-Sagheer, Afaf; Brown, Tom
err分享
err收藏

研究方向

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合作学者
合作期刊
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Richard H. Friend
H 指数: 195 · 论文数: 1.5K
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Carlos Bustamante
H 指数: 113 · 论文数: 566
C
Christopher J. Schofield
H 指数: 112 · 论文数: 1.3K
M
Matthew J. A. Wood
H 指数: 101 · 论文数: 581
D
Douglas R. Higgs
H 指数: 98 · 论文数: 461
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