Seungil Han - Publications, H-index & Citations

Seungil Han

Pfizer

39H指数

114论文数

5.7K被引数

收录论文 44

发表时间

Discovery of Potent and Brain-Penetrant Inverse Agonists for GPR61; an Orphan G Protein-Coupled Receptor 发现强效且能透过血脑屏障的GPR61反向激动剂；一种孤儿G蛋白偶联受体

Journal of Medicinal Chemistry

IF6.8

2026-03-15

PREAI

Ethan L. Fisher; Anne-Marie Dechert Schmitt; Jamison B. Tuttle; Ray Unwalla; Gabrielle H. Lovett; Bethany L. Kormos; Karen J. Coffman; Dahui Zhou; Michael Moran; Jade Williams; Jun Xiao; Erik A. LaChapelle; Jean-Philippe Fortin; Abdul Q. Sheikh; Kimberly A. Stevens; Jimmy X. Kong; Emily A. G. Hughes; Ryan M. Esquejo; Stephanie Joaquim; Nalissa L. Amar; Danielle Archambault; Jeonifer Garren; Danna Breen; Srinath Jagarlapudi; Robert Dullea; Rebecca E. O’Connor; Erika Koslov-Davino; Ernesto Callegari; João M. Dias; Joshua A. Lees; Kris Borzilleri; Seungil Han; Jonathan Brooks; Felix F. Vajdos; Ashish Goyal; Lei Zhang; Yuan Zhang

Structure-based design of an immunogenic, conformationally stabilized FimH antigen for a urinary tract infection vaccine

PLOS PATHOGENS

IF4.9

2025-02-19

OAAI

de Monerri, Natalie C. Silmon; Che, Ye; Lees, Joshua A.; Jasti, Jayasankar; Wu, Huixian; Griffor, Matthew C.; Kodali, Srinivas; Hawkins, Julio Cesar; Lypowy, Jacqueline; Ponce, Christopher; Curley, Kieran; Esadze, Alexandre; Carcamo, Juan; Mclellan, Thomas; Keeney, David; Illenberger, Arthur; Matsuka, Yury V.; Shanker, Suman; Chorro, Laurent; Gribenko, Alexey V.; Han, Seungil; Anderson, Annaliesa S.; Donald, Robert G. K.

Structural basis for CCR6 modulation by allosteric antagonists

NATURE COMMUNICATIONS

IF15.7

2024-08-31

OAAI

Wasilko, David Jonathan; Gerstenberger, Brian S.; Farley, Kathleen A.; Li, Wei; Alley, Jennifer; Schnute, Mark E.; Unwalla, Ray J.; Victorino, Jorge; Crouse, Kimberly K.; Ding, Ru; Sahasrabudhe, Parag V.; Vincent, Fabien; Frisbie, Richard K.; Dermenci, Alpay; Flick, Andrew; Choi, Chulho; Chinigo, Gary; Mousseau, James J.; Trujillo, John I.; Nuhant, Philippe; Mondal, Prolay; Lombardo, Vincent; Lamb, Daniel; Hogan, Barbara J.; Minhas, Gurdeep Singh; Segala, Elena; Oswald, Christine; Windsor, Ian W.; Han, Seungil; Rappas, Mathieu; Cooke, Robert M.; Calabrese, Matthew F.; Berstein, Gabriel; Thorarensen, Atli; Wu, Huixian

In Retrospect: Root-Cause Analysis of Structure-Activity Relationships in IRAK4 Inhibitor Zimlovisertib (PF-06650833)

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-03-21

PREAI

Wright, Stephen W.; Farley, Kathleen A.; Han, Seungil; Knafels, John D.; Lee, Katherine L.

Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD1

NUCLEIC ACIDS RESEARCH

IF13.1

2023-11-01

OAAI

Orris, Benjamin; Sung, Min Woo; Bhat, Shridhar; Xu, Yingrong; Huynh, Kevin W.; Han, Seungil; Johnson, Darren C.; Bosbach, Benedikt; Shields, David J.; Stivers, James T.

An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism

NATURE COMMUNICATIONS

IF15.7

2023-09-23

OAAI

Lees, Joshua A.; Dias, Joao M.; Rajamohan, Francis; Fortin, Jean-Philippe; O'Connor, Rebecca; Kong, Jimmy X.; Hughes, Emily A. G.; Fisher, Ethan L.; Tuttle, Jamison B.; Lovett, Gabrielle; Kormos, Bethany L.; Unwalla, Rayomand J.; Zhang, Lei; Dechert Schmitt, Anne-Marie; Zhou, Dahui; Moran, Michael; Stevens, Kimberly A.; Fennell, Kimberly F.; Varghese, Alison E.; Maxwell, Andrew; Cote, Emmaline E.; Zhang, Yuan; Han, Seungil

Rational design of a highly immunogenic prefusion- stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-04-26

PREAI

Che, Ye; Gribenko, Alexey, V; Song, Xi; Handke, Luke D.; Efferen, Kari S.; Tompkins, Kristin; Kodali, Srinivas; Nunez, Lorna; Prasad, A. Krishna; Phelan, Lynn M.; Ammirati, Mark; Yu, Xiaodi; Lees, Joshua A.; Chen, Wei; Martinez, Lyndsey; Roopchand, Vidia; Han, Seungil; Qiu, Xiayang; DeVincenzo, John P.; Jansen, Kathrin U.; Dormitzer, Philip R.; Swanson, Kena A.

Structural basis of the acyl-transfer mechanism of human GPAT1

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-12-15

PREAI

Johnson, Zachary Lee; Ammirati, Mark; Wasilko, David Jonathan; Chang, Jeanne S.; Noell, Stephen; Foley, Timothy L.; Yoon, Hyejin; Smith, Kathleen; Asano, Shoh; Hales, Katherine; Wan, Min; Yang, Qingyi; Piotrowski, Mary A.; Farley, Kathleen A.; Gilbert, Tamara; Aschenbrenner, Lisa M.; Fennell, Kimberly F.; Dutra, Jason K.; Xu, Mary; Guo, Chunyang; Varghese, Alison E.; Bellenger, Justin; Quinn, Alandra; Ende, Christopher Am W.; West, Graham M.; Griffor, Matthew C.; Bennett, Donald; Calabrese, Matthew; Steppan, Claire M.; Han, Seungil; Wu, Huixian

Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2022-07-14

OAAI

McCorvie, Thomas J.; Loria, Paula M.; Tu, Meihua; Han, Seungil; Shrestha, Leela; Froese, D. Sean; Ferreira, Igor M.; Berg, Allison P.; Yue, Wyatt W.

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation and ssDNA binding kinetics

NUCLEIC ACIDS RESEARCH

IF13.1

2022-07-08

OAAI

Orris, Benjamin; Huynh, Kevin W.; Ammirati, Mark; Han, Seungil; Bolanos, Ben; Carmody, Jason; Petroski, Matthew D.; Bosbach, Benedikt; Shields, David J.; Stivers, James T.

A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-06-01

OAAI

Griffith, David A.; Edmonds, David J.; Fortin, Jean-Philippe; Kalgutkar, Amit S.; Kuzmiski, J. Brent; Loria, Paula M.; Saxena, Aditi R.; Bagley, Scott W.; Buckeridge, Clare; Curto, John M.; Derksen, David R.; Dias, Joao M.; Griffor, Matthew C.; Han, Seungil; Jackson, V. Margaret; Landis, Margaret S.; Lettiere, Daniel; Limberakis, Chris; Liu, Yuhang; Mathiowetz, Alan M.; Patel, Jayesh C.; Piotrowski, David W.; Price, David A.; Ruggeri, Roger B.; Tess, David A.

Applications of Cryo-EM in small molecule and biologics drug design

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2021-11-23

OAAI

Lees, Joshua A.; Dias, Joao M.; Han, Seungil

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression 胡椒碱对TRPV2的变构拮抗剂调节会损害胶质母细胞瘤的进展

ACS CENTRAL SCIENCE

IF10.4

2021-04-14

OAAI

Conde, Joao; Pumroy, Ruth A.; Baker, Charlotte; Rodrigues, Tiago; Guerreiro, Ana; Sousa, Barbara B.; Marques, Marta C.; de Almeida, Bernardo P.; Lee, Sohyon; Leites, Elvira P.; Picard, Daniel; Samanta, Amrita; Vaz, Sandra H.; Sieglitz, Florian; Langini, Maike; Remke, Marc; Roque, Rafael; Weiss, Tobias; Weller, Michael; Liu, Yuhang; Han, Seungil; Corzana, Francisco; Morais, Vanessa A.; Faria, Claudia C.; Carvalho, Tania; Filippakopoulos, Panagis; Snijder, Berend; Barbosa-Morais, Nuno L.; Moiseenkova-Bell, Vera Y.; Bernardes, Goncalo J. L.

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

SCIENCE ADVANCES

IF12.5

2021-03-05

OAAI

Liu, Yuhang; Heim, Kyle P.; Che, Ye; Chi, Xiaoyuan; Qiu, Xiayang; Han, Seungil; Dormitzer, Philip R.; Yang, Xinzhen

Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease[S]人溶酶体酸性脂肪酶的晶体结构及其在胆固醇酯贮积病中的意义 [S]

JOURNAL OF LIPID RESEARCH

IF4.1

2020-08-01

OAAI

Rajamohan, Francis; Reyes, Allan R.; Tu, Meihua; Nedoma, Nicole L.; Hoth, Lise R.; Schwaid, Adam G.; Kurumbail, Ravi G.; Ward, Jessica; Han, Seungil

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

NATURE COMMUNICATIONS

IF15.7

2020-06-15

OAAI

Wasilko, David Jonathan; Johnson, Zachary Lee; Ammirati, Mark; Che, Ye; Griffor, Matthew C.; Han, Seungil; Wu, Huixian

Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins

NATURE COMMUNICATIONS

IF15.7

2020-03-27

OAAI

Mukherjee, Somnath; Erramilli, Satchal K.; Ammirati, Mark; Alvarez, Frances J. D.; Fennell, Kimberly F.; Purdy, Michael D.; Skrobek, Blazej M.; Radziwon, Katarzyna; Coukos, John; Kang, Yanyong; Dutka, Przemyslaw; Gao, Xiang; Qiu, Xiayang; Yeager, Mark; Xu, H. Eric; Han, Seungil; Kossiakoff, Anthony A.

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

ELIFE

IF0

2019-10-03

OAAI

Yu, Xiaodi; Plotnikova, Olga; Bonin, Paul D.; Subashi, Timothy A.; McLellan, Thomas J.; Dumlao, Darren; Che, Ye; Dong, Yin Yao; Carpenter, Elisabeth P.; West, Graham M.; Qiu, Xiayang; Culp, Jeffrey S.; Han, Seungil

Molecular mechanism of TRPV2 channel modulation by cannabidiol

ELIFE

IF0

2019-09-30

124

OAAI

Pumroy, Ruth A.; Samanta, Amrita; Liu, Yuhang; Hughes, Taylor E. T.; Zhao, Siyuan; Yudin, Yevgen; Rohacs, Tibor; Han, Seungil; Moiseenkova-Bell, Vera Y.

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism

NATURE COMMUNICATIONS

IF15.7

2019-05-17

127

OAAI

Fox, Nicholas G.; Yu, Xiaodi; Feng, Xidong; Bailey, Henry J.; Martelli, Alain; Nabhan, Joseph F.; Strain-Damerell, Claire; Bulawa, Christine; Yue, Wyatt W.; Han, Seungil

研究方向