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S

Steve R. Roffler

d institute of biomedical sciences

47H指数
245论文数
7.5K被引数
收录论文 90
发表时间
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Antitumor efficacy achieved by targeting PEGylated nanomedicines to netrin-1 in the extracellular matrix or EphA2 on the cancer cell membrane通过靶向细胞外基质中的netrin-1或癌细胞膜上的EphA2实现的聚乙二醇化纳米药物的抗肿瘤疗效
errJournal of Controlled Release
IF11.5
err2025-07-14
err0
PREAI
errPo-Chuan Chiu; Yi-Chen Lin; Trieu Thi My Tran; Kai-Wen Ho; Shih-Hung Yang; Daniel Lin; Yong Sze Ong; Chun-Hung Lin; Yu-Lin Leu; Benjamin Gibert; Steve R. Roffler
err分享
err收藏
PEGylation technology: addressing concerns, moving forward聚乙二醇化技术：解决疑虑，向前发展
errDRUG DELIVERY
IF8.1
err2025-04-23
err0
errOAAI
errDmitri Simberg; Yechezkel Barenholz; Steve R. Roffler; Katharina Landfester; Alexander V. Kabanov; Seyed M. Moghimi
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Targeted internalization and activation of glycosidic switch liposomes by a biological macromolecule mPEGxEphA2 increases therapeutic efficacy against lung cancer靶向内化和激活糖苷开关脂质体，由生物大分子mPEGxEphA2实现，可提高对肺癌的治疗效果
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-04-01
err0
PREAI
errHo, Kai-Wen; Liu, Yen-Ling; Huang, Bo-Cheng; Hong, Shih-Ting; Yang, Shih-Hung; Liao, Tzu-Yi; Liu, En-Shuo; Chen, Yu-Tung; Huang, Yi-Zhong; Leu, Yu-Lin; Chen, Chiao-Yun; Chen, Bing-Mae; Roffler, Steve R.; Cheng, Tian-Lu
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Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo
errBIOMATERIALS RESEARCH
IF9.6
err2024-12-11
err0
errOAAI
errLiu, Yen-Ling; Liao, Tzu-Yi; Ho, Kai-Wen; Liu, En-Shuo; Huang, Bo-Cheng; Hong, Shih-Ting; Hsieh, Yuan-Chin; Chang, Mu-Shen; Wu, Bing-Tsung; Chen, Fang-Ming; Roffler, Steve R.; Chen, Chiao-Yun; Yang, Yuan-Chieh; Cheng, Tian-Lu
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Liposomes with Low Levels of Grafted Poly(ethylene glycol) Remain Susceptible to Destabilization by Anti-Poly(ethylene glycol) Antibodies
errACS NANO
IF16
err2024-08-09
err0
errOAAI
errChen, Bing-Mae; Chen, Even; Lin, Yi-Chen; Tran, Trieu Thi My; Turjeman, Keren; Yang, Shih-Hung; Cheng, Tian-Lu; Barenholz, Yechezkel; Roffler, Steve R.
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Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2024-05-01
err0
PREAI
errTseng, Yi-Han; Lin, Hsuan-Per; Lin, Sung-Yao; Chen, Bing-Mae; Vo, Thanh Nguyet Nguyen; Yang, Shih-Hung; Lin, Yi-Chen; Prijovic, Zeljko; Czosseck, Andreas; Leu, Yu-Lin; Roffler, Steve R.
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Interactions between nanoparticle corona proteins and the immune system
errCURRENT OPINION IN BIOTECHNOLOGY
IF7
err2023-12-01
err0
PREAI
errTran, Trieu T. M.; Roffler, Steve R.
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Bispecific antibodies for targeted delivery of anti-cancer therapeutic agents: A review
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2023-07-01
err17
PREAI
errBeishenaliev, Adilet; Loke, Yean Leng; Goh, Sook Jing; Geo, Hui Nee; Mugila, Malar; Misran, Misni; Chung, Lip Yong; Kiew, Lik Voon; Roffler, Steve; Teo, Yin Yin
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Antibodies against Poly(ethylene glycol) Activate Innate Immune Cells and Induce Hypersensitivity Reactions to PEGylated Nanomedicines聚乙二醇抗体激活天然免疫细胞并诱导对聚乙二醇化纳米药物的超敏反应
errACS NANO
IF16
err2023-03-16
err25
errOAAI
errChen, Wei-An; Chang, Deng-Yuan; Chen, Bing-Mae; Lin, Yi-Chen; Barenholz, Yechezekel; Roffler, Steve R.
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Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture抗甲氧基PEG抗体的加速清除取决于聚乙二醇化结构
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2023-02-01
err13
errOAAI
errLin, Yi-Chen; Chen, Bing-Mae; Tran, Trieu Thi My; Chang, Tien-Ching; Al-Qaisi, Talal Salem; Roffler, Steve R.
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Anti-PEG antibodies before and after a first dose of Comirnaty? (mRNA-LNP-based SARS-CoV-2 vaccine)抗PEG抗体之前和之后的第一个剂量的Comirnaty？(基于mrna-lnp的SARS-CoV-2疫苗)
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2023-02-01
err35
errOAAI
errBavli, Yaelle; Chen, Bing-Mae; Gross, Guy; Hershko, Alon; Turjeman, Keren; Roffler, Steve; Barenholz, Yechezkel
err分享
err收藏
Glucuronides: From biological waste to bio-nanomedical applications葡糖苷酸: 从生物废物到生物纳米医学应用
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2022-09-01
err3
PREAI
errBurnouf, Pierre-Alain; Roffler, Steve R.; Wu, Chia-Ching; Su, Yu-Cheng
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Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group
errCOMMUNICATIONS CHEMISTRY
IF6.2
err2022-08-01
err15
errOAAI
errNguyen, Minh-Tram T.; Shih, Yu-Chien; Lin, Meng-Hsuan; Roffler, Steve R.; Hsiao, Chiao-Yu; Cheng, Tian-Lu; Lin, Wen-Wei; Lin, En-Chi; Jong, Yuh-Jyh; Chang, Chin-Yuan; Su, Yu-Cheng
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Development of Irinotecan Liposome Armed with Dual-Target Anti-Epidermal Growth Factor Receptor and Anti-Fibroblast Activation Protein-Specific Antibody for Pancreatic Cancer Treatment
errPHARMACEUTICS
IF5.5
err2022-06-05
err8
errOAAI
errLin, Hung-Jun; Liang, Tien-Li; Chang, Yao-Yuan; Liu, Der-Zen; Fan, Jia-Yu; Roffler, Steve R.; Lin, Shyr-Yi
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Translational development of a tumor junction opening technology
errSCIENTIFIC REPORTS
IF3.9
err2022-05-11
err4
errOAAI
errKim, Jiho; Li, Chang; Wang, Hongjie; Kaviraj, Swarnendu; Singh, Sanjay; Savergave, Laxman; Raghuwanshi, Arjun; Gil, Sucheol; Germond, Audrey; Baldessari, Audrey; Chen, Bingmae; Roffler, Steve; Fender, Pascal; Drescher, Charles; Carter, Darrick; Lieber, Andre
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Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy用于癌症免疫化疗的双特异性T细胞接合器非共价修饰的载药聚乙二醇化纳米载体
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2022-04-01
err7
PREAI
errCheng, Wei-Jie; Chuang, Kuo-Hsiang; Lo, Yu-Ju; Chen, Michael; Chen, Yi-Jou; Roffler, Steve R.; Ho, Hsiu-O; Lin, Shyr-Yi; Sheu, Ming-Thau
err分享
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Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis
errPHARMACOLOGICAL RESEARCH
IF10.5
err2022-03-01
err15
PREAI
errCheng, Kai-Wen; Tseng, Chih-Hua; Chen, I. -Ju; Huang, Bo-Cheng; Liu, Hui-Ju; Ho, Kai-Wen; Lin, Wen-Wei; Chuang, Chih-Hung; Huang, Ming-Yii; Leu, Yu-Lin; Roffler, Steve R.; Wang, Jaw-Yuan; Chen, Yeh-Long; Cheng, Tian-Lu
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Impact of anti-PEG antibody affinity on accelerated blood clearance of pegylated epoetin beta in mice
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2022-02-01
err13
errOAAI
errChang, Tien-Ching; Chen, Bing-Mae; Wu, Jer-Yuan; Cheng, Tian-Lu; Roffler, Steve
err分享
err收藏
The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
errCOMMUNICATIONS BIOLOGY
IF5.1
err2022-01-11
err50
errOAAI
errAl-Aghbar, Mohammad Ameen; Jainarayanan, Ashwin K.; Dustin, Michael L.; Roffler, Steve R.
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A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor
errBIOMATERIALS SCIENCE
IF5.7
err2022-01-01
err10
errOAAI
errChen, Michael; Sheu, Ming-Thau; Cheng, Tian-Lu; Roffler, Steve R.; Lin, Shyr-Yi; Chen, Yi-Jou; Cheng, Yi-An; Cheng, Jing-Jy; Chang, Hsin-Yu; Wu, Tung-Yun; Kao, An-Pei; Ho, Yuan-Soon; Chuang, Kuo-Hsiang
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研究方向

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合作学者
合作期刊
M
Michael L. Dustin
H 指数: 129 · 论文数: 831
K
Katharina Landfester
H 指数: 111 · 论文数: 1.1K
A
Alexander V. Kabanov
H 指数: 107 · 论文数: 638
Y
Yechezkel Barenholz
H 指数: 86 · 论文数: 516
R
Raymond M. Schiffelers
H 指数: 85 · 论文数: 343
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