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J

Jonathan P. McMullen

Merck & Co., Inc.

22H指数
60论文数
3.2K被引数
收录论文 41
发表时间
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A Comparative Study of Strategies for Incorporating Uncertainty in Design Space Determination for Pharmaceutical Manufacturing制药制造中设计空间确定中纳入不确定性的策略比较研究
errIndustrial & Engineering Chemistry Research
IF3.9
err2025-10-29
err0
PREAI
errIman Moshiritabrizi; Jonathan P. McMullen; Brian M. Wyvratt; Kimberley B. McAuley
err分享
err收藏
Using extent of reaction to simplify dynamic kinetic models with fast equilibrium reactions利用反应程度简化包含快速平衡反应的动力学模型
errChemical Engineering Science
IF4.3
err2025-09-14
err0
PREAI
errAnh-Duong D. Vo; Iman Moshiritabrizi; Scott Bowen; Jonathan P. McMullen; Brian M. Wyvratt; Kimberley B. McAuley
err分享
err收藏
Editorial overview: Digital design of pharmaceutical manufacturing processes编辑概述：制药制造过程的数字化设计
errCURRENT OPINION IN CHEMICAL ENGINEERING
IF6.8
err2025-06-01
err0
PREAI
errMcauley, Kimberley B.; Mcmullen, Jonathan P.; Munoz, Salvador Garcia
err分享
err收藏
Development and simulation of annular flow photoreactors: integration of light-diffusing fibers as optical diffusers with laser diodes
errREACTION CHEMISTRY & ENGINEERING
IF3.1
err2025-01-01
err0
errOAAI
errDe Hert, Sergio Carrillo; Lopez-Rodriguez, Rafael; Di Maso, Michael J.; McMullen, Jonathan P.; Ferguson, Steven
err分享
err收藏
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation-Lithiation as a Batch-Flow Process
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-05-09
err0
PREAI
errOtte, Douglas A. L.; Larson, Reed T.; Alwedi, Embarek; Armiger, Travis; Chen, Yonggang; Chung, Cheol K.; Corry, James; Desmond, Richard; Fier, Patrick S.; Franklin, Robert D.; Guetschow, Erik D.; Hall, Jackson R.; Halsey, Holst M.; Hartmanshenn, Clara; Jellett, Lisa; Kuhl, Nadine; Levesque, Francois; McMullen, Jonathan P.; Patel, Pratiq A.; Paulines, Mellie June; Ren, Hong; Rodrigues, Vailankanni L.; Ruccolo, Serge; Tan, Lushi; Thaisrivongs, David A.; Xiao, Kai-Jiong
err分享
err收藏
Integrating Functional Principal Component Analysis with Data-Rich Experimentation for Enhanced Drug Substance Development
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-03-04
err4
PREAI
errMcmullen, Jonathan P.; Wyvratt, Brian M.; Hong, Cynthia M.; Purohit, Akasha K.
err分享
err收藏
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-02-19
err19
PREAI
errCheung-Lee, Wai Ling; Kolev, Joshua N.; Mcintosh, John A.; Gil, Agnieszka A.; Pan, Weilan; Xiao, Li; Velasquez, Juan E.; Gangam, Rekha; Winston, Matthew S.; Li, Shasha; Abe, Kotoe; Alwedi, Embarek; Dance, Zachary E. X.; Fan, Haiyang; Hiraga, Kaori; Kim, Jungchul; Kosjek, Birgit; Le, Diane N.; Marzijarani, Nastaran Salehi; Mattern, Keith; Mcmullen, Jonathan P.; Narsimhan, Karthik; Vikram, Ajit; Wang, Wei; Yan, Jia-Xuan; Yang, Rong-Sheng; Zhang, Victoria; Zhong, Wendy; Dirocco, Daniel A.; Morris, William J.; Murphy, Grant S.; Maloney, Kevin M.
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5-Chemoenzymatic Diastereoselective Fluorination/DKR
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-02-07
err4
PREAI
errMccann, Scott D.; Dubina, Sean H.; Kosjek, Birgit; Alwedi, Embarek; Behre, Taylor; Burgess, Samantha A.; Dal Poggetto, Guilherme; Dirocco, Daniel A.; Hartmanshenn, Clara; Mcmullen, Jonathan P.; Padivitage, Nilusha; Sun, Alexandra C.
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6-Development of a Nucleophilic Aromatic Substitution in Water
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-02-05
err4
PREAI
errLe, Diane N.; Wright, Timothy J.; Alwedi, Embarek; Hartmanshenn, Clara; Li, Hong; McMullen, Jonathan P.; DiRocco, Daniel A.
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1-Process History and Development Strategy
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-02-05
err6
PREAI
errDiRocco, Daniel A.; Zhong, Yong-Li; Le, Diane N.; McCann, Scott D.; Hethcox, J. Caleb; Kim, Jungchul; Kolev, Joshua N.; Kosjek, Birgit; Dalby, Stephen M.; Mcmullen, Jonathan P.; Gangam, Rekha; Morris, William J.
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 3-Development of a Scalable Enzymatic Oxidation ProcessBelzutifan绿色和可持续制造工艺的发展: 第3部分-可扩展的酶促氧化工艺的开发
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-02-01
err12
PREAI
errKim, Jungchul; Zhang, Victoria; Abe, Kotoe; Qin, Yangzhong; Dirocco, Daniel A.; McMullen, Jonathan P.; Sun, Alexandra; Gangam, Rekha; Chow, Matthew; Pitts-McCoy, Anthony; Malkani, Arnav Sunil
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4-Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-02-01
err4
PREAI
errQin, Yangzhong; Mattern, Keith A.; Zhang, Victoria; Abe, Kotoe; Kim, Jungchul; Zheng, Michelle; Gangam, Rekha; Kalinin, Alexei; Kolev, Joshua N.; Axnanda, Stephanus; Dance, Zachary E. X.; Ayesa, Umme; Ji, Yining; Grosser, Shane T.; Appiah-Amponsah, Emmanuel; McMullen, Jonathan P.
err分享
err收藏
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 2-Development of a Scalable Nickel-Catalyzed Sulfonylation
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2024-01-30
err12
PREAI
errHethcox, J. Caleb; Kim, Jungchul; Johnson, Heather C.; Ji, Yining; Chow, Matthew; Newman, Justin A.; Dirocco, Daniel A.; Mcmullen, Jonathan P.
err分享
err收藏
Accelerating reaction optimization through data-rich experimentation and machine-assisted process development
errREACTION CHEMISTRY & ENGINEERING
IF3.1
err2024-01-01
err1
PREAI
errMcMullen, Jonathan P.; Jurica, Jon A.
err分享
err收藏
Process knowledge for drug substance production via kinetic modeling, parameter estimability analysis and reaction optimization
errREACTION CHEMISTRY & ENGINEERING
IF3.1
err2024-01-01
err0
PREAI
errMoshiritabrizi, Iman; McMullen, Jonathan P.; Wyvratt, Brian M.; McAuley, Kimberley B.
err分享
err收藏
Use of a Dynamic Flow Platform To Translate a Batch Immobilized Transaminase Process to a Packed Bed Reactor for the Synthesis of an Intermediate of Nemtabrutinib使用动态流动平台将分批固定化转氨酶过程转化为填充床反应器，以合成内姆他布替尼中间体
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2023-12-15
err4
PREAI
errDi Maso, Michael J.; Kuethe, Jeffrey T.; Narsimhan, Karthik; Burris, Matthew; Chung, Cheol K.; DiBenedetto, Michael; Forstater, Jacob H.; Grosser, Shane T.; Kuhl, Nadine; Levesque, Francois; Maguire, Anne; Maloney, Kevin M.; McMullen, Jonathan P.; Prier, Christopher K.; Qi, Ji; Rivera, Nelo R.; Wang, Zhixun; Wyvratt, Brian M.; Zewge, Daniel
err分享
err收藏
Parameter estimation and estimability analysis in pharmaceutical models with uncertain inputs不确定输入药物模型的参数估计和可估性分析
errAICHE JOURNAL
IF4
err2023-06-29
err4
errOAAI
errMoshiritabrizi, Iman; Abdi, Kaveh; McMullen, Jonathan P.; Wyvratt, Brian M.; McAuley, Kimberley B.
err分享
err收藏
Amination of a Green Solvent via Immobilized Biocatalysis for the Synthesis of Nemtabrutinib通过固定化生物催化对绿色溶剂进行胺化以合成Nemtabrutinib
errACS CATALYSIS
IF13.1
err2023-05-26
err8
errOAAI
errPrier, Christopher K.; Camacho Soto, Karla; Forstater, Jacob H.; Kuhl, Nadine; Kuethe, Jeffrey T.; Cheung-Lee, Wai Ling; Di Maso, Michael J.; Eberle, Claire M.; Grosser, Shane T.; Ho, Hsing-, I; Hoyt, Erik; Maguire, Anne; Maloney, Kevin M.; Makarewicz, Amanda; McMullen, Jonathan P.; Moore, Jeffrey C.; Murphy, Grant S.; Narsimhan, Karthik; Pan, Weilan; Rivera, Nelo R.; Saha-Shah, Anumita; Thaisrivongs, David A.; Verma, Deeptak; Wyatt, Adeya; Zewge, Daniel
err分享
err收藏
Automated optimization under dynamic flow conditions
errREACTION CHEMISTRY & ENGINEERING
IF3.1
err2023-01-01
err18
PREAI
errMcMullen, Jonathan P.; Wyvratt, Brian M.
err分享
err收藏
Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction
errORGANIC PROCESS RESEARCH & DEVELOPMENT
IF3.5
err2021-11-12
err23
PREAI
errPirnot, Michael; Stone, Kevin; Wright, Timothy J.; Lamberto, David J.; Schoell, Jochen; Lam, Yu-hong; Zawatzky, Kerstin; Wang, Xiao; Dalby, Stephen M.; Fine, Adam J.; McMullen, Jonathan P.
err分享
err收藏

研究方向

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