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Pragmatic nationwide master observational trial based on genomic alterations in advanced solid tumors: KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS)-II study protocol KCSG AL-22-09 Kim, Sun Young; Kim, Jee Hyun; Kim, Tae-Yong; Park, Sook Ryun; Yoon, Shinkyo; Lee, Soohyeon; Lee, Se-Hoon; Kim, Tae Min; Han, Sae-Won; Kim, Hye Ryun; Yun, Hongseok; Lee, Sejoon; Kim, Jihun; Choi, Yoon-La; Choi, Kui Son; Chae, Heejung; Ryu, Hyewon; Lee, Gyeong-Won; Zang, Dae Young; Ahn, Joong Bae 分享 收藏
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial Divarasib联合西妥昔单抗治疗KRAS G12C-positive结直肠癌: 1b期临床试验 Desai, Jayesh; Alonso, Guzman; Kim, Se Hyun; Cervantes, Andres; Karasic, Thomas; Medina, Laura; Shacham-Shmueli, Einat; Cosman, Rasha; Falcon, Alejandro; Gort, Eelke; Guren, Tormod; Massarelli, Erminia; Miller Jr, Wilson H.; Paz-Ares, Luis; Prenen, Hans; Amatu, Alessio; Cremolini, Chiara; Kim, Tae Won; Moreno, Victor; Ou, Sai-Hong I.; Passardi, Alessandro; Sacher, Adrian; Santoro, Armando; Stec, Rafal; Ulahannan, Susanna; Arbour, Kathryn; Lorusso, Patricia; Luo, Jia; Patel, Manish R.; Choi, Yoonha; Shi, Zhen; Mandlekar, Sandhya; Lin, Mark T.; Royer-Joo, Stephanie; Chang, Julie; Jun, Tomi; Dharia, Neekesh V.; Schutzman, Jennifer L.; Han, Sae-Won 分享 收藏
Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation 单药Divarasib (GDC-6036) 在具有KRAS G12C突变的实体瘤中 Sacher, Adrian; LoRusso, Patricia; Patel, Manish R.; Miller, Wilson H.; Garralda, Elena; Forster, Martin D.; Santoro, Armando; Falcon, Alejandro; Kim, Tae Won; Paz-Ares, Luis; Bowyer, Samantha; de Miguel, Maria; Han, Sae-Won; Krebs, Matthew G.; Lee, Jong-Seok; Cheng, Michael L.; Arbour, Kathryn; Massarelli, Erminia; Choi, Yoonha; Shi, Zhen; Mandlekar, Sandhya; Lin, Mark T.; Royer-Joo, Stephanie; Chang, Julie; Dharia, Neekesh V.; Schutzman, Jennifer L.; Desai, Jayesh 分享 收藏
Total neoadjuvant therapy with short-course radiotherapy Versus long-course neoadjuvant chemoradiotherapy in Locally Advanced Rectal cancer, Korean trial (TV-LARK trial): study protocol of a multicentre randomized controlled trial Kim, Min Jung; Lee, Dae Won; Kang, Hyun-Cheol; Park, Ji Won; Ryoo, Seung-Bum; Han, Sae-Won; Kim, Kyung Su; Chie, Eui Kyu; Oh, Jae Hwan; Jeong, Woon Kyung; Kim, Byoung Hyuck; Nam, Eun Mi; Jeong, Seung-Yong 分享 收藏
Personalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer Ryoo, Seung-Bum; Heo, Sunghoon; Lim, Yoojoo; Lee, Wookjae; Cho, Su Han; Ahn, Jongseong; Kang, Jun-Kyu; Kim, Su Yeon; Kim, Hwang-Phill; Bang, Duhee; Kang, Sung-Bum; Yu, Chang Sik; Oh, Seong Taek; Park, Ji Won; Jeong, Seung-Yong; Kim, Young-Joon; Park, Kyu Joo; Han, Sae-Won; Kim, Tae-You 分享 收藏
Mutational evolution after chemotherapy-progression in metastatic colorectal cancer revealed by circulating tumor DNA analysis 循环肿瘤DNA分析揭示转移性结直肠癌化疗进展后的突变演变 Kim, Sheehyun; Cha, Yongjun; Lim, Yoojoo; Roh, Hanseong; Kang, Jun-Kyu; Lee, Kyung-Hun; Kim, Min Jung; Park, Ji Won; Ryoo, Seung-Bum; Kim, Hwang-Phill; Jeong, Seung-Yong; Park, Kyu Joo; Han, Sae-Won; Kim, Tae-You 分享 收藏
A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors Murciano-Goroff, Yonina R.; Heist, Rebecca S.; Kuboki, Yasutoshi; Koyama, Takafumi; Ammakkanavar, Natraj Reddy; Hollebecque, Antoine; Patnaik, Amita; Shimizu, Toshio; Spira, Alexander I.; Nagasaka, Misako; Han, Ji-Youn; Iams, Wade Thomas; Deming, Dustin; Call, Justin; Cassier, Philippe; Han, Sae-Won; Chu, Quincy Siu-Chung; Cosman, Rasha; Durm, Gregory; Burns, Timothy; Willard, Melinda D.; Liu, Shiyao; Callies, Sophie; Balar, Arjun V.; Sabari, Joshua K. 分享 收藏
Phase Ib study of GDC-6036 in combination with cetuximab in patients with colorectal cancer (CRC) with KRAS G12C mutation Desai, Jayesh; Han, Sae-Won; Lee, Jong-Seok; Shacham-Shmueli, Einat; Massarelli, Erminia; Cervantes, Andres; Garralda, Elena; Falcon, Alejandro; Miller, Wilson H.; Gort, Eelke; Karasic, Thomas; Siena, Salvatore; Stec, Rafal; Medina, Laura; Paz-Arez, Luis; Delmonte, Angelo; Sacher, Adrian; Prenen, Hans; Forster, Martin; Kim, Tae Won; Krebs, Matthew G.; Cosman, Rasha; Choi, Yoonha; Mandlekar, Sandhya; Lin, Mark T.; Yau, Kenneth K.; Chang, Julie; Royer-Joo, Stephanie; Dharia, Neekesh V.; Schutzman, Jennifer L.; Patel, Manish 分享 收藏
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization Young, Lucy C.; de Salazar, Ruby Goldstein; Han, Sae-Won; Huang, Zi Yi Stephanie; Merk, Alan; Drew, Matthew; Darling, Joseph; Wall, Vanessa; Grisshammer, Reinhard; Cheng, Alice; Allison, Madeline R.; Sale, Matthew J.; Nissley, Dwight V.; Esposito, Dominic; Ognjenovic, Jana; McCormick, Frank 分享 收藏
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Timaul, Neilawattie Merna; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S.; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M.; Janne, Pasi A.; McCormick, Frank; Yao, Zhan; Rosen, Neal 分享 收藏
Clinical utility of circulating tumor DNA (ctDNA) during disease course of metastatic colorectal cancer (mCRC) Lim, Yoojoo; Kim, Sheehyun; Kang, Jun-Kyu; Kim, Hwang-Phil; Roh, Hanseong; Kim, Su Yeon; Lee, Dongin; Bang, Duhee; Jeong, Seung-Yong; Park, Kyu Joo; Han, Sae-Won; Kim, Tae-You 分享 收藏
Dynamic changes in longitudinal circulating tumour DNA profile during metastatic colorectal cancer treatment Kim, Sheehyun; Lim, Yoojoo; Kang, Jun-Kyu; Kim, Hwang-Phill; Roh, Hanseong; Kim, Su Yeon; Lee, Dongin; Bang, Duhee; Jeong, Seung-Yong; Park, Kyu Joo; Han, Sae-Won; Kim, Tae-You 分享 收藏
Prognostic Impact of Extramural Lymphatic, Vascular, and Perineural Invasion in Stage II Colon Cancer: A Comparison With Intramural Invasion II期结肠癌壁外淋巴，血管和神经周围浸润的预后影响: 与壁内浸润的比较 Cho, Sang Sik; Park, Ji Won; Kang, Gyeong Hoon; Kim, Jung Ho; Bae, Jeong Mo; Han, Sae-Won; Kim, Tae-You; Kim, Min Jung; Ryoo, Seung-Bum; Jeong, Seung-Yong; Park, Kyu Joo 分享 收藏
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Patient-derived organoids as a preclinical platform for precision medicine in colorectal cancer 患者来源的类器官作为结直肠癌精准医学的临床前平台 Cho, Young-Won; Min, Dong-Wook; Kim, Hwang-Phill; An, Yohan; Kim, Sheehyun; Youk, Jeonghwan; Chun, Jaeyoung; Im, Jong Pil; Song, Sang-Hyun; Ju, Young Seok; Han, Sae-Won; Park, Kyu Joo; Kim, Tae-You 分享 收藏
Circulating tumor DNA sequencing in colorectal cancer patients treated with first-line chemotherapy with anti-EGFR Lim, Yoojoo; Kim, Sheehyun; Kang, Jun-Kyu; Kim, Hwang-Phill; Jang, Hoon; Han, Hyojun; Kim, Hyoki; Kim, Min Jung; Lee, Kyung-Hun; Ryoo, Seung-Bum; Park, Ji Won; Jeong, Seung-Yong; Park, Kyu Joo; Kang, Gyeong Hoon; Han, Sae-Won; Kim, Tae-You 分享 收藏
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A phase 1 dose-escalation and dose-expansion study to assess the safety and efficacy of CKD-516, a novel vascular disrupting agent, in combination with Irinotecan in patients with previously treated metastatic colorectal cancer Jeong, Hyehyun; Hong, Yong Sang; Kim, Jeong Eun; Lim, Hyeong-Seok; Ahn, Joong Bae; Shin, Sang Joon; Park, Young Suk; Kim, Seung Tae; Han, Sae-Won; Kim, Tae-You; Kim, Tae Won 分享 收藏
Phase II Study of Avelumab in Patients with Advanced Hepatocellular Carcinoma Previously Treated with Sorafenib Lee, Dae-Won; Cho, Eun Ju; Lee, Jeong-Hoon; Yu, Su Jong; Kim, Yoon Jun; Yoon, Jung-Hwan; Kim, Tae-Yong; Han, Sae-Won; Oh, Youn; Im, Seock-Ah; Kim, Tae-You; Lee, Youngeun; Kim, Haeryoung; Lee, Kyung-Hun 分享 收藏
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