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4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress Calbert, Marissa L.; Chandramouly, Gurushankar; Adams, Clare M.; Saez-Ayala, Magali; Kent, Tatiana; Tyagi, Mrityunjay; Ayyadevara, V. S. S. Abhinav; Wang, Yifan; Krais, John J.; Gordon, John; Atkins, Jessica; Toma, Monika M.; Betzi, Stephane; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Goldman, Aaron R.; Gorman, Nicole; Mitra, Ramkrishna; Childers, Wayne E.; Grana, Xavier; Skorski, Tomasz; Johnson, Neil; Hurtz, Christian; Morelli, Xavier; Eischen, Christine M.; Pomerantz, Richard T. 分享 收藏
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Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms 靶向胶质母细胞瘤核心漏洞的联合药物筛选揭示了药理协同作用 Ariey-Bonnet, Jeremy; Berges, Raphael; Montero, Marie-Pierre; Mouysset, Baptiste; Piris, Patricia; Muller, Kevin; Pinna, Guillaume; Failes, Tim W.; Arndt, Greg M.; Morando, Philippe; Baeza-Kallee, Nathalie; Colin, Carole; Chinot, Olivier; Braguer, Diane; Morelli, Xavier; Andre, Nicolas; Carre, Manon; Tabouret, Emeline; Figarella-Branger, Dominique; Le Grand, Marion; Pasquier, Eddy 分享 收藏
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia Saez-Ayala, Magali; Hoffer, Laurent; Abel, Sebastien; Ben Yaala, Khaoula; Sicard, Benoit; Andrieu, Guillaume P.; Latiri, Mehdi; Davison, Emma K.; Ciufolini, Marco A.; Bremond, Paul; Rebuffet, Etienne; Roche, Philippe; Derviaux, Carine; Voisset, Edwige; Montersino, Camille; Castellano, Remy; Collette, Yves; Asnafi, Vahid; Betzi, Stephane; Dubreuil, Patrice; Combes, Sebastien; Morelli, Xavier 分享 收藏
Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/ Syntenin Protein-Protein Interaction: A Semi-Automated Hit Identification-to-Optimization Approach Hoffer, Laurent; Garcia, Manon; Leblanc, Raphael; Feracci, Mikael; Betzi, Stephane; Ben Yaala, Khaoula; Daulat, Avais M.; Zimmermann, Pascale; Roche, Philippe; Barral, Karine; Morelli, Xavier 分享 收藏
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CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation Carrasco, Kendall; Montersino, Camille; Derviaux, Carine; Saez-Ayala, Magali; Hoffer, Laurent; Restouin, Audrey; Castellano, Remy; Casassa, Justine; Roche, Philippe; Pasquier, Eddy; Combes, Sebastien; Morelli, Xavier; Collette, Yves; Betzi, Stephane 分享 收藏
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread Garcia, Manon; Hoffer, Laurent; Leblanc, Raphael; Benmansour, Fatiha; Feracci, Mikael; Derviaux, Carine; Egea-Jimenez, Antonio Luis; Roche, Philippe; Zimmermann, Pascale; Morelli, Xavier; Barral, Karine 分享 收藏
Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex Cherrak, Y.; Filella-Merce, I.; Schmidt, V.; Byrne, D.; Sgoluppi, V.; Chaiaheloudjou, R.; Betzi, S.; Morelli, X.; Nilges, M.; Pellarin, R.; Durand, E. 分享 收藏
Synergy and allostery in ligand binding by HIV-1 Nef Aldehaiman, Abdullah; Momin, Afaque A.; Restouin, Audrey; Wang, Luyao; Shi, Xiaoli; Aljedani, Safia; Opi, Sandrine; Lugari, Adrien; Hameed, Umar F. Shahul; Ponchon, Luc; Morelli, Xavier; Huang, Mingdong; Dumas, Christian; Collette, Yves; Arold, Stefan T. 分享 收藏
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo syntenin PDZ2结构域的药理学抑制会损害乳腺癌细胞的活性以及syndecan和EpCAM货物的外泌体负载 Leblanc, R.; Kashyap, R.; Barral, K.; Egea-Jimenez, A. L.; Kovalskyy, D.; Feracci, M.; Garcia, M.; Derviaux, C.; Betzi, S.; Ghossoub, R.; Platonov, M.; Roche, P.; Morelli, X.; Hoffer, L.; Zimmermann, Pascale 分享 收藏
In silicomolecular target prediction unveils mebendazole as a potent MAPK14 inhibitor Ariey-Bonnet, Jeremy; Carrasco, Kendall; Le Grand, Marion; Hoffer, Laurent; Betzi, Stephane; Feracci, Mikael; Tsvetkov, Philipp; Devred, Francois; Collette, Yves; Morelli, Xavier; Ballester, Pedro; Pasquier, Eddy 分享 收藏
Fr-PPIChem: An Academic Compound Library Dedicated to Protein- Protein Interactions Bosc, Nicolas; Muller, Christophe; Hoffer, Laurent; Lagorce, David; Bourg, Stephane; Derviaux, Carine; Gourdel, Marie-Edith; Rain, Jean-Christophe; Miller, Thomas W.; Villoutreix, Bruno O.; Miteva, Maria; Bonnet, Pascal; Morelli, Xavier; Sperandio, Olivier; Roche, Philippe 分享 收藏
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Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach Hoffer, Laurent; Voitovich, Yuliia V.; Raux, Brigitt; Carrasco, Kendall; Muller, Christophe; Fedorov, Aleksey Y.; Derviaux, Carine; Amouric, Agnes; Betzi, Stephane; Horvath, Dragos; Varnek, Alexandre; Collette, Yves; Combes, Sebastien; Roche, Philippe; Morelli, Xavier 分享 收藏
Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology 用于合理设计多药理学的双重蛋白激酶和核苷激酶调节剂 Hammam, Kahina; Saez-Ayala, Magali; Rebuffet, Etienne; Gros, Laurent; Lopez, Sophie; Hajem, Berengere; Humbert, Martine; Baudelet, Emilie; Audebert, Stephane; Betzi, Stephane; Lugari, Adrien; Combes, Sebastien; Letard, Sebastien; Casteran, Nathalie; Mansfield, Colin; Moussy, Alain; De Sepulveda, Paulo; Morelli, Xavier; Dubreuil, Patrice 分享 收藏
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