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A

Alfred Y. Lee

Merck & Co. Inc.

19H指数
62论文数
2.6K被引数
收录论文 31
发表时间
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Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide生物催化级联实现大环肽enlicitide的制造
errScience
IF45.8
err2026-05-07
err0
PREAI
errArtis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong
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Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution通过重审多晶型景观、晶体结构预测及形式4结构解析来预测利托那韦危机
errCommunications Chemistry
IF6.2
err2025-12-22
err0
errOAAI
errLuca Iuzzolino; Andrew W. Kelly; Mohammad T. Chaudhry; Cristian Jandl; Danny Stam; Alfred Y. Lee
err分享
err收藏
A Conceptual Framework for the Crystallizability of Organic Compounds有机化合物结晶性概念框架
errJournal of the American Chemical Society
IF15.6
err2025-12-10
err0
errOAAI
errJacco van de Streek; Hanno Dietrich; Dzmitry Firaha; Martin Ludwig; Alexander Ovchinnikov; Kiran Sasikumar; Antonio G. DiPasquale; Luca Iuzzolino; Andrew W. Kelly; Pierre Lafarguette; Alfred Y. Lee; Benoît Robert; Grahame R. Woollam; Marcus A. Neumann
err分享
err收藏
Revisiting the solid-state landscape of creatine citric acid: A salt or a cocrystal?
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2025-01-01
err0
PREAI
errYork, Gregory; Kelly, Andrew W.; Robison, Lee; Iuzzolino, Luca; Lee, Alfred Y.
err分享
err收藏
Structure Elucidation of Pharmaceutically Relevant Compounds Within Pyrene-Based Frameworks
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2024-10-16
err1
PREAI
errChaudhry, Mohammad T.; Newman, Justin A.; Lee, Alfred Y.; Patel, Anisha
err分享
err收藏
Interrogating the Solid-Solid Phase Transition Behavior of a Molecular Crystal with a Diverse Range of Solid-State Analytical Techniques and Computational Predictions
errCRYSTAL GROWTH & DESIGN
IF3.4
err2024-09-30
err0
PREAI
errZhu, Xiaolong; Kelly, Andrew W.; Cao, Tuyen; Iuzzolino, Luca; Gozzo, Fabia; Reinle-Schmitt, Mathilde; Robison, Lee; Patel, Anisha; Lee, Alfred Y.
err分享
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Unprecedented Packing Polymorphism of Oxindole: An Exploration Inspired by Crystal Structure Prediction羟吲哚的空前堆积多态性: 受晶体结构预测启发的探索
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-07-17
err0
PREAI
errWu, Emily J.; Kelly, Andrew W.; Iuzzolino, Luca; Lee, Alfred Y.; Zhu, Xiaolong
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err收藏
Formation, Selective Encapsulation, and Tautomerization Control of Isoindolone Utilizing Guanidinium Sulfonate Frameworks
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2024-05-17
err2
PREAI
errChaudhry, Mohammad T.; Newman, Justin A.; Lee, Alfred Y.
err分享
err收藏
Benchmarking Guanidinium Organosulfonate Hydrogen-Bonded Frameworks for Structure Determination of Encapsulated Guests用于确定封装客体结构的基准测试有机磺酸胍氢键框架
errACS MATERIALS LETTERS
IF8.7
err2024-04-10
err3
errOAAI
errYusov, Anna; Dillon, Alexandra M.; Chaudhry, Mohammad T.; Newman, Justin A.; Lee, Alfred Y.; Ward, Michael D.
err分享
err收藏
Supramolecular Mille-Feuille: Adaptive Guest Inclusion in a New Aliphatic Guanidinium Monosulfonate Hydrogen-Bonded Framework
errCRYSTAL GROWTH & DESIGN
IF3.4
err2024-04-04
err5
errOAAI
errDillon, Alexandra M.; Yusov, Anna; Chaudhry, Mohammad T.; Newman, Justin A.; Demkiw, Krystyna M.; Woerpel, K. A.; Lee, Alfred Y.; Ward, Michael D.
err分享
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Gefapixant Citrate (MK-7264) Sulfonamide Step Speciation Study: Investigation into Precipitation-Dissolution Events during Addition of Chlorosulfonic Acid
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-02-08
err2
PREAI
errRivera, Nelo R.; Cohen, Ryan D.; Zhang, Si-Wei; Dance, Zachary E. X.; Halsey, Holst M.; Song, Siqing; Bu, Xiaodong; Reibarkh, Mikhail; Ren, Hong; Lee, Alfred Y.; Chang, Darryl; Lohani, Sachin
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Understanding crystal nucleation mechanisms: where do we stand? General discussion了解晶体成核机制: 我们的立场是什么？一般讨论
errFARADAY DISCUSSIONS
IF3.1
err2022-01-01
err16
errOAAI
errAnderson, Michael W.; Bennett, Matthew; Cedeno, Ruel; Colfen, Helmut; Cox, Stephen J.; Cruz-Cabeza, Aurora J.; De Yoreo, James J.; Drummond-Brydson, Rik; Dudek, Marta K.; Fichthorn, Kristen A.; Finney, Aaron R.; Ford, Ian; Galloway, Johanna M.; Gebauer, Denis; Grossier, Romain; Harding, John H.; Hare, Alan; Horvath, Dezso; Hunter, Liam; Kim, Joonsoo; Kimura, Yuki; Kirschhock, Christine E. A.; Kiselev, Alexei A.; Kras, Weronika; Kuttner, Christian; Lee, Alfred Y.; Liao, Zhiyu; Maini, Lucia; Nilsson Lill, Sten O.; Pellens, Nick; Price, Sarah L.; Rietveld, Ivo B.; Rimer, Jeffrey D.; Roberts, Kevin J.; Rogal, Jutta; Salvalaglio, Matteo; Sandei, Ilaria; Schuszter, Gabor; Sefcik, Jan; Sun, Wenhao; ter Horst, Joop H.; Ukrainczyk, Marko; Van Driessche, Alexander E. S.; Veesler, Stephane; Vekilov, Peter G.; Verma, Vivek; Whale, Thomas; Wheatcroft, Helen P.; Zeglinski, Jacek
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Bullet-Proofing Doravirine (MK-1439) Starting Material Supply: Rapid Identification and Response to a New Polymorph of Ethyl Ester
errCRYSTAL GROWTH & DESIGN
IF3.4
err2021-06-14
err2
PREAI
errLarpent, Patrick; Iuzzolino, Luca; Schoell, Jochen; Codan, Lorenzo; Tan, Melissa; Newman, Justin A.; Lee, Alfred Y.
err分享
err收藏
Advanced characterisation techniques: multi-scale, in situ, and time-resolved: general discussion
errFARADAY DISCUSSIONS
IF3.1
err2021-01-01
err2
PREAI
errBrammer, Lee; Burrows, Andrew D.; Chong, Samantha Yu-ling; Craig, Gavin; Evans, Jack; Farha, Omar; Farrusseng, David; Fischer, Michael; Goodwin, Andrew; Huang, Zhehao; Johnson, Ben; Kaskel, Stefan; Kitagawa, Susumu; Lavenn, Christophe; Lee, Alfred Y.; Lee, Jet-Sing M.; Matsuda, Ryotaro; Phillips, Anthony E.; Rainer, Daniel N.; Ryder, Matthew R.; Schmid, Rochus; Shivanna, Mohana; Sumby, Christopher; Taddei, Marco; Terry, Lui; Ting, Valeska P.; van der Veen, Monique A.; West, Norton G.
err分享
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 6: Development of an Improved Commercial Salt Formation Process
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2020-10-23
err6
PREAI
errMaloney, Kevin M.; Zhang, Si-Wei; Mohan, Anne E.; Lee, Alfred Y.; Larpent, Patrick; Ren, Hong; Humphrey, Guy R.; Desmond, Richard; DiBenedetto, Michael; Liu, Wenjun; Lee, Ivan H.; Sirota, Eric; Di Maso, Michael J.; Alwedi, Embarek; Song, Siqing; Chang, Hsieh Yao D.
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264). Part 5: Completion of the API Free Base via a Direct Chlorosulfonylation Process
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2020-10-20
err8
PREAI
errDi Maso, Michael J.; Ren, Hong; Zhang, Si-Wei; Liu, Wenjun; Desmond, Richard; Alwedi, Embarek; Narsimhan, Karthik; Kalinin, Alexei; Larpent, Patrick; Lee, Alfred Y.; Ren, Sumei; Maloney, Kevin M.
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 2: Development of a Robust Process for Phenol Synthesis
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2020-10-16
err14
PREAI
errPeng, Feng; Humphrey, Guy R.; Maloney, Kevin M.; Lehnherr, Dan; Weisel, Mark; Levesque, Francois; Naber, John R.; Brunskill, Andrew P. J.; Larpent, Patrick; Zhang, Si-Wei; Lee, Alfred Y.; Arvary, Rebecca A.; Lee, Claire H.; Bishara, Daniel; Narsimhan, Karthik; Sirota, Eric; Whittington, Michael
err分享
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Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2020-10-16
err21
PREAI
errRen, Hong; Maloney, Kevin M.; Basu, Kallol; Di Maso, Michael J.; Humphrey, Guy R.; Peng, Feng; Desmond, Richard; Otte, Douglas A. L.; Alwedi, Embarek; Liu, Wenjun; Zhang, Si-Wei; Song, Siqing; Arvary, Rebecca A.; Zompa, Michael A.; Lehnherr, Dan; Martin, Gary E.; Chang, Hsieh Yao D.; Mohan, Anne E.; Guzman, Francisco J.; Jellett, Lisa; Lee, Alfred Y.; Spencer, Glenn; Fisher, Elizabeth S.; Naber, John R.; Gao, Hong; Lohani, Sachin; Ruck, Rebecca T.; Campeau, Louis-Charles
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Process Development of the HCV NS5B Site D Inhibitor MK-8876
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2016-07-01
err11
PREAI
errWilliams, Michael J.; Chen, Qinghao; Codan, Lorenzo; Dermenjian, Renee K.; Dreher, Spencer; Gibson, Andrew W.; He, Xianliang; Jin, Yan; Keen, Stephen P.; Lee, Alfred Y.; Lieberman, David R.; Lin, Wei; Liu, Guiquan; McLaughlin, Mark; Reibarkh, Mikhail; Scott, Jeremy P.; Strickfuss, Sophie; Tan, Lushi; Varsolona, Richard J.; Wen, Feng
err分享
err收藏
One-Phase Crystal Disorder in Pharmaceutical Solids and Its Implication for Solid-State Stability
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2011-10-01
err5
PREAI
errClawson, Jacalyn S.; Kennedy-Gabb, Sonya; Lee, Alfred Y.; Copley, Royston C. B.
err分享
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