王理 (Li Wang)

harbin medical university教授

H指数:18

被引数:1,166

个人简介

"教授、博士生导师，黑龙江省高层次人才、省领军人才梯队后备带头人、黑龙江省优青、哈医大星联人才。担任国家自然科学基金（面上、地区、青年项目）评审专家、中国科协科技人才评价专家，中国博士后科学基金评审专家，黑龙江省慢性病管理学会医学影像专业委员会副主委、黑龙江省生物信息学学会副秘书长、中国计算机学会生物信息学专委会委员、中国生物工程学会计算生物学与生物信息学专委会委员、中国自动化学会智能健康与生物信息专业委员会委员、中国细胞生物学学会功能基因组信息学与系统生物学委员会委员及中国生物信息学学会（筹）重大疾病组学信息学专委会委员。\n主持国家自然科学基金项目4项，黑龙江省优秀青年项目、中国博士后特别资助等10余项基金项目；作为骨干参与科技创新2030、“癌症、心血管、呼吸和代谢性疾病研究”国家科技重大专项、“脑科学与类脑研究”重大专项等3项。以第一作者或通讯作者等在《Nucleic Acids Research》IF：19.16)、《Molecular Therapy-Nucleic Acids》(IF:10.183)、《Oncogene》(IF:9.8)、《Scientific Data》(IF:9.8)等杂志发表SCI论文30余篇。近几年获得全国大学生数学建模优秀指导教师，校级优秀科研工作者、十佳青年岗位能手、优秀教师、五四青年奖章等殊荣。作为主编编写“十三五”规划教材《结构信息学理论与实践》，作为副主编编写全国高等医药教育“十五五”规划教材《信号处理技术》，作为编委参与编写“十三五”全国高等医学院校本科规划教材《医用高等数学》、Springer出版社《Non-codingRNAsInComplexDisease》等多部教材与专著。获黑龙江省高等教育教学成果奖特等奖1项，黑龙江省高校科学技术奖一等奖1项，发明专利4项，软件著作权6项。指导研究生获国家奖学金1项，黑龙江省三好学生等；指导本科生获全美大学生数学建模M奖（一等奖）、全国大学生数学建模竞赛国家级二等奖、省级一等奖、二等奖多项。\n近3年代表作（部分）\nSo3D: a comprehensive three-dimensional spatial omics resource for decoding tissue architecture in physiology and disease.Nucleic Acids Research, 2026,Jan 6;54(D1):D1281-D1290.（SCI IF:19.16，通讯作者） An in-depth transcriptomic atlas deciphering traditional Chinese medicine mechanisms and disease associations.Scientific Data, 2026，Mar 5.(SCI IF: 9.8,通讯作者) Antitumor effects of cannabidiol (CBD) on osteosarcoma by targeting TNF-α/NF-κB/CCL5 signaling axis.Phytomedicine. 2025,Sep;145:157066.(SCI IF:8.3，通讯作者) Identification of somatic mutation-driven enhancers and their clinical utility in breast cancer.iScience, 2024, Jan 5;27(2):108780.(SCI IF:5.8，通讯作者) Comprehensive quantitative radiogenomic evaluation reveals novel radiomic subtypes with distinct immune pattern in glioma.Computers in Biology and Medicine, 2024, May 20:177:108636.(SCI IF:7.7，通讯作者) LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA-target regulations in human diseases.Nucleic acids research, 2023, 51(D1):D199-D207（SCI IF: 19.16,通讯作者） Identifying tumour microenvironment-related signature that correlates with prognosis and immunotherapy response in breast cancer.Scientific Data, 2023, 10(1):119.(SCI IF: 9.8,通讯作者) Integrated analysis of single-cell and bulk RNA sequencing data reveals immune-related lncRNA-mRNA prognostic signature in triple-negative breast cancer.Genes & diseases, 2023,May 10;11(2):571-574.(SCI IF:9.4，通讯作者) Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma.Genes & diseases, 2023,Sep 12;11(5):101107(SCI IF:9.4，通讯作者) Comprehensive identification and potential application of genetic alteration-driven enhancer RNAs for eRNA-targeted therapy in breast cancer.Genes & diseases, 2023,Sep 23;11(5):101124(SCI IF:9.4，通讯作者) The dynamic dysregulated network identifies stage-specific markers during lung adenocarcinoma malignant progression and metastasis.Molecular Therapy-Nucleic Acids, 2022, 30: 633-647.(SCI IF:10.183，第一作者) Identifying enhancer-driven subtype-specific prognostic markers in breast cancer based on multi-omics data.Frontiers in Immunology, 2022, 13:990143.(SCI IF: 7.3,通讯作者) Comprehensive characterization of clonality of driver genes revealing their clinical relevance in colorectal cancer.Journal of Translational Medicine, 2022;20(1):362.(SCI: 7.4,通讯作者) Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes.Molecular Therapy-Nucleic Acids, 2021, 23: 667-681.(SCI IF: 10.183,通讯作者,ESI高被引论文) LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases.Nucleic acids research, 2020, 48(D1):D118-D126.( SCI IF: 19.16,通讯作者) Identifying functions and prognostic biomarkers of network motifs marked by diverse chromatin states in human cell lines.Oncogene, 2020, 39(3):677-689.(SCI IF: 9.867,第一作者)"