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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir (vol 15, pg e00465, 2024) Dinh, Tung; Tber, Zahira; Rey, Juan S.; Mengshetti, Seema; Annamalai, Arun S.; Haney, Reed; Briganti, Lorenzo; Amblard, Franck; Fuchs, James R.; Cherepanov, Peter; Kim, Kyungjin; Schinazi, Raymond F.; Perilla, Juan R.; Kim, Baek; Kvaratskhelia, Mamuka 分享 收藏
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Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir M66I衣壳变体对lenacapavir耐药的结构和机制基础 Briganti, Lorenzo; Annamalai, Arun S.; Bester, Stephanie M.; Wei, Guochao; Andino-Moncada, Jonathan R.; Singh, Satya P.; Kleinpeter, Alex B.; Tripathi, Meghna; Nguyen, Binh; Radhakrishnan, Rajalingam; Singh, Parmit K.; Greenwood, Juliet; Schope, Lauren I.; Haney, Reed; Huang, Szu-Wei; Freed, Eric O.; Engelman, Alan N.; Francis, Ashwanth C.; Kvaratskhelia, Mamuka 分享 收藏
The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir Huang, Szu-Wei; Briganti, Lorenzo; Annamalai, Arun S.; Greenwood, Juliet; Shkriabai, Nikoloz; Haney, Reed; Armstrong, Michael L.; Wempe, Michael F.; Singh, Satya Prakash; Francis, Ashwanth C.; Engelman, Alan N.; Kvaratskhelia, Mamuka 分享 收藏
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The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir Dinh, Tung; Tber, Zahira; Rey, Juan S.; Mengshetti, Seema; Annamalai, Arun S.; Haney, Reed; Briganti, Lorenzo; Amblard, Franck; Fuchs, James R.; Cherepanov, Peter; Kim, Kyungjin; Schinazi, Raymond F.; Perilla, Juan R.; Kim, Baek; Kvaratskhelia, Mamuka 分享 收藏
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions Patacchini, Elisa; Madia, Valentina Noemi; Albano, Aurora; Ruggieri, Giuseppe; Messore, Antonella; Ialongo, Davide; Saccoliti, Francesco; Scipione, Luigi; Cosconati, Sandro; Koneru, Pratibha C.; Haney, Reed; Kvaratskhelia, Mamuka; Di Santo, Roberto; Costi, Roberta 分享 收藏
Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants Li, Min; Passos, Dario Oliveira; Shan, Zelin; Smith, Steven J.; Sun, Qinfang; Biswas, Avik; Choudhuri, Indrani; Strutzenberg, Timothy S.; Haldane, Allan; Deng, Nanjie; Li, Zhaoyang; Zhao, Xue Zhi; Briganti, Lorenzo; Kvaratskhelia, Mamuka; Burke Jr, Terrence R. R.; Levy, Ronald M.; Hughes, Stephen H.; Craigie, Robert; Lyumkis, Dmitry 分享 收藏
The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function Singer, Matthew R.; Dinh, Tung; Levintov, Lev; Annamalai, Arun S.; Rey, Juan S.; Briganti, Lorenzo; Cook, Nicola J.; Pye, Valerie E.; Taylor, Ian A.; Kim, Kyungjin; Engelman, Alan N.; Kim, Baek; Perilla, Juan R.; Kvaratskhelia, Mamuka; Cherepanova, Peter 分享 收藏
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Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection Wei, Guochao; Iqbal, Naseer; Courouble, Valentine V.; Francis, Ashwanth C.; Singh, Parmit K.; Hudait, Arpa; Annamalai, Arun S.; Bester, Stephanie; Huang, Szu-Wei; Shkriabai, Nikoloz; Briganti, Lorenzo; Haney, Reed; KewalRamani, Vineet N.; Voth, Gregory A.; Engelman, Alan N.; Melikyan, Gregory B.; Griffin, Patrick R.; Asturias, Francisco; Kvaratskhelia, Mamuka 分享 收藏
HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA Sapp, Nicklas; Burge, Nathaniel; Cox, Khan; Prakash, Prem; Balasubramaniam, Muthukumar; Thapa, Santosh; Christensen, Devin; Li, Min; Linderberger, Jared; Kvaratskhelia, Mamuka; Pandhare, Jui; Craigie, Robert; Poirier, Michael G.; Dash, Chandravanu 分享 收藏
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Identification and Optimization of a Novel HIV-1 Integrase Inhibitor Adu-Ampratwum, Daniel; Pan, Yuhan; Koneru, Pratibha C.; Antwi, Janet; Hoyte, Ashley C.; Kessl, Jacques; Griffin, Patrick R.; Kvaratskhelia, Mamuka; Fuchs, James R.; Larue, Ross C. 分享 收藏
A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site Maehigashi, Tatsuya; Ahn, Seohyun; Kim, Uk-Il; Lindenberger, Jared; Oo, Adrian; Koneru, Pratibha C.; Mahboubi, Bijan; Engelman, Alan N.; Kvaratskhelia, Mamuka; Kim, Kyungjin; Kim, Baek 分享 收藏
ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling Li, Zhengke; Wang-Heaton, Hui; Cartwright, Brian M.; Makinwa, Yetunde; Hilton, Benjamin A.; Musich, Phillip R.; Shkriabai, Nikolozi; Kvaratskhelia, Mamuka; Guan, Shengheng; Chen, Qian; Yu, Xiaochun; Zou, Yue 分享 收藏
Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis Elliott, Jennifer L.; Eschbach, Jenna E.; Koneru, Pratibha C.; Li, Wen; Puray-Chavez, Maritza; Townsend, Dana; Lawson, Dana Q.; Engelman, Alan N.; Kvaratskhelia, Mamuka; Kutluay, Sebla B. 分享 收藏
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