Ovanes Mekenyan - Publications, H-index & Citations

Ovanes Mekenyan

laboratory of mathematical chemistry, as. zlatarov university , bourgas ,

46H指数

212论文数

6.4K被引数

收录论文 53

发表时间

Modeling metabolism: Evolution of toxicodynamic and toxicokinetic considerations. Adding a new kinetics layer 代谢建模：毒效动力学和毒代动力学考量的演变。添加新的动力学层

Computational Toxicology

IF2.9

2025-12-02

PREAI

A. Chapkanov; H. Ivanova; G. Poryazova; I. Todorova; T.W. Schultz; O.G. Mekenyan

N-nitrosamines: in silico modelling of DNA reactivity and identification of metabolic precursors N-亚硝胺：基于计算机的DNA反应性建模及代谢前体的鉴定

Mutagenesis

IF4.3

2025-07-07

OAAI

Hristiana Ivanova; Petko I Petkov; Sunil Kulkarni; Tara Barton-Maclaren; Elena Kaloyanova; Stefan Kotov; Kalin Kirilov; Terry W Schultz; Ovanes G Mekenyan

In silico predictions of sub-chronic effects: Read-across using metabolic relationships between parents and transformation products

COMPUTATIONAL TOXICOLOGY

IF2.9

2024-06-01

PREAI

Yordanova, Darina G.; Kuseva, Chanita D.; Ivanova, Hristiana; Schultz, Terry W.; Rocha, Vanessa; Natsch, Andreas; Laue, Heike; Mekenyan, Ovanes G.

Uncertainty in the results from oral repeated dose toxicity tests: Impact on regulatory classifications

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2024-01-01

PREAI

Chapkanov, Atanas; Schultz, Terry W.; Mekenyan, Ovanes G.

Estimating uncertainty in LLNA EC3 data and its impact on regulatory classifications

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2023-03-01

PREAI

Chapkanov, Atanas; Schultz, Terry W.; Yordanova, Darina; Kirilov, Kalin; Ivanova, Hristiana; Mekenyan, Ovanes G.

Predicting explosive properties of chemicals accounting for thermodynamic and kinetic factors

COMPUTATIONAL TOXICOLOGY

IF2.9

2022-08-01

PREAI

Kuseva, Chanita; Marinov, Valentin; Pavlov, Todor; Petkov, Todor; Chapkanov, Atanas; Dimitrova, Detelina; Wombacher, Tobias; Mullen-Hinkle, Sarah; Zhu, Wisdom; Siebold, Michael; Mekenyan, Ovanes

Assessment of uncertainty and credibility of predictions by the OECD QSAR Toolbox automated read-across workflow for predicting acute oral toxicity 通过OECD QSAR工具箱评估预测的不确定性和可信度预测急性口服毒性的自动读取工作流程

COMPUTATIONAL TOXICOLOGY

IF2.9

2022-05-01

PREAI

Schultz, Terry W.; Chapkanov, Atanas; Kutsarova, Stela; Mekenyan, Ovanes G.

Estimating the reliability of simulated metabolism using documented data and theoretical knowledge. QSAR application

COMPUTATIONAL TOXICOLOGY

IF2.9

2022-05-01

PREAI

Dermen, Irina A.; Ivanova, Hristiana I.; Kaloyanova, Elena K.; Dimitrov, Nadezhda H.; Kesova, Antonia D.; Pavlov, Todor S.; Schultz, Terry W.; Mekenyan, Ovanes G.

Differences between in vitro and in vivo genotoxicity due to metabolism: The role of kinetics

COMPUTATIONAL TOXICOLOGY

IF2.9

2022-05-01

PREAI

Petkov, P. I.; Ivanova, H.; Honma, M.; Yamada, T.; Morita, T.; Furuhama, A.; Kotov, S.; Kaloyanova, E.; Dimitrova, G.; Mekenyan, O.

The QSAR Toolbox automated read-across workflow for predicting acute oral toxicity: II. Verification and validation 用于预测急性口服毒性的QSAR工具箱自动读取工作流程: II。验证和确认

COMPUTATIONAL TOXICOLOGY

IF2.9

2021-11-01

PREAI

Kutsarova, Stela; Schultz, Terry W.; Chapkanov, Atanas; Cherkezova, Daniela; Mehmed, Aycel; Stoeva, Stoyanka; Kuseva, Chanita; Yordanova, Darina; Georgiev, Marin; Petkov, Todor; Mekenyan, Ovanes G.

Automated read-across workflow for predicting acute oral toxicity: I. The decision scheme in the QSAR toolbox 用于预测急性口服毒性的自动阅读工作流程: I.QSAR工具箱中的决策方案

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2021-10-01

PREAI

Kutsarova, Stela; Mehmed, Aycel; Cherkezova, Daniela; Stoeva, Stoyanka; Georgiev, Marin; Petkov, Todor; Chapkanov, Atanas; Schultz, Terry W.; Mekenyan, Ovanes G.

Selection of Representative Constituents for Unknown, Variable, Complex, or Biological Origin Substance Assessment Based on Hierarchical Clustering

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

IF2.8

2021-09-09

PREAI

Yordanova, Darina G.; Patterson, Timothy J.; North, Colin M.; Camenzuli, Louise; Chapkanov, Atanas S.; Pavlov, Todor S.; Mekenyan, Ovanes G.

Criteria for quantitative assessment of metabolic similarity between chemicals. II. Application to human health endpoints

COMPUTATIONAL TOXICOLOGY

IF2.9

2021-08-01

PREAI

Kuseva, Chanita; Yordanova, Darina; Ivanova, Hristiana; Poryazova, Gergana; Dermen, Irina; Kesova, Antonia; Pavlov, Todor; Schultz, Terry; Mekenyan, Ovanes G.

Assessing metabolic similarity for read-across predictions

COMPUTATIONAL TOXICOLOGY

IF2.9

2021-05-01

PREAI

Yordanova, Darina G.; Schultz, Terry W.; Kuseva, Chanita D.; Mekenyan, Ovanes G.

Criteria for assessing the reliability of the predictions: II. CATALOGIC BOD and BCF base-line models

COMPUTATIONAL TOXICOLOGY

IF2.9

2021-02-01

PREAI

Dermen, I. A.; Dimitrova, N. H.; Schultz, T. W.; Mekenyan, O. G.

Criteria for assessing the reliability of toxicity predictions: I. TIMES Ames mutagenicity model

COMPUTATIONAL TOXICOLOGY

IF2.9

2021-02-01

PREAI

Petkov, P. I.; Ivanova, H.; Schultz, T. W.; Mekenyan, O. G.

Mechanistic relationship between biodegradation and bioaccumulation. Practical outcomes

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2019-10-01

PREAI

Dimitrov, Sabcho D.; Dermen, Irina A.; Dimitrova, Nadezhda H.; Vasilev, Krasimir G.; Schultz, Terry W.; Mekenyan, Ovanes G.

The implementation of RAAF in the OECD QSAR Toolbox

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2019-07-01

PREAI

Kuseva, Chanita; Schultz, Terry W.; Yordanova, Darina; Tankova, Ksenia; Kutsarova, Stela; Pavlov, Todor; Chapkanov, Atanas; Georgiev, Marin; Gissi, Andrea; Sobanski, Tomasz; Mekenyan, Ovanes G.

UVCB substances II: Development of an endpoint-nonspecific procedure for selection of computationally generated representative constituents

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

IF2.8

2019-01-14

PREAI

Kutsarova, Stela S.; Yordanova, Darina G.; Karakolev, Yordan H.; Stoeva, Stoyanka; Comber, Mike; Hughes, Christopher B.; Vaiopoulou, Eleni; Dimitrov, Sabcho D.; Mekenyan, Ovanes G.

Development of a Decision Tree for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2018-07-17

OAAI

Enoch, Steven J.; Schultz, Terry W.; Popova, Ioanna G.; Vasilev, Krasimir G.; Mekenyan, Ovanes G.

研究方向