Louise Fairall - Publications, H-index & Citations

Louise Fairall

University of Leicester

43H指数

88论文数

7.0K被引数

收录论文 39

发表时间

A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome MIDEAS基因中的一个新生错义变异导致MiDAC HDAC复合物的去乙酰化酶活性增加，从而引起一种神经发育综合征。

Nature Communications

IF15.7

2025-11-25

OAAI

Louise Fairall; Kristupas Sirvydis; Robert E. Turnbull; Suzan JG Knottnerus; Oksana Gonchar; Frederick W. Muskett; Rebekah Jukes-Jones; Lonneke van Brussel; Ellen van de Geer; Koen van Gassen; Paul Badenhorst; Diana Johnson; Paulien A. Terhal; Peter M. van Hasselt; Richard H. van Jaarsveld; John WR Schwabe

Mutations on the surface of HDAC1 reveal molecular determinants of specific complex assembly and their requirement for gene regulation HDAC1表面的突变揭示了特异性复合物组装的分子决定因素及其对基因调控的需求

NUCLEIC ACIDS RESEARCH

IF13.1

2025-09-23

PREAI

Alshehri, Ahmad; Baker, India-May; English, David M.; Fairall, Louise; Collins, Mark O.; Schwabe, John W. R.; Cowley, Shaun M.

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-11-25

OAAI

Whedon, Samuel D.; Lee, Kwangwoon; Wang, Zhipeng A.; Zahn, Emily; Lu, Congcong; Abeywardana, Maheeshi Yapa; Fairall, Louise; Nam, Eunju; DuBois-Coyne, Sarah; De Ioannes, Pablo; Sheng, Xinlei; Andrei, Adelina; Lundberg, Emily; Jiang, Jennifer; Armache, Karim-Jean; Zhao, Yingming; Schwabe, John W. R.; Wu, Mingxuan; Garcia, Benjamin A.; Cole, Philip A.

Structural insights into the complex of oncogenic KRas4BG12V and Rgl2, a RalA/B activator

LIFE SCIENCE ALLIANCE

IF2.9

2023-10-13

OAAI

Tariq, Mishal; Ikeya, Teppei; Togashi, Naoyuki; Fairall, Louise; Kamei, Shun; Mayooramurugan, Sannojah; Abbott, Lauren R.; Hasan, Anab; Bueno-Alejo, Carlos; Sukegawa, Sakura; Romartinez-Alonso, Beatriz; Campillo, Miguel Angel Muro; Hudson, Andrew J.; Ito, Yutaka; Schwabe, John W. R.; Dominguez, Cyril; Tanaka, Kayoko

A potential histone-chaperone activity for the MIER1 histone deacetylase complex

NUCLEIC ACIDS RESEARCH

IF13.1

2023-04-26

OAAI

Wang, Siyu; Fairall, Louise; Pham, Trong Khoa; Ragan, Timothy J.; Vashi, Dipti; Collins, Mark O.; Dominguez, Cyril; Schwabe, John W. R.

Structure-Guided Approach to Relieving Transcriptional Repression in Resistance to Thyroid Hormone α 结构引导的方法来缓解对甲状腺激素 α 的抵抗中的转录抑制

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-02-27

OAAI

Romartinez-Alonso, Beatriz; Agostini, Maura; Jones, Heulyn; McLellan, Jayde; Sood, D. Eilidh; Tomkinson, Nicholas; Marelli, Federica; Gentile, Ilaria; Visser, W. Edward; Schoenmakers, Erik; Fairall, Louise; Privalsky, Martin; Moran, Carla; Persani, Luca; Chatterjee, Krishna; Schwabe, John W. R.

Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-02-17

OAAI

Wang, Zhipeng A.; Whedon, Samuel D.; Wu, Mingxuan; Wang, Siyu; Brown, Edward A.; Anmangandla, Ananya; Regan, Liam; Lee, Kwangwoon; Du, Jianfeng; Hong, Jun Young; Fairall, Louise; Kay, Taylor; Lin, Hening; Zhao, Yingming; Schwabe, John W. R.; Cole, Philip A.

Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate

NATURE COMMUNICATIONS

IF15.7

2021-02-05

OAAI

Fox, Joanna L.; Hughes, Michelle A.; Meng, Xin; Sarnowska, Nikola A.; Powley, Ian R.; Jukes-Jones, Rebekah; Dinsdale, David; Ragan, Timothy J.; Fairall, Louise; Schwabe, John W. R.; Morone, Nobuhiro; Cain, Kelvin; MacFarlane, Marion

The topology of chromatin-binding domains in the NuRD deacetylase complex

NUCLEIC ACIDS RESEARCH

IF13.1

2020-12-02

OAAI

Millard, Christopher J.; Fairall, Louise; Ragan, Timothy J.; Savva, Christos G.; Schwabe, John W. R.

Hyperthyroxinemia and Hypercortisolemia due to Familial Dysalbuminemia

THYROID

IF6.7

2020-11-01

OAAI

Moran, Carla; Seger, Christoph; Taylor, Kevin; Oddy, Susan; Burling, Keith; Rajanayagam, Odelia; Fairall, Louise; McGowan, Anne; Lyons, Greta; Halsall, David; Gurnell, Mark; Schwabe, John; Chatterjee, Krishna; Strey, Christopher

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

NATURE COMMUNICATIONS

IF15.7

2020-06-26

OAAI

Turnbull, Robert E.; Fairall, Louise; Saleh, Almutasem; Kelsall, Emma; Morris, Kyle L.; Ragan, T. J.; Savva, Christos G.; Chandru, Aditya; Millard, Christopher J.; Makarova, Olga V.; Smith, Corinne J.; Roseman, Alan M.; Fry, Andrew M.; Cowley, Shaun M.; Schwabe, John W. R.

Diverse nucleosome Site-Selectivity among histone deacetylase complexes

ELIFE

IF0

2020-06-05

OAAI

Wang, Zhipeng A.; Millard, Christopher J.; Lin, Chia-Liang; Gurnett, Jennifer E.; Wu, Mingxuan; Lee, Kwangwoon; Fairall, Louise; Schwabe, John W. R.; Cole, Philip A.

Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex

CELL REPORTS

IF6.9

2020-02-01

OAAI

Song, Yun; Dagil, Lisbeth; Fairall, Louise; Robertson, Naomi; Wu, Mingxuan; Ragan, T. J.; Savva, Christos G.; Saleh, Almutasem; Morone, Nobuhiro; Kunze, Micha B. A.; Jamieson, Andrew G.; Cole, Philip A.; Hansen, D. Flemming; Schwabe, John W. R.

Heme binding to human CLOCK affects interactions with the E-box

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2019-09-16

OAAI

Freeman, Samuel L.; Kwon, Hanna; Portolano, Nicola; Parkin, Gary; Girija, Umakhanth Venkatraman; Basran, Jaswir; Fielding, Alistair J.; Fairall, Louise; Svistunenko, Dimitri A.; Moody, Peter C. E.; Schwabe, John W. R.; Kyriacou, Charalambos P.; Raven, Emma L.

A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations

DIABETES

IF7.5

2018-04-05

OAAI

Agostini, Maura; Schoenmakers, Erik; Beig, Junaid; Fairall, Louise; Szatmari, Istvan; Rajanayagam, Odelia; Muskett, Frederick W.; Adams, Claire; Marais, A. David; O'Rahilly, Stephen; Semple, Robert K.; Nagy, Laszlo; Majithia, Amit R.; Schwabe, John W. R.; Blom, Dirk J.; Murphy, Rinki; Chatterjee, Krishna; Savage, David B.

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

NATURE COMMUNICATIONS

IF15.7

2018-01-04

221

OAAI

Kalin, Jay H.; Wu, Muzhou; Gomez, Andrea V.; Song, Yun; Das, Jayanta; Hayward, Dawn; Adejola, Nkosi; Wu, Mingxuan; Panova, Izabela; Chung, Hye Jin; Kim, Edward; Roberts, Holly J.; Roberts, Justin M.; Prusevich, Polina; Jeliazkov, Jeliazko R.; Burman, Shourya S. Roy; Fairall, Louise; Milano, Charles; Eroglu, Abdulkerim; Proby, Charlotte M.; Dinkova-Kostova, Albena T.; Hancock, Wayne W.; Gray, Jeffrey J.; Bradner, James E.; Valente, Sergio; Mai, Antonello; Anders, Nicole M.; Rudek, Michelle A.; Hu, Yong; Ryu, Byungwoo; Schwabe, John W. R.; Mattevi, Andrea; Alani, Rhoda M.; Cole, Philip A.

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor 1 Mutant Proteins 对甲状腺激素 α 抗性的不同表型与甲状腺激素受体1突变蛋白的不同特性相关

THYROID

IF6.7

2017-07-01

OAAI

Moran, Carla; Agostini, Maura; McGowan, Anne; Schoenmakers, Erik; Fairall, Louise; Lyons, Greta; Rajanayagam, Odelia; Watson, Laura; Offiah, Amaka; Barton, John; Price, Susan; Schwabe, John; Chatterjee, Krishna

Genetic disorders of nuclear receptors 核受体遗传性疾病

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2017-04-03

OAAI

Achermann, John C.; Schwabe, John; Fairall, Louise; Chatterjee, Krishna

Targeting Class I Histone Deacetylases in a Complex Environment

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2017-04-01

141

PREAI

Millard, Christopher J.; Watson, Peter J.; Fairall, Louise; Schwabe, John W. R.

Mutations in TBL1X Are Associated With Central Hypothyroidism

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2016-12-01

OAAI

Heinen, Charlotte A.; Losekoot, Monique; Sun, Yu; Watson, Peter J.; Fairall, Louise; Joustra, Sjoerd D.; Zwaveling-Soonawala, Nitash; Oostdijk, Wilma; van den Akker, Erica L. T.; Alders, Marielle; Santen, Gijs W. E.; van Rijn, Rick R.; Dreschler, Wouter A.; Surovtseva, Olga V.; Biermasz, Nienke R.; Hennekam, Raoul C.; Wit, Jan M.; Schwabe, John W. R.; Boelen, Anita; Fliers, Eric; van Trotsenburg, A. S. Paul

研究方向