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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay 一种通用的作用于大麻素CB1和CB2受体的TR-FRET动力学配体结合测定法 Borrega-Roman, Leire; Hoare, Bradley L.; Kosar, Miroslav; Sarott, Roman C.; Patej, Kacper J.; Bouma, Jara; Scott-Dennis, Morgan; Koers, Eline J.; Gazzi, Thais; Mach, Leonard; Barrondo, Sergio; Salles, Joan; Guba, Wolfgang; Kusznir, Eric; Nazare, Marc; Rufer, Arne C.; Grether, Uwe; Heitman, Laura H.; Sykes, David A.; Veprintsev, Dmitry B. 分享 收藏
Profiling Allosteric Modulators of CB1R with an Allosteric Fluoroprobe 使用别构荧光探针表征CB1R别构调节剂 Kosar, Miroslav; Perera, Themiya; Ganzoni, Rudolf L. Z.; Sarott, Roman C.; Borrega-Roman, Leire; Vitale, Rosa Maria; Ligresti, Alessia; Rufer, Arne C.; Guba, Wolfgang; Grether, Uwe; Carreira, Erick M.; Veprintsev, Dmitry B.; Sykes, David A. 分享 收藏
Novel Macrocyclic NLRP3 Inhibitors Mesch, Stefanie; Shannon, Jonathan; Miller, David; Macleod, Angus; Bouche, Lea; Johnston, Heather J.; Matthews, Kim; Paehler, Axel; Best, Stuart; Guba, Wolfgang; Alanine, Thomas; Halai, Reena; Charge, Lorna; Garside, Samantha; Thom, Stephen; Incerti-Pradillos, Celia; Mcpherson, Christopher; Carrillo, Jokin; St-Gallay, Steve; Rigo, Pierre; Schlicht, Sonja; Hendrick, Alan G.; Lerner, Christian; Piali, Luca; Blaising, Julie; Mracsko, Eva Z.; Jaeschke, Georg; Cooper, Matthew A. 分享 收藏
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB1R) 大麻素受体1型 (CB1R) 的高选择性药物衍生荧光探针 Mach, Leonard; Omran, Anahid; Bouma, Jara; Radetzki, Silke; Sykes, David A.; Guba, Wolfgang; Li, Xiaoting; Hoeffelmeyer, Calvin; Hentsch, Axel; Gazzi, Thais; Mostinski, Yelena; Wasinska-Kalwa, Malgorzata; de Molnier, Fabio; van der Horst, Cas; von Kries, Jens Peter; Vendrell, Marc; Hua, Tian; Veprintsev, Dmitry B.; Heitman, Laura H.; Grether, Uwe; Nazare, Marc 分享 收藏
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists Kosar, Miroslav; Sarott, Roman C.; Sykes, David A.; Viray, Alexander E. G.; Vitale, Rosa Maria; Tomasevic, Natasa; Li, Xiaoting; Ganzoni, Rudolf L. Z.; Kicin, Bilal; Reichert, Lisa; Patej, Kacper J.; Gomez-Bouzo, Uxia; Guba, Wolfgang; McCormick, Peter J.; Hua, Tian; Gruber, Christian W.; Veprintsev, Dmitry B.; Frank, James A.; Grether, Uwe; Carreira, Erick M. 分享 收藏
Visualization of membrane localization and the functional state of CB2R pools using matched agonist and inverse agonist probe pairs Wasinska-Kalwa, M.; Omran, A.; Mach, L.; Scipioni, L.; Bouma, J.; Li, X.; Radetzki, S.; Mostinski, Y.; Schippers, M.; Gazzi, T.; van der Horst, C.; Brennecke, B.; Hanske, A.; Kolomeets, Y.; Guba, W.; Sykes, D.; von Kries, J. P.; Broichhagen, J.; Hua, T.; Veprintsev, D.; Heitman, L. H.; Oddi, S.; MacCarrone, M.; Grether, U.; Nazare, M. 分享 收藏
Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells Kosar, Miroslav; Sykes, David A.; Viray, Alexander E. G.; Vitale, Rosa Maria; Sarott, Roman C.; Ganzoni, Rudolf L.; Onion, David; Tobias, Janelle M.; Leippe, Philipp; Ullmer, Christoph; Zirwes, Elisabeth A.; Guba, Wolfgang; Grether, Uwe; Frank, James A.; Veprintsev, Dmitry B.; Carreira, Erick M. 分享 收藏
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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Korn, Claudia; Sykes, David; Forn-Cuni, Gabriel; Pfaff, Patrick; Sarott, Roman C.; Westphal, Matthias, V; Mostinski, Yelena; Mach, Leonard; Wasinska-Kalwa, Malgorzata; Weise, Marie; Hoare, Bradley L.; Miljus, Tamara; Mexi, Maira; Roth, Nicolas; Koers, Eline J.; Guba, Wolfgang; Alker, Andre; Rufer, Arne C.; Kusznir, Eric A.; Huber, Sylwia; Raposo, Catarina; Zirwes, Elisabeth A.; Osterwald, Anja; Pavlovic, Anto; Moes, Svenja; Beck, Jennifer; Nettekoven, Matthias; Benito-Cuesta, Irene; Grande, Teresa; Drawnel, Faye; Widmer, Gabriella; Holzer, Daniela; van der Wel, Tom; Mandhair, Harpreet; Honer, Michael; Fingerle, Jurgen; Scheffel, Joerg; Broichhagen, Johannes; Gawrisch, Klaus; Romero, Julian; Hillard, Cecilia J.; Varga, Zoltan V.; van der Stelt, Mario; Pacher, Pal; Gertsch, Jurg; Ullmer, Christoph; McCormick, Peter J.; Oddi, Sergio; Spaink, Herman P.; Maccarrone, Mauro; Veprintsev, Dmitry B.; Carreira, Erick M.; Grether, Uwe; Nazare, Marc 分享 收藏
Novel β-Glucocerebrosidase Activators That Bind to a New Pocket at a Dimer Interface and Induce Dimerization Benz, Joerg; Rufer, Arne C.; Huber, Sylwia; Ehler, Andreas; Hug, Melanie; Topp, Andreas; Guba, Wolfgang; Hofmann, Eva Carolina; Jagasia, Ravi; Rodriguez Sarmiento, Rosa Maria 分享 收藏
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells Sarott, Roman C.; Westphal, Matthias, V; Pfaff, Patrick; Korn, Claudia; Sykes, David A.; Gazzi, Thais; Brennecke, Benjamin; Atz, Kenneth; Weise, Marie; Mostinski, Yelena; Hompluem, Pattarin; Koers, Eline; Miljus, Tamara; Roth, Nicolas J.; Asmelash, Hermon; Vong, Man C.; Piovesan, Jacopo; Guba, Wolfgang; Rufer, Arne C.; Kusznir, Eric A.; Huber, Sylwia; Raposo, Catarina; Zirwes, Elisabeth A.; Osterwald, Anja; Pavlovic, Anto; Moes, Svenja; Beck, Jennifer; Benito-Cuesta, Irene; Grande, Teresa; de Martin Esteban, Samuel Ruiz; Yeliseev, Alexei; Drawnel, Faye; Widmer, Gabriella; Holzer, Daniela; van der Wel, Tom; Mandhair, Harpreet; Yuan, Cheng-Yin; Drobyski, William R.; Saroz, Yurii; Grimsey, Natasha; Honer, Michael; Fingerle, Juergen; Gawrisch, Klaus; Romero, Julian; Hillard, Cecilia J.; Varga, Zoltan V.; van der Stelt, Mario; Pacher, Pal; Gertsch, Juerg; McCormick, Peter J.; Ullmer, Christoph; Oddi, Sergio; Maccarrone, Mauro; Veprintsev, Dmitry B.; Nazare, Marc; Grether, Uwe; Carreira, Erick M. 分享 收藏
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes Westphal, Matthias, V; Sarott, Roman C.; Zirwes, Elisabeth A.; Osterwald, Anja; Guba, Wolfgang; Ullmer, Christoph; Grether, Uwe; Carreira, Erick M. 分享 收藏
Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors Haider, Ahmed; Kretz, Julian; Gobbi, Luca; Ahmed, Hazem; Atz, Kenneth; Burkler, Markus; Bartelmus, Christian; Fingerle, Jurgen; Guba, Wolfgang; Ullmer, Christoph; Honer, Michael; Knuesel, Irene; Weber, Markus; Brink, Andreas; Herde, Adrienne Mueller; Keller, Claudia; Schibli, Roger; Mu, Linjing; Grether, Uwe; Ametamey, Simon M. 分享 收藏
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis Porter, Richard Frederick; Szczesniak, Anna-Maria; Toguri, James Thomas; Gebremeskel, Simon; Johnston, Brent; Lehmann, Christian; Fingerle, Juergen; Rothenhaeusler, Benno; Perret, Camille; Rogers-Evans, Mark; Kimbara, Atsushi; Nettekoven, Matthias; Guba, Wolfgang; Grether, Uwe; Ullmer, Christoph; Kelly, Melanie E. M. 分享 收藏
Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells Soethoudt, Marjolein; Stolze, Sara C.; Westphal, Matthias V.; van Stralen, Luuk; Martella, Andrea; van Rooden, Eva J.; Guba, Wolfgang; Varga, Zoltan V.; Deng, Hui; van Kasteren, Sander I.; Grether, Uwe; IJzerman, Adriaan P.; Pacher, Pal; Carreira, Erick M.; Overkleeft, Herman S.; Ioan-Facsinay, Andreea; Heitman, Laura H.; van der Stelt, Mario 分享 收藏
Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport Ruderisch, Nadine; Schlatter, Daniel; Kuglstatter, Andreas; Guba, Wolfgang; Huber, Sylwia; Cusulin, Carlo; Benz, Jorg; Rufer, Arne Christian; Hoernschemeyer, Joerg; Schweitzer, Christophe; Bulau, Tina; Gaertner, Achim; Hoffmann, Eike; Niewoehner, Jens; Patsch, Christoph; Baumann, Karlheinz; Loetscher, Hansruedi; Kitas, Eric; Freskgard, Per-Ola 分享 收藏
A Real-World Perspective on Molecular Design Kuhn, Bernd; Guba, Wolfgang; Hert, Jerome; Banner, David; Bissantz, Caterina; Ceccarelli, Simona; Haap, Wolfgang; Koerner, Matthias; Kuglstatter, Andreas; Lerner, Christian; Mattei, Patrizio; Neidhart, Werner; Pinard, Emmanuel; Rudolph, Markus G.; Schulz-Gasch, Tanja; Wokering, Thomas; Stahl, Martin 分享 收藏
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