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张

张志民 (Zhimin Zhang)

jinan university

33H指数
184论文数
4.5K被引数
收录论文 97
发表时间
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Dual-Site Covalent Targeting Enables BD2-Selective BET Inhibition With Potent Antitumor Activity in Mice双位点共价靶向实现BD2选择性BET抑制，并展现强大的抗肿瘤活性（小鼠）
errAngewandte Chemie-International Edition
IF16.9
err2026-09-05
err0
PREAI
errJibo Kang; Xuan Wang; Hong Zhang; Jieying Lin; Peng Chen; Zuqin Wang; Zengjun Hao; Fengfei Miao; Fengcai Zhang; Tao Li; Yusheng Xie; Junjian Wang; Zhi-Min Zhang; Shao Q. Yao; Xiaoyun Lu
err分享
err收藏
Creating highly active fluoroacetate dehalogenases via gate-based synergetic chain design通过基于门控的协同链设计创建高活性氟乙酸盐脱卤酶
errNature Communications
IF15.7
err2026-04-30
err0
errOAAI
errCui-zhen Wang; Huisi Huang; Zhihui Hu; Longwei Gao; Zhi-qiao Lin; Ming Shi; Zhiyong Song; Min Li; Yueming Wang; Ke-Wei Chen; Yu Liu; Yuanhong Ma; Bo Chen; Qipeng Yan; Zhi-Min Zhang; Jian-bo Wang
err分享
err收藏
Structure-Based Design of Potent and Highly Selective NUAK1 Inhibitors by Exploiting a Unique Glutamate Switch for the Prevention of Tumor Growth; Migration; and Invasion基于独特谷氨酸开关的结构设计：高效且高选择性NUAK1抑制剂的研发，用于预防肿瘤生长、迁移及侵袭
errJournal of Medicinal Chemistry
IF6.8
err2026-03-19
err0
PREAI
errShan Li; Yingao Wang; Xuechen Liu; Hong Zhang; Chong Lei; Zhen Wang; Yuqing Zhang; Xiaoli Du; Lingrui Xu; Ziwen Li; Yuyan Shi; Xinpeng Ning; Ji Cao; Zhi-Min Zhang; Dawei Ma; Ke Ding
err分享
err收藏
Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids通过调节prenyltransferases中芳香笼的占有率，实现了稀有c-prenylated flavonoids的选择性高效生产
errNature Communications
IF15.7
err2026-02-19
err0
errOAAI
errRuiying Qiu; Huisi Huang; Junxi Chi; Longwei Gao; Qilin Gao; Min Li; Menghao Cai; Haishuang Yu; Shijie Wang; Zhilan Qian; Minchuan Jiang; Yu Liu; Bo Chen; Yang Zhou; Zhi-Min Zhang; Jian-bo Wang
err分享
err收藏
Discovery of SKP2-Recruiting PROTACs for Target Protein Degradation
errAdvanced Science
IF14.1
err2026-02-04
err0
errOAAI
errGuanjun Dong; Aima Huang; Ziqing Zhao; Bikai Lai; Xin Pan; Huiyu Yang; Xiaohan Xu; Tianwei Wang; Fangchen Zhao; Zhimin Zhang; Yongbo Xue; Guanjun Deng; Wenbin Deng; Jianwei Chen
err分享
err收藏
USP18 confers protection against allergic asthma by suppressing CCL8 production in alveolar type II epithelial cellsUSP18通过抑制肺泡II型上皮细胞中CCL8的产生，赋予对过敏性哮喘的保护作用。
errRespiratory Research
IF5
err2025-12-08
err0
errOAAI
errHuihui Zhang; Zhi Rao; Xiaoke Liu; Yahai Shu; Wuju Zhang; Jiachun Cai; Zehui Yao; Ying Lin; Zhiqing Cai; Zhimin Zhang; Pinglin Lai; Sheng Zhang; Yuxin Wang; Hong Wang; Wenping Chen; Wenjun Mao; Ran Wei; Xiaochun Bai
err分享
err收藏
Structural insights into heme-iron dependent N–N bond formation enzyme LnzB血红素铁依赖性N–N键形成酶LnzB的结构洞察
errCommunications Chemistry
IF6.2
err2025-11-10
err0
errOAAI
errHuisi Huang; Lu Wang; Pujian Chen; Tao Yang; Chengjun Zhu; Shaoyang Li; Yang Zhou; Yi Tan; Zhengqiu Li; Hong Zhang; Jianwei Chen; Zhi-Min Zhang
err分享
err收藏
Structural and Mechanistic Insights into Bacterial Hydrazine Biosynthesis细菌肼生物合成的结构与机制洞察
errJournal of the American Chemical Society
IF15.6
err2025-11-05
err0
PREAI
errGuiyun Zhao; Huisi Huang; Yifan Li; Jian Yang; Yuan-Yang Guo; Liqiao Xu; Lu Wang; Jingkun Shi; Miaolian Wu; Yu Feng; Binju Wang; Zhi-Min Zhang; Yi-Ling Du
err分享
err收藏
The design and synthesis of selective and potent selenium-containing KRASG12D inhibitors选择性且高效的含硒KRASG12D抑制剂的分子设计合成
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-07-24
err0
PREAI
errLiping Zhou; Yayuan Yang; Bingzhong Chen; Jie Wang; Ping Zhang; Yang Zhou; Jinwei Zhang; Xiaomei Ren; Zhen Wang; Weixue Huang; Zhimin Zhang; Xin Zhang; Shingpan Chan; Fengtao Zhou
err分享
err收藏
New insights into ER stress mediated by ATF6 and IRE1-XBP1 signals in yellow catfish under hypoxia
errAQUACULTURE
IF3.9
err2025-02-01
err0
PREAI
errWan, Ying; Liu, Haokun; Jin, Junyan; Zhang, Zhimin; Yang, Yunxia; Zhu, Xiaoming; Xie, Shouqi; Han, Dong
err分享
err收藏
β-Hydroxybutyrate ameliorates osteoarthritis through activation of the ERBB3 signaling pathway in miceΒ-羟基丁酸通过激活ERBB3信号通路改善小鼠骨关节炎
errJOURNAL OF BONE AND MINERAL RESEARCH
IF5.9
err2024-11-05
err2
PREAI
errCai, Zhiqing; Zhang, Zhimin; Leng, Jiarong; Xie, Mengyun; Zhang, Kang; Zhang, Jingyi; Zhang, Haiyan; Hu, Hongling; Deng, Yinghu; Bai, Xiaochun; Song, Qiancheng; Lai, Pinglin
err分享
err收藏
An efficient C-glycoside production platform enabled by rationally tuning the chemoselectivity of glycosyltransferases
errNATURE COMMUNICATIONS
IF15.7
err2024-10-15
err0
errOAAI
errLi, Min; Zhou, Yang; Wen, Zexing; Ni, Qian; Zhou, Ziqin; Liu, Yiling; Zhou, Qiang; Jia, Zongchao; Guo, Bin; Ma, Yuanhong; Chen, Bo; Zhang, Zhi-Min; Wang, Jian-bo
err分享
err收藏
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies通过共价键和前药/双药靶向策略理性设计的BCR-ABL激酶抑制剂，以改善白血病治疗
errJournal of Advanced Research
IF13
err2024-09-08
err0
errOAAI
errJie Sun; Liang Lou; Chengjun Zhu; Peng Chen; Guanghui Tang; Mingxi Gu; Shu Xia; Xiao Dong; Zhi-Min Zhang; Liqian Gao; Shao Q. Yao; Qicai Xiao
err分享
err收藏
Small Molecule-Induced Post-Translational Acetylation of Catalytic Lysine of Kinases in Mammalian Cells
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-08-20
err1
PREAI
errTang, Guanghui; Wang, Xuan; Huang, Huisi; Xu, Manyi; Ma, Xingyu; Miao, Fengfei; Lu, Xiaoyun; Zhang, Chong-Jing; Gao, Liqian; Zhang, Zhi-Min; Yao, Shao Q.
err分享
err收藏
Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-08-20
err1
PREAI
errWang, Chaofan; Fang, Yan; Zhou, Ziqin; Liu, Zhuoheng; Feng, Fang; Wan, Xuan; Li, Yan; Liu, Shuang; Ding, Jian; Zhang, Zhi-Min; Xie, Hua; Lu, Xiaoyun
err分享
err收藏
Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
errLIPIDS IN HEALTH AND DISEASE
IF4.2
err2024-06-27
err1
errOAAI
errLin, Xiu-lian; Zeng, Ya-ling; Ning, Jie; Cao, Zhe; Bu, Lan-lan; Liao, Wen-Jing; Zhang, Zhi-min; Zhao, Tan-jun; Fu, Rong-geng; Yang, Xue-Feng; Gong, Yong-zhen; Lin, Li-Mei; Cao, De-liang; Zhang, Cai-ping; Liao, Duan-fang; Li, Ya-Mei; Zeng, Jian-Guo
err分享
err收藏
Kinase Inhibition via Small Molecule-Induced Intramolecular Protein Cross-Linking
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-06-07
err0
PREAI
errWang, Xuan; Sun, Jie; Huang, Huisi; Tang, Guanghui; Chen, Peng; Xiang, Menghua; Li, Lin; Zhang, Zhi-Min; Gao, Liqian; Yao, Shao Q.
err分享
err收藏
Discovery of potent and orally bioavailable degraders of HPK1 based on a novel HPK1 binder
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errZhang, Zhimin; Wu, Mengqiang; Wang, Ling; Yang, Xi; Zhang, Zhiping; Guo, Liubin; Pan, Hao; Zhao, Mengting; Wang, Linli; Liu, Sirui; Dong, Zhao; Jiang, Chunhua; Zheng, Haowen; Liu, Dongzhou
err分享
err收藏
Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-02-13
err0
PREAI
errYang, Fang; Lin, Qianmeng; Song, Xiaojuan; Huang, Huisi; Chen, Xiaojuan; Tan, Jianwen; Li, Yun; Zhou, Yang; Tu, Zhengchao; Du, Hongli; Zhang, Zhi-min; Ortega, Raquel; Lin, Xiaojing; Patterson, Adam V.; Smaill, Jeff B.; Chen, Yongheng; Lu, Xiaoyun
err分享
err收藏
Case study on the influence of serving temperature on the aroma release and perception of Huangjiu, a fermented alcoholic beverage
errFOOD RESEARCH INTERNATIONAL
IF8
err2024-02-01
err2
PREAI
errZhou, Zhilei; Wang, Yan; Zhang, Zhimin; Ren, Qingxi; Ji, Zhongwei; Xu, Xibiao; Xu, Yuezheng; Mao, Jian
err分享
err收藏

研究方向

潜在药物靶标的作用机制研究酶催化药物分子的生物合成机制药物与靶蛋白作用机制研究
合作学者
合作期刊
N
Norbert Perrimon
H 指数: 154 · 论文数: 868
D
Dinshaw J. Patel
H 指数: 135 · 论文数: 837
李
李林 (Lin Li)
H 指数: 115 · 论文数: 3.0K
H
Hong Mā
H 指数: 106 · 论文数: 492
M
Marie D. Burdick
H 指数: 100 · 论文数: 293
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