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Cryo-EM-guided enhancement of target selectivity of a novel p97 inhibitor for treating multiple myeloma and acute myeloid leukemia Crawford, Jason; Munuganti, Ravi; Leung, Charles; Singh, Kriti; Gates, Ellen; Zhu, Xing; Bally, Marcel; Dos Santos, Nancy; Sharifiaghdam, Maryam; Nosrati, Zeynab; Axerio-Cilies, Peter; Berezuk, Alison; Cholak, Spencer; Subramaniam, Sriram 分享 收藏
Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein Mannar, Dhiraj; Saville, James W.; Poloni, Chad; Zhu, Xing; Bezeruk, Alison; Tidey, Keith; Ahmed, Sana; Tuttle, Katharine S.; Vahdatihassani, Faezeh; Cholak, Spencer; Cook, Laura; Steiner, Theodore S.; Subramaniam, Sriram 分享 收藏
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Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM Marcus, Kendra; Huang, Yongjian; Subramanian, Subu; Gee, Christine L.; Gorday, Kent; Ghaffari-Kashani, Sam; Luo, Xiao Ran; Zheng, Lisa; O'Donnell, Michael; Subramaniam, Sriram; Kuriyan, John 分享 收藏
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SARS-CoV-2 Variants Omicron BA.4/5 and XBB.1.5 Significantly Escape T Cell Recognition in Solid-organ Transplant Recipients Vaccinated Against the Ancestral Strain SARS-CoV-2变体Omicron BA.4/5和XBB.1.5在接种了祖先菌株的实体器官移植受者中显着逃脱了T细胞识别 Halvorson, Torin; Ivison, Sabine; Huang, Qing; Ladua, Gale; Yotis, Demitra M.; Mannar, Dhiraj; Subramaniam, Sriram; Ferreira, Victor H.; Kumar, Deepali; Belga, Sara; Levings, Megan K. 分享 收藏
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold 使用刚性成像支架在3å 分辨率下确定小治疗蛋白靶标的cryo-em结构 Castells-Graells, Roger; Meador, Kyle; Arbing, Mark A.; Sawaya, Michael R.; Gee, Morgan; Cascio, Duilio; Gleave, Emma; Debreczeni, Judit E.; Breed, Jason; Leopold, Karoline; Patel, Ankoor; Jahagirdar, Dushyant; Lyons, Bronwyn; Subramaniam, Sriram; Phillips, Chris; Yeates, Todd O. 分享 收藏
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SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization Mannar, Dhiraj; Saville, James W.; Sun, Zehua; Zhu, Xing; Marti, Michelle M.; Srivastava, Shanti S.; Berezuk, Alison M.; Zhou, Steven; Tuttle, Katharine S.; Sobolewski, Michele D.; Kim, Andrew; Treat, Benjamin R.; Castanha, Priscila Mayrelle Da Silva; Jacobs, Jana L.; Barratt-Boyes, Simon M.; Mellors, John W.; Dimitrov, Dimiter S.; Li, Wei; Subramaniam, Sriram 分享 收藏
Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation Fraser, Bryan J.; Beldar, Serap; Seitova, Almagul; Hutchinson, Ashley; Mannar, Dhiraj; Li, Yanjun; Kwon, Daniel; Tan, Ruiyan; Wilson, Ryan P.; Leopold, Karoline; Subramaniam, Sriram; Halabelian, Levon; Arrowsmith, Cheryl H.; Benard, Francois 分享 收藏
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants Saville, James W.; Mannar, Dhiraj; Zhu, Xing; Srivastava, Shanti S.; Berezuk, Alison M.; Demers, Jean-Philippe; Zhou, Steven; Tuttle, Katharine S.; Sekirov, Inna; Kim, Andrew; Li, Wei; Dimitrov, Dimiter S.; Subramaniam, Sriram 分享 收藏
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Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding Mannar, Dhiraj; Saville, James W.; Zhu, Xing; Srivastava, Shanti S.; Berezuk, Alison M.; Zhou, Steven; Tuttle, Katharine S.; Kim, Andrew; Li, Wei; Dimitrov, Dimiter S.; Subramaniam, Sriram 分享 收藏
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Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake Schureck, Marc A.; Darling, Joseph E.; Merk, Alan; Shao, Jinfeng; Daggupati, Geervani; Srinivasan, Prakash; Olinares, Paul Dominic B.; Rout, Michael P.; Chait, Brian T.; Wollenberg, Kurt; Subramaniam, Sriram; Desai, Sanjay A. 分享 收藏
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